| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shruti Patrick, Kirti Lathoria, Vaishali Suri, Ellora Se. Reduced YAP1 and FOLR1 in gliomas predict better response to chemotherapeutics. Cellular signalling. 2023-06-03. PMID:37269960. |
enhanced dna damage in idh1 mutant cells, as evidenced by γh2ax formation (phosphorylation of histone variant h2a.x) and atm (serine/threonine kinase; ataxia telangiectasia mutated) phosphorylation, was accompanied by reduced folr1 (folate receptor 1) expression. |
2023-06-03 |
2023-08-14 |
Not clear |
| Yi-Ping Lee, Chin-Ru Lin, Sih-Shang Chen, Rong-Jane Chen, Yuan-Hua Wu, Ying-Hui Chen, Bu-Miin Huan. Combination treatment of cordycepin and radiation induces MA-10 mouse Leydig tumor cell death via ROS accumulation and DNA damage. American journal of cancer research. vol 13. issue 4. 2023-05-11. PMID:37168338. |
subsequently, pronounced dna damage with phosphorylated h2a histone family member x (γ-h2ax) increase and activation of dna damage-related signaling pathways including double and single stranded break-induced ataxia telangiectasia mutated (atm)/checkpoint kinase (chk)2 and ataxia telangiectasia mutated and rad3 related (atr)/chk1 signaling axes were identified. |
2023-05-11 |
2023-08-14 |
mouse |
| Shiyuan Luo, Zhuochen Lyu, Lingling Ge, Yinjiao Li, Yuqi Liu, Yuan Yuan, Rui Zhao, Lei Huang, Jianyuan Zhao, Hongjun Huang, Yan Lu. ATM protects against lipopolysaccaride-induced blood-brain barrier disruption by regulating ATK/DRP1-mediated mitochondrial homeostasis. Shock (Augusta, Ga.). 2023-05-04. PMID:37141173. |
protein kinase ataxia telangiectasia mutated (atm) regulates the function of endothelial cells and responds quickly to endotoxin. |
2023-05-04 |
2023-08-14 |
Not clear |
| Simon Deacon, William Dalleywater, Charles Peat, Simon M L Paine, Rob A Dinee. Disproportionate Expression of ATM in Cerebellar Cortex During Human Neurodevelopment. Cerebellum (London, England). 2023-04-29. PMID:37120494. |
cerebellar neurodegeneration is a classical feature of ataxia telangiectasia (a-t), an autosomal recessive condition caused by loss-of-function mutation of the atm gene, a gene with multiple regulatory functions. |
2023-04-29 |
2023-08-14 |
human |
| Simon Deacon, William Dalleywater, Charles Peat, Simon M L Paine, Rob A Dinee. Disproportionate Expression of ATM in Cerebellar Cortex During Human Neurodevelopment. Cerebellum (London, England). 2023-04-29. PMID:37120494. |
the increased vulnerability of cerebellar neurones to degeneration compared to cerebral neuronal populations in individuals with ataxia telangiectasia implies a specific importance of intact atm function in the cerebellum. |
2023-04-29 |
2023-08-14 |
human |
| Simon Deacon, William Dalleywater, Charles Peat, Simon M L Paine, Rob A Dinee. Disproportionate Expression of ATM in Cerebellar Cortex During Human Neurodevelopment. Cerebellum (London, England). 2023-04-29. PMID:37120494. |
using atm transcription data from the brainspan atlas of the developing human brain, we demonstrate a rapid increase in cerebellar atm expression relative to expression in other brain regions during gestation and remaining elevated during early childhood, a period corresponding to the emergence of cerebellar neurodegeneration in ataxia telangiectasia patients. |
2023-04-29 |
2023-08-14 |
human |
| Audrey Turchick, Astrid Zimmermann, Li-Ya Chiu, Heike Dahmen, Brian Elenbaas, Frank T Zenke, Andree Blaukat, Lyubomir T Vassile. Selective inhibition of ATM-dependent double-strand break repair and checkpoint control synergistically enhances the efficacy of ATR inhibitors. Molecular cancer therapeutics. 2023-04-20. PMID:37079339. |
