| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| X K Tong, E Hame. Regional cholinergic denervation of cortical microvessels and nitric oxide synthase-containing neurons in Alzheimer's disease. Neuroscience. vol 92. issue 1. 1999-10-06. PMID:10392839. |
regional cholinergic denervation of cortical microvessels and nitric oxide synthase-containing neurons in alzheimer's disease. |
1999-10-06 |
2023-08-12 |
human |
| X K Tong, E Hame. Regional cholinergic denervation of cortical microvessels and nitric oxide synthase-containing neurons in Alzheimer's disease. Neuroscience. vol 92. issue 1. 1999-10-06. PMID:10392839. |
in the present study, we investigated in the human cerebral cortex whether, as in the rat, basal forebrain cholinergic neurons innervate cortical microvessels and nitric oxide synthase-containing neurons and, further, we compared the status of this innervation between aged controls and neuropathologically confirmed cases of alzheimer's disease. |
1999-10-06 |
2023-08-12 |
human |
| X K Tong, E Hame. Regional cholinergic denervation of cortical microvessels and nitric oxide synthase-containing neurons in Alzheimer's disease. Neuroscience. vol 92. issue 1. 1999-10-06. PMID:10392839. |
the data indicate that intracortical microvessels and nitric oxide neurons in alzheimer's disease are deprived of a cholinergic neurogenic control, a situation which is likely to result in a compromised ability to adapt cortical perfusion to neuronal activation during functional tasks related to cognition, arousal and attention. |
1999-10-06 |
2023-08-12 |
human |
| E Gahtan, J B Overmie. Inflammatory pathogenesis in Alzheimer's disease: biological mechanisms and cognitive sequeli. Neuroscience and biobehavioral reviews. vol 23. issue 5. 1999-08-23. PMID:10392655. |
the effects of brain inflammation, mediated through cytokines and other secretory products of activated glial cells, on neurotransmission (specifically, nitric oxide, glutamate, and acetylcholine), amyloidogenesis, proteolysis, and oxidative stress are discussed within the context of the pathogenesis of learning and memory dysfunction in alzheimer's disease. |
1999-08-23 |
2023-08-12 |
human |
| D T Yew, H W Wong, W P Li, H W Lai, W H Y. Nitric oxide synthase neurons in different areas of normal aged and Alzheimer's brains. Neuroscience. vol 89. issue 3. 1999-07-07. PMID:10199604. |
this study investigated the distribution of nitric oxide synthase-containing neurons in the cerebral cortex of individuals with alzheimer's disease, and compared them with age-matched controls. |
1999-07-07 |
2023-08-12 |
human |
| D T Yew, H W Wong, W P Li, H W Lai, W H Y. Nitric oxide synthase neurons in different areas of normal aged and Alzheimer's brains. Neuroscience. vol 89. issue 3. 1999-07-07. PMID:10199604. |
in the frontal cortex of the alzheimer group, while a decrease in the number of nitric oxide synthase-positive neurons was evident, the nitric oxide synthase neurons, on the other hand, showed an increased optical density in layers ii-iv when compared with those of normal ageing. |
1999-07-07 |
2023-08-12 |
human |
| M F McCart. Vascular nitric oxide may lessen Alzheimer's risk. Medical hypotheses. vol 51. issue 6. 1999-05-17. PMID:10052865. |
vascular nitric oxide may lessen alzheimer's risk. |
1999-05-17 |
2023-08-12 |
Not clear |
| H J Lüth, T Arend. Nitric oxide and Alzheimer's disease. Journal fur Hirnforschung. vol 39. issue 2. 1999-05-07. PMID:10022348. |
nitric oxide and alzheimer's disease. |
1999-05-07 |
2023-08-12 |
Not clear |
| H Tohgi, T Abe, K Yamazaki, T Murata, C Isobe, E Ishizak. The cerebrospinal fluid oxidized NO metabolites, nitrite and nitrate, in Alzheimer's disease and vascular dementia of Binswanger type and multiple small infarct type. Journal of neural transmission (Vienna, Austria : 1996). vol 105. issue 10-12. 1999-04-15. PMID:9928897. |
the concentration of the nitric oxide (no) metabolites nitrite (no2-) and nitrate (no3-) in the cerebrospinal fluid from patients with alzheimer's disease (ad), vascular dementia of the binswanger type (vdbt) or multiple small infarct type (msid), and controls were determined using high performance liquid chromatography. |
1999-04-15 |
2023-08-12 |
Not clear |
| M A Smith, M Vasák, M Knipp, R J Castellani, G Perr. Dimethylargininase, a nitric oxide regulatory protein, in Alzheimer disease. Free radical biology & medicine. vol 25. issue 8. 1999-02-25. PMID:9840734. |
dimethylargininase, a nitric oxide regulatory protein, in alzheimer disease. |
1999-02-25 |
2023-08-12 |
Not clear |
