| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| En-Sheng Yao, Yan Tang, Xing-Hua Liu, Ming-Huan Wan. TPPU protects tau from H Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 36. issue 6. 2017-05-05. PMID:27924507. |
tppu protects tau from h neurofibrillary pathology of abnormally hyperphosphorylated tau is a hallmark of alzheimer's disease (ad) and other tauopathies. |
2017-05-05 |
2023-08-13 |
Not clear |
| Sook Wern Chua, Alberto Cornejo, Janet van Eersel, Claire H Stevens, Inmaculada Vaca, Mercedes Cueto, Michael Kassiou, Amadeus Gladbach, Alex Macmillan, Lev Lewis, Renee Whan, Lars M Ittne. The Polyphenol Altenusin Inhibits in Vitro Fibrillization of Tau and Reduces Induced Tau Pathology in Primary Neurons. ACS chemical neuroscience. vol 8. issue 4. 2017-05-02. PMID:28067492. |
in alzheimer's disease, the microtubule-associated protein tau forms intracellular neurofibrillary tangles (nfts). |
2017-05-02 |
2023-08-13 |
mouse |
| Olga Voevodskaya, Pia C Sundgren, Olof Strandberg, Henrik Zetterberg, Lennart Minthon, Kaj Blennow, Lars-Olof Wahlund, Eric Westman, Oskar Hansso. Myo-inositol changes precede amyloid pathology and relate to APOE genotype in Alzheimer disease. Neurology. vol 86. issue 19. 2017-04-28. PMID:27164711. |
we aimed to test whether in vivo levels of magnetic resonance spectroscopy (mrs) metabolites myo-inositol (mi), n-acetylaspartate (naa), and choline are abnormal already during preclinical alzheimer disease (ad), relating these changes to amyloid or tau pathology, and functional connectivity. |
2017-04-28 |
2023-08-13 |
Not clear |
| Ana Lopez, Suzee E Lee, Kevin Wojta, Eliana Marisa Ramos, Eric Klein, Jason Chen, Adam L Boxer, Maria Luisa Gorno-Tempini, Daniel H Geschwind, Lars Schlotawa, Nikolay V Ogryzko, Eileen H Bigio, Emily Rogalski, Sandra Weintraub, Marsel M Mesulam, Angeleen Fleming, Giovanni Coppola, Bruce L Miller, David C Rubinsztei. A152T tau allele causes neurodegeneration that can be ameliorated in a zebrafish model by autophagy induction. Brain : a journal of neurology. vol 140. issue 4. 2017-04-25. PMID:28334843. |
a rare tau variant p.a152t was reported as a risk factor for frontotemporal dementia spectrum and alzheimer's disease in an initial case-control study. |
2017-04-25 |
2023-08-13 |
human |
| A S M Hung, Y Liang, Tony C H Chow, H C Tang, Sharon L Y Wu, M S M Wai, D T Ye. Mutated tau, amyloid and neuroinflammation in Alzheimer disease-A brief review. Progress in histochemistry and cytochemistry. vol 51. issue 1. 2017-04-21. PMID:26851150. |
mutated tau, amyloid and neuroinflammation in alzheimer disease-a brief review. |
2017-04-21 |
2023-08-13 |
Not clear |
| A S M Hung, Y Liang, Tony C H Chow, H C Tang, Sharon L Y Wu, M S M Wai, D T Ye. Mutated tau, amyloid and neuroinflammation in Alzheimer disease-A brief review. Progress in histochemistry and cytochemistry. vol 51. issue 1. 2017-04-21. PMID:26851150. |
this review discussed the importance of mutated tau, amyloid and neuroinflammatory factors and microglia in alzheimer disease. |
2017-04-21 |
2023-08-13 |
Not clear |
| Zhihui Gai, Kang Li, Huanrui Sun, Xiaojun She, Bo Cui, Rui Wan. Effects of chronic noise on mRNA and protein expression of CRF family molecules and its relationship with p-tau in the rat prefrontal cortex. Journal of the neurological sciences. vol 368. 2017-04-21. PMID:27538655. |
chronic noise exposure has been associated with alzheimer's disease (ad)-like pathological changes, such as tau hyperphosphorylation and β-amyloid peptide accumulation in the prefrontal cortex (pfc). |
