| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tharick A Pascoal, Andrea L Benedet, Dana L Tudorascu, Joseph Therriault, Sulantha Mathotaarachchi, Melissa Savard, Firoza Z Lussier, Cécile Tissot, Mira Chamoun, Min Su Kang, Jenna Stevenson, Gassan Massarweh, Marie-Christine Guiot, Jean-Paul Soucy, Serge Gauthier, Pedro Rosa-Net. Longitudinal 18F-MK-6240 tau tangles accumulation follows Braak stages. Brain : a journal of neurology. 2021-09-13. PMID:34515754. |
our results suggest that [18f]mk-6240 suvr is able to detect longitudinal tau accumulation in asymptomatic and symptomatic alzheimer's disease. |
2021-09-13 |
2023-08-13 |
human |
| Tharick A Pascoal, Andrea L Benedet, Dana L Tudorascu, Joseph Therriault, Sulantha Mathotaarachchi, Melissa Savard, Firoza Z Lussier, Cécile Tissot, Mira Chamoun, Min Su Kang, Jenna Stevenson, Gassan Massarweh, Marie-Christine Guiot, Jean-Paul Soucy, Serge Gauthier, Pedro Rosa-Net. Longitudinal 18F-MK-6240 tau tangles accumulation follows Braak stages. Brain : a journal of neurology. 2021-09-13. PMID:34515754. |
finally, our postmortem findings supported [18f]mk-6240 suvr as a biomarker to stage tau pathology in alzheimer's disease patients. |
2021-09-13 |
2023-08-13 |
human |
| Masato Hosokawa, Masami Masuda-Suzukake, Hiroshi Shitara, Aki Shimozawa, Genjiro Suzuki, Hiromi Kondo, Takashi Nonaka, William Campbell, Tetsuaki Arai, Masato Hasegaw. Development of a novel tau propagation mouse model endogenously expressing 3 and 4 repeat tau isoforms. Brain : a journal of neurology. 2021-09-13. PMID:34515757. |
although a number of models for tau propagation have been reported, most utilize 4-repeat human tau transgenic mice or adult wild-type mice expressing only endogenous 4-repeat tau and these models have not been able to reproduce the pathology of alzheimer's disease in which 3-repeat and 4-repeat tau accumulate simultaneously, or that of pick's disease in which only 3-repeat tau is aggregated. |
2021-09-13 |
2023-08-13 |
mouse |
| Masato Hosokawa, Masami Masuda-Suzukake, Hiroshi Shitara, Aki Shimozawa, Genjiro Suzuki, Hiromi Kondo, Takashi Nonaka, William Campbell, Tetsuaki Arai, Masato Hasegaw. Development of a novel tau propagation mouse model endogenously expressing 3 and 4 repeat tau isoforms. Brain : a journal of neurology. 2021-09-13. PMID:34515757. |
at 8-9 months following intracerebral injection of mice, histopathological and biochemical analyses revealed that the abnormal accumulation of tau was seed-dependent, with 3- and 4-repeat tau in alzheimer's disease-injected brains, 4-repeat tau only in corticobasal degeneration-injected brains, and 3-repeat tau only in pick disease-injected brains, all of which contained isoforms related to those found in the injected seeds. |
2021-09-13 |
2023-08-13 |
mouse |
| Kristof Van Kolen, Thomas J Malia, Clara Theunis, Rupesh Nanjunda, Alexey Teplyakov, Robin Ernst, Sheng-Jiun Wu, Jinquan Luo, Marianne Borgers, Marc Vandermeeren, Astrid Bottelbergs, Cindy Wintmolders, Eilyn Lacy, Hervé Maurin, Peter Larsen, Roland Willems, Tom Van De Casteele, Gallen Triana-Baltzer, Randy Slemmon, Wendy Galpern, John Q Trojanowski, Hong Sun, Marc H Mercke. Discovery and Functional Characterization of hPT3, a Humanized Anti-Phospho Tau Selective Monoclonal Antibody. Journal of Alzheimer's disease : JAD. vol 77. issue 4. 2021-09-10. PMID:32894244. |
as a consequence of the discovery of an extracellular component responsible for the progression of tau pathology, tau immunotherapy is being extensively explored in both preclinical and clinical studies as a disease modifying strategy for the treatment of alzheimer's disease. |
2021-09-10 |
2023-08-13 |
Not clear |
