| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Asgeir Kobro-Flatmoen, Maria Jose Lagartos-Donate, Yahyah Aman, Paul Edison, Menno P Witter, Evandro F Fan. Re-emphasizing early Alzheimer's disease pathology starting in select entorhinal neurons, with a special focus on mitophagy. Ageing research reviews. vol 67. 2021-04-19. PMID:33621703. |
re-emphasizing early alzheimer's disease pathology starting in select entorhinal neurons, with a special focus on mitophagy. |
2021-04-19 |
2023-08-13 |
Not clear |
| Sue Kulason, Eileen Xu, Daniel J Tward, Arnold Bakker, Marilyn Albert, Laurent Younes, Michael I Mille. Entorhinal and Transentorhinal Atrophy in Preclinical Alzheimer's Disease. Frontiers in neuroscience. vol 14. 2020-11-24. PMID:32973425. |
entorhinal and transentorhinal atrophy in preclinical alzheimer's disease. |
2020-11-24 |
2023-08-13 |
human |
| Gillian Coughlan, Peter Zhukovsky, Vaisakh Puthusseryppady, Rachel Gillings, Anne-Marie Minihane, Donnie Cameron, Michael Hornberge. Functional connectivity between the entorhinal and posterior cingulate cortices underpins navigation discrepancies in at-risk Alzheimer's disease. Neurobiology of aging. vol 90. 2020-10-29. PMID:32171591. |
functional connectivity between the entorhinal and posterior cingulate cortices underpins navigation discrepancies in at-risk alzheimer's disease. |
2020-10-29 |
2023-08-13 |
Not clear |
| Heiko Braak, Kelly Del Tredic. From the Entorhinal Region via the Prosubiculum to the Dentate Fascia: Alzheimer Disease-Related Neurofibrillary Changes in the Temporal Allocortex. Journal of neuropathology and experimental neurology. vol 79. issue 2. 2020-07-27. PMID:31913466. |
from the entorhinal region via the prosubiculum to the dentate fascia: alzheimer disease-related neurofibrillary changes in the temporal allocortex. |
2020-07-27 |
2023-08-13 |
Not clear |
| Sara Fernández-Cabello, Martin Kronbichler, Koene R A Van Dijk, James A Goodman, R Nathan Spreng, Taylor W Schmit. Basal forebrain volume reliably predicts the cortical spread of Alzheimer's degeneration. Brain : a journal of neurology. vol 143. issue 3. 2020-07-06. PMID:32203580. |
the prevailing model used to guide in vivo human neuroimaging and non-human animal research assumes that alzheimer's degeneration starts in the entorhinal cortices, before spreading to the temporoparietal cortex. |
2020-07-06 |
2023-08-13 |
human |
| Sara Fernández-Cabello, Martin Kronbichler, Koene R A Van Dijk, James A Goodman, R Nathan Spreng, Taylor W Schmit. Basal forebrain volume reliably predicts the cortical spread of Alzheimer's degeneration. Brain : a journal of neurology. vol 143. issue 3. 2020-07-06. PMID:32203580. |
our findings suggest that degeneration of the basal forebrain cholinergic projection system is a robust and reliable upstream event of entorhinal and neocortical degeneration, calling into question a prevailing view of alzheimer's disease pathogenesis. |
2020-07-06 |
2023-08-13 |
human |
| Kamil A Grajski, Steven L Bressle. Differential medial temporal lobe and default-mode network functional connectivity and morphometric changes in Alzheimer's disease. NeuroImage. Clinical. vol 23. 2020-06-29. PMID:31158694. |
in early mild cognitive impairment these changes involved medial temporal lobe regions of transentorhinal, perirhinal and entorhinal cortices (associated with the earliest stages of neurofibrillary changes in alzheimer's disease), hippocampus, parahippocampal gyrus and temporal pole, and cortical regions comprising or co-activated with the default-mode network, including rostral and medial prefrontal cortex, anterior cingulate cortex, precuneus and inferior temporal cortex. |
2020-06-29 |
2023-08-13 |
human |
| B Thomas, R Sheelakumari, S Kannath, S Sarma, R N Meno. Regional Cerebral Blood Flow in the Posterior Cingulate and Precuneus and the Entorhinal Cortical Atrophy Score Differentiate Mild Cognitive Impairment and Dementia Due to Alzheimer Disease. AJNR. American journal of neuroradiology. vol 40. issue 10. 2020-06-12. PMID:31515217. |