however, activation of cell cycle checkpoints controlled by ataxia telangiectasia mutated (atm) kinase could minimize the lethal consequences of atr inhibition and protect cancer cells. |
2023-04-20 |
2023-08-14 |
Not clear |
| Jinghui Liu, Yue Zhao, Daheng He, Katelyn M Jones, Shan Tang, Derek B Allison, Yanquan Zhang, Jing Chen, Qiongsi Zhang, Xinyi Wang, Chaohao Li, Chi Wang, Lang Li, Xiaoqi Li. A kinome-wide CRISPR screen identifies CK1α as a target to overcome enzalutamide resistance of prostate cancer. Cell reports. Medicine. vol 4. issue 4. 2023-04-19. PMID:37075701. |
mechanistically, ck1α phosphorylates the serine residue s1270 and modulates the protein abundance of ataxia telangiectasia mutated (atm), a primary initiator of dna double-strand break (dsb)-response signaling, which is compromised in enza-resistant cells and patients. |
2023-04-19 |
2023-08-14 |
Not clear |
| Avinash Khadela, Humzah Postwala, Deval Rana, Hetvi Dave, Ketan Ranch, Sai H S Bodd. A review of recent advances in the novel therapeutic targets and immunotherapy for lung cancer. Medical oncology (Northwood, London, England). vol 40. issue 5. 2023-04-18. PMID:37071269. |
sclc targeting pathway includes poly (adp-ribose) polymerases (parp) inhibitors, checkpoint kinase 1 (chk 1) pathway, wee1 pathway, ataxia telangiectasia and rad3-related (atr)/ataxia telangiectasia mutated (atm), and delta-like canonical notch ligand 3 (dll-immune checkpoint inhibitors like programmed cell death protein 1 (pd-1)/ programmed death-ligand 1 (pd-l1) inhibitors and cytotoxic t-lymphocyte-associated antigen-4 (ctla4) blockade are also utilized in the management of lung cancer. |
2023-04-18 |
2023-08-14 |
rat |
| You Na Seo, Ji Sue Baik, Song Mi Lee, Ji Eun Lee, Hye Rim Ahn, Min Seo Lim, Moon-Taek Park, Sung Dae Ki. Ionizing Radiation Selectively Increases CXC Ligand 10 Level via the DNA-Damage-Induced p38 MAPK-STAT1 Pathway in Murine J774A.1 Macrophages. Cells. vol 12. issue 7. 2023-04-13. PMID:37048082. |
pretreatment with ku55933, an ataxia telangiectasia mutated (atm) kinase inhibitor, significantly inhibited ir-induced cxcl10 production. |
2023-04-13 |
2023-08-14 |
Not clear |
| Dianwen Yu, Hui Wang, Hui Liu, Rong X. Liposomal ATM siRNA delivery for enhancing triple-negaitive breast cancer immune checkpoint blockade therapy. Journal of biomaterials applications. 2023-04-05. PMID:37016537. |
ataxia telangiectasia mutated (atm) is a critical factor in the dna damage response (ddr) pathway, which is associated with the development of tumors. |
2023-04-05 |
2023-08-14 |
Not clear |
| Zhi-Jun Liu, Ya-Ling Wang, Yan X. Two novel heterozygote mutations of ATM in a Chinese family with dystonia-dominant ataxia telangiectasia and literature review. Frontiers in pediatrics. vol 11. 2023-04-03. PMID:37009283. |
two novel heterozygote mutations of atm in a chinese family with dystonia-dominant ataxia telangiectasia and literature review. |
2023-04-03 |
2023-08-14 |
Not clear |
| Watanya Trakarnphornsombat, Hiroshi Kimur. Live-Cell Tracking of γ-H2AX Kinetics Reveals the Distinct Modes of ATM and DNA-PK in Immediate Response to DNA Damage. Journal of cell science. 2023-03-31. PMID:36999484. |
on the induction of dsbs, histone h2ax becomes phosphorylated by kinases, including ataxia telangiectasia-mutated (atm), ataxia telangiectasia and rad3-related (atr), and dna-dependent protein kinase (dna-pk). |
