| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Heba M Mansour, Ahmed M Fathi, Aiman S El-Khatib, Mahmoud M Khatta. Kinases control of Regulated Cell Death Revealing Druggable Targets for Parkinson's disease. Ageing research reviews. 2023-01-07. PMID:36608709. |
hence, we will address an overview and analysis of different kinases regulating apoptosis such as receptor-interacting protein kinase 1 (ripk-1), ripk3, mixed lineage kinase (mlk), ataxia telangiectasia muted (atm), cyclin-dependent kinase (cdk), death-associated protein kinase 1 (dapk1), apoptosis-signaling kinase-1 (ask-1), and leucine-rich repeat kinase-2 (lrrk2). |
2023-01-07 |
2023-08-14 |
Not clear |
| Emily Sible, Mary Attaway, Giuseppe Fiorica, Genesis Michel, Jayanta Chaudhuri, Bao Q Vuon. Ataxia Telangiectasia Mutated and MSH2 Control Blunt DNA End Joining in Ig Class Switch Recombination. Journal of immunology (Baltimore, Md. : 1950). 2023-01-05. PMID:36603026. |
ataxia telangiectasia mutated (atm)-dependent phosphorylation of aid at serine 38 (ps38-aid) promotes its interaction with apurinic/apyrimidinic endonuclease 1 (ape1), a ber protein, suggesting that atm regulates csr through ber. |
2023-01-05 |
2023-08-14 |
mouse |
| Byung Chul Jung, Hyun-Kyung Kim, Sung Hoon Kim, Yoon Suk Ki. Triglyceride induces DNA damage leading to monocyte death by activating caspase-2 and caspase-8. BMB reports. 2023-01-02. PMID:36593108. |
in addition, tg induced dna damage and activated the ataxia telangiectasia mutated (atm)/checkpoint kinase 2 and atm-and rad3-related (atr)/checkpoint kinase 1 pathways, leading to the cell death. |
2023-01-02 |
2023-08-14 |
Not clear |
| Theodoros Eleftheriadis, Georgios Pissas, Georgios Filippidis, Maria Efthymiadi, Vassilios Liakopoulos, Ioannis Stefanidi. Dapagliflozin Prevents High-Glucose-Induced Cellular Senescence in Renal Tubular Epithelial Cells. International journal of molecular sciences. vol 23. issue 24. 2022-12-23. PMID:36555751. |
the latter induced dna damage, ataxia telangiectasia mutated kinase (atm), and p53 phosphorylation. |
2022-12-23 |
2023-08-14 |
human |
| Ming Li, Zhifeng Yang, Zhaoyuan Song, Cunxiang Bo, Shuo Wang, Qiang Ji. ATM deficiency aggravates the progression of liver fibrosis induced by carbon tetrachloride in mice. Toxicology. 2022-12-16. PMID:36526012. |
ataxia telangiectasia mutated (atm) is a pivotal sensor during the dna damage response that slows cell passage through the cell cycle checkpoints to facilitate dna repair, and liver fibrosis is an irreversible pathological consequence of the sustained wound-healing process, however, the effects of atm on the development of liver fibrosis are still not fully understood. |
2022-12-16 |
2023-08-14 |
mouse |
| Priyal Lnu, Vineet Sehgal, Saniya Kapila, Nihal Gulati, Lucky Bhalla Sehga. Ataxia Telangiectasia Presenting as Cervical Dystonia. Cureus. vol 14. issue 10. 2022-11-28. PMID:36439585. |
the ataxia telangiectasia mutant (atm) protein is a sensor and signal transducer that amplifies and communicates signals of dna damage further to the mediators of cell cycle arrest, apoptosis, and senescence (p16, p19, p21, bax etc.) |
2022-11-28 |
2023-08-14 |
Not clear |
| Priyal Lnu, Vineet Sehgal, Saniya Kapila, Nihal Gulati, Lucky Bhalla Sehga. Ataxia Telangiectasia Presenting as Cervical Dystonia. Cureus. vol 14. issue 10. 2022-11-28. PMID:36439585. |
