| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhen Lan, Long-Jie Qu, Ying Liang, Li-Qiu Chen, Shuai Xu, Jian-Wei Ge, Zhi-Wei Xue, Xin-Yu Bao, Sheng-Nan Xia, Hai-Yan Yang, Jing Huang, Yun Xu, Xiao-Lei Zh. AZD1390, an ataxia telangiectasia mutated inhibitor, attenuates microglia-mediated neuroinflammation and ischemic brain injury. CNS neuroscience & therapeutics. vol 30. issue 4. 2024-04-26. PMID:38668740. |
azd1390, an ataxia telangiectasia mutated (atm) specific inhibitor, has been shown to promote radio-sensitization and survival in central nervous system malignancies, while the role of azd1390 in ischemic stroke remains unknown. |
2024-04-26 |
2024-04-28 |
Not clear |
| Petra Marttila, Nadilly Bonagas, Christina Chalkiadaki, Hannah Stigsdotter, Korbinian Schelzig, Jianyu Shen, Crystal M Farhat, Amber Hondema, Julian Albers, Elisée Wiita, Azita Rasti, Ulrika Warpman Berglund, Ana Slipicevic, Oliver Mortusewicz, Thomas Helleda. The one-carbon metabolic enzyme MTHFD2 promotes resection and homologous recombination after ionizing radiation. Molecular oncology. 2024-03-27. PMID:38533616. |
here, we observe that nuclear mthfd2 protein levels and association with chromatin increase following ionizing radiation (ir) in an ataxia telangiectasia mutated (atm)- and dna-dependent protein kinase (dna-pk)-dependent manner. |
2024-03-27 |
2024-03-29 |
Not clear |
| Qiang Zhang, Long Jiang, Weiwei Wang, Amanda K Huber, Victoria M Valvo, Kassidy M Jungles, Erin A Holcomb, Ashley N Pearson, Stephanie The, Zhuwen Wang, Leslie A Parsels, Joshua D Parsels, Daniel R Wahl, Arvind Rao, Vaibhav Sahai, Theodore S Lawrence, Michael D Green, Meredith A Morga. Potentiating the radiation-induced type I interferon antitumoral immune response by ATM inhibition in pancreatic cancer. JCI insight. vol 9. issue 6. 2024-03-22. PMID:38376927. |
radiotherapy induces a type i interferon-mediated (t1ifn-mediated) antitumoral immune response that we hypothesized could be potentiated by a first-in-class ataxia telangiectasia mutated (atm) inhibitor, leading to enhanced innate immune signaling, t1ifn expression, and sensitization to immunotherapy in pancreatic cancer. |
2024-03-22 |
2024-03-24 |
mouse |
| Dimitra Mavroeidi, Anastasia Georganta, Emmanouil Panagiotou, Konstantinos Syrigos, Vassilis L Soulioti. Targeting ATR Pathway in Solid Tumors: Evidence of Improving Therapeutic Outcomes. International journal of molecular sciences. vol 25. issue 5. 2024-03-13. PMID:38474014. |
critical regulators of the ddr network include the dna damage kinases ataxia telangiectasia mutated rad3-related kinase (atr) and ataxia-telangiectasia mutated (atm). |
2024-03-13 |
2024-03-15 |
Not clear |
| Phillip R Woolley, Xuemei Wen, Olivia M Conway, Nicolette A Ender, Ji-Hoon Lee, Tanya T Paul. Regulation of transcription patterns, poly(ADP-ribose), and RNA-DNA hybrids by the ATM protein kinase. Cell reports. vol 43. issue 3. 2024-03-05. PMID:38442018. |
the ataxia telangiectasia mutated (atm) protein kinase is a master regulator of the dna damage response and also an important sensor of oxidative stress. |
2024-03-05 |
2024-03-08 |
human |
| Zun-Hong Liang, Shi-Shuai Lin, Zhi-Yang Qiu, Yun-Chuan Pan, Nan-Fang Pan, Yun Li. GLI family zinc finger protein 2 promotes skin fibroblast proliferation and DNA damage repair by targeting the miR-200/ataxia telangiectasia mutated axis in diabetic wound healing. The Kaohsiung journal of medical sciences. 2024-02-22. PMID:38385859. |
luciferase reporter gene and rna immunoprecipitation assays determined the interaction with mir-200a/b/c-3p and gli family zinc finger protein 2 (gli2) or ataxia telangiectasia mutated (atm) kinase. |
2024-02-22 |
2024-02-24 |
mouse |
| Zhan Xu, Mingnan Qu, Chuanlin Shi, Hong Zhang, Wu Chen, Hongge Qian, Zhipeng Zhang, Jiehua Qiu, Qian Qian, Lianguang Shan. The MRE11-ATM-SOG1 DNA damage signaling pathway confers rice immunity to Xanthomonas oryzae. Plant communications. 2024-01-31. PMID:38160258. |
