| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Monica Pontearso, Jakub Slepicka, Anirban Bhattacharyya, Diana Spicarova, Jiri Palece. Dual effect of anandamide on spinal nociceptive transmission in control and inflammatory conditions. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 173. 2024-03-07. PMID:38452657. |
anandamide (aea) is an important modulator of nociception in the spinal dorsal horn, acting presynaptically through cannabinoid (cb |
2024-03-07 |
2024-03-10 |
Not clear |
| Jessica Parnell, Newton Martin, Annemarie Dedek, Christopher Rudyk, Jeffrey Landrigan, Justin Bellavance, Simon VanDerLoo, Eve C Tsai, Michael E Hildebran. Cannabinoid CB1 Receptor Expression and Localization in the Dorsal Horn of Male and Female Rat and Human Spinal Cord. Canadian journal of pain = Revue canadienne de la douleur. vol 7. issue 2. 2024-01-03. PMID:38170158. |
cannabinoid cb1 receptor expression and localization in the dorsal horn of male and female rat and human spinal cord. |
2024-01-03 |
2024-01-06 |
human |
| Jie Cheng, Xueling Chen, Hui Xia, Fanli Kong, Li Wang, Liang Zhong, Jiang W. Endogenous Cannabinoid Receptors Modulate Plasticity at Immature Synapses. Journal of integrative neuroscience. vol 21. issue 4. 2022-07-22. PMID:35864772. |
to explore the mechanism of endocannabinoid cannabinoid receptor 1 (cb1) receptor pathway that regulates synaptic plasticity in the dorsal horn of the spinal cord of rats with neuropathic pain at different ages. |
2022-07-22 |
2023-08-14 |
rat |
| Yulin Zhang, Jin Ke, Yuan Zhou, Xue Liu, Tianwen Huang, Feng Wan. Sex-specific characteristics of cells expressing the cannabinoid 1 receptor in the dorsal horn of the lumbar spinal cord. The Journal of comparative neurology. 2022-05-17. PMID:35580011. |
sex-specific characteristics of cells expressing the cannabinoid 1 receptor in the dorsal horn of the lumbar spinal cord. |
2022-05-17 |
2023-08-13 |
Not clear |
| Priodarshi Roychoudhury, Astha Koolwal Kapoor, Declan Walsh, Henry Cortes, Hance Clark. State of the science: cannabis and cannabinoids in palliative medicine-the potential. BMJ supportive & palliative care. vol 11. issue 3. 2021-08-23. PMID:33903260. |
opioid and cannabinoid receptors have overlapping neuroanatomical receptor distribution, particularly at the dorsal horn, dorsal striatum and locus coeruleus. |
2021-08-23 |
2023-08-13 |
Not clear |
| Enza Palazzo, Livio Luongo, Vito de Novellis, Francesco Rossi, Sabatino Maion. The Role of Cannabinoid Receptors in the Descending Modulation of Pain. Pharmaceuticals (Basel, Switzerland). vol 3. issue 8. 2020-10-01. PMID:27713370. |
like opioids, cannabinoids produce centrally-mediated analgesia by activating a descending pathway which includes pag and its projection to downstream rvm neurons, which in turn send inhibitory projections to the dorsal horn of the spinal cord. |
2020-10-01 |
2023-08-13 |
Not clear |
| Juan Niu, Dujuan Huang, Rui Zhou, MingXia Yue, Tao Xu, Junna Yang, Li He, Hong Tian, XiaoHong Liu, Junwei Zen. Activation of dorsal horn cannabinoid CB2 receptor suppresses the expression of P2Y Journal of neuroinflammation. vol 14. issue 1. 2018-05-29. PMID:28899427. |
activation of dorsal horn cannabinoid cb2 receptor suppresses the expression of p2y more evidence suggests that dorsal spinal cord microglia is an important site contributing to cb2 receptor-mediated analgesia. |
2018-05-29 |
2023-08-13 |
Not clear |
