| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fen Zhuge, Liujie Zheng, Yuxiang Pan, Liyang Ni, Zhengwei Fu, Junping Shi, Yinhua N. DPP-4 inhibition by linagliptin ameliorates age-related mild cognitive impairment by regulating microglia polarization in mice. Experimental neurology. 2024-01-10. PMID:38199510. |
extensive preclinical evidence demonstrates a causative link between insulin signaling dysfunction and the pathogenesis of alzheimer's disease (ad), and diabetic drugs may represent a promising approach to fighting ad. |
2024-01-10 |
2024-01-13 |
mouse |
| Benedetta Bigio, Shofiul Azam, Aleksander A Mathé, Carla Nasc. The neuropsychopharmacology of acetyl-L-carnitine (LAC): basic, translational and therapeutic implications. Discover mental health. vol 4. issue 1. 2024-01-03. PMID:38169018. |
furthermore, mitochondrial dysfunction is linked to other processes implicated in the pathophysiology of both major depressive disorders and alzheimer's disease, such as oxidative stress, inflammation, and insulin resistance. |
2024-01-03 |
2024-01-06 |
Not clear |
| Alex J T Yang, Ahmad Mohammad, Michael S Finch, Evangelia Tsiani, Gaynor Spencer, Aleksandar Necakov, Rebecca E K MacPherso. Influence of metabolic stress and metformin on synaptic protein profile in SH-SY5Y-derived neurons. Physiological reports. vol 11. issue 22. 2023-11-28. PMID:38010200. |
insulin resistance (ir) is associated with reductions in neuronal proteins often observed with alzheimer's disease (ad), however, the mechanisms through which ir promotes neurodegeneration/ad pathogenesis are poorly understood. |
2023-11-28 |
2023-11-29 |
Not clear |
| Dokyun Na, Do-Hwan Lim, Jae-Sang Hong, Hyang-Mi Lee, Daeahn Cho, Myeong-Sang Yu, Bilal Shaker, Jun Ren, Bomi Lee, Jae Gwang Song, Yuna Oh, Kyungeun Lee, Kwang-Seok Oh, Mi Young Lee, Min-Seok Choi, Han Saem Choi, Yang-Hee Kim, Jennifer M Bui, Kangseok Lee, Hyung Wook Kim, Young Sik Lee, Jörg Gspone. A multi-layered network model identifies Akt1 as a common modulator of neurodegeneration. Molecular systems biology. 2023-11-20. PMID:37984409. |
when applied to the four nds alzheimer's disease (ad), huntington's disease, and spinocerebellar ataxia types 1 and 3, we predicted multiple members of the insulin pathway, including pdk1, akt1, inr, and sgg (gsk-3β), as common modifiers. |
2023-11-20 |
2023-11-29 |
mouse |
| Hamed A Abosharaf, Yasmin Elsonbaty, Ehab Tousson, Tarek M Mohame. Alzheimer's disease-related brain insulin resistance and the prospective therapeutic impact of metformin. Journal of neuroendocrinology. 2023-11-20. PMID:37985011. |
alzheimer's disease-related brain insulin resistance and the prospective therapeutic impact of metformin. |
2023-11-20 |
2023-11-29 |
rat |
| Hamed A Abosharaf, Yasmin Elsonbaty, Ehab Tousson, Tarek M Mohame. Alzheimer's disease-related brain insulin resistance and the prospective therapeutic impact of metformin. Journal of neuroendocrinology. 2023-11-20. PMID:37985011. |
besides covid-19, two of the most critical outbreaks of our day are insulin resistance, type 2 diabetes mellitus (t2dm), and alzheimer's disease (ad). |
2023-11-20 |
2023-11-29 |
rat |
| A N Ishmuratova, M A Abramov, K O Kuznetsov, M V Ivanyuta, Z F Shakirova, A I Kitapova, M D Usmonov, L M Chernousova, L I Valeeva, A Yu Kuznetsova, A S Baislamov, A R Shaihetdinova, A A Mirgaliev, S T Orozberdiev, K I Yakupov. [The role of antidiabetic drugs in the treatment of Alzheimer's disease: systematic review]. Problemy endokrinologii. vol 69. issue 5. 2023-11-16. PMID:37968954. |
recent studies show that alzheimer's disease (ad) has many common links with conditions associated with insulin resistance, including neuroinflammation, impaired insulin signaling, oxidative stress, mitochondrial dysfunction and metabolic syndrome. |