classic ataxia telangiectasia is associated with homozygous mutations of the atm gene, the complete absence of its kinase activity and/or deleterious atm gene mutations such as truncation/nonsense mutations, loss of function mutation, non-conservative substitutions, frameshift, and deletions. |
2022-11-28 |
2023-08-14 |
Not clear |
| Amrita Sule, Sarah E Golding, Syed F Ahmad, James Watson, Mostafa H Ahmed, Glen E Kellogg, Tytus Bernas, Sean Koebley, Jason C Reed, Lawrence F Povirk, Kristoffer Valeri. ATM phosphorylates PP2A subunit A resulting in nuclear export and spatiotemporal regulation of the DNA damage response. Cellular and molecular life sciences : CMLS. vol 79. issue 12. 2022-11-26. PMID:36434396. |
ataxia telangiectasia mutated (atm) is a serine-threonine protein kinase and important regulator of the dna damage response (ddr). |
2022-11-26 |
2023-08-14 |
mouse |
| Wen-Jie Jiang, Ming-Hong Sun, Xiao-Han Li, Song-Hee Lee, Geun Heo, Dongjie Zhou, Xiang-Shun Cu. E2F4 regulates cell cycle to mediate embryonic development in pigs. Theriogenology. vol 196. 2022-11-25. PMID:36427391. |
moreover, a decrease in e2f4 expression increased phosphorylated h2a.x variant histones and activated ataxia telangiectasia mutated (atm) and p53-p21 pathway. |
2022-11-25 |
2023-08-14 |
Not clear |
| Anastasia Ricci, Federica Biancucci, Gianluca Morganti, Mauro Magnani, Michele Menott. New human ATM variants are able to regain ATM functions in ataxia telangiectasia disease. Cellular and molecular life sciences : CMLS. vol 79. issue 12. 2022-11-24. PMID:36422718. |
new human atm variants are able to regain atm functions in ataxia telangiectasia disease. |
2022-11-24 |
2023-08-14 |
human |
| Shuyue Yang, Dezhi Song, Ziyi Wang, Yuangang Su, Junchun Chen, Yansi Xian, Jian Huang, Jing Li, Jiake Xu, Jinmin Zhao, Qian Li. AKT/GSK3β/NFATc1 and ROS signal axes are involved in AZD1390-mediated inhibitory effects on osteoclast and OVX-induced osteoporosis. International immunopharmacology. vol 113. issue Pt A. 2022-11-03. PMID:36327872. |
azd1390 (azd), an inhibitor of ataxia telangiectasia mutated (atm), has been reported for antitumor effects, but little is known about how it plays a function in metabolic bone disease. |
2022-11-03 |
2023-08-14 |
mouse |
| Sayanthooran Saravanabavan, Gopala K Ranga. Kidney Cyst Lining Epithelial Cells Are Resistant to Low-Dose Cisplatin-Induced DNA Damage in a Preclinical Model of Autosomal Dominant Polycystic Kidney Disease. International journal of molecular sciences. vol 23. issue 20. 2022-10-27. PMID:36293397. |
we hypothesized that inhibiting ataxia telangiectasia mutated (atm; a proximal ddr kinase) together with low-dose cisplatin overwhelms the ddr response and leads to selective apoptosis of cyst-lining epithelial cells (cecs). |
2022-10-27 |
2023-08-14 |
Not clear |
| Yue Hou, Jie Zi, Shuo Liu, Qinyu Ge, Zheng G. Mutational profiling of circulating tumor DNA and clinical characteristics in lymphoma: Based on next generation sequencing. Molecular carcinogenesis. 2022-10-27. PMID:36300887. |
somatic alterations were identified in 12 of 20 patients and the total 11 mutations were: ataxia telangiectasia mutated (atm), tp53, bcl2, btg2, cd28, ep300, idh2, irf8, jak3, notch1, and nras. |
2022-10-27 |
2023-08-14 |
Not clear |
| Jinyou Qi, Wei Fa. miR-18a-5p and ATM Expression in Esophageal Squamous Cell Carcinoma and Their Correlations with Clinicopathological Features. Computational and mathematical methods in medicine. vol 2022. 2022-10-21. PMID:36267307. |
to investigate mir-18a-5p and ataxia telangiectasia muted (atm) expression in esophageal squamous cell carcinoma (escc) and their correlations with clinicopathological features. |
