| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiao Zhang, Qing Zhao, Tao Wang, Qilin Long, Yixin Sun, Liqun Jiao, Monika Gullerov. DNA damage response, a double-edged sword for vascular aging. Ageing research reviews. 2023-11-25. PMID:38007046. |
on the other hand, over-activation of some ddr proteins, such as poly (adp ribose) polymerase (parp) and ataxia telangiectasia mutated (atm), also can enhance the process of vascular aging, suggesting that ddr can have both positive and negative effects on vascular aging. |
2023-11-25 |
2023-11-28 |
Not clear |
| Tanja Hirch, Nadine Brander, Franziska Schenk, Simon J Pöllmann, Janine Reichenbach, Ralf Schubert, Ute Modlic. Expression of a large coding sequence: Gene therapy vectors for Ataxia Telangiectasia. Scientific reports. vol 13. issue 1. 2023-11-08. PMID:37938627. |
ataxia telangiectasia is a monogenetic disorder caused by mutations in the atm gene. |
2023-11-08 |
2023-11-20 |
Not clear |
| Heba M Mansour, Aiman S El-Khati. Exploring Parkinson-associated Kinases for CRISPR/Cas9-Based Gene Editing: Beyond Alpha-Synuclein. Ageing research reviews. 2023-11-04. PMID:37924981. |
we provide an overview of novel kinases to be targeted by the crispr/cas9 system such as g-protein coupled receptor kinases (grks), cyclin-g-associated kinases (gaks), cyclin-dependent kinase 5 (cdk5), ataxia telangiectasia mutated (atm), c-abl, and rearranged during transfection (ret) receptors. |
2023-11-04 |
2023-11-08 |
Not clear |
| Zaixia Liu, Shaoyin Fu, Xiaolong He, Lingli Dai, Xuewen Liu, Narisu, Caixia Shi, Mingjuan Gu, Yu Wang, Manda, Lili Guo, Yanchun Bao, Baiyinbatu, Chencheng Chang, Yongbin Liu, Wenguang Zhan. Integrated Multi-Tissue Transcriptome Profiling Characterizes the Genetic Basis and Biomarkers Affecting Reproduction in Sheep ( Genes. vol 14. issue 10. 2023-10-30. PMID:37895230. |
the functional enrichment analysis showed that the genes expressed in the spleen, uterus, and ovary were significantly enriched in the ataxia telangiectasia mutated protein (atm) signaling pathway, and most genes in the liver, spleen, and ovary were enriched in the immune response pathway. |
2023-10-30 |
2023-11-08 |
Not clear |
| Xinyao Zhang, Haiqi Chen, Jiawen Han, Zongren Wang, Yu Guo, Zhongyang Zhou, Rong Luo, Meiqin Dai, Wei Ou, Lingwu Chen, Lan Sha. ATM-AMPKα mediated LAG-3 expression suppresses T cell function in prostate cancer. Cellular immunology. vol 393-394. 2023-10-19. PMID:37857190. |
gene array analysis revealed that insufficient ataxia telangiectasia mutated (atm) gene expression in pca t cells was responsible for the elevated lag3 expression. |
2023-10-19 |
2023-11-08 |
Not clear |
| Bopei Cui, Lifang Song, Qian Wang, Kelei Li, Qian He, Xing Wu, Fan Gao, Mingchen Liu, Chaoqiang An, Qiushuang Gao, Chaoying Hu, Xiaotian Hao, Fangyu Dong, Jiuyue Zhou, Dong Liu, Ziyang Song, Xujia Yan, Jialu Zhang, Yu Bai, Qunying Mao, Xiaoming Yang, Zhenglun Lian. Non-small cell lung cancers (NSCLCs) oncolysis using coxsackievirus B5 and synergistic DNA-damage response inhibitors. Signal transduction and targeted therapy. vol 8. issue 1. 2023-09-24. PMID:37743418. |
for refractory nsclcs, dna-dependent protein kinase (dna-pk) or ataxia telangiectasia mutated protein (atm) inhibitors can synergize with cv-b5/f to promote refractory cell death. |
2023-09-24 |
2023-10-07 |
human |
| Hongliang Jin, Jin Zhu, Rui Xuan, Yibin Zhou, Boxin Xue, Dongrong Yang, Jie Gao, Yachen Zang, Lijun X. A Crosstalk Between Castration-Resistant Prostate Cancer Cells, M2 Macrophages, and NK Cells: Role of the ATM-PI3K/AKT-PD-L1 Pathway. Immunological investigations. 2023-09-21. PMID:37732622. |
based on the recent research findings, the expression levels of ataxia telangiectasia mutant kinase (atm) in prostate cancer (pc) tissues collected from crpc patients were higher than hormone-dependent pc patients. |
2023-09-21 |
2023-10-07 |
Not clear |
| Minglian Xu, Dezhi Song, Xiaoxiao Xie, Yiwu Qin, Jian Huang, Chaofeng Wang, Junchun Chen, Yuangang Su, Jiake Xu, Jinmin Zhao, Qian Li. CGK733 alleviates ovariectomy-induced bone loss through blocking RANKL-mediated Ca iScience. vol 26. issue 10. 2023-09-18. PMID:37720109. |