2023-11-16 |
2023-11-20 |
human |
| A N Ishmuratova, M A Abramov, K O Kuznetsov, M V Ivanyuta, Z F Shakirova, A I Kitapova, M D Usmonov, L M Chernousova, L I Valeeva, A Yu Kuznetsova, A S Baislamov, A R Shaihetdinova, A A Mirgaliev, S T Orozberdiev, K I Yakupov. [The role of antidiabetic drugs in the treatment of Alzheimer's disease: systematic review]. Problemy endokrinologii. vol 69. issue 5. 2023-11-16. PMID:37968954. |
the authors conducted an electronic search for publications in the pubmed/medline and google scholar databases using the keywords "amyloid beta", "alzheimer type-3-diabetes", "intranasal insulin", "metformin", "type 2 diabetes mellitus", "incretins" and "ppary agonists». |
2023-11-16 |
2023-11-20 |
human |
| A N Ishmuratova, M A Abramov, K O Kuznetsov, M V Ivanyuta, Z F Shakirova, A I Kitapova, M D Usmonov, L M Chernousova, L I Valeeva, A Yu Kuznetsova, A S Baislamov, A R Shaihetdinova, A A Mirgaliev, S T Orozberdiev, K I Yakupov. [The role of antidiabetic drugs in the treatment of Alzheimer's disease: systematic review]. Problemy endokrinologii. vol 69. issue 5. 2023-11-16. PMID:37968954. |
human studies involving patients with mild cognitive impairment and alzheimer's disease have shown that the administration of certain antidiabetic drugs, such as intranasal insulin, metformin, incretins and thiazolidinediones, can improve cognitive function and memory. |
2023-11-16 |
2023-11-20 |
human |
| Gamze Camlik, Besa Bilakaya, Yildiz Ozsoy, Ismail Tuncer Degi. A new approach for the treatment of Alzheimer's Disease: Insulin-Quantum Dots. Journal of microencapsulation. 2023-11-15. PMID:37966713. |
the potential use of insulin supplementation for alzheimer's disease(ad) was aimed to investigate and explore cqds as an alternative delivery system. |
2023-11-15 |
2023-11-20 |
Not clear |
| Medha Sharma, Yamini Yadav, Chinmoy Sankar De. Neuronal insulin signaling and resistance: a balancing act of kinases and phosphatases. The Journal of endocrinology. 2023-11-06. PMID:37930675. |
any impairment in neuronal insulin signaling affecting neuronal glucose uptake has been associated with neurodegenerative disorders like alzheimer's disorder, which is now being termed as type-3 diabetes. |
2023-11-06 |
2023-11-08 |
Not clear |
| Ayesha Fauzi, Ewen Se Thoe, Tang Yin Quan, Adeline Chia Yoke Yi. Insights from insulin resistance pathways: Therapeutic approaches against Alzheimer associated diabetes mellitus. Journal of diabetes and its complications. vol 37. issue 11. 2023-11-05. PMID:37866274. |
insights from insulin resistance pathways: therapeutic approaches against alzheimer associated diabetes mellitus. |
2023-11-05 |
2023-11-08 |
Not clear |
| b' Angela Maria Ottomana, Martina Presta, Aet O\'Leary, Mair\\xc3\\xa9ad Sullivan, Edoardo Pisa, Giovanni Laviola, Jeffrey C Glennon, Francesca Zoratto, David A Slattery, Simone Macr\\xc3\\xa. A Systematic Review of Preclinical Studies Exploring the Role of Insulin Signalling in Executive Function and Memory. Neuroscience and biobehavioral reviews. 2023-11-01. PMID:37913873.' |
beside its involvement in somatic dysfunctions, altered insulin signalling constitutes a risk factor for the development of mental disorders like alzheimer's disease and obsessive-compulsive disorder. |
2023-11-01 |
2023-11-08 |
Not clear |
| Chloé Sarnowski, Tianxiao Huan, Yiyi Ma, Roby Joehanes, Alexa Beiser, Charles S DeCarli, Nancy L Heard-Costa, Daniel Levy, Honghuang Lin, Ching-Ti Liu, Chunyu Liu, James B Meigs, Claudia L Satizabal, Jose C Florez, Marie-France Hivert, Josée Dupuis, Philip L De Jager, David A Bennett, Sudha Seshadri, Alanna C Morriso. Multi-tissue epigenetic analysis identifies distinct associations underlying insulin resistance and Alzheimer's disease at CPT1A locus. Clinical epigenetics. vol 15. issue 1. 2023-10-30. PMID:37891690. |