| M M Mesula. Some cholinergic themes related to Alzheimer's disease: synaptology of the nucleus basalis, location of m2 receptors, interactions with amyloid metabolism, and perturbations of cortical plasticity. Journal of physiology, Paris. vol 92. issue 3-4. 1999-01-13. PMID:9789826. |
the depletion of cortical m2 in alzheimer's disease (ad) appears to reflect the loss of presynaptic autoreceptors located on incoming axons from the nucleus basalis of meynert (nbm) and also the loss of postsynaptic receptors located on a novel group of nitric oxide producing interstitial neurons in the cerebral cortex. |
1999-01-13 |
2023-08-12 |
Not clear |
| G A Bubenik, D E Blask, G M Brown, G J Maestroni, S F Pang, R J Reiter, M Viswanathan, N Zisape. Prospects of the clinical utilization of melatonin. Biological signals and receptors. vol 7. issue 4. 1998-11-16. PMID:9730580. |
because it easily penetrates the blood-brain barrier, this antioxidant may, in the future, be used for the treatment of alzheimer's and parkinson's diseases, stroke, nitric oxide, neurotoxicity and hyperbaric oxygen exposure. |
1998-11-16 |
2023-08-12 |
human |
| M P Vitek, J Snell, H Dawson, C A Colto. Modulation of nitric oxide production in human macrophages by apolipoprotein-E and amyloid-beta peptide. Biochemical and biophysical research communications. vol 240. issue 2. 1997-12-23. PMID:9388488. |
since alzheimer's is strongly associated with the presence of an apoe4 allele, our study predicts a mechanism where apoe and a beta regulate nitric oxide production in human brain. |
1997-12-23 |
2023-08-12 |
mouse |
| P Grammas, T R Botchlet, P Moore, P H Weige. Production of neurotoxic factors by brain endothelium in Alzheimer's disease. Annals of the New York Academy of Sciences. vol 826. 1997-11-13. PMID:9329680. |
we have previously demonstrated that brain microvessels in alzheimer's disease produce high, potentially toxic, levels of nitric oxide. |
1997-11-13 |
2023-08-12 |
Not clear |
| J A Navarro, J A Molina, F J Jiménez-Jiménez, J Benito-León, M Ortí-Pareja, T Gasalla, F Cabrera-Valdivia, C Vargas, F de Bustos, J Arena. Cerebrospinal fluid nitrate levels in patients with Alzheimer's disease. Acta neurologica Scandinavica. vol 94. issue 6. 1997-04-30. PMID:9017029. |
it has been suggested that nitric oxide could be implicated in the pathogenesis of alzheimer's disease (ad). |
1997-04-30 |
2023-08-12 |
Not clear |
| M A Smith, P L Richey Harris, L M Sayre, J S Beckman, G Perr. Widespread peroxynitrite-mediated damage in Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 8. 1997-04-28. PMID:9092586. |
in this study, we examine whether peroxynitrite, a powerful oxidant produced from the reaction of superoxide with nitric oxide, is involved in alzheimer's disease. |
1997-04-28 |
2023-08-12 |
Not clear |
| C Colton, S Wilt, D Gilbert, O Chernyshev, J Snell, M Dubois-Dalc. Species differences in the generation of reactive oxygen species by microglia. Molecular and chemical neuropathology. vol 28. issue 1-3. 1997-01-23. PMID:8871937. |
in order to understand how microglia contribute to changes in oxidative status of the cns and how this might related to disease states, such as alzheimer disease (ad), we have examined the regulation of superoxide anion and nitric oxide production from rodent and human microglia. |
1997-01-23 |
2023-08-12 |
mouse |
| P F Good, P Werner, A Hsu, C W Olanow, D P Per. Evidence of neuronal oxidative damage in Alzheimer's disease. The American journal of pathology. vol 149. issue 1. 1996-08-21. PMID:8686745. |
these findings further implicate nitric oxide expression and excitotoxicity in the pathogenesis of cell death in alzheimer's disease. |
1996-08-21 |
2023-08-12 |
Not clear |
| R O Kuljis, R L Schelpe. Alterations in nitrogen monoxide-synthesizing cortical neurons in amyotrophic lateral sclerosis with dementia. Journal of neuropathology and experimental neurology. vol 55. issue 1. 1996-02-28. PMID:8558169. |
nitric oxide) synthase (nos)-/nadph diaphorase-containing neurons (nosn) in three patients with mnd and dementia (mnd+d), two patients with mnd without dementia, and 19 controls that included patients with alzheimer and non-alzheimer dementias. |
1996-02-28 |
2023-08-12 |
Not clear |
| J L Goodwin, E Uemura, J E Cunnic. Microglial release of nitric oxide by the synergistic action of beta-amyloid and IFN-gamma. Brain research. vol 692. issue 1-2. 1996-02-20. PMID:8548305. |
these findings warrant a further investigation into the role of microglia in the neurodegeneration of alzheimer's disease via nitric oxide toxicity induced by the synergistic action of beta-amyloid and a costimulatory factor. |
1996-02-20 |
2023-08-12 |
rat |