| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Coco Newton, Marianna Pope, Catarina Rua, Richard Henson, Zilong Ji, Neil Burgess, Christopher T Rodgers, Matthias Stangl, Maria-Eleni Dounavi, Andrea Castegnaro, Ivan Koychev, Paresh Malhotra, Thomas Wolbers, Karen Ritchie, Craig W Ritchie, John O'Brien, Li Su, Dennis Cha. Entorhinal-based path integration selectively predicts midlife risk of Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-02-29. PMID:38421123. |
entorhinal cortex (ec) is the first cortical region to exhibit neurodegeneration in alzheimer's disease (ad), associated with ec grid cell dysfunction. |
2024-02-29 |
2024-03-02 |
Not clear |
| Anika Wuestefeld, Hannah Baumeister, Jenna N Adams, Robin de Flores, Carl J Hodgetts, Negar Mazloum-Farzaghi, Rosanna K Olsen, Vyash Puliyadi, Tammy T Tran, Arnold Bakker, Kelsey L Canada, Marshall A Dalton, Ana M Daugherty, Renaud La Joie, Lei Wang, Madigan L Bedard, Esther Buendia, Eunice Chung, Amanda Denning, María Del Mar Arroyo-Jiménez, Emilio Artacho-Pérula, David J Irwin, Ranjit Ittyerah, Edward B Lee, Sydney Lim, María Del Pilar Marcos-Rabal, Maria Mercedes Iñiguez de Onzoño Martin, Monica Munoz Lopez, Carlos de la Rosa Prieto, Theresa Schuck, Winifred Trotman, Alicia Vela, Paul Yushkevich, Katrin Amunts, Jean C Augustinack, Song-Lin Ding, Ricardo Insausti, Olga Kedo, David Berron, Laura E M Wiss. Comparison of histological delineations of medial temporal lobe cortices by four independent neuroanatomy laboratories. Hippocampus. 2024-02-28. PMID:38415962. |
the medial temporal lobe (mtl) cortex, located adjacent to the hippocampus, is crucial for memory and prone to the accumulation of certain neuropathologies such as alzheimer's disease neurofibrillary tau tangles. |
2024-02-28 |
2024-03-01 |
human |
| Yachiyo Mitsuishi, Masaki Nakano, Hirotatsu Kojima, Takayoshi Okabe, Masaki Nishimur. Reduction of Amyloid-β Production without Inhibiting Secretase Activity by MS-275. ACS chemical neuroscience. 2024-02-28. PMID:38416107. |
chronic ms-275 treatment decreased aβ deposition in the cerebral cortex and hippocampus in an alzheimer's disease mouse model. |
2024-02-28 |
2024-03-01 |
mouse |
| Zhengshi Yang, Jefferson W Kinney, Dietmar Cordes, The Alzheimer's Disease Neuroimaging Initiativ. Uptake of 18F-AV45 in the Putamen Provides Additional Insights into Alzheimer's Disease beyond the Cortex. Biomolecules. vol 14. issue 2. 2024-02-24. PMID:38397394. |
uptake of 18f-av45 in the putamen provides additional insights into alzheimer's disease beyond the cortex. |
2024-02-24 |
2024-02-26 |
human |
| Zhengshi Yang, Jefferson W Kinney, Dietmar Cordes, The Alzheimer's Disease Neuroimaging Initiativ. Uptake of 18F-AV45 in the Putamen Provides Additional Insights into Alzheimer's Disease beyond the Cortex. Biomolecules. vol 14. issue 2. 2024-02-24. PMID:38397394. |
cortical uptake in brain amyloid positron emission tomography (pet) is increasingly used for the biological diagnosis of alzheimer's disease (ad); however, the clinical and biological relevance of the striatum beyond the cortex in amyloid pet scans remains unclear. |
2024-02-24 |
2024-02-26 |
human |
| Anna Flavia Cantone, Chiara Burgaletto, Giulia Di Benedetto, Anna Pannaccione, Agnese Secondo, Carlo Maria Bellanca, Egle Augello, Antonio Munafò, Paola Tarro, Renato Bernardini, Giuseppina Cantarell. Taming Microglia in Alzheimer's Disease: Exploring Potential Implications of Choline Alphoscerate via α7 nAChR Modulation. Cells. vol 13. issue 4. 2024-02-23. PMID:38391922. |
alzheimer's disease (ad), marked by cognitive impairment, predominantly affects the brain regions regulated by cholinergic innervation, such as the cerebral cortex and hippocampus. |
2024-02-23 |
2024-02-25 |
Not clear |
| Malin Wennström, Nina Schultz, Paula Mille Gallardo, The Netherlands Brain Bank, Geidy E Serrano, Thomas G Beach, Suchira Bose, Oskar Hansso. The Relationship between p-tau217, p-tau231, and p-tau205 in the Human Brain Is Affected by the Cellular Environment and Alzheimer's Disease Pathology. Cells. vol 13. issue 4. 2024-02-23. PMID:38391945. |