multi-tissue epigenetic analysis identifies distinct associations underlying insulin resistance and alzheimer's disease at cpt1a locus. |
2023-10-30 |
2023-11-08 |
Not clear |
| Chloé Sarnowski, Tianxiao Huan, Yiyi Ma, Roby Joehanes, Alexa Beiser, Charles S DeCarli, Nancy L Heard-Costa, Daniel Levy, Honghuang Lin, Ching-Ti Liu, Chunyu Liu, James B Meigs, Claudia L Satizabal, Jose C Florez, Marie-France Hivert, Josée Dupuis, Philip L De Jager, David A Bennett, Sudha Seshadri, Alanna C Morriso. Multi-tissue epigenetic analysis identifies distinct associations underlying insulin resistance and Alzheimer's disease at CPT1A locus. Clinical epigenetics. vol 15. issue 1. 2023-10-30. PMID:37891690. |
insulin resistance (ir) is a major risk factor for alzheimer's disease (ad) dementia. |
2023-10-30 |
2023-11-08 |
Not clear |
| Bhumsoo Kim, Yoon-Tae Kang, Faye E Mendelson, John M Hayes, Masha G Savelieff, Sunitha Nagrath, Eva L Feldma. Palmitate and glucose increase amyloid precursor protein in extracellular vesicles: Missing link between metabolic syndrome and Alzheimer's disease. Journal of extracellular vesicles. vol 12. issue 11. 2023-10-30. PMID:37898562. |
the metabolic syndrome (mets) and alzheimer's disease share several pathological features, including insulin resistance, abnormal protein processing, mitochondrial dysfunction and elevated inflammation and oxidative stress. |
2023-10-30 |
2023-11-08 |
human |
| Bhumsoo Kim, Yoon-Tae Kang, Faye E Mendelson, John M Hayes, Masha G Savelieff, Sunitha Nagrath, Eva L Feldma. Palmitate and glucose increase amyloid precursor protein in extracellular vesicles: Missing link between metabolic syndrome and Alzheimer's disease. Journal of extracellular vesicles. vol 12. issue 11. 2023-10-30. PMID:37898562. |
insulin resistance, which develops from a diet rich in sugars and saturated fatty acids, such as palmitate, is shared by the mets and alzheimer's disease. |
2023-10-30 |
2023-11-08 |
human |
| Bhumsoo Kim, Yoon-Tae Kang, Faye E Mendelson, John M Hayes, Masha G Savelieff, Sunitha Nagrath, Eva L Feldma. Palmitate and glucose increase amyloid precursor protein in extracellular vesicles: Missing link between metabolic syndrome and Alzheimer's disease. Journal of extracellular vesicles. vol 12. issue 11. 2023-10-30. PMID:37898562. |
however, the role of palmitate- and glucose-induced insulin resistance in the brain and its potential link through evs to alzheimer's disease is unknown. |
2023-10-30 |
2023-11-08 |
human |
| Bhumsoo Kim, Yoon-Tae Kang, Faye E Mendelson, John M Hayes, Masha G Savelieff, Sunitha Nagrath, Eva L Feldma. Palmitate and glucose increase amyloid precursor protein in extracellular vesicles: Missing link between metabolic syndrome and Alzheimer's disease. Journal of extracellular vesicles. vol 12. issue 11. 2023-10-30. PMID:37898562. |
overall, our findings suggest a novel theory underlying the increased risk of alzheimer's disease in mets mediated by evs, which spread alzheimer's pathology and insulin resistance. |
2023-10-30 |
2023-11-08 |
human |
| Meng Mei, Maochang Liu, Yan Mei, Jing Zhao, Yang L. Sphingolipid metabolism in brain insulin resistance and neurological diseases. Frontiers in endocrinology. vol 14. 2023-10-24. PMID:37867511. |
in addition to metabolic diseases, like type 2 diabetes, brain insulin resistance is also involved in the progression of neurodegenerative diseases including alzheimer's disease and parkinson's disease. |
2023-10-24 |
2023-11-08 |
Not clear |