| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Shigeta, M Takagi, D Delia, L Chessa, S Iwata, Y Kanke, M Asada, M Eguchi, S Mizutan. Defective control of apoptosis and mitotic spindle checkpoint in heterozygous carriers of ATM mutations. Cancer research. vol 59. issue 11. 1999-06-29. PMID:10363981. |
ataxia telangiectasia (at) carrier-derived lymphoblastoid cell lines (at-lcls/hetero) with suboptimal atm protein expression were examined for the regulation of radiosensitivity, apoptosis, and mitotic spindle checkpoint in response to dna-damaging agents. |
1999-06-29 |
2023-08-12 |
Not clear |
| K D Mills, D A Sinclair, L Guarent. MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks. Cell. vol 97. issue 5. 1999-06-29. PMID:10367890. |
mec1 is a homolog of atm, mutations in which cause ataxia telangiectasia (a-t), a disease characterized by various neurologic and immunologic abnormalities, a predisposition for cancer, and a cellular defect in repair of dsbs. |
1999-06-29 |
2023-08-12 |
human |
| L Izatt, C Vessey, S V Hodgson, E Solomo. Rapid and efficient ATM mutation detection by fluorescent chemical cleavage of mismatch: identification of four novel mutations. European journal of human genetics : EJHG. vol 7. issue 3. 1999-06-28. PMID:10234507. |
mutations in the ataxia telangiectasia mutated (atm) gene are responsible for the autosomal recessive disease ataxia telangiectasia (a-t). |
1999-06-28 |
2023-08-12 |
Not clear |
| T Kamijo, E van de Kamp, M J Chong, F Zindy, J A Diehl, C J Sherr, P J McKinno. Loss of the ARF tumor suppressor reverses premature replicative arrest but not radiation hypersensitivity arising from disabled atm function. Cancer research. vol 59. issue 10. 1999-06-17. PMID:10344759. |
animals lacking a functional ataxia telangiectasia (atm) gene are exquisitely sensitive to ionizing radiation; atm-null mouse embryo fibroblasts (mefs) undergo premature replicative arrest, which is relieved by the loss of p53. |
1999-06-17 |
2023-08-12 |
mouse |
| D M Sabatini, R K Barrow, S Blackshaw, P E Burnett, M M Lai, M E Field, B A Bahr, J Kirsch, H Betz, S H Snyde. Interaction of RAFT1 with gephyrin required for rapamycin-sensitive signaling. Science (New York, N.Y.). vol 284. issue 5417. 1999-06-08. PMID:10325225. |
raft1 (rapamycin and fkbp12 target 1; also called frap or mtor) is a member of the atm (ataxia telangiectasia mutated)-related family of proteins and functions as the in vivo mediator of the effects of the immunosuppressant rapamycin and as an important regulator of messenger rna translation. |
1999-06-08 |
2023-08-12 |
Not clear |
| R G Shao, C X Cao, H Zhang, K W Kohn, M S Wold, Y Pommie. Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes. The EMBO journal. vol 18. issue 5. 1999-04-29. PMID:10064605. |
this response appears to be due to dna-dependent protein kinase (dna-pk) and to be independent of p53 or the ataxia telangiectasia mutated (atm) protein. |
1999-04-29 |
2023-08-12 |
human |
| P Hande, P Slijepcevic, A Silver, S Bouffler, P van Buul, P Bryant, P Lansdor. Elongated telomeres in scid mice. Genomics. vol 56. issue 2. 1999-04-22. PMID:10051409. |
dna-pkcs is a member of the phosphatidylinositol 3-kinase superfamily, which includes the human protein atm (ataxia telangiectasia mutated) and the yeast protein tel1. |
1999-04-22 |
2023-08-12 |
mouse |
| M J Liao, C Yin, C Barlow, A Wynshaw-Boris, T van Dyk. Atm is dispensable for p53 apoptosis and tumor suppression triggered by cell cycle dysfunction. Molecular and cellular biology. vol 19. issue 4. 1999-04-20. PMID:10082576. |
in this study, we tested the role of murine ataxia telangiectasia protein (atm) in a transgenic mouse brain tumor model in which p53-mediated apoptosis results in tumor suppression. |
1999-04-20 |
2023-08-12 |
mouse |
| D P Gately, J C Hittle, G K Chan, T J Ye. Characterization of ATM expression, localization, and associated DNA-dependent protein kinase activity. Molecular biology of the cell. vol 9. issue 9. 1999-03-22. PMID:9725899. |
ataxia telangiectasia-mutated gene (atm) is a 350-kda protein whose function is defective in the autosomal recessive disorder ataxia telangiectasia (at). |
1999-03-22 |
2023-08-12 |
human |
| J Knittwei. An ataxia telangiectasia model: inefficient cell differentiation and possible reversal by serine protease inhibitors, tumor necrosis factor inhibitors, dexamethasone, and glutathione enhancers. Medical hypotheses. vol 51. issue 1. 1999-03-22. PMID:9881837. |
the ataxia telangiectasia gene (atm) may reduce differentiation by suppressing cell responsivity to insulin. |
1999-03-22 |
2023-08-12 |
Not clear |
