| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Su-Man Kim, Bo-Ram Mun, Sun-Jun Lee, Yechan Joh, Hwa-Youn Lee, Kon-Young Ji, Ha-Rim Choi, Eun-Hee Lee, Eun-Mi Kim, Ji-Hye Jang, Hyeong-Woo Song, Inhee Mook-Jung, Won-Seok Choi, Hyung-Sik Kan. TREM2 promotes Aβ phagocytosis by upregulating C/EBPα-dependent CD36 expression in microglia. Scientific reports. vol 7. issue 1. 2019-06-11. PMID:28894284. |
trem2 plays a critical role in the alleviation of alzheimer's disease by promoting aβ phagocytosis by microglia, but the detailed molecular mechanism underlying trem2-induced direct phagocytic activity of aβ remains to be revealed. |
2019-06-11 |
2023-08-13 |
mouse |
| Yuan Dong, Xiaoheng Li, Jinbo Cheng, Lin Ho. Drug Development for Alzheimer's Disease: Microglia Induced Neuroinflammation as a Target? International journal of molecular sciences. vol 20. issue 3. 2019-06-04. PMID:30696107. |
drug development for alzheimer's disease: microglia induced neuroinflammation as a target? |
2019-06-04 |
2023-08-13 |
Not clear |
| Suhayl Dhib-Jalbu. Friend or foe? Targeting microglia in Alzheimer's disease. Cytokine. vol 86. 2019-05-30. PMID:27442003. |
targeting microglia in alzheimer's disease. |
2019-05-30 |
2023-08-13 |
Not clear |
| Izumi Maezawa, Hai M Nguyen, Jacopo Di Lucente, David Paul Jenkins, Vikrant Singh, Silvia Hilt, Kyoungmi Kim, Srikant Rangaraju, Allan I Levey, Heike Wulff, Lee-Way Ji. Kv1.3 inhibition as a potential microglia-targeted therapy for Alzheimer's disease: preclinical proof of concept. Brain : a journal of neurology. vol 141. issue 2. 2019-05-30. PMID:29272333. |
microglia significantly contribute to the pathophysiology of alzheimer's disease but an effective microglia-targeted therapeutic approach is not yet available clinically. |
2019-05-30 |
2023-08-13 |
mouse |
| Izumi Maezawa, Hai M Nguyen, Jacopo Di Lucente, David Paul Jenkins, Vikrant Singh, Silvia Hilt, Kyoungmi Kim, Srikant Rangaraju, Allan I Levey, Heike Wulff, Lee-Way Ji. Kv1.3 inhibition as a potential microglia-targeted therapy for Alzheimer's disease: preclinical proof of concept. Brain : a journal of neurology. vol 141. issue 2. 2019-05-30. PMID:29272333. |
likewise, ex vivo microglia acutely isolated from the alzheimer's model 5xfad mice co-expressed kv1.3 and kir2.1 as well as markers traditionally associated with m1 and m2 activation suggesting that amyloid-β oligomer induces a microglial activation state that is more complex than previously thought. |
2019-05-30 |
2023-08-13 |
mouse |
| Izumi Maezawa, Hai M Nguyen, Jacopo Di Lucente, David Paul Jenkins, Vikrant Singh, Silvia Hilt, Kyoungmi Kim, Srikant Rangaraju, Allan I Levey, Heike Wulff, Lee-Way Ji. Kv1.3 inhibition as a potential microglia-targeted therapy for Alzheimer's disease: preclinical proof of concept. Brain : a journal of neurology. vol 141. issue 2. 2019-05-30. PMID:29272333. |
since we further observed that kv1.3 was highly expressed in microglia of transgenic alzheimer's mouse models and human alzheimer's disease brains, we hypothesized that pharmacological kv1.3 inhibition could mitigate the pathology induced by amyloid-β aggregates. |
2019-05-30 |
2023-08-13 |
mouse |
| Niloufar Yousefi, Fattah Sotoodehnejadnematalahi, Nooshin Heshmati-Fakhr, Mohammad Sayyah, Masoud Hoseini, Soheil Ghassemi, Shayan Aliakbari, Hamid Gholami Pourbadi. Prestimulation of Microglia Through TLR4 Pathway Promotes Interferon Beta Expression in a Rat Model of Alzheimer's Disease. Journal of molecular neuroscience : MN. vol 67. issue 4. 2019-05-29. PMID:30610591. |