2023-03-31 |
2023-08-14 |
Not clear |
| Yangyang Li, Yixuan Cen, Mengyan Tu, Zhenzhen Xiang, Sangsang Tang, Weiguo Lu, Hongbo Zhang, Junfen X. Nanoengineered Gallium Ion Incorporated Formulation for Safe and Efficient Reversal of PARP Inhibition and Platinum Resistance in Ovarian Cancer. Research (Washington, D.C.). vol 6. 2023-03-17. PMID:36930754. |
mechanistically, the combined treatment induced dna damage, which elicited the activation of ataxia telangiectasia mutated (atm)/amt- and rad3-related (atr) checkpoint kinase 1 (chk1)/chk2 signal transduction pathways. |
2023-03-17 |
2023-08-14 |
Not clear |
| Hongbin Wang, Qiyu Tian, Zhixin Xu, Min Du, Mei-Jun Zh. Metabolomic profiling for the preventive effects of dietary grape pomace against colorectal cancer. The Journal of nutritional biochemistry. 2023-03-03. PMID:36868505. |
moreover, mdm2, a protein in the ataxia telangiectasia mutated (atm) signaling, was decreased by gp supplementation. |
2023-03-03 |
2023-08-14 |
mouse |
| Xiaoquan Li, Chan-I Chung, JunJiao Yang, Sibapriya Chaudhuri, Pamela N Munster, Xiaokun Sh. ATM-SPARK: A GFP phase separation-based activity reporter of ATM. Science advances. vol 9. issue 9. 2023-03-01. PMID:36857446. |
the kinase ataxia telangiectasia mutated (atm) plays a key role in the dna damage response (ddr). |
2023-03-01 |
2023-08-14 |
Not clear |
| Jiayi Zhao, Xin Gui, Ziming Ren, Huiqi Fu, Chao Yang, Wenyi Wang, Qingpei Liu, Min Zhang, Chong Wang, Arp Schnittger, Bing Li. ATM-Mediated Double-Strand Break Repair Is Required for Meiotic Genome Stability at High Temperature. The Plant journal : for cell and molecular biology. 2023-02-14. PMID:36786716. |
the conserved kinase ataxia telangiectasia mutated (atm) regulates multiple processes in meiotic homologous recombination including dna double-strand break (dsb) formation and repair, synaptonemal complex organization, and crossover formation and distribution. |
2023-02-14 |
2023-08-14 |
Not clear |
| Shuang Zheng, Jiaming Song, Dongli Linghu, Riyao Yang, Boning Liu, Zhen Xue, Qihui Chen, Chengjie Liu, Diansheng Zhong, Mien-Chie Hung, Linlin Su. Galectin-9 blockade synergizes with ATM inhibition to induce potent anti-tumor immunity. International journal of biological sciences. vol 19. issue 3. 2023-02-13. PMID:36778120. |
here we show that antibody neutralization of gal-9, in combination with inhibition of ataxia telangiectasia mutated (atm), a kinase essential for dna damage response (ddr), is a promising modality for cancer immunotherapy. |
2023-02-13 |
2023-08-14 |
mouse |
| Kyle Concannon, Benjamin B Morris, Carl M Gay, Lauren A Byer. Combining targeted DNA repair inhibition and immune-oncology approaches for enhanced tumor control. Molecular cell. 2023-01-20. PMID:36669489. |
seminal studies have shown that these agents are highly effective in a pan-cancer class of tumors with genetic defects in key dna repair genes such as brca1/2, brca-related genes, ataxia telangiectasia mutated (atm), and others. |
2023-01-20 |
2023-08-14 |
Not clear |
| Li-Ya Chiu, Qing Sun, Frank T Zenke, Andree Blaukat, Lyubomir T Vassile. Selective ATM inhibition augments radiation-induced inflammatory signaling and cancer cell death. Aging. vol 15. 2023-01-19. PMID:36656721. |
ataxia telangiectasia mutated (atm) kinase is a key regulator of cellular response to dna double strand breaks and a potential target for radiosensitization. |
2023-01-19 |
2023-08-14 |
human |