| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrew L Zhou, Suresh K Swaminathan, Vrishali S Salian, Lushan Wang, Geoffry L Curran, Hoon-Ki Min, Val J Lowe, Karunya K Kandimall. Insulin Signaling Differentially Regulates the Trafficking of Insulin and Amyloid Beta Peptides at the Blood-Brain Barrier. Molecular pharmaceutics. 2024-04-16. PMID:38625027. |
in alzheimer's disease (ad) brain, increased aβ levels are paralleled by decreased insulin levels, which are accompanied by insulin signaling deficits at the bbb. |
2024-04-16 |
2024-04-18 |
mouse |
| Qun-Shan Lu, Lin Ma, Wen-Jing Jiang, Xing-Bang Wang, Mei L. KAT7/HMGN1 signaling epigenetically induces tyrosine phosphorylation-regulated kinase 1A expression to ameliorate insulin resistance in Alzheimer's disease. World journal of psychiatry. vol 14. issue 3. 2024-04-15. PMID:38617985. |
kat7/hmgn1 signaling epigenetically induces tyrosine phosphorylation-regulated kinase 1a expression to ameliorate insulin resistance in alzheimer's disease. |
2024-04-15 |
2024-04-17 |
Not clear |
| b' Melina Rojas-Criollo, Nil Novau-Ferr\\xc3\\xa9, Laia Gutierrez-Tordera, Miren Ettcheto, Jaume Folch, Christopher Papandreou, Laura Panisello, Amanda Cano, Hamza Mostafa, Javier Mateu-Fabregat, Marina Carrasco, Antoni Camins, M\\xc3\\xb2nica Bull\\xc3\\xb. Effects of a High-Fat Diet on Insulin-Related miRNAs in Plasma and Brain Tissue in APP Nutrients. vol 16. issue 7. 2024-04-13. PMID:38612989.' |
effects of a high-fat diet on insulin-related mirnas in plasma and brain tissue in app insulin resistance (ir)-related mirnas have been associated with the development and progression of alzheimer's disease (ad). |
2024-04-13 |
2024-04-15 |
Not clear |
| Punya Sachdeva, Kannan Badri Narayanan, Jitendra Kumar Sinha, Saurabh Gupta, Shampa Ghosh, Krishna Kumar Singh, Rakesh Bhaskar, Abdulmajeed G Almutary, James H Zothantluanga, Kranthi Kumar Kotta, Vinod Kumar Nelson, Ana Cláudia Paiva-Santos, Mosleh Mohammad Abomughaid, Mehnaz Kamal, Danish Iqbal, Mohammed Hamoud ALHarbi, Awadh Aedh ALMutairi, Saikat Dewanjee, Mohana Vamsi Nuli, Shanmugam Vippamakula, Saurabh Kumar Jha, Shreesh Ojha, Niraj Kumar Jh. Recent Advances in Drug Delivery Systems Targeting Insulin Signalling for the Treatment of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2024-04-12. PMID:38607755. |
recent advances in drug delivery systems targeting insulin signalling for the treatment of alzheimer's disease. |
2024-04-12 |
2024-04-15 |
Not clear |
| Mubeen A Ansari, Aishah Al-Jarallah, Muddanna S Rao, Ahmed Babiker, Khaled Bensalama. Upregulation of NADPH-oxidase, inducible nitric oxide synthase and apoptosis in the hippocampus following impaired insulin signaling in the rats: Development of sporadic Alzheimer's disease. Brain research. 2024-03-29. PMID:38552936. |
upregulation of nadph-oxidase, inducible nitric oxide synthase and apoptosis in the hippocampus following impaired insulin signaling in the rats: development of sporadic alzheimer's disease. |
2024-03-29 |
2024-04-01 |
rat |
| Alosh Greeny, Ayushi Nair, Prashant Sadanandan, Sairaj Satarker, Ademola C Famurewa, Madhavan Nampoothir. Epigenetic Alterations in Alzheimer's Disease: Impact on Insulin Signaling and Advanced Drug Delivery Systems. Biology. vol 13. issue 3. 2024-03-27. PMID:38534427. |
epigenetic alterations in alzheimer's disease: impact on insulin signaling and advanced drug delivery systems. |
2024-03-27 |
2024-03-29 |
Not clear |
