| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Sawada, K Imamura, T Nagats. Role of cytokines in inflammatory process in Parkinson's disease. Journal of neural transmission. Supplementum. issue 70. 2006-10-24. PMID:17017556. |
toxic change of activated microglia may also occur in alzheimer's disease and other neurodegenerative diseases in which inflammatory process is found. |
2006-10-24 |
2023-08-12 |
mouse |
| Chie Usui, Nobuto Shibata, Tohru Ohnuma, Shinji Higashi, Taku Ohkubo, Akira Ueki, Masatsugu Nagao, Heii Ara. No genetic association between the myeloperoxidase gene -463 polymorphism and estrogen receptor-alpha gene polymorphisms and Japanese sporadic Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 21. issue 5-6. 2006-10-17. PMID:16484808. |
myeloperoxidase (mpo) presence has been demonstrated in microglia associated with senile plaques and contributes to alzheimer's disease (ad) pathology through oxidation-induced damage. |
2006-10-17 |
2023-08-12 |
Not clear |
| A Cagnin, M Kassiou, S R Meikle, R B Banat. In vivo evidence for microglial activation in neurodegenerative dementia. Acta neurologica Scandinavica. Supplementum. vol 185. 2006-10-02. PMID:16866919. |
evidence from numerous neuropathological observations and in vivo clinical imaging studies suggests a prominent role of activated microglia, the main effector cell of the brain's innate immune system, in alzheimer's disease and other neurodegenerative diseases. |
2006-10-02 |
2023-08-12 |
Not clear |
| Matt Baker, Ian R Mackenzie, Stuart M Pickering-Brown, Jennifer Gass, Rosa Rademakers, Caroline Lindholm, Julie Snowden, Jennifer Adamson, A Dessa Sadovnick, Sara Rollinson, Ashley Cannon, Emily Dwosh, David Neary, Stacey Melquist, Anna Richardson, Dennis Dickson, Zdenek Berger, Jason Eriksen, Todd Robinson, Cynthia Zehr, Chad A Dickey, Richard Crook, Eileen McGowan, David Mann, Bradley Boeve, Howard Feldman, Mike Hutto. Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17. Nature. vol 442. issue 7105. 2006-09-22. PMID:16862116. |
moreover, pgrn expression is increased in activated microglia in many neurodegenerative diseases including creutzfeldt-jakob disease, motor neuron disease and alzheimer's disease. |
2006-09-22 |
2023-08-12 |
Not clear |
| Hideyuki Takeuchi, Shijie Jin, Jinyan Wang, Guiqin Zhang, Jun Kawanokuchi, Reiko Kuno, Yoshifumi Sonobe, Tetsuya Mizuno, Akio Suzumur. Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner. The Journal of biological chemistry. vol 281. issue 30. 2006-09-18. PMID:16720574. |
glutamate released by activated microglia induces excitoneurotoxicity and may contribute to neuronal damage in neurodegenerative diseases, including alzheimer disease, parkinson disease, amyotrophic lateral sclerosis, and multiple sclerosis. |
2006-09-18 |
2023-08-12 |
Not clear |
| Pedro Garção, Catarina R Oliveira, Paula Agostinh. Comparative study of microglia activation induced by amyloid-beta and prion peptides: role in neurodegeneration. Journal of neuroscience research. vol 84. issue 1. 2006-09-08. PMID:16634056. |
the inflammatory responses in alzheimer's disease (ad) and prion-related encephalopathies (pre) are dominated by microglia activation. |
2006-09-08 |
2023-08-12 |
rat |
| Takashi Mori, Terrence Town, Jun Tan, Nobumichi Yada, Yuko Horikoshi, Junki Yamamoto, Taiji Shimoda, Yoshihisa Kamanaka, Narito Tateishi, Takao Asan. Arundic Acid ameliorates cerebral amyloidosis and gliosis in Alzheimer transgenic mice. The Journal of pharmacology and experimental therapeutics. vol 318. issue 2. 2006-08-31. PMID:16709678. |
like microglia, reactive astrocytes produce a myriad of neurotoxic substances in various brain pathologies, such as alzheimer's disease (ad), trauma, and cerebral ischemia. |
2006-08-31 |
2023-08-12 |
mouse |
| Clive S McKimmie, Douglas Roy, Thorsten Forster, John K Fazakerle. Innate immune response gene expression profiles of N9 microglia are pathogen-type specific. Journal of neuroimmunology. vol 175. issue 1-2. 2006-07-26. PMID:16697053. |
glial cells, particularly microglia, are thought to play a pivotal role in initiating and guiding innate immune responses to cns infections and in perpetuating inflammation and pathology in cns diseases such as multiple sclerosis and alzheimer's disease. |
2006-07-26 |
2023-08-12 |
Not clear |
| Alejandro D Roth, Gigliola Ramírez, Rodrigo Alarcón, Rommy Von Bernhard. Oligodendrocytes damage in Alzheimer's disease: beta amyloid toxicity and inflammation. Biological research. vol 38. issue 4. 2006-07-18. PMID:16579521. |
research on alzheimer's disease (ad) focuses mainly on neuronal death and synaptic impairment induced by beta-amyloid peptide (abeta), events at least partially mediated by astrocyte and microglia activation. |
2006-07-18 |
2023-08-12 |
Not clear |