prestimulation of microglia through tlr4 pathway promotes interferon beta expression in a rat model of alzheimer's disease. |
2019-05-29 |
2023-08-13 |
rat |
| Yinquan Fang, Jianing Wang, Lemeng Yao, Chenhui Li, Jing Wang, Yuan Liu, Xia Tao, Hao Sun, Hong Lia. The adhesion and migration of microglia to β-amyloid (Aβ) is decreased with aging and inhibited by Nogo/NgR pathway. Journal of neuroinflammation. vol 15. issue 1. 2019-05-20. PMID:30029608. |
alzheimer's disease is characterized by progressive accumulation of β-amyloid (aβ)-containing amyloid plaques, and microglia play a critical role in internalization and degradation of aβ. |
2019-05-20 |
2023-08-13 |
Not clear |
| Ken-Ichi Isob. Mechanism of immune aging. Nihon rinsho. Japanese journal of clinical medicine. vol 74. issue 9. 2019-05-06. PMID:30557483. |
production of inflammatory cytokines by microglia, one of tissue macrophages increases by aging, which causes alzheimer disease. |
2019-05-06 |
2023-08-13 |
human |
| Aurélie Le Page, Gilles Dupuis, Eric H Frost, Anis Larbi, Graham Pawelec, Jacek M Witkowski, Tamas Fulo. Role of the peripheral innate immune system in the development of Alzheimer's disease. Experimental gerontology. vol 107. 2019-04-29. PMID:29275160. |
microglia in the brain are innate immune cells, and brain-initiated inflammatory responses reflected in the periphery suggests that alzheimer's disease is to some extent also a systemic inflammatory disease. |
2019-04-29 |
2023-08-13 |
Not clear |
| Francisca Cornejo, Marianne Vruwink, Claudia Metz, Paola Muñoz, Nicole Salgado, Joaquín Poblete, María Estela Andrés, Jaime Eugenín, Rommy von Bernhard. Scavenger Receptor-A deficiency impairs immune response of microglia and astrocytes potentiating Alzheimer's disease pathophysiology. Brain, behavior, and immunity. vol 69. 2019-04-23. PMID:29246456. |
scavenger receptor-a deficiency impairs immune response of microglia and astrocytes potentiating alzheimer's disease pathophysiology. |
2019-04-23 |
2023-08-13 |
mouse |
| Mi Eun Kim, Ju Yong Na, Yong-Duk Park, Jun Sik Le. Anti-Neuroinflammatory Effects of Vanillin Through the Regulation of Inflammatory Factors and NF-κB Signaling in LPS-Stimulated Microglia. Applied biochemistry and biotechnology. vol 187. issue 3. 2019-04-17. PMID:30097802. |
microglia plays a complex role in neuroinflammation, which has been implicated in neurodegenerative diseases such as alzheimer's disease and parkinson's disease. |
2019-04-17 |
2023-08-13 |
Not clear |
| Annabelle C Singer, Anthony J Martorell, J Miller Douglas, Fatema Abdurrob, Matthew K Attokaren, John Tipton, Hansruedi Mathys, Chinnakkaruppan Adaikkan, Li-Huei Tsa. Noninvasive 40-Hz light flicker to recruit microglia and reduce amyloid beta load. Nature protocols. vol 13. issue 8. 2019-04-15. PMID:30072722. |
we recently showed that using noninvasive exposure to 40-hz white-light (4,000 k) flicker to drive 40-hz neural activity transforms microglia into an engulfing state and reduces amyloid beta, a peptide thought to initiate neurotoxic events in alzheimer's disease (ad). |
2019-04-15 |
2023-08-13 |
Not clear |
| Siok Lam Lim, Diana Nguyen Tran, Joannee Zumkehr, Christine Chen, Sagar Ghiaar, Zanett Kieu, Emmanuel Villanueva, Victoria Gallup, Carlos J Rodriguez-Ortiz, Masashi Kitazaw. Inhibition of hematopoietic cell kinase dysregulates microglial function and accelerates early stage Alzheimer's disease-like neuropathology. Glia. vol 66. issue 12. 2019-04-15. PMID:30277607. |
