| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yanli Zhang-James, Tania DasBanerjee, Terje Sagvolden, Frank A Middleton, Stephen V Faraon. SLC9A9 mutations, gene expression, and protein-protein interactions in rat models of attention-deficit/hyperactivity disorder. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 156B. issue 7. 2012-01-17. PMID:21858920. |
we examined the slc9a9 gene sequence and expression profile in prefrontal cortex, dorsal striatum and hippocampus in two genetic rat models of adhd. |
2012-01-17 |
2023-08-12 |
human |
| Elseline Hoekzema, Susanna Carmona, J Antoni Ramos-Quiroga, Erika Barba, Anna Bielsa, Virginia Tremols, Mariana Rovira, Juan Carlos Soliva, Miguel Casas, Antoni Bulbena, Adolf Tobeña, Oscar Vilarroy. Training-induced neuroanatomical plasticity in ADHD: a tensor-based morphometric study. Human brain mapping. vol 32. issue 10. 2012-01-13. PMID:21365715. |
moreover, the dorsolateral prefrontal cortex and cerebellum are commonly considered sites of volumetric reduction in adhd, and the inferior-posterior lobule of the cerebellum is associated with progressive symptom-related volume loss. |
2012-01-13 |
2023-08-12 |
Not clear |
| T J Renner, T T Nguyen, M Romanos, S Walitza, C Röser, A Reif, H Schäfer, A Warnke, M Gerlach, K P Lesc. No evidence for association between a functional promoter variant of the Norepinephrine Transporter gene SLC6A2 and ADHD in a family-based sample. Attention deficit and hyperactivity disorders. vol 3. issue 3. 2012-01-05. PMID:21739117. |
the norepinephrine transporter facilitates the reuptake of norepinephrine and dopamine in the prefrontal cortex and represents the main target of atomoxetine, an effective drug in the treatment of adhd. |
2012-01-05 |
2023-08-12 |
Not clear |
| Alexander Prehn-Kristensen, Robert Göder, Jochen Fischer, Ines Wilhelm, Mareen Seeck-Hirschner, Josef Aldenhoff, Lioba Bavin. Reduced sleep-associated consolidation of declarative memory in attention-deficit/hyperactivity disorder. Sleep medicine. vol 12. issue 7. 2011-12-06. PMID:21697007. |
given that the consolidation of declarative memory during sleep is supported by slow oscillations, which are predominantly generated by the prefrontal cortex, and that adhd patients display low prefrontal brain activity, we assumed that adhd patients show reduced sleep-associated consolidation of declarative memory. |
2011-12-06 |
2023-08-12 |
Not clear |
| Simona Spinelli, Roma A Vasa, Suresh Joel, Tess E Nelson, James J Pekar, Stewart H Mostofsk. Variability in post-error behavioral adjustment is associated with functional abnormalities in the temporal cortex in children with ADHD. Journal of child psychology and psychiatry, and allied disciplines. vol 52. issue 7. 2011-11-18. PMID:21175614. |
we hypothesized that children with adhd, compared to typically developing (td) controls, would exhibit reduced pfc activation during post-error (versus post-correct inhibition) trials and reduced dacc activation during error (versus correct inhibition) trials. |
2011-11-18 |
2023-08-12 |
Not clear |
| Qin Hong, Yan-Ping Wang, Min Zhang, Xiao-Qin Pan, Mei Guo, Fei Li, Mei-Ling Tong, Rong-Hua Chen, Xi-Rong Guo, Xia Ch. Homer expression in the hippocampus of an animal model of attention-deficit/hyperactivity disorder. Molecular medicine reports. vol 4. issue 4. 2011-09-30. PMID:21523321. |
since these changes were observed in the prefrontal cortex (pfc), a critical structure in adhd, it was hypothesized that these homer isoforms may play a role in adhd. |
2011-09-30 |
2023-08-12 |
rat |
| Qin Hong, Yan-Ping Wang, Min Zhang, Xiao-Qin Pan, Mei Guo, Fei Li, Mei-Ling Tong, Rong-Hua Chen, Xi-Rong Guo, Xia Ch. Homer expression in the hippocampus of an animal model of attention-deficit/hyperactivity disorder. Molecular medicine reports. vol 4. issue 4. 2011-09-30. PMID:21523321. |
the present study aimed to extend these findings to the hippocampus, which has direct connections to the pfc and subserves attention and cognition, two functions that are disturbed in adhd. |
2011-09-30 |
2023-08-12 |
rat |
| Qin Hong, Yan-Ping Wang, Min Zhang, Xiao-Qin Pan, Mei Guo, Fei Li, Mei-Ling Tong, Rong-Hua Chen, Xi-Rong Guo, Xia Ch. Homer expression in the hippocampus of an animal model of attention-deficit/hyperactivity disorder. Molecular medicine reports. vol 4. issue 4. 2011-09-30. PMID:21523321. |
the animal model of adhd may have altered expression of homer 1a and homer 2a/b in the hippocampus, in addition to the pfc. |
2011-09-30 |
2023-08-12 |
rat |
| Craig W Berridge, David M Devilbis. Psychostimulants as cognitive enhancers: the prefrontal cortex, catecholamines, and attention-deficit/hyperactivity disorder. Biological psychiatry. vol 69. issue 12. 2011-09-29. PMID:20875636. |
specifically, when administered at low and clinically relevant doses, psychostimulants improve a variety of behavioral and cognitive processes dependent on the prefrontal cortex (pfc) in subjects with and without adhd. |
