| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Young Sim, Da Hyun Choi, Jong Youl Kim, Eun Ran Kim, A-Ra Goh, Yong-Ho Lee, Jong Eun Le. SGLT2 and DPP4 inhibitors improve Alzheimer's disease-like pathology and cognitive function through distinct mechanisms in a T2D-AD mouse model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 168. 2023-10-23. PMID:37871560. |
alzheimer's disease (ad) and type 2 diabetes mellitus (t2d) share common features, including insulin resistance. |
2023-10-23 |
2023-11-08 |
mouse |
| Laryssa Alves-Borba, Verónica Espinosa-Fernández, Ania Canseco-Rodríguez, Ana María Sánchez-Pére. ABA Supplementation Rescues IRS2 and BDNF mRNA Levels in a Triple-Transgenic Mice Model of Alzheimer's Disease. Journal of Alzheimer's disease reports. vol 7. issue 1. 2023-10-18. PMID:37849638. |
insulin resistance underlies alzheimer's disease (ad) by affecting neuroinflammation and brain-derived neurotrophic factor (bdnf) expression. |
2023-10-18 |
2023-11-08 |
mouse |
| Naotaka Izuo, Nobuhiro Watanabe, Yoshihiro Noda, Takashi Saito, Takaomi C Saido, Koutaro Yokote, Harumi Hotta, Takahiko Shimiz. Insulin resistance induces earlier initiation of cognitive dysfunction mediated by cholinergic deregulation in a mouse model of Alzheimer's disease. Aging cell. 2023-10-12. PMID:37822109. |
insulin resistance induces earlier initiation of cognitive dysfunction mediated by cholinergic deregulation in a mouse model of alzheimer's disease. |
2023-10-12 |
2023-10-15 |
mouse |
| Naotaka Izuo, Nobuhiro Watanabe, Yoshihiro Noda, Takashi Saito, Takaomi C Saido, Koutaro Yokote, Harumi Hotta, Takahiko Shimiz. Insulin resistance induces earlier initiation of cognitive dysfunction mediated by cholinergic deregulation in a mouse model of Alzheimer's disease. Aging cell. 2023-10-12. PMID:37822109. |
although insulin resistance increases the risk of alzheimer's disease (ad), the mechanisms remain unclear, partly because no animal model exhibits the insulin-resistant phenotype without persistent hyperglycemia. |
2023-10-12 |
2023-10-15 |
mouse |
| Miriam Corraliza-Gomez, Teresa Bermejo, Jingtao Lilue, Noelia Rodriguez-Iglesias, Jorge Valero, Irene Cozar-Castellano, Eduardo Arranz, Diego Sanchez, Maria Dolores Ganfornin. Insulin-degrading enzyme (IDE) as a modulator of microglial phenotypes in the context of Alzheimer's disease and brain aging. Journal of neuroinflammation. vol 20. issue 1. 2023-10-10. PMID:37817156. |
besides insulin, ide is able to cleave many substrates in vitro, including amyloid beta peptides, making this enzyme a candidate pathophysiological link between alzheimer's disease (ad) and type 2 diabetes (t2d). |
2023-10-10 |
2023-10-15 |
mouse |
| Komal Jabeen, Kanwal Rehman, Muhammad Sajid Hamid Akash, Ahmed Nadeem, Tahir Maqbool Mi. Neuroprotective and Cardiometabolic Role of Vitamin E: Alleviating Neuroinflammation and Metabolic Disturbance Induced by AlCl Biomedicines. vol 11. issue 9. 2023-09-28. PMID:37760893. |
neuroprotective and cardiometabolic role of vitamin e: alleviating neuroinflammation and metabolic disturbance induced by alcl cardiovascular diseases (cvds) and neurodegenerative disorders, such as diabetes mellitus and alzheimer's disease, share a common pathophysiological link involving insulin resistance (ir), inflammation, and hypertension. |
2023-09-28 |
2023-10-07 |
Not clear |