2017-04-21 |
2023-08-13 |
rat |
| Hideyuki Takahashi, Zoe A Klein, Sarah M Bhagat, Adam C Kaufman, Mikhail A Kostylev, Tsuneya Ikezu, Stephen M Strittmatte. Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network. Acta neuropathologica. vol 133. issue 5. 2017-04-20. PMID:28070672. |
here, we show that the grn ad risk variant has no significant effects on florbetapir positron emission tomographic amyloid imaging and cerebrospinal fluid (csf) aβ levels, whereas it is associated with increased csf tau levels in human subjects of the alzheimer's disease neuroimaging initiative studies. |
2017-04-20 |
2023-08-13 |
mouse |
| Peng Wang, Gerard Joberty, Arjan Buist, Alexandre Vanoosthuyse, Ilie-Cosmin Stancu, Bruno Vasconcelos, Nathalie Pierrot, Maria Faelth-Savitski, Pascal Kienlen-Campard, Jean-Noël Octave, Marcus Bantscheff, Gerard Drewes, Diederik Moechars, Ilse Dewachte. Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo. Acta neuropathologica. vol 133. issue 5. 2017-04-20. PMID:28083634. |
in alzheimer's disease (ad), progression of symptoms closely correlates with spatiotemporal progression of tau aggregation, with "early" oligomeric tau forms rather than mature neurofibrillary tangles (nfts) considered to be pathogenetic culprits. |
2017-04-20 |
2023-08-13 |
mouse |
| Robert John Hatch, Yan Wei, Di Xia, Jürgen Göt. Hyperphosphorylated tau causes reduced hippocampal CA1 excitability by relocating the axon initial segment. Acta neuropathologica. vol 133. issue 5. 2017-04-20. PMID:28091722. |
hyperphosphorylated tau has a critical role in tauopathies such as alzheimer's disease and frontotemporal dementia, impairing neuronal function and eventually leading to neurodegeneration. |
2017-04-20 |
2023-08-13 |
mouse |
| Eri Saijo, Bernardino Ghetti, Gianluigi Zanusso, Adrian Oblak, Jennifer L Furman, Marc I Diamond, Allison Kraus, Byron Caughe. Ultrasensitive and selective detection of 3-repeat tau seeding activity in Pick disease brain and cerebrospinal fluid. Acta neuropathologica. vol 133. issue 5. 2017-04-20. PMID:28293793. |
the diagnosis and treatment of diseases involving tau-based pathology such as alzheimer disease and certain frontotemporal dementias is hampered by the inability to detect pathological forms of tau with sufficient sensitivity, specificity and practicality. |
2017-04-20 |
2023-08-13 |
Not clear |
| Gabriel Pascual, Jehangir S Wadia, Xueyong Zhu, Elissa Keogh, Başak Kükrer, Jeroen van Ameijde, Hanna Inganäs, Berdien Siregar, Gerrard Perdok, Otto Diefenbach, Tariq Nahar, Imke Sprengers, Martin H Koldijk, Els C Brinkman-van der Linden, Laura A Peferoen, Heng Zhang, Wenli Yu, Xinyi Li, Michelle Wagner, Veronica Moreno, Julie Kim, Martha Costa, Kiana West, Zara Fulton, Lucy Chammas, Nancy Luckashenak, Lauren Fletcher, Trevin Holland, Carrie Arnold, R Anthony Williamson, Jeroen J Hoozemans, Adrian Apetri, Frederique Bard, Ian A Wilson, Wouter Koudstaal, Jaap Goudsmi. Immunological memory to hyperphosphorylated tau in asymptomatic individuals. Acta neuropathologica. vol 133. issue 5. 2017-04-20. PMID:28341999. |
several reports have described the presence of antibodies against alzheimer's disease-associated hyperphosphorylated forms of tau in serum of healthy individuals. |
2017-04-20 |
2023-08-13 |
Not clear |
| Bianca Gonzalez, Edsel M Abud, Abigail M Abud, Wayne W Poon, Karen H Gyly. Tau Spread, Apolipoprotein E, Inflammation, and More: Rapidly Evolving Basic Science in Alzheimer Disease. Neurologic clinics. vol 35. issue 2. 2017-04-20. PMID:28410655. |