| Masashi Kitazawa, Tritia R Yamasaki, Frank M LaFerl. Microglia as a potential bridge between the amyloid beta-peptide and tau. Annals of the New York Academy of Sciences. vol 1035. 2006-07-13. PMID:15681802. |
inflammation is a critical component of the pathogenesis of alzheimer's disease (ad), consisting of the activation of both microglia and astrocytes. |
2006-07-13 |
2023-08-12 |
Not clear |
| Sandra K Pope, Stephen B Kritchevsky, Christine Ambrosone, Kristine Yaffe, Frances Tylavsky, Eleanor M Simonsick, Caterina Rosano, Scott Stewart, Tamara Harri. Myeloperoxidase polymorphism and cognitive decline in older adults in the Health, Aging, and Body Composition Study. American journal of epidemiology. vol 163. issue 12. 2006-07-13. PMID:16641309. |
rarely found in normal brain tissue, myeloperoxidase has been detected in microglia associated with alzheimer's disease plaques. |
2006-07-13 |
2023-08-12 |
human |
| Haruhiko Akiyam. [Abeta, tau and alpha-synuclein and glial cells]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 26. issue 1. 2006-06-15. PMID:16637593. |
in the alzheimer brain, once-deposited, insoluble abeta is also removed by phagocytosis by activated microglia. |
2006-06-15 |
2023-08-12 |
mouse |
| Timothy J Seabrook, Liying Jiang, Marcel Maier, Cynthia A Lemer. Minocycline affects microglia activation, Abeta deposition, and behavior in APP-tg mice. Glia. vol 53. issue 7. 2006-06-12. PMID:16534778. |
activated microglia and reactive astrocytes invade and surround cerebral beta amyloid (abeta) plaques in alzheimer's disease (ad), but the role of microglia in plaque development is still unclear. |
2006-06-12 |
2023-08-12 |
mouse |
| Antonietta Bernardo, Laura Gasparini, Ennio Ongini, Luisa Minghett. Dynamic regulation of microglial functions by the non-steroidal anti-inflammatory drug NCX 2216: implications for chronic treatments of neurodegenerative diseases. Neurobiology of disease. vol 22. issue 1. 2006-06-01. PMID:16307889. |
the dynamic regulation of the functional state of activated microglia by ncx 2216 helps explaining recent findings in alzheimer's disease animal models and may offer new therapeutic opportunities for treating neurodegenerative diseases. |
2006-06-01 |
2023-08-12 |
Not clear |
| Magdalena Sastre, Thomas Klockgether, Michael T Henek. Contribution of inflammatory processes to Alzheimer's disease: molecular mechanisms. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 24. issue 2-3. 2006-05-25. PMID:16472958. |
there is compelling evidence that alzheimer's disease (ad) amyloid-beta (abeta) deposition is associated with a local inflammatory response, which is initiated by the activation of microglia and the recruitment of astrocytes. |
2006-05-25 |
2023-08-12 |
Not clear |
| Elisabetta Vegeto, Silvia Belcredito, Serena Ghisletti, Clara Meda, Sabrina Etteri, Adriana Magg. The endogenous estrogen status regulates microglia reactivity in animal models of neuroinflammation. Endocrinology. vol 147. issue 5. 2006-05-23. PMID:16469811. |
using the app23 mice, an animal model of alzheimer's disease reproducing chronic neuroinflammation, we demonstrate that ovary ablation increases microglia activation at beta-amyloid (abeta) deposits and facilitates the progression of these cells toward a highly reactive state. |
2006-05-23 |
2023-08-12 |
mouse |
| Angela M Floden, Colin K Comb. Beta-amyloid stimulates murine postnatal and adult microglia cultures in a unique manner. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 17. 2006-05-23. PMID:16641245. |
reactive microglia are commonly observed in association with the beta-amyloid (abeta) plaques of alzheimer's disease brains. |
2006-05-23 |
2023-08-12 |
Not clear |
| Douglas G Walker, John Link, Lih-Fen Lue, Jessica E Dalsing-Hernandez, Barry E Boye. Gene expression changes by amyloid beta peptide-stimulated human postmortem brain microglia identify activation of multiple inflammatory processes. Journal of leukocyte biology. vol 79. issue 3. 2006-05-02. PMID:16365156. |
a central feature of the inflammatory pathology in alzheimer's disease is activated microglia clustered around aggregated amyloid beta (abeta) peptide-containing plaques. |
2006-05-02 |
2023-08-12 |
human |
| Alain R Simard, Denis Soulet, Genevieve Gowing, Jean-Pierre Julien, Serge Rives. Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease. Neuron. vol 49. issue 4. 2006-04-28. PMID:16476660. |
bone marrow-derived microglia play a critical role in restricting senile plaque formation in alzheimer's disease. |
2006-04-28 |
2023-08-12 |
mouse |
| Alain R Simard, Denis Soulet, Genevieve Gowing, Jean-Pierre Julien, Serge Rives. Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease. Neuron. vol 49. issue 4. 2006-04-28. PMID:16476660. |
here we show a massive infiltration of highly ramified and elongated microglia within the core of amyloid plaques in transgenic mouse models of alzheimer's disease (ad). |
2006-04-28 |
2023-08-12 |
mouse |