to investigate if the three p-tau variants are found to the same degree in different tau structures and if their co-localization is affected by the diagnosis and presence of aß plaques, we immunostained sections of the entorhinal cortex (ec) and inferior temporal gyrus (itg) from non-demented controls (nc), patients with alzheimer's disease (ad), and primary age-related tauopathy (part) against p-tau217, p-tau231, and p-tau205 together with methoxi-x04. |
2024-02-23 |
2024-02-25 |
human |
| Samira A Maboudian, Ethan H Willbrand, William J Jagust, Kevin S Weine. Defining overlooked structures reveals new associations between cortex and cognition in aging and Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-02-21. PMID:38383497. |
defining overlooked structures reveals new associations between cortex and cognition in aging and alzheimer's disease. |
2024-02-21 |
2024-02-24 |
human |
| Samira A Maboudian, Ethan H Willbrand, William J Jagust, Kevin S Weine. Defining overlooked structures reveals new associations between cortex and cognition in aging and Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-02-21. PMID:38383497. |
recent work suggests that indentations of the cerebral cortex, or sulci, may be uniquely vulnerable to atrophy in aging and alzheimer's disease (ad) and that posteromedial cortex (pmc) is particularly vulnerable to atrophy and pathology accumulation. |
2024-02-21 |
2024-02-24 |
human |
| Inna Slutsk. Linking activity dyshomeostasis and sleep disturbances in Alzheimer disease. Nature reviews. Neuroscience. 2024-02-20. PMID:38374463. |
the presymptomatic phase of alzheimer disease (ad) starts with the deposition of amyloid-β in the cortex and begins a decade or more before the emergence of cognitive decline. |
2024-02-20 |
2024-02-22 |
Not clear |
| Megan E Bosch, Hemraj B Dodiya, Julia Michalkiewicz, Choonghee Lee, Shabana M Shaik, Ian Q Weigle, Can Zhang, Jack Osborn, Aishwarya Nambiar, Priyam Patel, Samira Parhizkar, Xiaoqiong Zhang, Marie L Laury, Prasenjit Mondal, Ashley Gomm, Matthew John Schipma, Dania Mallah, Oleg Butovsky, Eugene B Chang, Rudolph E Tanzi, Jack A Gilbert, David M Holtzman, Sangram S Sisodi. Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner. Molecular neurodegeneration. vol 19. issue 1. 2024-02-16. PMID:38365827. |
bulk rnaseq analysis unveiled sex-specific changes in cerebral cortex transcriptome profiles, but most importantly, the transcriptome changes in the gv-971-treated male group revealed the involvement of microglia and inflammatory responses.conclusions in conclusion, these studies demonstrate the connection between the gut microbiome, neuroinflammation, and alzheimer's disease pathology while highlighting the potential therapeutic effect of gv-971. |
2024-02-16 |
2024-02-19 |
mouse |
| Riki Koike, Yoshiyuki Soeda, Atsushi Kasai, Yusuke Fujioka, Shinsuke Ishigaki, Akihiro Yamanaka, Yuta Takaichi, James K Chambers, Kazuyuki Uchida, Hirohisa Watanabe, Akihiko Takashim. Path integration deficits are associated with phosphorylated tau accumulation in the entorhinal cortex. Brain communications. vol 6. issue 1. 2024-02-13. PMID:38347945. |
to this end, we developed a 3d virtual reality task sensitive to the activity of grid cells in the entorhinal cortex, which is the region that first exhibits neurofibrillary tangles in alzheimer's disease. |
2024-02-13 |
2024-02-15 |
mouse |
| Sabrina Petralla, Liudmila Saveleva, Katja M Kanninen, Julia S Oster, Maria Panayotova, Gert Fricker, Elena Puri. Increased Expression of Transferrin Receptor 1 in the Brain Cortex of 5xFAD Mouse Model of Alzheimer's Disease Is Associated with Activation of HIF-1 Signaling Pathway. Molecular neurobiology. 2024-01-31. PMID:38296900. |
increased expression of transferrin receptor 1 in the brain cortex of 5xfad mouse model of alzheimer's disease is associated with activation of hif-1 signaling pathway. |
2024-01-31 |
2024-02-03 |
mouse |
