| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Mulder, L-O Wahlund, M Blomberg, S de Jong, G J van Kamp, P Scheltens, T Teerlin. Alzheimer's disease is not associated with altered concentrations of the nitric oxide synthase inhibitor asymmetric dimethylarginine in cerebrospinal fluid. Journal of neural transmission (Vienna, Austria : 1996). vol 109. issue 9. 2002-11-06. PMID:12203047. |
nitric oxide (no) may play a role in the pathophysiology of alzheimer's disease (ad). |
2002-11-06 |
2023-08-12 |
human |
| C S Casley, L Canevari, J M Land, J B Clark, M A Sharp. Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities. Journal of neurochemistry. vol 80. issue 1. 2002-01-29. PMID:11796747. |
isolated rat brain mitochondria have been incubated with the beta-amyloid alone or together with nitric oxide, which is known to be elevated in alzheimer's brain. |
2002-01-29 |
2023-08-12 |
rat |
| H Wilms, P Rosenstiel, J Sievers, G Deuschl, R Luciu. Cerebrospinal fluid from patients with neurodegenerative and neuroinflammatory diseases: no evidence for rat glial activation in vitro. Neuroscience letters. vol 314. issue 3. 2002-01-04. PMID:11704295. |
to determine the possible contribution of glial cells via oxidative stress/cytokine secretion in the pathogenesis of parkinson's disease (pd), alzheimer disease (ad), amyotrophic lateral sclerosis (als) or multiple sclerosis (ms) the concentration of nitric oxide (no) (by the griess method) and interleukin-6 (il-6) (by enzyme-linked immunosorbent assay) were measured in resting rat microglial and astrocytic cell culture supernatants stimulated by cerebrospinal fluid (csf) (dilution 1:4, 1:10) from patients with the aforementioned diseases. |
2002-01-04 |
2023-08-12 |
rat |
| T Abe, H Tohgi, T Murata, C Isobe, C Sat. Reduction in asymmetrical dimethylarginine, an endogenous nitric oxide synthase inhibitor, in the cerebrospinal fluid during aging and in patients with Alzheimer's disease. Neuroscience letters. vol 312. issue 3. 2001-12-18. PMID:11602339. |
to investigate the significance of nitric oxide (no) -mediated neuron death in aging and alzheimer's disease (ad), the concentration of asymmetrical dimethylarginine (adma), an endogenous no synthase inhibitor, in the cerebrospinal fluid was determined in neurologically normal controls and patients with ad. |
2001-12-18 |
2023-08-12 |
Not clear |
| H J Lüth, M Holzer, U Gärtner, M Staufenbiel, T Arend. Expression of endothelial and inducible NOS-isoforms is increased in Alzheimer's disease, in APP23 transgenic mice and after experimental brain lesion in rat: evidence for an induction by amyloid pathology. Brain research. vol 913. issue 1. 2001-12-12. PMID:11532247. |
all three isoforms are aberrantly expressed in alzheimer's disease giving rise to elevated levels of nitric oxide apparently involved in the pathogenesis of this disease by various different mechanisms including oxidative stress and activation of intracellular signalling mechanisms. |
2001-12-12 |
2023-08-12 |
mouse |
| S Johnso. Gradual micronutrient accumulation and depletion in Alzheimer's disease. Medical hypotheses. vol 56. issue 6. 2001-08-23. PMID:11399105. |
therefore, it is possible that cd also hyperactivates the microglia, playing a role in alzheimer's disease (ad).fe also accumulates in the brain as we age and catalyzes super oxide (o2-) formation, which reacts with nitric oxide (no) to form the very harmful peroxynitrite (onoo-). |
2001-08-23 |
2023-08-12 |
Not clear |
| J C Rah, H S Kim, S S Kim, J H Bach, Y S Kim, C H Park, J H Seo, S J Jeong, Y H Su. Effects of carboxyl-terminal fragment of Alzheimer's amyloid precursor protein and amyloid beta-peptide on the production of cytokines and nitric oxide in glial cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 15. issue 8. 2001-07-05. PMID:11387258. |
effects of carboxyl-terminal fragment of alzheimer's amyloid precursor protein and amyloid beta-peptide on the production of cytokines and nitric oxide in glial cells. |
2001-07-05 |
2023-08-12 |
Not clear |
| A Law, S Gauthier, R Quirio. Say NO to Alzheimer's disease: the putative links between nitric oxide and dementia of the Alzheimer's type. Brain research. Brain research reviews. vol 35. issue 1. 2001-06-21. PMID:11245887. |
say no to alzheimer's disease: the putative links between nitric oxide and dementia of the alzheimer's type. |
2001-06-21 |
2023-08-12 |
Not clear |
| G C Chiou, B Xuan, Q Liu, T Yamasaki, T Okawar. Inhibition of interleukin-1-induced uveitis and corneal fibroblast proliferation by interleukin-1 blockers. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. vol 16. issue 5. 2001-05-31. PMID:11110032. |
interleukin-1 (il-1) is known to trigger induction of inducible nitric oxide synthase (inos) to persistently mass produce nitric oxide (no) to induce various diseases such as cancer, inflammation, alzheimer's disease and eye diseases, including uveitis, retinopathy, age-related macular degeneration, glaucoma and myopia. |
2001-05-31 |
2023-08-12 |
Not clear |
