| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sara Garcia-Ratés, Paul Morrill, Henry Tu, Gwenael Pottiez, Antoine-Scott Badin, Cristina Tormo-Garcia, Catherine Heffner, Clive W Coen, Susan A Greenfiel. (I) Pharmacological profiling of a novel modulator of the α7 nicotinic receptor: Blockade of a toxic acetylcholinesterase-derived peptide increased in Alzheimer brains. Neuropharmacology. vol 105. 2017-06-21. PMID:26867503. |
here we show for the first time that (1) a peptide derived from acetylcholinesterase, with independent trophic functions that turn toxic in maturity, is significantly raised in the alzheimer midbrain and cerebrospinal fluid; (2) a synthetic version of this peptide enhances calcium influx and eventual production of amyloid beta and tau phosphorylation via an allosteric site on the α7 nicotinic receptor; (3) a synthetic cyclic version of this peptide is neuroprotective against the toxicity not only of its linear counterpart but also of amyloid beta, thereby opening up the prospect of a novel therapeutic approach. |
2017-06-21 |
2023-08-13 |
Not clear |
| Yujin Seo, Kwang-Su Park, Taewoong Ha, Mi Kyoung Kim, Yu Jin Hwang, Junghee Lee, Hoon Ryu, Hyunah Choo, Youhoon Chon. A Smart Near-Infrared Fluorescence Probe for Selective Detection of Tau Fibrils in Alzheimer's Disease. ACS chemical neuroscience. vol 7. issue 11. 2017-06-21. PMID:27576176. |
a smart near-infrared fluorescence probe for selective detection of tau fibrils in alzheimer's disease. |
2017-06-21 |
2023-08-13 |
Not clear |
| Meryem Tardivel, Séverine Bégard, Luc Bousset, Simon Dujardin, Audrey Coens, Ronald Melki, Luc Buée, Morvane Coli. Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies. Acta neuropathologica communications. vol 4. issue 1. 2017-06-21. PMID:27809932. |
we show that the microtubule-associated protein tau, a key player in alzheimer's disease, is a bona fide constituent of tnts. |
2017-06-21 |
2023-08-13 |
Not clear |
| Yue Hu, Kai-Yi Zhou, Ze-Jian Wang, Yang Lu, Ming Yi. N-stearoyl-l-Tyrosine inhibits the cell senescence and apoptosis induced by H Chemico-biological interactions. vol 272. 2017-06-20. PMID:28526263. |
therefore, tau protein has been focused recently as the new target for the treatment of alzheimer's disease. |
2017-06-20 |
2023-08-13 |
human |
| Tara E Tracy, Peter Dongmin Sohn, S Sakura Minami, Chao Wang, Sang-Won Min, Yaqiao Li, Yungui Zhou, David Le, Iris Lo, Ravikumar Ponnusamy, Xin Cong, Birgit Schilling, Lisa M Ellerby, Richard L Huganir, Li Ga. Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss. Neuron. vol 90. issue 2. 2017-06-19. PMID:27041503. |
tau toxicity has been implicated in the emergence of synaptic dysfunction in alzheimer's disease (ad), but the mechanism by which tau alters synapse physiology and leads to cognitive decline is unclear. |
2017-06-19 |
2023-08-13 |
mouse |
| Frederik J R Rombouts, José-Ignacio Andrés, Manuela Ariza, José Manuel Alonso, Nigel Austin, Astrid Bottelbergs, Lu Chen, Vladimir Chupakhin, Erna Cleiren, Katleen Fierens, Alberto Fontana, Xavier Langlois, Joseph E Leenaerts, Jonas Mariën, Carolina Martínez Lamenca, Rhys Salter, Mark E Schmidt, Paula Te Riele, Cindy Wintmolders, Andrés A Trabanco, Wei Zhang, Gregor Macdonald, Dieder Moechar. Discovery of N-(Pyridin-4-yl)-1,5-naphthyridin-2-amines as Potential Tau Pathology PET Tracers for Alzheimer's Disease. Journal of medicinal chemistry. vol 60. issue 4. 2017-06-16. PMID:28106992. |
discovery of n-(pyridin-4-yl)-1,5-naphthyridin-2-amines as potential tau pathology pet tracers for alzheimer's disease. |
2017-06-16 |
2023-08-13 |
human |
| Roberto Cappa. 'From past to future' - deciphering the molecular basis of Alzheimer's disease through the pages of the Journal of Neurochemistry. Journal of neurochemistry. vol 139 Suppl 2. 2017-06-15. PMID:26996965. |