| Jennifer E Bramen, Prabha Siddarth, Emily S Popa, Gavin T Kress, Molly K Rapozo, John F Hodes, Aarthi S Ganapathi, Colby B Slyapich, Ryan M Glatt, Kyron Pierce, Verna R Porter, Claudia Wong, Mihae Kim, Richelin V Dye, Stella Panos, Tess Bookheimer, Tori Togashi, Spencer Loong, Cyrus A Raji, Susan Y Bookheimer, Jared C Roach, David A Merril. Impact of Eating a Carbohydrate-Restricted Diet on Cortical Atrophy in a Cross-Section of Amyloid Positive Patients with Alzheimer's Disease: A Small Sample Study. Journal of Alzheimer's disease : JAD. 2023-09-24. PMID:37742646. |
a carbohydrate-restricted diet aimed at lowering insulin levels has the potential to slow alzheimer's disease (ad). |
2023-09-24 |
2023-10-07 |
Not clear |
| Pedro Cisternas, Camila Gherardelli, Joel Gutierrez, Paulina Salazar, Carolina Mendez-Orellana, G William Wong, Nibaldo C Inestros. Adiponectin and resistin modulate the progression of Alzheimer´s disease in a metabolic syndrome model. Frontiers in endocrinology. vol 14. 2023-09-21. PMID:37732123. |
metabolic syndrome (mets), a cluster of metabolic conditions that include obesity, hyperlipidemia, and insulin resistance, increases the risk of several aging-related brain diseases, including alzheimer's disease (ad). |
2023-09-21 |
2023-10-07 |
mouse |
| Skylar Davidson, Gayle Allenback, Boris Decourt, Marwan N Sabbag. Type 2 Diabetes Comorbidity and Cognitive Decline in Patients with Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2023-09-18. PMID:37718812. |
although insulin dysregulation and resistance likely participate in alzheimer's disease (ad) etiologies, little is known about the correlation between type 2 diabetes mellitus (t2dm) and the progression of cognitive decline in patients with ad. |
2023-09-18 |
2023-10-07 |
Not clear |
| Thi Kim Chung Le, Xuan Dat Dao, Dang Vung Nguyen, Duc Huy Luu, Thi Minh Hanh Bui, Thi Huong Le, Huu Thang Nguyen, Tran Ngoan Le, Toshio Hosaka, Thi Thu Thao Nguye. Insulin signaling and its application. Frontiers in endocrinology. vol 14. 2023-09-04. PMID:37664840. |
finally, we discuss the recent applications including the diseases related to insulin resistance (obesity, cardiovascular disease, alzheimer's disease, and cancer) and the potential treatment of those based on insulin resistance mechanisms. |
2023-09-04 |
2023-09-07 |
Not clear |
| Marine Monney, François R Jornayvaz, Karim Garian. GLP-1 receptor agonists effect on cognitive function in patients with and without type 2 diabetes. Diabetes & metabolism. 2023-09-01. PMID:37657738. |
type 2 diabetes appears to share common pathophysiological mechanisms with the development of cognitive disorders, such as alzheimer's and parkinson's disease, related to insulin resistance. |
2023-09-01 |
2023-09-07 |
Not clear |
| Jinyi Yao, Zhijun He, Guanying You, Qiong Liu, Nan L. The Deficits of Insulin Signal in Alzheimer's Disease and the Mechanisms of Vanadium Compounds in Curing AD. Current issues in molecular biology. vol 45. issue 8. 2023-08-25. PMID:37623221. |
the deficits of insulin signal in alzheimer's disease and the mechanisms of vanadium compounds in curing ad. |
2023-08-25 |
2023-09-07 |
Not clear |
| Mahima Singh, Ajay Guru, Raghul Murugan, Muthukaruppan Gopi, Jesu Arockiara. Circular RNA ciRS-7 signature as a potential biomarker for the early detection of diabetes with Alzheimer's disease: a hypothesis. Molecular biology reports. 2023-08-24. PMID:37620738. |
additionally, an excess of insulin can impact the brain's chemical balance, contributing to the development of alzheimer's disease. |
2023-08-24 |
2023-09-07 |
Not clear |
