| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Suélen Santos Alves, Gabriel Servilha-Menezes, Leticia Rossi, Rui Milton Patrício da Silva Junior, Norberto Garcia-Cairasc. Evidence of Disturbed Insulin Signaling in Animal Models of Alzheimer's Disease. Neuroscience and biobehavioral reviews. 2023-07-21. PMID:37479008. |
in addition, alterations in the regulation of central insulin pathways have been observed in the brains of alzheimer's disease (ad) patients. |
2023-07-21 |
2023-08-14 |
Not clear |
| Suélen Santos Alves, Gabriel Servilha-Menezes, Leticia Rossi, Rui Milton Patrício da Silva Junior, Norberto Garcia-Cairasc. Evidence of Disturbed Insulin Signaling in Animal Models of Alzheimer's Disease. Neuroscience and biobehavioral reviews. 2023-07-21. PMID:37479008. |
evidence of disturbed insulin signaling in animal models of alzheimer's disease. |
2023-07-21 |
2023-08-14 |
Not clear |
| Víctor Navalón-Monllor, Laura Soriano-Romaní, Mariana Silva, María-Carmen López de Las Hazas, Natalia Hernando-Quintana, Teodoro Suárez Diéguez, Pere Morell Esteve, Juan Antonio Niet. Microbiota dysbiosis caused by dietetic patterns as a promoter of Alzheimer's disease through metabolic syndrome mechanisms. Food & function. 2023-07-20. PMID:37470232. |
at the brain and neuronal levels, the generated insulin resistance, low-grade chronic inflammation, leptin resistance, age production and lps increase directly impact the secretase enzymes and tau hyperphosphorylation, creating an enabling environment for β-amyloid senile plaque and tau tangled formations and, as a consequence, alzheimer's initiation, development and maintenance. |
2023-07-20 |
2023-08-14 |
Not clear |
| Hoau-Yan Wang, Zhe Pei, Kuo-Chieh Lee, Boris Nikolov, Tamara Doehner, John Puente, Nadav Friedmann, Lindsay H Burn. Simufilam suppresses overactive mTOR and restores its sensitivity to insulin in Alzheimer's disease patient lymphocytes. Frontiers in aging. vol 4. 2023-07-17. PMID:37457922. |
simufilam suppresses overactive mtor and restores its sensitivity to insulin in alzheimer's disease patient lymphocytes. |
2023-07-17 |
2023-08-14 |
Not clear |
| Ewa Trojan, Katarzyna Curzytek, Paulina Cieślik, Joanna M Wierońska, Johannes Graff, Władysław Lasoń, Takashi Saito, Takaomi C Saido, Agnieszka Basta-Kai. Prenatal stress aggravates age-dependent cognitive decline, insulin signaling dysfunction, and the pro-inflammatory response in the APP Neurobiology of disease. 2023-07-08. PMID:37422091. |
prenatal stress aggravates age-dependent cognitive decline, insulin signaling dysfunction, and the pro-inflammatory response in the app accumulating evidence indicates that early adverse life experiences may be involved in the pathogenesis of alzheimer's disease (ad). |
2023-07-08 |
2023-08-14 |
Not clear |
| Chaojie Ye, Lijie Kong, Yiying Wang, Jie Zheng, Min Xu, Yu Xu, Mian Li, Zhiyun Zhao, Jieli Lu, Yuhong Chen, Weiqing Wang, Guang Ning, Yufang Bi, Tiange Wan. Causal associations of sarcopenia-related traits with cardiometabolic disease and Alzheimer's disease and the mediating role of insulin resistance: A Mendelian randomization study. Aging cell. 2023-07-05. PMID:37403750. |
causal associations of sarcopenia-related traits with cardiometabolic disease and alzheimer's disease and the mediating role of insulin resistance: a mendelian randomization study. |
2023-07-05 |
2023-08-14 |
human |
| Chaojie Ye, Lijie Kong, Yiying Wang, Jie Zheng, Min Xu, Yu Xu, Mian Li, Zhiyun Zhao, Jieli Lu, Yuhong Chen, Weiqing Wang, Guang Ning, Yufang Bi, Tiange Wan. Causal associations of sarcopenia-related traits with cardiometabolic disease and Alzheimer's disease and the mediating role of insulin resistance: A Mendelian randomization study. Aging cell. 2023-07-05. PMID:37403750. |