this coincided with a number of the highly cited alzheimer's disease studies which described fundamental aspects of the neurochemistry of alzheimer's disease and encompassed the themes of oxidative stress and post-translational modifications, cholinergic system, tau, purification of aβ, defining the aβ toxic species, mechanism of amyloid precursor protein processing, and the development of diagnostics and therapeutics. |
2017-06-15 |
2023-08-13 |
Not clear |
| Todd E Gold. Overcoming translational barriers impeding development of Alzheimer's disease modifying therapies. Journal of neurochemistry. vol 139 Suppl 2. 2017-06-15. PMID:27145445. |
it has now been ~ 30 years since the alzheimer's disease (ad) research entered what may be termed the 'molecular era' that began with the identification of the amyloid β protein (aβ) as the primary component of amyloid within senile plaques and cerebrovascular amyloid and the microtubule-associated protein tau as the primary component of neurofibrillary tangles in the ad brain. |
2017-06-15 |
2023-08-13 |
Not clear |
| Susanne Wegmann, Samantha Nicholls, Shuko Takeda, Zhanyun Fan, Bradley T Hyma. Formation, release, and internalization of stable tau oligomers in cells. Journal of neurochemistry. vol 139. issue 6. 2017-06-14. PMID:27731899. |
tau is a neuronal microtubule-binding protein that, in alzheimer's disease and other neurodegenerative diseases, can form oligomeric and large fibrillar aggregates, which deposit in neurofibrillary tangles. |
2017-06-14 |
2023-08-13 |
Not clear |
| Andre Voelzmann, Pilar Okenve-Ramos, Yue Qu, Monika Chojnowska-Monga, Manuela Del Caño-Espinel, Andreas Prokop, Natalia Sanchez-Sorian. Tau and spectraplakins promote synapse formation and maintenance through Jun kinase and neuronal trafficking. eLife. vol 5. 2017-06-13. PMID:27501441. |
therefore, our findings suggest novel explanations for intellectual disability in tau deficient individuals, as well as early synapse loss in dementias including alzheimer's disease. |
2017-06-13 |
2023-08-13 |
drosophila_melanogaster |
| Lakshini H S Mendis, Angus C Grey, Richard L M Faull, Maurice A Curti. Hippocampal lipid differences in Alzheimer's disease: a human brain study using matrix-assisted laser desorption/ionization-imaging mass spectrometry. Brain and behavior. vol 6. issue 10. 2017-06-12. PMID:27781133. |
alzheimer's disease (ad), the leading cause of dementia, is pathologically characterized by β-amyloid plaques and tau tangles. |
2017-06-12 |
2023-08-13 |
human |
| Hanna Cho, Jae Yong Choi, Mi Song Hwang, You Jin Kim, Hye Mi Lee, Hye Sun Lee, Jae Hoon Lee, Young Hoon Ryu, Myung Sik Lee, Chul Hyoung Lyo. In vivo cortical spreading pattern of tau and amyloid in the Alzheimer disease spectrum. Annals of neurology. vol 80. issue 2. 2017-06-06. PMID:27323247. |
in vivo cortical spreading pattern of tau and amyloid in the alzheimer disease spectrum. |
2017-06-06 |
2023-08-13 |
Not clear |
| Hanna Cho, Jae Yong Choi, Mi Song Hwang, You Jin Kim, Hye Mi Lee, Hye Sun Lee, Jae Hoon Lee, Young Hoon Ryu, Myung Sik Lee, Chul Hyoung Lyo. In vivo cortical spreading pattern of tau and amyloid in the Alzheimer disease spectrum. Annals of neurology. vol 80. issue 2. 2017-06-06. PMID:27323247. |
to determine the in vivo cortical spreading pattern of tau and amyloid and to establish positron emission tomography (pet) image-based tau staging in the alzheimer disease (ad) spectrum. |
2017-06-06 |
2023-08-13 |
Not clear |
| Jason Chen, Jin-Tai Yu, Kevin Wojta, Hui-Fu Wang, Henrik Zetterberg, Kaj Blennow, Jennifer S Yokoyama, Michael W Weiner, Joel H Kramer, Howard Rosen, Bruce L Miller, Giovanni Coppola, Adam L Boxe. Genome-wide association study identifies Neurology. vol 88. issue 7. 2017-06-06. PMID:28100725. |
