| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ji Yeon Kim, Tae Hyong Kim, Soung Soo Ki. Anti-inflammatory effect of a human prothrombin fragment-2-derived peptide, NSA9, in EOC2 microglia. Biochemical and biophysical research communications. vol 368. issue 3. 2008-04-07. PMID:18261978. |
pro-inflammatory mediators, such as nitric oxide (no), prostaglandin e(2) (pge(2)), and several cytokines (tumor necrosis factor (tnf)-alpha, interleukin (il)-1beta, and il-6) are responsible for central nervous system (cns) injuries that include ischemia, alzheimer's disease, and neural death. |
2008-04-07 |
2023-08-12 |
human |
| Undurti N Da. Folic acid and polyunsaturated fatty acids improve cognitive function and prevent depression, dementia, and Alzheimer's disease--but how and why? Prostaglandins, leukotrienes, and essential fatty acids. vol 78. issue 1. 2008-03-20. PMID:18054217. |
epa, dha, and arachidonic acid (aa) are of benefit in dementia and alzheimer's disease by up-regulating gene expression concerned with neurogenesis, neurotransmission and connectivity, improving endothelial nitric oxide (eno) generation, enhancing brain acetylcholine levels, and suppressing the production of pro-inflammatory cytokines. |
2008-03-20 |
2023-08-12 |
Not clear |
| Allam A Rao, Gumpeny R Sridhar, Undurti N Da. Elevated butyrylcholinesterase and acetylcholinesterase may predict the development of type 2 diabetes mellitus and Alzheimer's disease. Medical hypotheses. vol 69. issue 6. 2008-01-03. PMID:17553629. |
plasma levels of c-reactive protein (crp), interleukin-6 (il-6), tumor necrosis factor-alpha (tnf-alpha), and lipid peroxides are elevated and concentrations of endothelial nitric oxide (eno) decreased in type 2 diabetes mellitus and alzheimer's disease. |
2008-01-03 |
2023-08-12 |
Not clear |
| Silke Walter, Maryse Letiembre, Yang Liu, Holger Heine, Botond Penke, Wenlin Hao, Barbara Bode, Nicole Manietta, Jessica Walter, Walter Schulz-Schuffer, Klaus Fassbende. Role of the toll-like receptor 4 in neuroinflammation in Alzheimer's disease. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 20. issue 6. 2007-12-19. PMID:17982277. |
here, we show that a spontaneous loss-of-function mutation in the tlr4 gene strongly inhibits microglial and monocytic activation by aggregated alzheimer amyloid peptide resulting in a significantly lower release of the inflammatory products il-6, tnfalpha and nitric oxide. |
2007-12-19 |
2023-08-12 |
mouse |
| L Trabace, K M Kendrick, S Castrignanò, M Colaianna, A De Giorgi, S Schiavone, C Lanni, V Cuomo, S Govon. Soluble amyloid beta1-42 reduces dopamine levels in rat prefrontal cortex: relationship to nitric oxide. Neuroscience. vol 147. issue 3. 2007-10-19. PMID:17560043. |
several studies suggest a pivotal role of amyloid beta (abeta)(1-42) and nitric oxide (no) in the pathogenesis of alzheimer's disease. |
2007-10-19 |
2023-08-12 |
rat |
| Tadeusz Malinsk. Nitric oxide and nitroxidative stress in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 11. issue 2. 2007-08-09. PMID:17522445. |
nitric oxide and nitroxidative stress in alzheimer's disease. |
2007-08-09 |
2023-08-12 |
Not clear |
| D M Wilcock, P T Jantzen, Q Li, D Morgan, M N Gordo. Amyloid-beta vaccination, but not nitro-nonsteroidal anti-inflammatory drug treatment, increases vascular amyloid and microhemorrhage while both reduce parenchymal amyloid. Neuroscience. vol 144. issue 3. 2007-04-11. PMID:17137722. |
vaccination with abeta(1-42) and treatment with ncx-2216, a novel nitric oxide releasing flurbiprofen derivative, have each been shown separately to reduce amyloid deposition in transgenic mice and have been suggested as potential therapies for alzheimer's disease. |
2007-04-11 |
2023-08-12 |
mouse |
| Daniela Puzzo, Agostino Palmeri, Ottavio Aranci. Involvement of the nitric oxide pathway in synaptic dysfunction following amyloid elevation in Alzheimer's disease. Reviews in the neurosciences. vol 17. issue 5. 2007-01-19. PMID:17180876. |
involvement of the nitric oxide pathway in synaptic dysfunction following amyloid elevation in alzheimer's disease. |
2007-01-19 |
2023-08-12 |
Not clear |
| Takashi Uehara, Tomohiro Nakamura, Dongdong Yao, Zhong-Qing Shi, Zezong Gu, Yuliang Ma, Eliezer Masliah, Yasuyuki Nomura, Stuart A Lipto. S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration. Nature. vol 441. issue 7092. 2006-06-27. PMID:16724068. |
here we show, in brains manifesting sporadic parkinson's or alzheimer's disease, that pdi is s-nitrosylated, a reaction transferring a nitric oxide (no) group to a critical cysteine thiol to affect protein function. |
2006-06-27 |
2023-08-12 |
Not clear |
| Rukhsana Sultana, H Fai Poon, Jian Cai, William M Pierce, Michael Merchant, Jon B Klein, William R Markesbery, D Allan Butterfiel. Identification of nitrated proteins in Alzheimer's disease brain using a redox proteomics approach. Neurobiology of disease. vol 22. issue 1. 2006-06-01. PMID:16378731. |