| J C de la Torre, G B Stefan. Evidence that Alzheimer's disease is a microvascular disorder: the role of constitutive nitric oxide. Brain research. Brain research reviews. vol 34. issue 3. 2001-02-02. PMID:11113503. |
evidence that alzheimer's disease is a microvascular disorder: the role of constitutive nitric oxide. |
2001-02-02 |
2023-08-12 |
Not clear |
| E Tarkowski, A Ringqvist, K Blennow, A Wallin, A Wennmal. Intrathecal release of nitric oxide in Alzheimer's disease and vascular dementia. Dementia and geriatric cognitive disorders. vol 11. issue 6. 2001-01-08. PMID:11044777. |
intrathecal release of nitric oxide in alzheimer's disease and vascular dementia. |
2001-01-08 |
2023-08-12 |
Not clear |
| O Ogawa, H Umegaki, D Sumi, T Hayashi, A Nakamura, N K Thakur, J Yoshimura, H Endo, A Iguch. Inhibition of inducible nitric oxide synthase gene expression by indomethacin or ibuprofen in beta-amyloid protein-stimulated J774 cells. European journal of pharmacology. vol 408. issue 2. 2000-12-27. PMID:11080519. |
recent studies show that a mononuclear phagocyte lineage, including microglia, plays a possible role in the pathogenesis of alzheimer's disease through nitric oxide (no)-mediated neurotoxicity. |
2000-12-27 |
2023-08-12 |
Not clear |
| M A Kuiper, T Teerlink, J J Visser, P L Bergmans, P Scheltens, E C Wolter. L-glutamate, L-arginine and L-citrulline levels in cerebrospinal fluid of Parkinson's disease, multiple system atrophy, and Alzheimer's disease patients. Journal of neural transmission (Vienna, Austria : 1996). vol 107. issue 2. 2000-09-21. PMID:10847559. |
alterations in neuronal nitric oxide (no) production may play a role in the pathophysiology of parkinson's disease (pd) alzheimer's disease (ad), and multiple system atrophy (msa). |
2000-09-21 |
2023-08-12 |
human |
| H Tohgi, T Abe, K Yamazaki, T Murata, E Ishizaki, C Isob. Alterations of 3-nitrotyrosine concentration in the cerebrospinal fluid during aging and in patients with Alzheimer's disease. Neuroscience letters. vol 269. issue 1. 2000-06-21. PMID:10821643. |
to investigate the significance of nitric oxide (no)-mediated neuron death in aging and alzheimer's disease (ad), the 3-nitrotyrosine concentration in the cerebrospinal fluid (csf) was investigated in neurologically normal controls and patients with ad. |
2000-06-21 |
2023-08-12 |
Not clear |
| L Gargiulo, M Bermejo, A Lira. [Reduced neuronal nitric oxide synthetase and c-protein kinase levels in Alzheimer's disease]. Revista de neurologia. vol 30. issue 4. 2000-06-14. PMID:10789135. |
[reduced neuronal nitric oxide synthetase and c-protein kinase levels in alzheimer's disease]. |
2000-06-14 |
2023-08-12 |
Not clear |
| S M de la Monte, Y K Sohn, D Etienne, J Kraft, J R Wand. Role of aberrant nitric oxide synthase-3 expression in cerebrovascular degeneration and vascular-mediated injury in Alzheimer's disease. Annals of the New York Academy of Sciences. vol 903. 2000-06-02. PMID:10818490. |
role of aberrant nitric oxide synthase-3 expression in cerebrovascular degeneration and vascular-mediated injury in alzheimer's disease. |
2000-06-02 |
2023-08-12 |
Not clear |
| T C Ma, X Z Zh. Effects of intrahippocampal infusion of interleukin-6 on passive avoidance and nitrite and prostaglandin levels in the hippocampus in rats. Arzneimittel-Forschung. vol 50. issue 3. 2000-05-09. PMID:10758772. |
these findings support the hypothesis that central il-6 participates in the pathogenesis of alzheimer's disease, and the overproduction of nitric oxide in the brain may partially mediate the amnesic effect of il-6. |
2000-05-09 |
2023-08-12 |
rat |
| M F McCart. Vascular nitric oxide, sex hormone replacement, and fish oil may help to prevent Alzheimer's disease by suppressing synthesis of acute-phase cytokines. Medical hypotheses. vol 53. issue 5. 2000-01-20. PMID:10616034. |
vascular nitric oxide, sex hormone replacement, and fish oil may help to prevent alzheimer's disease by suppressing synthesis of acute-phase cytokines. |
2000-01-20 |
2023-08-12 |
Not clear |
| R Alvarez, V Alvarez, C H Lahoz, C Martínez, J Peña, J M Sánchez, L M Guisasola, J Salas-Puig, G Morís, J A Vidal, R Ribacoba, B B Menes, D Uría, E Cot. Angiotensin converting enzyme and endothelial nitric oxide synthase DNA polymorphisms and late onset Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. vol 67. issue 6. 1999-12-29. PMID:10567488. |
nitric oxide (no) production by microglial cells, astrocytes, and brain microvessels is enhanced in patients with alzheimer's disease. |
1999-12-29 |
2023-08-12 |
Not clear |
| F Casamenti, C Prosperi, C Scali, L Giovannelli, M A Colivicchi, M S Faussone-Pellegrini, G Pepe. Interleukin-1beta activates forebrain glial cells and increases nitric oxide production and cortical glutamate and GABA release in vivo: implications for Alzheimer's disease. Neuroscience. vol 91. issue 3. 1999-10-08. PMID:10391466. |
interleukin-1beta activates forebrain glial cells and increases nitric oxide production and cortical glutamate and gaba release in vivo: implications for alzheimer's disease. |
1999-10-08 |
2023-08-12 |
rat |