| Lucindo J Quintans-Júnior, Adriano A S Araújo, Renan G Brito, Priscila L Santos, Jullyana S S Quintans, Paula P Menezes, Mairim R Serafini, Gabriel F Silva, Flavio M S Carvalho, Nicole K Brogden, Kathleen A Sluk. β-caryophyllene, a dietary cannabinoid, complexed with β-cyclodextrin produced anti-hyperalgesic effect involving the inhibition of Fos expression in superficial dorsal horn. Life sciences. vol 149. 2016-07-28. PMID:26883973. |
β-caryophyllene, a dietary cannabinoid, complexed with β-cyclodextrin produced anti-hyperalgesic effect involving the inhibition of fos expression in superficial dorsal horn. |
2016-07-28 |
2023-08-13 |
mouse |
| Elaine M Jennings, Bright N Okine, Weredeselam M Olango, Michelle Roche, David P Fin. Repeated forced swim stress differentially affects formalin-evoked nociceptive behaviour and the endocannabinoid system in stress normo-responsive and stress hyper-responsive rat strains. Progress in neuro-psychopharmacology & biological psychiatry. vol 64. 2016-05-31. PMID:25988529. |
given the well-documented role of the endocannabinoid system in stress and pain, we investigated associated alterations in endocannabinoid signalling in the dorsal horn of the spinal cord and amygdala. |
2016-05-31 |
2023-08-13 |
rat |
| Eszter Horváth, Stephen G Woodhams, Rita Nyilas, Christopher M Henstridge, Masanobu Kano, Kenji Sakimura, Masahiko Watanabe, István Katon. Heterogeneous presynaptic distribution of monoacylglycerol lipase, a multipotent regulator of nociceptive circuits in the mouse spinal cord. The European journal of neuroscience. vol 39. issue 3. 2014-09-25. PMID:24494682. |
moreover, the presence of mgl in additional terminal types raises the possibility that mgl may play distinct regulatory roles in synaptic endocannabinoid or prostaglandin signaling according to its different cellular locations in the dorsal horn pain circuitry. |
2014-09-25 |
2023-08-12 |
mouse |
| Zoltán Hegyi, Krisztina Holló, Gréta Kis, Ken Mackie, Miklós Anta. Differential distribution of diacylglycerol lipase-alpha and N-acylphosphatidylethanolamine-specific phospholipase d immunoreactivity in the superficial spinal dorsal horn of rats. Glia. vol 60. issue 9. 2013-01-14. PMID:22573306. |
although it is documented that cannabinoid-1 receptors are strongly expressed in the superficial spinal dorsal horn, the cellular distribution of enzymes that can synthesize endocannabinoid ligands is less well studied. |
2013-01-14 |
2023-08-12 |
rat |
| Wei Xiong, Tanxing Cui, Kejun Cheng, Fei Yang, Shao-Rui Chen, Dan Willenbring, Yun Guan, Hui-Lin Pan, Ke Ren, Yan Xu, Li Zhan. Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors. The Journal of experimental medicine. vol 209. issue 6. 2012-08-13. PMID:22585736. |
the cannabinoids significantly potentiate glycine currents in dorsal horn neurons in rat spinal cord slices. |
2012-08-13 |
2023-08-12 |
mouse |
| Akiko Okada-Ogawa, Masayuki Kurose, Ian D Men. Attenuation of cannabinoid-induced inhibition of medullary dorsal horn neurons by a kappa-opioid receptor antagonist. Brain research. vol 1359. 2011-01-25. PMID:20807519. |
the present study examined the ability of nor-bni to prevent cannabinoid-induced inhibition of medullary dorsal horn (mdh) nociceptive neurons and antinociception produced by the cannabinoid agonist win 55,212-2 (win-2). |
2011-01-25 |
2023-08-12 |
rat |