ataxia telangiectasia mutated (atm) inhibitor cgk733 (cg) was reported to have a sensitizing impact in treating malignancies. |
2023-09-18 |
2023-10-07 |
Not clear |
| David Hodson, Hitesh Mistry, Sofia Guzzetti, Michael Davies, Anna Staniszewska, Paul Farrington, Elaine Cadogan, James Yates, Leon Aarons, Kayode Ogungbenr. Mixed effects modeling of radiotherapy in combination with immune checkpoint blockade or inhibitors of the DNA damage response pathway. CPT: pharmacometrics & systems pharmacology. 2023-09-18. PMID:37722071. |
the model was fitted using preclinical data, where mc38 tumors were treated in vivo with rt alone or in combination with anti-pd-l1 as well as with either olaparib or the ataxia telangiectasia mutated (atm) inhibitor-azd0156. |
2023-09-18 |
2023-10-07 |
Not clear |
| Thais Sobanski, Amila Suraweera, Joshua T Burgess, Iain Richard, Chee Man Cheong, Keyur Dave, Maddison Rose, Mark N Adams, Kenneth J O'Byrne, Derek J Richard, Emma Bolderso. The fructose-bisphosphate, Aldolase A (ALDOA), facilitates DNA-PKcs and ATM kinase activity to regulate DNA double-strand break repair. Scientific reports. vol 13. issue 1. 2023-09-13. PMID:37704669. |
in support of the defective repair observed in its absence, aldoa was found to associate with the major dsb repair effector kinases, dna-dependent protein kinase (dna-pk) and ataxia telangiectasia mutated (atm) and their autophosphorylation was decreased when aldoa was depleted. |
2023-09-13 |
2023-10-07 |
Not clear |
| Byung Chul Jung, Sung Hoon Kim, Yoonjung Cho, Yoon Suk Ki. Tumor suppressor Parkin induces p53-mediated cell cycle arrest in human lung and colorectal cancer cells. BMB reports. 2023-09-07. PMID:37679297. |
in addition, parkin caused dna damage and atm (ataxia telangiectasia mutated) activation, which subsequently led to p53 activation. |
2023-09-07 |
2023-10-07 |
human |
| Nadav Elkoshi, Shivang Parikh, Hagar Malcov-Brog, Roma Parikh, Paulee Manich, Francesca Netti, Avishai Maliah, Hana Elkoshi, Majd Haj, Ido Rippin, Jacob Frand, Tomer Perluk, Rivi Haiat-Factor, Tamar Golan, Neta Regev-Rudzki, Edo Kiper, Ronen Brenner, Pinchas Gonen, Iris Dror, Hagai Levi, Ofir Hameiri, Mazal Cohen-Gulkar, Hagit Eldar-Finkelman, Gil Ast, Eran Nizri, Yael Ziv, Rani Elkon, Mehdi Khaled, Yuval Ebenstein, Yosef Shiloh, Carmit Lev. Ataxia Telangiectasia Mutated Signaling Delays Skin Pigmentation upon UV Exposure by Mediating MITF Function toward DNA Repair Mode. The Journal of investigative dermatology. 2023-08-20. PMID:37236596. |
in this study, we found that the uvb-induced dna repair system, led by the ataxia telangiectasia mutated (atm) protein kinase, represses mitf transcriptional activity of pigmentation genes while placing mitf in dna repair mode, thus directly inhibiting pigment production. |
2023-08-20 |
2023-09-07 |
mouse |
| Qigang Fan, Ruifen He, Yi Li, Pu Gao, Runchun Huang, Rong Li, Jiayu Zhang, Hongli Li, Xiaolei Lian. Studying the effect of hyperoside on recovery from cyclophosphamide induced oligoasthenozoospermia. Systems biology in reproductive medicine. 2023-08-14. PMID:37578152. |
hyperoside also promoted the cell cycle of germ cells and up-regulated meiosis and spermatogenesis-related genes, including dna meiotic recombinase 1 (dmc1), ataxia telangiectasia mutated (atm) and rad21 cohesin complex component (rad21). |
2023-08-14 |
2023-08-16 |
mouse |
| Sathyapriya Chandramohan, Oishi Chatterjee, Sankar Pajaniradje, Srividya Subramanian, Suhail Ahmad Bhat, Rukkumani Rajagopala. Role of indole curcumin in the epigenetic activation of apoptosis and cell cycle regulating genes. Journal of cancer research and therapeutics. vol 19. issue 3. 2023-07-20. PMID:37470582. |
head-and-neck squamous cell carcinoma is associated with the epigenetic silencing of various genes such as dapk, ataxia telangiectasia mutated (atm), brca1, p16 |
2023-07-20 |
2023-08-14 |
Not clear |
| Jingfei Xu, Noah Bradley, Yuan H. Structure and function of the apical PIKKs in double-strand break repair. Current opinion in structural biology. vol 82. 2023-07-12. PMID:37437397. |