| Elizabeth M Rhea, Manon Leclerc, Hussein N Yassine, Ana W Capuano, Han Tong, Vladislav A Petyuk, Shannon L Macauley, Xavier Fioramonti, Owen Carmichael, Frederic Calon, Zoe Arvanitaki. State of the Science on Brain Insulin Resistance and Cognitive Decline Due to Alzheimer's Disease. Aging and disease. 2023-08-23. PMID:37611907. |
state of the science on brain insulin resistance and cognitive decline due to alzheimer's disease. |
2023-08-23 |
2023-09-07 |
Not clear |
| Brian J Sandri, Kathleen Ennis-Czerniak, Priya Kanajam, William H Frey, Eric F Lock, Raghavendra Ra. Intranasal Insulin Treatment Partially Corrects the Altered Gene Expression Profile in the Hippocampus of Developing Rats with Perinatal Iron Deficiency. American journal of physiology. Regulatory, integrative and comparative physiology. 2023-08-21. PMID:37602386. |
intranasal insulin administration improves cognitive deficits in adult humans with alzheimer's disease and type 2 diabetes and could provide benefits in fed-induced hippocampal dysfunction. |
2023-08-21 |
2023-09-07 |
rat |
| Yosra Hussein AboEl-Azm, Mohamed El-Samahy, Nada Ibrahim Hendi, Amina Arar, Noha Samy Yasen, Shrouk Ramadan, Esraa M Zedan, Nada Mostafa Al-Dardery, Abdulrhman Khait. Safety and efficacy of intranasal insulin in patients with Alzheimer's disease: a systematic review and meta-analysis. Journal of clinical and translational research. vol 9. issue 4. 2023-08-11. PMID:37564252. |
safety and efficacy of intranasal insulin in patients with alzheimer's disease: a systematic review and meta-analysis. |
2023-08-11 |
2023-08-16 |
Not clear |
| Yosra Hussein AboEl-Azm, Mohamed El-Samahy, Nada Ibrahim Hendi, Amina Arar, Noha Samy Yasen, Shrouk Ramadan, Esraa M Zedan, Nada Mostafa Al-Dardery, Abdulrhman Khait. Safety and efficacy of intranasal insulin in patients with Alzheimer's disease: a systematic review and meta-analysis. Journal of clinical and translational research. vol 9. issue 4. 2023-08-11. PMID:37564252. |
we performed this meta-analysis to evaluate the safety and efficacy of intranasal insulin in alzheimer's disease (ad) patients. |
2023-08-11 |
2023-08-16 |
Not clear |
| Li Lin, Rashmita Basu, Debolina Chatterjee, Andrew T Templin, Jonathan N Flak, Travis S Johnso. Disease-associated astrocytes and microglia markers are upregulated in mice fed high fat diet. Scientific reports. vol 13. issue 1. 2023-08-09. PMID:37558676. |
high-fat diet (hfd) is associated with alzheimer's disease (ad) and type 2 diabetes risk, which share features such as insulin resistance and amylin deposition. |
2023-08-09 |
2023-08-16 |
mouse |
| Junyi Sun, Zengshuo Xie, Yuzhong Wu, Xiao Liu, Jianyong Ma, Yugang Dong, Chen Liu, Min Ye, Wengen Zh. Association of the triglyceride-glucose index with risk of Alzheimer's disease: a prospective cohort study. American journal of preventive medicine. 2023-07-27. PMID:37499890. |
triglyceride-glucose (tyg) index is a reliable surrogate marker of insulin resistance (ir), whereas ir has been implicated in alzheimer's disease (ad) pathophysiology. |
2023-07-27 |
2023-08-14 |
Not clear |
| Zhuo Yuan, Dongke Yu, Tingting Gou, Guoyuan Tang, Chun Guo, Jianyou Sh. Research progress of NLRP3 inflammasome and its inhibitors with aging diseases. European journal of pharmacology. 2023-07-26. PMID:37495038. |
it is associated with the development of insulin resistance, alzheimer's disease, parkinson's, cardiovascular aging, hearing and vision loss. |
2023-07-26 |
2023-08-14 |
Not clear |