| Akiko Okada-Ogawa, Masayuki Kurose, Ian D Men. Attenuation of cannabinoid-induced inhibition of medullary dorsal horn neurons by a kappa-opioid receptor antagonist. Brain research. vol 1359. 2011-01-25. PMID:20807519. |
these results indicate that cannabinoid inhibition of nociceptive reflexes produced by win-2 and thc may result from inhibition of dorsal horn neurons through a kor-dependent mechanism. |
2011-01-25 |
2023-08-12 |
rat |
| Zoltán Hegyi, Gréta Kis, Krisztina Holló, Catherine Ledent, Miklós Anta. Neuronal and glial localization of the cannabinoid-1 receptor in the superficial spinal dorsal horn of the rodent spinal cord. The European journal of neuroscience. vol 30. issue 2. 2010-01-08. PMID:19614976. |
although it is extensively documented that the cannabinoid-1 receptor (cb(1)-r) is strongly expressed in the superficial spinal dorsal horn, its cellular distribution is poorly defined, hampering our interpretation of the effect of cannabinoids on pain processing spinal neural circuits. |
2010-01-08 |
2023-08-12 |
Not clear |
| Alejandro J Pernía-Andrade, Ako Kato, Robert Witschi, Rita Nyilas, István Katona, Tamás F Freund, Masahiko Watanabe, Jörg Filitz, Wolfgang Koppert, Jürgen Schüttler, Guangchen Ji, Volker Neugebauer, Giovanni Marsicano, Beat Lutz, Horacio Vanegas, Hanns Ulrich Zeilhofe. Spinal endocannabinoids and CB1 receptors mediate C-fiber-induced heterosynaptic pain sensitization. Science (New York, N.Y.). vol 325. issue 5941. 2009-08-20. PMID:19661434. |
we found that endocannabinoids, produced upon strong nociceptive stimulation, activated type 1 cannabinoid (cb1) receptors on inhibitory dorsal horn neurons to reduce the synaptic release of gamma-aminobutyric acid and glycine and thus rendered nociceptive neurons excitable by nonpainful stimuli. |
2009-08-20 |
2023-08-12 |
Not clear |
| Akiko Ogawa, Ian D Men. Differential effects of the cannabinoid receptor agonist, WIN 55,212-2, on lamina I and lamina V spinal trigeminal nucleus caudalis neurons. Pain. vol 141. issue 3. 2009-04-28. PMID:19114295. |
direct application of cannabinoids to the medullary dorsal horn (mdh) inhibits lamina v nociceptive neurons. |
2009-04-28 |
2023-08-12 |
rat |
| A Ogawa, I D Men. The cannabinoid receptor agonist, WIN 55,212-2, inhibits cool-specific lamina I medullary dorsal horn neurons. Neuroscience. vol 143. issue 1. 2007-01-26. PMID:16949215. |
the effect of cannabinoids on thermoreceptive specific neurons in the spinal or medullary dorsal horn remains unknown. |
2007-01-26 |
2023-08-12 |
rat |
| A Ogawa, I D Men. The cannabinoid receptor agonist, WIN 55,212-2, inhibits cool-specific lamina I medullary dorsal horn neurons. Neuroscience. vol 143. issue 1. 2007-01-26. PMID:16949215. |
the cannabinoid cb1/cb2 receptor agonist, win 55,212-2 (win-2), was locally applied to the medullary dorsal horn and the neuronal activity evoked by cooling the receptive field was recorded. |
2007-01-26 |
2023-08-12 |
rat |
| Yasuhiko Kawasaki, Tatsuro Kohno, Ru-Rong J. Different effects of opioid and cannabinoid receptor agonists on C-fiber-induced extracellular signal-regulated kinase activation in dorsal horn neurons in normal and spinal nerve-ligated rats. The Journal of pharmacology and experimental therapeutics. vol 316. issue 2. 2006-04-04. PMID:16221738. |
in this study, we examined whether opioids and cannabinoids can affect c-fiber-induced erk phosphorylation (perk) in dorsal horn neurons in spinal cord slices from normal and spinal nerve-ligated rats. |
2006-04-04 |
2023-08-12 |
rat |