| J Tabitha Hees, Simone Wanderoy, Jana Lindner, Marlena Helms, Hariharan Murali Mahadevan, Angelika B Harbaue. Insulin signalling regulates Pink1 mRNA localization via modulation of AMPK activity to support PINK1 function in neurons. Nature metabolism. 2024-03-20. PMID:38504131. |
induction of insulin resistance in vitro by the key genetic alzheimer risk factor apolipoprotein e4 retains pink1 mrna at the mitochondria and prevents proper pink1 activity, especially in neurites. |
2024-03-20 |
2024-03-23 |
Not clear |
| Xin Cheng, Yejun Tan, Hongli Li, Zhen Zhang, Shan Hui, Zheyu Zhang, Weijun Pen. Mechanistic Insights and Potential Therapeutic Implications of NRF2 in Diabetic Encephalopathy. Molecular neurobiology. 2024-03-14. PMID:38483656. |
mounting evidence has demonstrated a close correlation between de and various factors, such as alzheimer's disease-like pathological changes, insulin resistance, inflammation, and oxidative stress. |
2024-03-14 |
2024-03-17 |
Not clear |
| Kylie Smith, Jinda Fan, Gwendolyn A Marriner, John Gerdes, Robert Kessler, Kurt R Zin. Distribution of insulin in primate brain following nose-to-brain transport. Alzheimer's & dementia (New York, N. Y.). vol 10. issue 1. 2024-03-12. PMID:38469552. |
nose-to-brain (n2b) insulin delivery has potential for alzheimer's disease (ad) therapy. |
2024-03-12 |
2024-03-14 |
Not clear |
| Xingzhi Guo, Peng Tang, Xin Zhang, Rui L. Revisiting the Effect of Leptin on Alzheimer's Disease and Parkinson's Disease: the Role of Insulin Sensitivity. The Journal of clinical endocrinology and metabolism. 2024-03-05. PMID:38441543. |
revisiting the effect of leptin on alzheimer's disease and parkinson's disease: the role of insulin sensitivity. |
2024-03-05 |
2024-03-07 |
Not clear |
| Chun Yuen Jerry Wong, Alberto Baldelli, Camilla M Hoyos, Ole Tietz, Hui Xin Ong, Daniela Train. Insulin Delivery to the Brain via the Nasal Route: Unraveling the Potential for Alzheimer's Disease Therapy. Drug delivery and translational research. 2024-03-05. PMID:38441832. |
insulin delivery to the brain via the nasal route: unraveling the potential for alzheimer's disease therapy. |
2024-03-05 |
2024-03-07 |
Not clear |
| Chun Yuen Jerry Wong, Alberto Baldelli, Camilla M Hoyos, Ole Tietz, Hui Xin Ong, Daniela Train. Insulin Delivery to the Brain via the Nasal Route: Unraveling the Potential for Alzheimer's Disease Therapy. Drug delivery and translational research. 2024-03-05. PMID:38441832. |
this comprehensive review delves into the potential of intranasal insulin delivery for managing alzheimer's disease (ad) while exploring the connection between ad and diabetes mellitus (dm). |
2024-03-05 |
2024-03-07 |
Not clear |
| Julia Eisenhardt de Mello, Fernanda Cardoso Teixeira, Alessandra Dos Santos, Karina Luduvico, Mayara Sandrielly Soares de Aguiar, William Borges Domingues, Vinicius Farias Campos, Rejane Giacomelli Tavares, Augusto Schneider, Francieli Moro Stefanello, Roselia Maria Spanevell. Treatment with Blackberry Extract and Metformin in Sporadic Alzheimer's Disease Model: Impact on Memory, Inflammation, Redox Status, Phosphorylated Tau Protein and Insulin Signaling. Molecular neurobiology. 2024-03-02. PMID:38430352. |
treatment with blackberry extract and metformin in sporadic alzheimer's disease model: impact on memory, inflammation, redox status, phosphorylated tau protein and insulin signaling. |
2024-03-02 |
2024-03-04 |
rat |