tau spread, apolipoprotein e, inflammation, and more: rapidly evolving basic science in alzheimer disease. |
2017-04-20 |
2023-08-13 |
human |
| S Lisi, S Scarano, S Fedeli, E Pascale, S Cicchi, C Ravelet, E Peyrin, M Minunn. Toward sensitive immuno-based detection of tau protein by surface plasmon resonance coupled to carbon nanostructures as signal amplifiers. Biosensors & bioelectronics. vol 93. 2017-04-18. PMID:27671197. |
interest on tau protein is fast increasing in alzheimer's disease (ad) diagnosis. |
2017-04-18 |
2023-08-13 |
Not clear |
| Hong Bian, Wei Bian, Xiaoying Lin, Zhaoyin Ma, Wen Chen, Ying P. RNA Interference Silencing of Glycogen Synthase Kinase 3β Inhibites Tau Phosphorylation in Mice with Alzheimer Disease. Neurochemical research. vol 41. issue 9. 2017-04-17. PMID:27255602. |
rna interference silencing of glycogen synthase kinase 3β inhibites tau phosphorylation in mice with alzheimer disease. |
2017-04-17 |
2023-08-13 |
mouse |
| Alberto Cornejo, Francisco Salgado, Julio Caballero, Reinaldo Vargas, Mario Simirgiotis, Carlos Arech. Secondary Metabolites in Ramalina terebrata Detected by UHPLC/ESI/MS/MS and Identification of Parietin as Tau Protein Inhibitor. International journal of molecular sciences. vol 17. issue 8. 2017-04-17. PMID:27548142. |
in addition, the extract and the four compounds isolated from this species were tested for the inhibitory activity of tau protein aggregation, which is a protein involved in alzheimer's disease (ad). |
2017-04-17 |
2023-08-13 |
Not clear |
| Zhao-Xu Zhang, Rui-Ping Zhao, De-Sheng Wang, Yan-Bing L. Fuzhisan Ameliorates the Memory Deficits in Aged SAMP8 Mice via Decreasing Aβ Production and Tau Hyperphosphorylation of the Hippocampus. Neurochemical research. vol 41. issue 11. 2017-04-05. PMID:27518086. |
the pathological features of alzheimer's disease (ad) include extracellular neuritic plaques containing β-amyloid (aβ) peptide, a cleaved fragment of amyloid precursor protein (app) via β-site amyloid precursor protein-cleaving enzyme 1 (bace1) and intracellular neurofibrillary tangles (nfts) composed of hyperphosphorylated tau. |
2017-04-05 |
2023-08-13 |
mouse |
| Scarlet Xiaoyan Wang, Desiree Acha, Ajit J Shah, Frank Hills, Ivan Roitt, Andreas Demosthenous, Richard H Bayfor. Detection of the tau protein in human serum by a sensitive four-electrode electrochemical biosensor. Biosensors & bioelectronics. vol 92. 2017-03-31. PMID:27829556. |
this study presents a novel approach based on a four-electrode electrochemical biosensor for the detection of tau protein - one of the possible markers for the prediction of alzheimer's disease (ad). |
2017-03-31 |
2023-08-13 |
human |
| Amy L Heffernan, Cameron Chidgey, Po Peng, Colin L Masters, Blaine R Robert. The Neurobiology and Age-Related Prevalence of the ε4 Allele of Apolipoprotein E in Alzheimer's Disease Cohorts. Journal of molecular neuroscience : MN. vol 60. issue 3. 2017-03-23. PMID:27498201. |
alzheimer's disease (ad) is a progressive neurodegenerative disease characterised by amyloid beta (aβ) plaques and tau neurofibrillary tangles in the brain. |
2017-03-23 |
2023-08-13 |
human |
| M A Busche, M Staufenbiel, M Willem, C Haass, H Först. [Mechanisms of Alzheimer's disease : Neuronal hyperactivity and hypoactivity as new therapeutic targets]. Der Nervenarzt. vol 87. issue 11. 2017-03-20. PMID:26781314. |
alzheimer's disease (ad) is characterized by the pathological accumulation of amyloid-beta (abeta) and tau peptides in the brain. |
2017-03-20 |
2023-08-13 |
Not clear |