genome-wide association study identifies to identify genetic loci associated with plasma tau concentrations in healthy elders and individuals with alzheimer disease. |
2017-06-06 |
2023-08-13 |
Not clear |
| Brian A Gordon, Karl Friedrichsen, Matthew Brier, Tyler Blazey, Yi Su, Jon Christensen, Patricia Aldea, Jonathan McConathy, David M Holtzman, Nigel J Cairns, John C Morris, Anne M Fagan, Beau M Ances, Tammie L S Benzinge. The relationship between cerebrospinal fluid markers of Alzheimer pathology and positron emission tomography tau imaging. Brain : a journal of neurology. vol 139. issue Pt 8. 2017-06-05. PMID:27286736. |
the relationship between cerebrospinal fluid markers of alzheimer pathology and positron emission tomography tau imaging. |
2017-06-05 |
2023-08-13 |
Not clear |
| Brian A Gordon, Karl Friedrichsen, Matthew Brier, Tyler Blazey, Yi Su, Jon Christensen, Patricia Aldea, Jonathan McConathy, David M Holtzman, Nigel J Cairns, John C Morris, Anne M Fagan, Beau M Ances, Tammie L S Benzinge. The relationship between cerebrospinal fluid markers of Alzheimer pathology and positron emission tomography tau imaging. Brain : a journal of neurology. vol 139. issue Pt 8. 2017-06-05. PMID:27286736. |
tau tracers have recently been introduced into the field, although the utility of the tracer and its relationship to other alzheimer biomarkers are still unknown. |
2017-06-05 |
2023-08-13 |
Not clear |
| Shuko Takeda, Caitlin Commins, Sarah L DeVos, Chloe K Nobuhara, Susanne Wegmann, Allyson D Roe, Isabel Costantino, Zhanyun Fan, Samantha B Nicholls, Alexis E Sherman, Ana T Trisini Lipsanopoulos, Clemens R Scherzer, George A Carlson, Rose Pitstick, Elaine R Peskind, Murray A Raskind, Ge Li, Thomas J Montine, Matthew P Frosch, Bradley T Hyma. Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients. Annals of neurology. vol 80. issue 3. 2017-06-05. PMID:27351289. |
seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of alzheimer's disease mouse model and human patients. |
2017-06-05 |
2023-08-13 |
mouse |
| Shuko Takeda, Caitlin Commins, Sarah L DeVos, Chloe K Nobuhara, Susanne Wegmann, Allyson D Roe, Isabel Costantino, Zhanyun Fan, Samantha B Nicholls, Alexis E Sherman, Ana T Trisini Lipsanopoulos, Clemens R Scherzer, George A Carlson, Rose Pitstick, Elaine R Peskind, Murray A Raskind, Ge Li, Thomas J Montine, Matthew P Frosch, Bradley T Hyma. Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients. Annals of neurology. vol 80. issue 3. 2017-06-05. PMID:27351289. |
cerebrospinal fluid (csf) tau is an excellent surrogate marker for assessing neuropathological changes that occur in alzheimer's disease (ad) patients. |
2017-06-05 |
2023-08-13 |
mouse |
| Ruben Smith, Andreas Puschmann, Michael Schöll, Tomas Ohlsson, John van Swieten, Michael Honer, Elisabet Englund, Oskar Hansso. 18F-AV-1451 tau PET imaging correlates strongly with tau neuropathology in MAPT mutation carriers. Brain : a journal of neurology. vol 139. issue Pt 9. 2017-06-05. PMID:27357347. |
this mutation results in 3- and 4-repeat tau aggregates similar to those in alzheimer's disease, and many of the mutation carriers initially suffer from memory impairment and temporal lobe atrophy. |
2017-06-05 |
2023-08-13 |
Not clear |
| Srinivas Ayyadevara, Meenakshisundaram Balasubramaniam, Paul A Parcon, Steven W Barger, W Sue T Griffin, Ramani Alla, Alan J Tackett, Samuel G Mackintosh, Emanuel Petricoin, Weidong Zhou, Robert J Shmookler Rei. Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls. Aging cell. vol 15. issue 5. 2017-06-05. PMID:27448508. |
although total detergent-insoluble aggregates from alzheimer's and controls had similar protein content, within the fractions isolated by tau or aβ1-42 pulldown, the protein constituents of alzheimer-derived aggregates were more abundant, diverse, and post-translationally modified than those from controls. |
2017-06-05 |
2023-08-13 |
human |