regional cerebral blood flow in the posterior cingulate and precuneus and the entorhinal cortical atrophy score differentiate mild cognitive impairment and dementia due to alzheimer disease. |
2020-06-12 |
2023-08-13 |
Not clear |
| B Thomas, R Sheelakumari, S Kannath, S Sarma, R N Meno. Regional Cerebral Blood Flow in the Posterior Cingulate and Precuneus and the Entorhinal Cortical Atrophy Score Differentiate Mild Cognitive Impairment and Dementia Due to Alzheimer Disease. AJNR. American journal of neuroradiology. vol 40. issue 10. 2020-06-12. PMID:31515217. |
the aim of this study was to test the utility of the entorhinal cortical atrophy score in combination with quantitative cbf in the posterior cingulate and precuneus using arterial spin-labeling to differentiate mild cognitive impairment and early alzheimer disease. |
2020-06-12 |
2023-08-13 |
Not clear |
| David Howett, Andrea Castegnaro, Katarzyna Krzywicka, Johanna Hagman, Deepti Marchment, Richard Henson, Miguel Rio, John A King, Neil Burgess, Dennis Cha. Differentiation of mild cognitive impairment using an entorhinal cortex-based test of virtual reality navigation. Brain : a journal of neurology. vol 142. issue 6. 2020-03-12. PMID:31121601. |
this study demonstrates that an entorhinal cortex-based virtual reality navigation task can differentiate patients with mild cognitive impairment at low and high risk of developing dementia, with classification accuracy superior to reference cognitive tests considered to be highly sensitive to early alzheimer's disease. |
2020-03-12 |
2023-08-13 |
human |
| John C Gant, Inga Kadish, Kuey-Chu Chen, Olivier Thibault, Eric M Blalock, Nada M Porter, Philip W Landfiel. Aging-Related Calcium Dysregulation in Rat Entorhinal Neurons Homologous with the Human Entorhinal Neurons in which Alzheimer's Disease Neurofibrillary Tangles First Appear. Journal of Alzheimer's disease : JAD. vol 66. issue 4. 2019-11-25. PMID:30412490. |
aging-related calcium dysregulation in rat entorhinal neurons homologous with the human entorhinal neurons in which alzheimer's disease neurofibrillary tangles first appear. |
2019-11-25 |
2023-08-13 |
human |
| Scott A Small, Larry W Swanso. A Network Explanation of Alzheimer's Regional Vulnerability. Cold Spring Harbor symposia on quantitative biology. vol 83. 2019-09-10. PMID:30642996. |
studies in patients and mouse models have pinpointed a precise zone in the cerebral cortex selectively vulnerable to the earliest stages of alzheimer's disease (ad): the borderzone covering the entorhinal and perirhinal cortical areas. |
2019-09-10 |
2023-08-13 |
mouse |
| Akinori Nakamura, Pablo Cuesta, Alberto Fernández, Yutaka Arahata, Kaori Iwata, Izumi Kuratsubo, Masahiko Bundo, Hideyuki Hattori, Takashi Sakurai, Koji Fukuda, Yukihiko Washimi, Hidetoshi Endo, Akinori Takeda, Kersten Diers, Ricardo Bajo, Fernando Maestú, Kengo Ito, Takashi Kat. Electromagnetic signatures of the preclinical and prodromal stages of Alzheimer's disease. Brain : a journal of neurology. vol 141. issue 5. 2019-07-08. PMID:29522156. |
the results demonstrated that regional spectral patterns of resting state activity could be separated into several types of meg signatures as follows: (i) the effects of amyloid-β deposition were expressed as the alpha band power augmentation in medial frontal areas; (ii) the delta band power increase in the same region was associated with disease progression within the alzheimer's disease continuum and was correlated with entorhinal atrophy and an alzheimer's disease-like regional decrease in glucose metabolism; and (iii) the global theta power augmentation, which was previously considered to be an alzheimer's disease-related eeg/meg signature, was associated with general cognitive decline and hippocampal atrophy, but was not specific to alzheimer's disease because these changes could be observed in the absence of amyloid-β deposition. |