| N Sandoval, M Platzer, A Rosenthal, T Dörk, R Bendix, B Skawran, M Stuhrmann, R D Wegner, K Sperling, S Banin, Y Shiloh, A Baumer, U Bernthaler, H Sennefelder, M Brohm, B H Weber, D Schindle. Characterization of ATM gene mutations in 66 ataxia telangiectasia families. Human molecular genetics. vol 8. issue 1. 1999-03-18. PMID:9887333. |
characterization of atm gene mutations in 66 ataxia telangiectasia families. |
1999-03-18 |
2023-08-12 |
Not clear |
| J Karlseder, D Broccoli, Y Dai, S Hardy, T de Lang. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science (New York, N.Y.). vol 283. issue 5406. 1999-03-12. PMID:10037601. |
the response was mediated by p53 and the atm (ataxia telangiectasia mutated) kinase, consistent with activation of a dna damage checkpoint. |
1999-03-12 |
2023-08-12 |
Not clear |
| M A Yuille, L J Coigne. The ataxia telangiectasia gene in familial and sporadic cancer. Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer. vol 154. 1999-03-05. PMID:10026998. |
the ataxia telangiectasia (a-t) gene, atm, predisposes affected homozygotes to a wide range of malignancies. |
1999-03-05 |
2023-08-12 |
Not clear |
| S B Chernikova, R L Wells, M M Elkin. Wortmannin sensitizes mammalian cells to radiation by inhibiting the DNA-dependent protein kinase-mediated rejoining of double-strand breaks. Radiation research. vol 151. issue 2. 1999-02-19. PMID:9952300. |
pretreatment with wortmannin enhanced the radiosensitivity of ataxia telangiectasia (at) cells, thereby precluding the participation of atm protein in the radiation sensitization by wortmannin. |
1999-02-19 |
2023-08-12 |
Not clear |
| S Kharbanda, Z M Yuan, R Weichselbaum, D Kuf. Determination of cell fate by c-Abl activation in the response to DNA damage. Oncogene. vol 17. issue 25. 1999-02-16. PMID:9916993. |
the ataxia telangiectasia mutated (atm) gene product also contributes to c-abl activation. |
1999-02-16 |
2023-08-12 |
Not clear |
| R A Clarke, R Kairouz, D Watters, M F Lavin, J H Kearsley, C S Le. Upregulation of ATM in sclerosing adenosis of the breast. Molecular pathology : MP. vol 51. issue 4. 1999-02-04. PMID:9893751. |
the gene mutated in ataxia telangiectasia (atm) has an established tumour suppressor role in breast cancer. |
1999-02-04 |
2023-08-12 |
Not clear |
| S Matsuoka, M Huang, S J Elledg. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science (New York, N.Y.). vol 282. issue 5395. 1998-12-28. PMID:9836640. |
chk2 was rapidly phosphorylated and activated in response to replication blocks and dna damage; the response to dna damage occurred in an ataxia telangiectasia mutated (atm)-dependent manner. |
1998-12-28 |
2023-08-12 |
Not clear |
| I Szumie. Monitoring and signaling of radiation-induced damage in mammalian cells. Radiation research. vol 150. issue 5 Suppl. 1998-11-20. PMID:9806612. |
this paper reviews the functions of and connections between the presumed dna damage sensors: poly(adp-ribose) polymerase (parp), dna-dependent protein kinase (dna-pk), the protein product of the ataxia telangiectasia mutated (atm) gene, and the tumor suppressor, p53. |
1998-11-20 |
2023-08-12 |
human |
| M Takagi, D Delia, L Chessa, S Iwata, T Shigeta, Y Kanke, K Goi, M Asada, M Eguchi, C Kodama, S Mizutan. Defective control of apoptosis, radiosensitivity, and spindle checkpoint in ataxia telangiectasia. Cancer research. vol 58. issue 21. 1998-11-18. PMID:9810001. |
we examined the regulation of apoptosis, radiosensitivity, and spindle checkpoint in response to dna-damaging agents in ataxia telangiectasia (at)-derived lymphoblastoid cell lines (at-lcls), which lack at mutated (atm) protein expression. |
1998-11-18 |
2023-08-12 |
Not clear |
| Y Hosoi, H Miyachi, Y Matsumoto, H Ikehata, J Komura, K Ishii, H J Zhao, M Yoshida, Y Takai, S Yamada, N Suzuki, T On. A phosphatidylinositol 3-kinase inhibitor wortmannin induces radioresistant DNA synthesis and sensitizes cells to bleomycin and ionizing radiation. International journal of cancer. vol 78. issue 5. 1998-11-17. PMID:9808536. |
in order to determine the contribution of atm and dna-pkcs to the increased sensitivity of cells to dna-damaging agents observed in the presence of pi3-kinase inhibitors, we examined the effects of a pi3-kinase inhibitor, wortmannin, on cellular sensitivity to bleomycin (blm), mitomycin c (mmc), x-irradiation and ultraviolet (uv)-irradiation using 2 human tumor cell lines (t98g and a172), a human fibroblast cell line (lm217), an ataxia telangiectasia (at) cell line (at3bisv), a scid murine cell line (scf) and a control murine cell line (cbf). |
1998-11-17 |
2023-08-12 |
mouse |