2011-09-29 |
2023-08-12 |
human |
| Craig W Berridge, David M Devilbis. Psychostimulants as cognitive enhancers: the prefrontal cortex, catecholamines, and attention-deficit/hyperactivity disorder. Biological psychiatry. vol 69. issue 12. 2011-09-29. PMID:20875636. |
these and other observations indicate a pivotal role of pfc catecholamines in the cognition-enhancing and therapeutic actions of psychostimulants, as well as other drugs used in the treatment of adhd. |
2011-09-29 |
2023-08-12 |
human |
| Craig W Berridge, David M Devilbis. Psychostimulants as cognitive enhancers: the prefrontal cortex, catecholamines, and attention-deficit/hyperactivity disorder. Biological psychiatry. vol 69. issue 12. 2011-09-29. PMID:20875636. |
this information may be particularly relevant for the development of novel pharmacological treatments for adhd and other conditions associated with pfc dysregulation. |
2011-09-29 |
2023-08-12 |
human |
| Sarah Durston, Janna van Belle, Patrick de Zeeu. Differentiating frontostriatal and fronto-cerebellar circuits in attention-deficit/hyperactivity disorder. Biological psychiatry. vol 69. issue 12. 2011-09-29. PMID:20965496. |
attention-deficit/hyperactivity disorder (adhd) has long been conceptualized as a neurobiological disorder of the prefrontal cortex and its connections. |
2011-09-29 |
2023-08-12 |
Not clear |
| Sarah Durston, Janna van Belle, Patrick de Zeeu. Differentiating frontostriatal and fronto-cerebellar circuits in attention-deficit/hyperactivity disorder. Biological psychiatry. vol 69. issue 12. 2011-09-29. PMID:20965496. |
circuits with the prefrontal cortex relevant to adhd include dorsal frontostriatal, orbitofronto-striatal, and fronto-cerebellar circuits. |
2011-09-29 |
2023-08-12 |
Not clear |
| Sarah Durston, Janna van Belle, Patrick de Zeeu. Differentiating frontostriatal and fronto-cerebellar circuits in attention-deficit/hyperactivity disorder. Biological psychiatry. vol 69. issue 12. 2011-09-29. PMID:20965496. |
neurobiological dysfunction in any of these circuits could lead to symptoms of adhd, as behavioral control could be disturbed by: 1) deficits in the prefrontal cortex itself; or 2) problems in the circuits relaying information to the prefrontal cortex, leading to reduced signaling for control. |
2011-09-29 |
2023-08-12 |
Not clear |
| Sarah Durston, Janna van Belle, Patrick de Zeeu. Differentiating frontostriatal and fronto-cerebellar circuits in attention-deficit/hyperactivity disorder. Biological psychiatry. vol 69. issue 12. 2011-09-29. PMID:20965496. |
this article suggests a model for differentiating between interlinked reciprocal circuits with the prefrontal cortex in adhd. |
2011-09-29 |
2023-08-12 |
Not clear |
| Amy F T Arnsten, Steven R Pliszk. Catecholamine influences on prefrontal cortical function: relevance to treatment of attention deficit/hyperactivity disorder and related disorders. Pharmacology, biochemistry, and behavior. vol 99. issue 2. 2011-09-29. PMID:21295057. |
research has shown that the prefrontal cortex (pfc) is essential for the "top-down" regulation of attention, behavior, and emotion, and that this brain region is underactive in many patients with adhd. |
2011-09-29 |
2023-08-12 |
Not clear |
| Amy F T Arnsten, Steven R Pliszk. Catecholamine influences on prefrontal cortical function: relevance to treatment of attention deficit/hyperactivity disorder and related disorders. Pharmacology, biochemistry, and behavior. vol 99. issue 2. 2011-09-29. PMID:21295057. |
stronger pfc regulation of attention, behavior, and emotion likely contributes to the therapeutic effects of these medications for the treatment of adhd. |
2011-09-29 |
2023-08-12 |
Not clear |
| Nao J Gamo, Amy F T Arnste. Molecular modulation of prefrontal cortex: rational development of treatments for psychiatric disorders. Behavioral neuroscience. vol 125. issue 3. 2011-09-29. PMID:21480691. |
dysfunction of the prefrontal cortex (pfc) is a central feature of many psychiatric disorders, such as attention deficit hyperactivity disorder (adhd), posttraumatic stress disorder (ptsd), schizophrenia, and bipolar disorder. |
2011-09-29 |
2023-08-12 |
Not clear |
| Nao J Gamo, Amy F T Arnste. Molecular modulation of prefrontal cortex: rational development of treatments for psychiatric disorders. Behavioral neuroscience. vol 125. issue 3. 2011-09-29. PMID:21480691. |
examples of successful translation from animals to humans include guanfacine for the treatment of adhd and related pfc disorders, and prazosin for the treatment of ptsd. |
2011-09-29 |
2023-08-12 |
Not clear |
| Amy F T Arnste. Catecholamine influences on dorsolateral prefrontal cortical networks. Biological psychiatry. vol 69. issue 12. 2011-09-29. PMID:21489408. |
all current pharmacological treatments for adhd facilitate catecholamine transmission, and basic research suggests that these compounds have prominent actions in the prefrontal cortex (pfc). |
2011-09-29 |
2023-08-12 |
Not clear |