2019-07-08 |
2023-08-13 |
Not clear |
| Kyoko Konishi, Ridha Joober, Judes Poirier, Kathleen MacDonald, Mallar Chakravarty, Raihaan Patel, John Breitner, Véronique D Bohbo. Healthy versus Entorhinal Cortical Atrophy Identification in Asymptomatic APOE4 Carriers at Risk for Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 61. issue 4. 2019-01-24. PMID:29278888. |
healthy versus entorhinal cortical atrophy identification in asymptomatic apoe4 carriers at risk for alzheimer's disease. |
2019-01-24 |
2023-08-13 |
Not clear |
| Frances Xia, Adelaide Yiu, Scellig S D Stone, Soojin Oh, Andres M Lozano, Sheena A Josselyn, Paul W Franklan. Entorhinal Cortical Deep Brain Stimulation Rescues Memory Deficits in Both Young and Old Mice Genetically Engineered to Model Alzheimer's Disease. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 42. issue 13. 2018-07-30. PMID:28540926. |
entorhinal cortical deep brain stimulation rescues memory deficits in both young and old mice genetically engineered to model alzheimer's disease. |
2018-07-30 |
2023-08-13 |
mouse |
| Charles B Malpa. Structural neuroimaging correlates of cognitive status in older adults: A person-oriented approach. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 30. 2017-03-10. PMID:27056675. |
the role of the entorhinal cortices in cluster formation is consistent with the known pathological substrate of alzheimer's disease. |
2017-03-10 |
2023-08-13 |
Not clear |
| Zachariah M Reagh, Huy D Ho, Stephanie L Leal, Jessica A Noche, Amanda Chun, Elizabeth A Murray, Michael A Yass. Greater loss of object than spatial mnemonic discrimination in aged adults. Hippocampus. vol 26. issue 4. 2016-12-13. PMID:26691235. |
memory for objects or items is thought to rely on perirhinal and lateral entorhinal cortices, among the first targets of alzheimer's related neurodegeneration. |
2016-12-13 |
2023-08-13 |
Not clear |
| Lucas Rasmussen, Roger W de Labio, Gustavo A Viani, Elizabeth Chen, Joao Villares, Paulo-Henrique Bertolucci, Thais S Minett, Gustavo Turecki, Danielle Cecyre, Sandra A Drigo, Marilia C Smith, Spencer L M Paya. Differential Expression of Ribosomal Genes in Brain and Blood of Alzheimer's Disease Patients. Current Alzheimer research. vol 12. issue 10. 2016-08-26. PMID:26502820. |
in this study, we investigated the mrna expression of ribosomal genes (28s/18s) and β-amyloid precursor protein (app) in different post mortem brain tissue regions (the entorhinal and auditory cortices and the hippocampus) of ad patients and elderly control subjects and also evaluated the extent of expression in peripheral blood from young, healthy, elderly, and alzheimer's disease patients in order to investigate whether these individuals experienced the effects of aging. |
2016-08-26 |
2023-08-13 |
human |
| Svetlana N Popova, Samuli Pesälä, Irina Alafuzof. To Stage Alzheimer's Disease Related Neurodegeneration Using one Section of Hippocampus. Journal of Alzheimer's disease : JAD. vol 48. issue 3. 2016-07-14. PMID:26402117. |
thus, to reliably stage the ad-related neurodegeneration, regions such as the entorhinal, transentorhinal, temporo-occipital, and occipital cortices should be assessed as has also been recommended in 2012 by the national institute on aging - alzheimer's association guidelines. |
2016-07-14 |
2023-08-13 |
Not clear |
| b' Anna Chiarini, Ubaldo Armato, Daisong Liu, Ilaria Dal Pr\\xc3\\xa. Calcium-Sensing Receptors of Human Neural Cells Play Crucial Roles in Alzheimer\'s Disease. Frontiers in physiology. vol 7. 2016-05-20. PMID:27199760.' |
in aged subjects, late-onset alzheimer's disease (load) starts in the lateral entorhinal allocortex where a failure of clearance mechanisms triggers an accumulation of neurotoxic amyloid-β42 oligomers (aβ42-os). |
2016-05-20 |
2023-08-13 |
human |