nitric oxide (no) has been implicated in the pathophysiology of a number of neurodegenerative diseases including alzheimer's disease (ad). |
2006-06-01 |
2023-08-12 |
Not clear |
| Małgorzata Chalimoniuk, J Głowacka, A Zabielna, A Eckert, J B Strosznajde. Nitric oxide alters arachidonic acid turnover in brain cortex synaptoneurosomes. Neurochemistry international. vol 48. issue 1. 2006-03-02. PMID:16216387. |
previously, we could show that alzheimer disease's amyloid-beta protein enhanced nitric oxide liberation. |
2006-03-02 |
2023-08-12 |
rat |
| Theodore Pak, Patrick Cadet, Kirk J Mantione, George B Stefan. Morphine via nitric oxide modulates beta-amyloid metabolism: a novel protective mechanism for Alzheimer's disease. Medical science monitor : international medical journal of experimental and clinical research. vol 11. issue 10. 2006-01-23. PMID:16192893. |
morphine via nitric oxide modulates beta-amyloid metabolism: a novel protective mechanism for alzheimer's disease. |
2006-01-23 |
2023-08-12 |
Not clear |
| Akinori Akaike, Hiroshi Katsuki, Toshiaki Kum. [Endogenous factors regulating neuronal apoptosis]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 25. issue 5. 2006-01-19. PMID:16313102. |
apoptosis and necrosis of neurons induced by glutamate and nitric oxide (no) are associated with various disorders including hypoxic-ischemic brain injury, alzheimer's disease and parkinson's disease. |
2006-01-19 |
2023-08-12 |
Not clear |
| Gregory R J Thatcher, Brian M Bennett, James N Reynold. Nitric oxide mimetic molecules as therapeutic agents in Alzheimer's disease. Current Alzheimer research. vol 2. issue 2. 2006-01-18. PMID:15974915. |
nitric oxide mimetic molecules as therapeutic agents in alzheimer's disease. |
2006-01-18 |
2023-08-12 |
Not clear |
| Yong-Jie Zhang, Ya-Fei Xu, Ying-Hua Liu, Jun Yin, Jian-Zhi Wan. Nitric oxide induces tau hyperphosphorylation via glycogen synthase kinase-3beta activation. FEBS letters. vol 579. issue 27. 2005-12-23. PMID:16253246. |
nitric oxide is associated with neurofibrillary tangle, which is composed mainly of hyperphosphorylated tau in the brain of alzheimer's disease (ad). |
2005-12-23 |
2023-08-12 |
Not clear |
| Anna Chiarini, Ilaria Dal Pra, Lia Menapace, Raffaella Pacchiana, James F Whitfield, Ubaldo Armat. Soluble amyloid beta-peptide and myelin basic protein strongly stimulate, alone and in synergism with combined proinflammatory cytokines, the expression of functional nitric oxide synthase-2 in normal adult human astrocytes. International journal of molecular medicine. vol 16. issue 5. 2005-12-14. PMID:16211247. |
the major neuron killers in the alzheimer brain include proinflammatory cytokines and no made by nos-2 (inducible nitric oxide synthase-2). |
2005-12-14 |
2023-08-12 |
human |
| Sang-Guk Shin, Ji Young Kim, Hae Young Chung, Ji-Cheon Jeon. Zingerone as an antioxidant against peroxynitrite. Journal of agricultural and food chemistry. vol 53. issue 19. 2005-10-31. PMID:16159194. |
peroxynitrite (onoo(-)), formed from the reaction of superoxide ((*)o(2)(-)) and nitric oxide ((*)no), induces cellular and tissue injury, resulting in several human diseases such as stroke, alzheimer's disease, and atherosclerosis. |
2005-10-31 |
2023-08-12 |
human |
| S Thameem Dheen, Yan Jun, Zhou Yan, Samuel S W Tay, Eng Ang Lin. Retinoic acid inhibits expression of TNF-alpha and iNOS in activated rat microglia. Glia. vol 50. issue 1. 2005-06-16. PMID:15602748. |
the release of proinflammatory mediators such as tumor necrosis factor-alpha (tnf-alpha) and nitric oxide by microglia has been implicated in neurotoxicity in chronic neurodegenerative diseases such as alzheimer's disease. |
2005-06-16 |
2023-08-12 |
rat |
| Dilara Seyidova, Ali Aliyev, Nizami Rzayev, Mark Obrenovich, Bruce T Lamb, Mark A Smith, Jack C de la Torre, George Perry, Gjumrakch Alie. The role of nitric oxide in the pathogenesis of brain lesions during the development of Alzheimer's disease. In vivo (Athens, Greece). vol 18. issue 3. 2005-03-07. PMID:15341188. |
the role of nitric oxide in the pathogenesis of brain lesions during the development of alzheimer's disease. |
2005-03-07 |
2023-08-12 |
Not clear |
| Silvia Mandel, Moussa B H Youdi. Catechin polyphenols: neurodegeneration and neuroprotection in neurodegenerative diseases. Free radical biology & medicine. vol 37. issue 3. 2005-02-16. PMID:15223064. |
neurodegeneration in parkinson's, alzheimer's, and other neurodegenerative diseases seems to be multifactorial, in that a complex set of toxic reactions including inflammation, glutamatergic neurotoxicity, increases in iron and nitric oxide, depletion of endogenous antioxidants, reduced expression of trophic factors, dysfunction of the ubiquitin-proteasome system, and expression of proapoptotic proteins leads to the demise of neurons. |
2005-02-16 |
2023-08-12 |
Not clear |