the causal influence of sarcopenia on cardiometabolic disease and alzheimer's disease and whether and to what extent insulin resistance plays a mediating role therein were unclear. |
2023-07-05 |
2023-08-14 |
human |
| Chaojie Ye, Lijie Kong, Yiying Wang, Jie Zheng, Min Xu, Yu Xu, Mian Li, Zhiyun Zhao, Jieli Lu, Yuhong Chen, Weiqing Wang, Guang Ning, Yufang Bi, Tiange Wan. Causal associations of sarcopenia-related traits with cardiometabolic disease and Alzheimer's disease and the mediating role of insulin resistance: A Mendelian randomization study. Aging cell. 2023-07-05. PMID:37403750. |
we performed two-step, two-sample mendelian randomization applying genetic instruments of sarcopenia-related traits based on gwass from the uk biobank (up to 461,026 european participants) to examine their causal associations with six cardiometabolic diseases and alzheimer's disease extracted from large-scale european descent gwass with adjustment for body fat percentage and physical activity, and to assess proportions of the causal effects mediated by insulin resistance. |
2023-07-05 |
2023-08-14 |
human |
| Chaojie Ye, Lijie Kong, Yiying Wang, Jie Zheng, Min Xu, Yu Xu, Mian Li, Zhiyun Zhao, Jieli Lu, Yuhong Chen, Weiqing Wang, Guang Ning, Yufang Bi, Tiange Wan. Causal associations of sarcopenia-related traits with cardiometabolic disease and Alzheimer's disease and the mediating role of insulin resistance: A Mendelian randomization study. Aging cell. 2023-07-05. PMID:37403750. |
these findings support improving sarcopenia-related traits as precautions against major cardiometabolic diseases and alzheimer's disease, with particular emphasis on insulin resistance as a target in the intervention of sarcopenia-related cardiometabolic risk. |
2023-07-05 |
2023-08-14 |
human |
| Syed Obaidur Rahman, Tahira Khan, Ashif Iqubal, Shivani Agarwal, Mohd Akhtar, Suhel Parvez, Zahoor Ahmad Shah, Abul Kalam Najm. Association between insulin and Nrf2 signalling pathway in Alzheimer's disease: A molecular landscape. Life sciences. 2023-07-02. PMID:37394097. |
association between insulin and nrf2 signalling pathway in alzheimer's disease: a molecular landscape. |
2023-07-02 |
2023-08-14 |
Not clear |
| Syed Obaidur Rahman, Tahira Khan, Ashif Iqubal, Shivani Agarwal, Mohd Akhtar, Suhel Parvez, Zahoor Ahmad Shah, Abul Kalam Najm. Association between insulin and Nrf2 signalling pathway in Alzheimer's disease: A molecular landscape. Life sciences. 2023-07-02. PMID:37394097. |
in 2005, dr. suzanne de la monte and her team reported that insulin might be involved in the pathogenesis of alzheimer's disease (ad) and thus coined a term "type-3 diabetes" this hypothesis was supported by several subsequent studies. |
2023-07-02 |
2023-08-14 |
Not clear |
| Jingwen Wang, Zhiling Yu, Ye Peng, Baojun X. Insights into prevention mechanisms of bioactive components from healthy diets against Alzheimer's disease. The Journal of nutritional biochemistry. 2023-06-10. PMID:37301484. |
alzheimer's disease (ad) is a progressive neurodegenerative disease in which senile plaques, neurofibrillary tangles, insulin resistance, oxidative stress, chronic neuroinflammation, and abnormal neurotransmission are the potential mechanisms involved in its onset and development. |
2023-06-10 |
2023-08-14 |
Not clear |
| Elham Sajadi, Javad Sajedianfard, Saeid Hosseinzadeh, Mahnaz Taherianfar. Effect of insulin and cinnamon extract on spatial memory and gene expression of GLUT1, 3, and 4 in streptozotocin-induced Alzheimer's model in rats. Iranian journal of basic medical sciences. vol 26. issue 6. 2023-06-06. PMID:37275760. |