the dsb signal transducer ataxia telangiectasia mutated (atm), but not the atm and rad3-related branch, confers resistance against xoo. |
2024-01-31 |
2024-02-03 |
Not clear |
| Sanami Takada, Thomas J Weitering, Nienke J H van Os, Likun Du, Ingrid Pico-Knijnenburg, Thomas B Kuipers, Hailiang Mei, Elisabeth Salzer, Michèl A A P Willemsen, Corry M R Weemaes, Qiang Pan-Hammarstrom, Mirjam van der Bur. Causative mechanisms and clinical impact of immunoglobulin deficiencies in Ataxia Telangiectasia. The Journal of allergy and clinical immunology. 2024-01-27. PMID:38280573. |
ataxia telangiectasia (at) is characterized by cerebellar ataxia, telangiectasia, immunodeficiency, and increased cancer susceptibility, caused by mutations in the ataxia telangiectasia mutated (atm) gene. |
2024-01-27 |
2024-01-30 |
Not clear |
| Chenying Liu, Xiaolong Qian, Chunyan Yu, Xiaoqing Xia, Jiazhen Li, Yaqing Li, Yongjie Xie, Guangshen Gao, Yuanming Song, Meiyan Zhang, Huiqin Xue, Xiaozi Wang, Hui Sun, Jing Liu, Weimin Deng, Xiaojing Gu. Inhibition of ATM promotes PD-L1 expression by activating JNK/c-Jun/TNF-α signaling axis in triple-negative breast cancer. Cancer letters. 2024-01-26. PMID:38278470. |
ataxia telangiectasia mutated (atm) is a switch molecule for homologous recombination and repair. |
2024-01-26 |
2024-01-29 |
Not clear |
| Abdalla Elbialy, Mai Kitauchi, Dai Yamanouch. Antioxidants and azd0156 Rescue Inflammatory Response in Autophagy-Impaired Macrophages. International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203340. |
this effect was reversed by treatment with antioxidants or azd0156, an ataxia telangiectasia mutated (atm) inhibitor. |
2024-01-11 |
2024-01-13 |
Not clear |
| Atar Singh Kushwah, Shireen Masood, Rajnikant Mishra, Monisha Banerje. Genetic and epigenetic alterations in DNA repair genes and treatment outcome of Chemoradiotherapy in Cervical cancer. Critical reviews in oncology/hematology. 2023-12-20. PMID:38122918. |
hpv oncoproteins e6 and e7 target p53 and rb (retinoblastoma) protein degradation, ataxia telangiectasia mutated (atm), atm-rad3-related (atr) inactivation and subsequent impairment of non-homologous end joining (nhej), homologous recombination, and base excision repair pathways. |
2023-12-20 |
2023-12-23 |
human |
| Mariane A P Silva, Drielle B S Figueiredo, Lídia R de Carvalho, Leandro G Braz, Mariana G Bra. Modulation of gene expression and influence of gene polymorphisms related to genotoxicity and redox status on occupational exposure to inhaled anesthetics. International journal of hygiene and environmental health. vol 256. 2023-12-18. PMID:38065035. |
additionally, x-ray repair cross complementing 1 (xrcc1 rs25487 and rs1799782) and ataxia telangiectasia mutated (atm rs600931) gene polymorphisms as well as genetic instability (micronucleus-mn and nuclear bud-nbud) and oxidative stress (malondialdehyde-mda and ferric reducing antioxidant power-frap) biomarkers were assessed in the groups (control and exposed) and in the subgroups of the exposed group according to job occupation (anesthesiologists versus surgeons/technicians). |
2023-12-18 |
2023-12-21 |
human |
| Giulia Bastianello, Giancarlo Porcella, Galina V Beznoussenko, Gururaj Kidiyoor, Flora Ascione, Qingsen Li, Angela Cattaneo, Vittoria Matafora, Andrea Disanza, Micaela Quarto, Alexander A Mironov, Amanda Oldani, Sara Barozzi, Angela Bachi, Vincenzo Costanzo, Giorgio Scita, Marco Foian. Cell stretching activates an ATM mechano-transduction pathway that remodels cytoskeleton and chromatin. Cell reports. vol 42. issue 12. 2023-12-13. PMID:38088930. |
ataxia telangiectasia mutated (atm) and ataxia telangiectasia and rad3-related (atr) dna damage response (ddr) kinases contain elastic domains. |
2023-12-13 |