| Luis Jesuino de Oliveira Andrade, Luís Matos de Oliveira, Alcina Maria Vinhaes Bittencourt, Letícia Góes de Carvalho Lourenço, Gabriela Correia Matos de Oliveir. Brain insulin resistance and Alzheimer's disease: a systematic review. Dementia & neuropsychologia. vol 18. 2024-03-01. PMID:38425702. |
brain insulin resistance and alzheimer's disease: a systematic review. |
2024-03-01 |
2024-03-03 |
Not clear |
| Francisco Irochima Pinheiro, Irami Araújo-Filho, Amália Cinthia Meneses do Rego, Eduardo Pereira de Azevedo, Ricardo Ney Cobucci, Fausto Pierdona Guze. Hepatopancreatic metabolic disorders and their implications in the development of Alzheimer's disease and vascular dementia. Ageing research reviews. 2024-02-28. PMID:38417711. |
glucose, insulin and igf-1 metabolized in the liver and pancreas probably have an important influence on the pathophysiology of the most common dementias: alzheimer's and vascular dementia. |
2024-02-28 |
2024-03-02 |
Not clear |
| Xin Jiang, Ji Li, Xiaohui Yao, Hao Ding, Aihong Gu, Zhen Zho. Neuroprotective effects of dipeptidyl peptidase 4 inhibitor on Alzheimer's disease: a narrative review. Frontiers in pharmacology. vol 15. 2024-02-26. PMID:38405664. |
insulin resistance in brain and amyloidogenesis are principal pathological features of diabetes-related cognitive decline and development of alzheimer's disease (ad). |
2024-02-26 |
2024-02-28 |
Not clear |
| Fan Wang, Hui Li, Tiantian Kong, Ligang Shan, Jiajia Guo, Yan Wu, Xingguang Luo, Senthil Kumaran Satyanarayanan, Kuan-Pin Su, Yanlong Li. Association of cigarette smoking with cerebrospinal fluid biomarkers of insulin sensitivity and neurodegeneration. Brain and behavior. vol 14. issue 2. 2024-02-16. PMID:38361318. |
cigarette smoking increases both the risk for insulin resistance and amyloid-β (aβ) aggregation, and impaired brain insulin/insulin-like growth factor 1 (igf1) signaling might increase risk factors for alzheimer's disease (ad). |
2024-02-16 |
2024-02-18 |
Not clear |
| Chiara Rossi, Mariarosaria Distaso, Francesco Raggi, Claudia Kusmic, Francesco Faita, Anna Solin. Lacking P2X7-receptors protects substantia nigra dopaminergic neurons and hippocampal-related cognitive performance from the deleterious effects of high-fat diet exposure in adult male mice. Frontiers in nutrition. vol 11. 2024-02-13. PMID:38344021. |
dietary fat consumption, involved in the pathogenesis of insulin resistance and impaired glucose metabolism, is linked with decline in cognitive functions, dementia, and development of parkinson's disease and alzheimer's disease. |
2024-02-13 |
2024-02-15 |
mouse |
| Mubeen A Ansari, Muddanna Sakkattu Rao, Aishah Al-Jaralla. Insights into early pathogenesis of sporadic Alzheimer's disease: role of oxidative stress and loss of synaptic proteins. Frontiers in neuroscience. vol 17. 2024-01-23. PMID:38260013. |
oxidative stress, induced by impaired insulin signaling in the brain contributes to cognitive loss in sporadic alzheimer's disease (sad). |
2024-01-23 |
2024-01-25 |
rat |
| Yang Hai, Ke Ren, Yarong Zhang, Lili Yang, Haoshi Cao, Xianxia Yuan, Linling Su, Hailong Li, Xiaoli Feng, Dongling Li. HIF-1α serves as a co-linker between AD and T2DM. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 171. 2024-01-19. PMID:38242039. |
alzheimer's disease (ad)-related brain deterioration is linked to the type 2 diabetes mellitus (t2dm) features hyperglycemia, hyperinsulinemia, and insulin resistance. |
2024-01-19 |
2024-01-22 |
Not clear |