| Shubir Dutt, Yanrong Li, Mara Mather, Daniel A Natio. Brainstem Volumetric Integrity in Preclinical and Prodromal Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 77. issue 4. 2021-09-10. PMID:32925030. |
neuropathological studies have suggested the tau pathology observed in alzheimer's disease (ad) originates in brainstem nuclei, but no studies to date have quantified brainstem volumes in clinical populations with biomarker-confirmed mild cognitive impairment (mci) or dementia due to ad or determined the value of brainstem volumetrics in predicting dementia. |
2021-09-10 |
2023-08-13 |
Not clear |
| Adam O Ghoweri, Peter Gagolewicz, Hilaree N Frazier, John C Gant, R David Andrew, Brian M Bennett, Olivier Thibaul. Neuronal Calcium Imaging, Excitability, and Plasticity Changes in the Aldh2-/- Mouse Model of Sporadic Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 77. issue 4. 2021-09-10. PMID:32925058. |
dysregulated signaling in neurons and astrocytes participates in pathophysiological alterations seen in the alzheimer's disease brain, including increases in amyloid-β, hyperphosphorylated tau, inflammation, calcium dysregulation, and oxidative stress. |
2021-09-10 |
2023-08-13 |
mouse |
| Leah C Beauchamp, Xiang M Liu, Amelia Sedjahtera, Mirjana Bogeski, Laura J Vella, Ashley I Bush, Paul A Adlard, Kevin J Barnha. S-Adenosylmethionine Rescues Cognitive Deficits in the rTg4510 Animal Model by Stabilizing Protein Phosphatase 2A and Reducing Phosphorylated Tau. Journal of Alzheimer's disease : JAD. vol 77. issue 4. 2021-09-10. PMID:32925070. |
alterations in the methionine cycle and abnormal tau phosphorylation are implicated in many neurodegenerative diseases, including alzheimer's disease and frontotemporal dementia. |
2021-09-10 |
2023-08-13 |
mouse |
| Feng Zhang, Ru-Jia Zhong, Cheng Cheng, Song Li, Wei-Dong L. New therapeutics beyond amyloid-β and tau for the treatment of Alzheimer's disease. Acta pharmacologica Sinica. vol 42. issue 9. 2021-09-10. PMID:33268824. |
new therapeutics beyond amyloid-β and tau for the treatment of alzheimer's disease. |
2021-09-10 |
2023-08-13 |
Not clear |
| Lei Zhu, Xiao-Jie Hou, Xiao-Hang Che, Ting-Shuo Zhou, Xiao-Qi Liu, Chun-Fu Wu, Jing-Yu Yan. Pseudoginsenoside-F11 attenuates cognitive dysfunction and tau phosphorylation in sporadic Alzheimer's disease rat model. Acta pharmacologica Sinica. vol 42. issue 9. 2021-09-10. PMID:33277592. |
pseudoginsenoside-f11 attenuates cognitive dysfunction and tau phosphorylation in sporadic alzheimer's disease rat model. |
2021-09-10 |
2023-08-13 |
mouse |
| Lei Zhu, Xiao-Jie Hou, Xiao-Hang Che, Ting-Shuo Zhou, Xiao-Qi Liu, Chun-Fu Wu, Jing-Yu Yan. Pseudoginsenoside-F11 attenuates cognitive dysfunction and tau phosphorylation in sporadic Alzheimer's disease rat model. Acta pharmacologica Sinica. vol 42. issue 9. 2021-09-10. PMID:33277592. |
we previously reported that pseudoginsenoside-f11 (pf11), an ocotillol-type saponin, significantly ameliorated alzheimer's disease (ad)-associated cognitive defects in app/ps1 and samp8 mice by inhibiting aβ aggregation and tau hyperphosphorylation, suggesting a potential therapeutic effect of pf11 in the treatment of ad. |
2021-09-10 |
2023-08-13 |
mouse |
| Dana Vigasova, Michal Nemergut, Barbora Liskova, Jiri Damborsk. Multi-pathogen infections and Alzheimer's disease. Microbial cell factories. vol 20. issue 1. 2021-09-10. PMID:33509204. |
alzheimer's disease (ad) is a chronic neurodegenerative disease associated with the overproduction and accumulation of amyloid-β peptide and hyperphosphorylation of tau proteins in the brain. |
2021-09-10 |
2023-08-13 |
Not clear |