2023-12-17 |
Not clear |
| Giulia Bastianello, Giancarlo Porcella, Galina V Beznoussenko, Gururaj Kidiyoor, Flora Ascione, Qingsen Li, Angela Cattaneo, Vittoria Matafora, Andrea Disanza, Micaela Quarto, Alexander A Mironov, Amanda Oldani, Sara Barozzi, Angela Bachi, Vincenzo Costanzo, Giorgio Scita, Marco Foian. Cell stretching activates an ATM mechano-transduction pathway that remodels cytoskeleton and chromatin. Cell reports. vol 42. issue 12. 2023-12-13. PMID:38088930. |
mre11 mediates atm activation following dna damage; atm mutations cause ataxia telangiectasia (a-t). |
2023-12-13 |
2023-12-17 |
Not clear |
| Prarthana Srikanth, Amit Roy Chowdhury, Grace Kah Mun Low, Radha Saraswathy, Akira Fujimori, Birendranath Banerjee, Wilner Martinez-Lopez, M Prakash Hand. Oxidative Damage Induced Telomere Mediated Genomic Instability in Cells from Ataxia Telangiectasia Patients. Genome integrity. vol 13. 2023-12-01. PMID:38021281. |
ataxia telangiectasia mutated (atm) protein was one of the first dna damage sensor proteins to be discovered as being involved in dna repair and as well as in telomere maintenance. |
2023-12-01 |
2023-12-07 |
Not clear |
| Prarthana Srikanth, Amit Roy Chowdhury, Grace Kah Mun Low, Radha Saraswathy, Akira Fujimori, Birendranath Banerjee, Wilner Martinez-Lopez, M Prakash Hand. Oxidative Damage Induced Telomere Mediated Genomic Instability in Cells from Ataxia Telangiectasia Patients. Genome integrity. vol 13. 2023-12-01. PMID:38021281. |
cells from ataxia telangiectasia (at) patients lack atm and accumulate chromosomal alterations. |
2023-12-01 |
2023-12-07 |
Not clear |
| Prarthana Srikanth, Amit Roy Chowdhury, Grace Kah Mun Low, Radha Saraswathy, Akira Fujimori, Birendranath Banerjee, Wilner Martinez-Lopez, M Prakash Hand. Oxidative Damage Induced Telomere Mediated Genomic Instability in Cells from Ataxia Telangiectasia Patients. Genome integrity. vol 13. 2023-12-01. PMID:38021281. |
ataxia telangiectasia mutated (atm) protein was one of the first dna damage sensor proteins to be discovered as being involved in dna repair and as well as in telomere maintenance. |
2023-11-29 |
2023-12-07 |
Not clear |
| Prarthana Srikanth, Amit Roy Chowdhury, Grace Kah Mun Low, Radha Saraswathy, Akira Fujimori, Birendranath Banerjee, Wilner Martinez-Lopez, M Prakash Hand. Oxidative Damage Induced Telomere Mediated Genomic Instability in Cells from Ataxia Telangiectasia Patients. Genome integrity. vol 13. 2023-12-01. PMID:38021281. |
cells from ataxia telangiectasia (at) patients lack atm and accumulate chromosomal alterations. |
2023-11-29 |
2023-12-07 |
Not clear |
| Yuzhen Zhou, Judit Börcsök, Elio Adib, Sophia C Kamran, Alexander J Neil, Konrad Stawiski, Dory Freeman, Dag Rune Stormoen, Zsofia Sztupinszki, Amruta Samant, Amin Nassar, Raie T Bekele, Timothy Hanlon, Henkel Valentine, Ilana Epstein, Bijaya Sharma, Kristen Felt, Philip Abbosh, Chin-Lee Wu, Jason A Efstathiou, David T Miyamoto, William Anderson, Zoltan Szallasi, Kent W Mou. ATM deficiency confers specific therapeutic vulnerabilities in bladder cancer. Science advances. vol 9. issue 47. 2023-11-25. PMID:37992168. |
furthermore, atm loss drives sensitivity to dna repair-targeted agents including poly(adp-ribose) polymerase (parp) and ataxia telangiectasia and rad3 related (atr) inhibitors. |
2023-11-25 |
2023-11-28 |
Not clear |
| Xiao Zhang, Qing Zhao, Tao Wang, Qilin Long, Yixin Sun, Liqun Jiao, Monika Gullerov. DNA damage response, a double-edged sword for vascular aging. Ageing research reviews. 2023-11-25. PMID:38007046. |
on the other hand, over-activation of some ddr proteins, such as poly (adp ribose) polymerase (parp) and ataxia telangiectasia mutated (atm), also can enhance the process of vascular aging, suggesting that ddr can have both positive and negative effects on vascular aging. |
2023-11-25 |
2023-11-28 |
Not clear |