emerging evidence have posited that dysregulated microglia impair clearance and containment of amyloid-β (aβ) species in the brain, resulting in aberrant buildup of aβ and onset of alzheimer's disease (ad). |
2019-04-15 |
2023-08-13 |
mouse |
| Hong Wang, Yupeng Li, John W Ryder, Justin T Hole, Philip J Ebert, David C Airey, Hui-Rong Qian, Benjamin Logsdon, Alice Fisher, Zeshan Ahmed, Tracey K Murray, Annalisa Cavallini, Suchira Bose, Brian J Eastwood, David A Collier, Jeffrey L Dage, Bradley B Miller, Kalpana M Merchant, Michael J O'Neill, Ronald B Dematto. Genome-wide RNAseq study of the molecular mechanisms underlying microglia activation in response to pathological tau perturbation in the rTg4510 tau transgenic animal model. Molecular neurodegeneration. vol 13. issue 1. 2019-04-12. PMID:30558641. |
activation of microglia, the resident immune cells of the central nervous system, is a prominent pathological hallmark of alzheimer's disease (ad). |
2019-04-12 |
2023-08-13 |
human |
| Jiang-Tao Li, Ying Zhan. TREM2 regulates innate immunity in Alzheimer's disease. Journal of neuroinflammation. vol 15. issue 1. 2019-04-08. PMID:29655369. |
recent research has shown that the triggering receptor expressed on myeloid cells 2 (trem2) in microglia is closely related to the pathogenesis of alzheimer's disease (ad). |
2019-04-08 |
2023-08-13 |
Not clear |
| Souvarish Sarkar, Emir Malovic, Deeksha Sarda, Vivek Lawana, Dharmin Rokad, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G Kanthasam. Characterization and comparative analysis of a new mouse microglial cell model for studying neuroinflammatory mechanisms during neurotoxic insults. Neurotoxicology. vol 67. 2019-04-08. PMID:29775624. |
microglia are the first responders of the central nervous system, acting as the key modulators of neuroinflammation observed during neurotoxic insults as well as in the pathophysiology of several neurodegenerative disorders including alzheimer's (ad), parkinson's (pd), and huntington's diseases (hd). |
2019-04-08 |
2023-08-13 |
mouse |
| Sudhanshu P Raikwar, Ramasamy Thangavel, Iuliia Dubova, Govindhasamy Pushpavathi Selvakumar, Mohammad Ejaz Ahmed, Duraisamy Kempuraj, Smita A Zaheer, Shankar S Iyer, Asgar Zahee. Targeted Gene Editing of Glia Maturation Factor in Microglia: a Novel Alzheimer's Disease Therapeutic Target. Molecular neurobiology. vol 56. issue 1. 2019-04-01. PMID:29704201. |
targeted gene editing of glia maturation factor in microglia: a novel alzheimer's disease therapeutic target. |
2019-04-01 |
2023-08-13 |
mouse |
| Willem Kamphuis, Lieneke Kooijman, Sjoerd Schetters, Marie Orre, Elly M Ho. Transcriptional profiling of CD11c-positive microglia accumulating around amyloid plaques in a mouse model for Alzheimer's disease. Biochimica et biophysica acta. vol 1862. issue 10. 2019-03-29. PMID:27425031. |
transcriptional profiling of cd11c-positive microglia accumulating around amyloid plaques in a mouse model for alzheimer's disease. |
2019-03-29 |
2023-08-13 |
mouse |
| Willem Kamphuis, Lieneke Kooijman, Sjoerd Schetters, Marie Orre, Elly M Ho. Transcriptional profiling of CD11c-positive microglia accumulating around amyloid plaques in a mouse model for Alzheimer's disease. Biochimica et biophysica acta. vol 1862. issue 10. 2019-03-29. PMID:27425031. |
amyloid plaques in alzheimer's disease (ad) mice are surrounded by activated microglia. |
2019-03-29 |
2023-08-13 |
mouse |