| Abdul-Hamid Emwas, Mawadda Alghrably, Manel Dhahri, Abeer Sharfalddin, Rawiah Alsiary, Mariusz Jaremko, Gavino Faa, Marcello Campagna, Terenzio Congiu, Monica Piras, Marco Piludu, Giuseppina Pichiri, Pierpaolo Coni, Joanna Izabela Lachowic. Living with the enemy: from protein-misfolding pathologies we know, to those we want to know. Ageing research reviews. vol 70. 2021-09-10. PMID:34119687. |
in this respect, aat polymorphism may cause an imbalance of metal ions, which could be correlated with the aggregation of amylin, tau, amyloid beta, and alpha synuclein proteins in type 2 diabetes mellitus (t2dm), alzheimer's and parkinson's diseases, respectively. |
2021-09-10 |
2023-08-13 |
Not clear |
| Huiqin Zhang, Wei Wei, Ming Zhao, Lina Ma, Xuefan Jiang, Hui Pei, Yu Cao, Hao L. Interaction between Aβ and Tau in the Pathogenesis of Alzheimer's Disease. International journal of biological sciences. vol 17. issue 9. 2021-09-10. PMID:34239348. |
interaction between aβ and tau in the pathogenesis of alzheimer's disease. |
2021-09-10 |
2023-08-13 |
Not clear |
| Huiqin Zhang, Wei Wei, Ming Zhao, Lina Ma, Xuefan Jiang, Hui Pei, Yu Cao, Hao L. Interaction between Aβ and Tau in the Pathogenesis of Alzheimer's Disease. International journal of biological sciences. vol 17. issue 9. 2021-09-10. PMID:34239348. |
extracellular neuritic plaques composed of amyloid‑β (aβ) protein and intracellular neurofibrillary tangles containing phosphorylated tau protein are the two hallmark proteins of alzheimer's disease (ad), and the separate neurotoxicity of these proteins in ad has been extensively studied. |
2021-09-10 |
2023-08-13 |
Not clear |
| Kai-Min Wu, Ya-Ru Zhang, Yu-Yuan Huang, Qiang Dong, Lan Tan, Jin-Tai Y. The role of the immune system in Alzheimer's disease. Ageing research reviews. vol 70. 2021-09-10. PMID:34273589. |
alzheimer's disease (ad) is the most common neurodegenerative disorder where the accumulation of amyloid plaques and the formation of tau tangles are the prominent pathological hallmarks. |
2021-09-10 |
2023-08-13 |
Not clear |
| Thomas Vogels, Gréta Vargová, Veronika Brezováková, Wim Hendricus Quint, Tomáš Hromádk. Viral Delivery of Non-Mutated Human Truncated Tau to Neurons Recapitulates Key Features of Human Tauopathy in Wild-Type Mice. Journal of Alzheimer's disease : JAD. vol 77. issue 2. 2021-09-09. PMID:32675411. |
neuronal accumulation of hyperphosphorylated and truncated tau aggregates is one of the major defining factors and key drivers of neurodegeneration in alzheimer's disease and other tauopathies. |
2021-09-09 |
2023-08-13 |
mouse |
| Andrea González, Leonardo Guzmán-Martínez, Ricardo B Maccion. Plasma Tau Variants Detected by a Novel Anti-Tau Monoclonal Antibody: A Potential Biomarker for Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 77. issue 2. 2021-09-09. PMID:32741827. |
plasma tau variants detected by a novel anti-tau monoclonal antibody: a potential biomarker for alzheimer's disease. |
2021-09-09 |
2023-08-13 |
Not clear |
| Yan-Juan Wang, Wei-Gang Gong, Qing-Guo Ren, Zhi-Jun Zhan. Escitalopram Alleviates Alzheimer's Disease-Type Tau Pathologies in the Aged P301L Tau Transgenic Mice. Journal of Alzheimer's disease : JAD. vol 77. issue 2. 2021-09-09. PMID:32741828. |
escitalopram alleviates alzheimer's disease-type tau pathologies in the aged p301l tau transgenic mice. |
2021-09-09 |
2023-08-13 |
mouse |
| Yan-Juan Wang, Wei-Gang Gong, Qing-Guo Ren, Zhi-Jun Zhan. Escitalopram Alleviates Alzheimer's Disease-Type Tau Pathologies in the Aged P301L Tau Transgenic Mice. Journal of Alzheimer's disease : JAD. vol 77. issue 2. 2021-09-09. PMID:32741828. |
the inhibition of tau hyperphosphorylation is one of the most promising therapeutic targets for the development of alzheimer's disease (ad) modifying drugs. |
2021-09-09 |
2023-08-13 |
mouse |