effect of insulin and cinnamon extract on spatial memory and gene expression of glut1, 3, and 4 in streptozotocin-induced alzheimer's model in rats. |
2023-06-06 |
2023-08-14 |
rat |
| Elham Sajadi, Javad Sajedianfard, Saeid Hosseinzadeh, Mahnaz Taherianfar. Effect of insulin and cinnamon extract on spatial memory and gene expression of GLUT1, 3, and 4 in streptozotocin-induced Alzheimer's model in rats. Iranian journal of basic medical sciences. vol 26. issue 6. 2023-06-06. PMID:37275760. |
since diminished hippocampal insulin signaling leads to memory impairment, insulin resistance and hyperinsulinemia are probably associated with alzheimer's disease (ad). |
2023-06-06 |
2023-08-14 |
rat |
| Yoshinori Marunak. Molecular Mechanisms of Obesity-Induced Development of Insulin Resistance and Promotion of Amyloid-β Accumulation: Dietary Therapy Using Weak Organic Acids via Improvement of Lowered Interstitial Fluid pH. Biomolecules. vol 13. issue 5. 2023-05-27. PMID:37238649. |
insulin resistance is one of the etiologies of type 2 diabetes mellitus (t2dm) and has been suggested to contribute to the development of alzheimer's disease by promoting amyloid-β accumulation. |
2023-05-27 |
2023-08-14 |
Not clear |
| Yoshinori Marunak. Molecular Mechanisms of Obesity-Induced Development of Insulin Resistance and Promotion of Amyloid-β Accumulation: Dietary Therapy Using Weak Organic Acids via Improvement of Lowered Interstitial Fluid pH. Biomolecules. vol 13. issue 5. 2023-05-27. PMID:37238649. |
elucidating the mechanisms underlying the development of insulin resistance is one of the key factors in developing methods to prevent the onset of t2dm and alzheimer's disease. |
2023-05-27 |
2023-08-14 |
Not clear |
| Sarah D Bauermeister, Michael Ben Yehuda, Graham Reid, Gregory Howgego, Karen Ritchie, Tam Watermeyer, Sarah Gregory, Graciela Muniz Terrera, Ivan Koyche. Insulin resistance, age and depression's impact on cognition in middle-aged adults from the PREVENT cohort. BMJ mental health. vol 26. issue 1. 2023-05-26. PMID:37236657. |
alzheimer's disease (ad), type 2 diabetes mellitus (characterised by insulin resistance) and depression are significant challenges facing public health. |
2023-05-26 |
2023-08-14 |
Not clear |
| Anne B Kim, Zoe Arvanitaki. Insulin resistance, cognition, and Alzheimer disease. Obesity (Silver Spring, Md.). vol 31. issue 6. 2023-05-19. PMID:37203336. |
insulin resistance, cognition, and alzheimer disease. |
2023-05-19 |
2023-08-14 |
Not clear |
| Wenqiang Chen, Qian Huang, Ekaterina Katie Lazdon, Antonio Gomes, Marisa Wong, Emily Stephens, Tabitha Grace Royal, Dan Frenkel, Weikang Cai, C Ronald Kah. Loss of insulin signaling in astrocytes exacerbates Alzheimer-like phenotypes in a 5xFAD mouse model. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 21. 2023-05-15. PMID:37186836. |
epidemiological studies have indicated a strong connection between type 2 diabetes (t2d) and neurodegenerative disorders, especially alzheimer's disease (ad), linked via dysregulation of insulin signaling, i.e., insulin resistance. |
2023-05-15 |
2023-08-14 |
mouse |
| Mohsin Ali Khan, Zaw Ali Khan, Fouzia Shoeb, Ghizal Fatima, Rizwan Hasan Khan, Mohammad M Kha. Role of de novo lipogenesis in inflammation and insulin resistance in alzheimer's disease. International journal of biological macromolecules. 2023-05-15. PMID:37187418. |
role of de novo lipogenesis in inflammation and insulin resistance in alzheimer's disease. |
2023-05-15 |
2023-08-14 |
Not clear |