| Veronica Astillero-Lopez, Sandra Villar-Conde, Melania Gonzalez-Rodriguez, Alicia Flores-Cuadrado, Isabel Ubeda-Banon, Daniel Saiz-Sanchez, Alino Martinez-Marco. Proteomic analysis identifies HSP90AA1, PTK2B, and ANXA2 in the human entorhinal cortex in Alzheimer's disease: Potential role in synaptic homeostasis and Aβ pathology through microglial and astroglial cells. Brain pathology (Zurich, Switzerland). 2024-01-22. PMID:38247340. |
proteomic analysis identifies hsp90aa1, ptk2b, and anxa2 in the human entorhinal cortex in alzheimer's disease: potential role in synaptic homeostasis and aβ pathology through microglial and astroglial cells. |
2024-01-22 |
2024-01-24 |
human |
| Giulia Quattrini, Lorenzo Pini, Ilaria Boscolo Galazzo, Ileana O Jelescu, Jorge Jovicich, Rosa Manenti, Giovanni B Frisoni, Moira Marizzoni, Francesca B Pizzini, Michela Pievan. Microstructural alterations in the locus coeruleus-entorhinal cortex pathway in Alzheimer's disease and frontotemporal dementia. Alzheimer's & dementia (Amsterdam, Netherlands). vol 16. issue 1. 2024-01-12. PMID:38213948. |
microstructural alterations in the locus coeruleus-entorhinal cortex pathway in alzheimer's disease and frontotemporal dementia. |
2024-01-12 |
2024-01-14 |
Not clear |
| Giulia Quattrini, Lorenzo Pini, Ilaria Boscolo Galazzo, Ileana O Jelescu, Jorge Jovicich, Rosa Manenti, Giovanni B Frisoni, Moira Marizzoni, Francesca B Pizzini, Michela Pievan. Microstructural alterations in the locus coeruleus-entorhinal cortex pathway in Alzheimer's disease and frontotemporal dementia. Alzheimer's & dementia (Amsterdam, Netherlands). vol 16. issue 1. 2024-01-12. PMID:38213948. |
we investigated in vivo the microstructural integrity of the pathway connecting the locus coeruleus to the transentorhinal cortex (lc-tec) in patients with alzheimer's disease (ad) and frontotemporal dementia (ftd). |
2024-01-12 |
2024-01-14 |
Not clear |
| Liangdong Zhou, Thanh D Nguyen, Gloria C Chiang, Xiuyuan H Wang, Ke Xi, Tsung-Wei Hu, Emily B Tanzi, Tracy A Butler, Mony J de Leon, Yi L. Parenchymal CSF fraction is a measure of brain glymphatic clearance and positively associated with amyloid beta deposition on PET. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-01-07. PMID:38184796. |
mapping of microscopic changes in the perivascular space (pvs) of the cerebral cortex, beyond magnetic resonance-visible pvs in white matter, may enhance our ability to diagnose alzheimer's disease (ad) early. |
2024-01-07 |
2024-01-09 |
Not clear |
| Xiang Zhou, Kangning Dong, Shihua Zhan. Integrating spatial transcriptomics data across different conditions, technologies and developmental stages. Nature computational science. vol 3. issue 10. 2024-01-04. PMID:38177758. |
we apply staligner to st datasets of the human cortex slices from different samples, the mouse olfactory bulb slices generated by two profiling technologies, the mouse hippocampus tissue slices under normal and alzheimer's disease conditions, and the spatiotemporal atlases of mouse organogenesis. |
2024-01-04 |
2024-01-07 |
mouse |
| Nisha Rani, Kylie H Alm, Caitlin A Corona-Long, Caroline L Speck, Anja Soldan, Corinne Pettigrew, Yuxin Zhu, Marilyn Albert, Arnold Bakke. Tau PET burden in Brodmann areas 35 and 36 is associated with individual differences in cognition in non-demented older adults. Frontiers in aging neuroscience. vol 15. 2024-01-01. PMID:38161595. |
the accumulation of neurofibrillary tau tangles, a neuropathological hallmark of alzheimer's disease (ad), occurs in medial temporal lobe (mtl) regions early in the disease process, with some of the earliest deposits localized to subregions of the entorhinal cortex. |
2024-01-01 |
2024-01-05 |
Not clear |
| Xingxing Li, Lei Chen, Kunqiang Yu, Wenhao Zhuang, Hui Zhu, Wenqiang Xu, Hui Yan, Gangqiao Qi, Dongsheng Zhou, Shaochang W. Impact of twice-a-day transcranial direct current stimulation intervention on cognitive function and motor cortex plasticity in patients with Alzheimer's disease. General psychiatry. vol 36. issue 6. 2023-12-29. PMID:38155843. |
impact of twice-a-day transcranial direct current stimulation intervention on cognitive function and motor cortex plasticity in patients with alzheimer's disease. |
2023-12-29 |
2023-12-31 |
Not clear |