2022-10-21 |
2023-08-14 |
Not clear |
| Yu-Ying Chao, Bu-Miin Huang, I-Chen Peng, Pei-Rong Lee, Yi-Shyun Lai, Wen-Tai Chiu, Yi-Syuan Lin, Shih-Chieh Lin, Jung-Hsuan Chang, Pai-Sheng Chen, Shaw-Jenq Tsai, Chia-Yih Wan. ATM- and ATR-induced primary ciliogenesis promotes cisplatin resistance in pancreatic ductal adenocarcinoma. Journal of cellular physiology. 2022-10-17. PMID:36251015. |
mechanistically, ataxia telangiectasia mutated (atm) and atm and rad3-related (atr), tumor suppressors that initiate dna damage responses, promoted the excessive formation of centriolar satellites (efocs) and autophagy activation. |
2022-10-17 |
2023-08-14 |
human |
| Siyao Deng, Tijana Vlatkovic, Moying Li, Tianzuo Zhan, Marlon R Veldwijk, Carsten Herskin. Targeting the DNA Damage Response and DNA Repair Pathways to Enhance Radiosensitivity in Colorectal Cancer. Cancers. vol 14. issue 19. 2022-10-14. PMID:36230796. |
in this review, we focus on the preclinical studies and advances in clinical trials of dna-dependent protein kinase catalytic subunit (dna-pkcs), ataxia telangiectasia mutated (atm), ataxia telangiectasia and rad3-related kinase (atr), checkpoint kinase 1 (chk1), checkpoint kinase 2 (chk2), wee1 and poly (adp-ribose) polymerase 1 (parp1) kinase inhibitors in crc. |
2022-10-14 |
2023-08-14 |
Not clear |
| Deanna V Maybee, Alexandra Maria Psaras, Tracy A Brooks, Mohammad A M Al. RYBP Sensitizes Cancer Cells to PARP Inhibitors by Regulating ATM Activity. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36233063. |
in addition, ataxia telangiectasia mutated (atm) kinase serves as an important sensor kinase in early stages of dna damage response. |
2022-10-14 |
2023-08-14 |
Not clear |
| Cameron M Callaghan, Ibrahim M Abukhiran, Amr Masaadeh, Richard V Van Rheeden, Amanda L Kalen, Samuel N Rodman, Michael S Petronek, Kranti A Mapuskar, Benjamin N George, Mitchell C Coleman, Prabhat C Goswami, Bryan G Allen, Douglas R Spitz, Joseph M Caste. Manipulation of Redox Metabolism using Pharmacologic Ascorbate Opens a Therapeutic Window for Radio-sensitization by ATM Inhibitors in Colorectal Cancer. International journal of radiation oncology, biology, physics. 2022-10-13. PMID:36228747. |
ataxia telangiectasia mutated kinase (atm) inhibitors are potent radiosensitizers that regulate dna damage responses and redox metabolism, but they have not been translated clinically because of the potential for excess normal tissue toxicity. |
2022-10-13 |
2023-08-14 |
Not clear |
| Yarui Zhang, Guomin Ou, Zhujing Ye, Zhou Zhou, Qianlin Cao, Mengting Li, Jingdong Wang, Jianping Cao, Hongying Yan. RPRM negatively regulates ATM levels through its nuclear translocation on irradiation mediated by CDK4/6 and IPO11. iScience. vol 25. issue 10. 2022-10-03. PMID:36185355. |
how the ataxia telangiectasia mutated (atm) protein kinase, a core protein in dna damage response, is regulated at post-transcription level remains unclear. |
2022-10-03 |
2023-08-14 |
Not clear |
| Jianli Zhou, Drew Sturtevant, Neha Biyani, Kishor Bhatia, Sandeep Dav. MCL-319 LP-284 - A Highly Potent Small Molecule Targeting Mantle Cell Lymphoma. Clinical lymphoma, myeloma & leukemia. vol 22 Suppl 2. 2022-09-27. PMID:36164123. |
approximately 40%-50% of mcl patients carry inactivating mutations in the gene ataxia telangiectasia mutated (atm), a core component of the cell's dna damage response system. |
2022-09-27 |
2023-08-14 |
Not clear |