members of the phosphatidylinositol 3' kinase (pi3k)-related kinases (pikks) family, including dna-dependent protein kinase catalytic subunit (dna-pkcs), ataxia telangiectasia mutated (atm), ataxia-telangiectasia mutated and rad3-related (atr), mammalian target of rapamycin (mtor), suppressor with morphological effect on genitalia 1 (smg1), and transformation/transcription domain-associated protein 1 (trrap/tra1), participate in a variety of physiological processes, such as cell-cycle control, metabolism, transcription, replication, and the dna damage response. |
2023-07-12 |
2023-08-14 |
Not clear |
| Aicha Sassi, Maxime Fredon, Alexia K Cotte, Camille Fuselier, Christophe Schneider, Laurent Martiny, David Monchaud, Leila Chekir-Ghedira, Virginie Aires, Dominique Delma. Chrysin-Induced Regression of Angiogenesis via an Induction of DNA Damage Response and Oxidative Stress in In Vitro and In Vivo Models of Melanoma. Cells. vol 12. issue 12. 2023-06-28. PMID:37371032. |
more specifically, herein, we show that chrysin induces single- and double-stranded dna breaks via the activation of the dna damage response pathway: atm (ataxia-telangiectasia-mutated)/chk2 (checkpoint kinase 2) and atr (ataxia telangiectasia and rad3-related)/chk1 (checkpoint kinase 1) pathways. |
2023-06-28 |
2023-08-14 |
Not clear |
| Yan Zhang, Hao Gong, Ji-Shuai Wang, Meng-Na Li, De-Li Cao, Jun Gu, Lin-Xia Zhao, Xin-Dan Zhang, Yu-Tao Deng, Fu-Lu Dong, Yong-Jing Gao, Wen-Xing Sun, Bao-Chun Jian. Nerve Injury-Induced γH2AX Reduction in Primary Sensory Neurons Is Involved in Neuropathic Pain Processing. International journal of molecular sciences. vol 24. issue 12. 2023-06-28. PMID:37373296. |
ataxia telangiectasia mutated (atm), which promotes γh2ax, was also down-regulated in drg after peripheral nerve injury. |
2023-06-28 |
2023-08-14 |
mouse |
| Xin Long, Anna Dai, Teng Huang, Wenhao Niu, Luoxia Liu, Hui Xu, Tao Yin, Tian'an Jiang, Shuguo Sun, Ping Lei, Chun Li, Xiaohua Zhu, Jun Zha. Simultaneous Delivery of Dual Inhibitors of DNA Damage Repair Sensitizes Pancreatic Cancer Response to Irreversible Electroporation. ACS nano. 2023-06-23. PMID:37352467. |
using reactive oxygen species-sensitive polymeric micelles coloaded with olaparib, an inhibitor of poly(adp-ribose) polymerase (parp), and azd0156, an inhibitor of ataxia telangiectasia mutated (atm), the resultant nanoformulation (m-tk-oa) disrupted both homologous recombination and nonhomologous end joining signaling of the ddr response and impaired colony formation in pancreatic cancer cells after re. |
2023-06-23 |
2023-08-14 |
Not clear |
| Jialu Shao, Lei Huang, Wenwen Lai, Yi Zou, Qihua Zh. Design, Synthesis, and Biological Evaluation of Potent and Selective Inhibitors of Ataxia Telangiectasia Mutated and Rad3-Related (ATR) Kinase for the Efficient Treatment of Cancer. Molecules (Basel, Switzerland). vol 28. issue 11. 2023-06-11. PMID:37298997. |
tumor cells with a loss of ddr function or defects in the ataxia telangiectasia mutated (atm) gene are generally more dependent on atr for survival, suggesting that atr is an attractive anticancer drug target based on its synthetic lethality. |
2023-06-11 |
2023-08-14 |
Not clear |
| Timothy A Yap, Elisa Fontana, Elizabeth K Lee, David R Spigel, Martin Højgaard, Stephanie Lheureux, Niharika B Mettu, Benedito A Carneiro, Louise Carter, Ruth Plummer, Gregory M Cote, Funda Meric-Bernstam, Joseph O'Connell, Joseph D Schonhoft, Marisa Wainszelbaum, Adrian J Fretland, Peter Manley, Yi Xu, Danielle Ulanet, Victoria Rimkunas, Mike Zinda, Maria Koehler, Ian M Silverman, Jorge S Reis-Filho, Ezra Rose. Camonsertib in DNA damage response-deficient advanced solid tumors: phase 1 trial results. Nature medicine. 2023-06-05. PMID:37277454. |
ataxia telangiectasia and rad3-related kinase inhibitors (atri) have been shown to be synthetic lethal with loss of function (lof) of ataxia telangiectasia-mutated (atm) kinase, and preclinical studies have identified atri-sensitizing alterations in other dna damage response (ddr) genes. |
2023-06-05 |
2023-08-14 |
Not clear |