| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Md Habibur Rahman, Mithilesh Kumar Jha, Jong-Heon Kim, Youngpyo Nam, Maan Gee Lee, Younghoon Go, Robert A Harris, Dong Ho Park, Hyun Kook, In-Kyu Lee, Kyoungho Su. Pyruvate Dehydrogenase Kinase-mediated Glycolytic Metabolic Shift in the Dorsal Root Ganglion Drives Painful Diabetic Neuropathy. The Journal of biological chemistry. vol 291. issue 11. 2016-08-08. PMID:26769971. |
pyruvate dehydrogenase kinase-mediated glycolytic metabolic shift in the dorsal root ganglion drives painful diabetic neuropathy. |
2016-08-08 |
2023-08-13 |
mouse |
| Md Habibur Rahman, Mithilesh Kumar Jha, Jong-Heon Kim, Youngpyo Nam, Maan Gee Lee, Younghoon Go, Robert A Harris, Dong Ho Park, Hyun Kook, In-Kyu Lee, Kyoungho Su. Pyruvate Dehydrogenase Kinase-mediated Glycolytic Metabolic Shift in the Dorsal Root Ganglion Drives Painful Diabetic Neuropathy. The Journal of biological chemistry. vol 291. issue 11. 2016-08-08. PMID:26769971. |
the dorsal root ganglion (drg) is a highly vulnerable site in diabetic neuropathy. |
2016-08-08 |
2023-08-13 |
mouse |
| Md Habibur Rahman, Mithilesh Kumar Jha, Jong-Heon Kim, Youngpyo Nam, Maan Gee Lee, Younghoon Go, Robert A Harris, Dong Ho Park, Hyun Kook, In-Kyu Lee, Kyoungho Su. Pyruvate Dehydrogenase Kinase-mediated Glycolytic Metabolic Shift in the Dorsal Root Ganglion Drives Painful Diabetic Neuropathy. The Journal of biological chemistry. vol 291. issue 11. 2016-08-08. PMID:26769971. |
however, the contribution of diabetes-induced metabolic dysfunctions in the drg to the pathogenesis of painful diabetic neuropathy remains ill-explored. |
2016-08-08 |
2023-08-13 |
mouse |
| Md Habibur Rahman, Mithilesh Kumar Jha, Jong-Heon Kim, Youngpyo Nam, Maan Gee Lee, Younghoon Go, Robert A Harris, Dong Ho Park, Hyun Kook, In-Kyu Lee, Kyoungho Su. Pyruvate Dehydrogenase Kinase-mediated Glycolytic Metabolic Shift in the Dorsal Root Ganglion Drives Painful Diabetic Neuropathy. The Journal of biological chemistry. vol 291. issue 11. 2016-08-08. PMID:26769971. |
in this study, we report that pyruvate dehydrogenase kinases (pdk2 and pdk4), key regulatory enzymes in glucose metabolism, mediate glycolytic metabolic shift in the drg leading to painful diabetic neuropathy. |
2016-08-08 |
2023-08-13 |
mouse |
| Md Habibur Rahman, Mithilesh Kumar Jha, Jong-Heon Kim, Youngpyo Nam, Maan Gee Lee, Younghoon Go, Robert A Harris, Dong Ho Park, Hyun Kook, In-Kyu Lee, Kyoungho Su. Pyruvate Dehydrogenase Kinase-mediated Glycolytic Metabolic Shift in the Dorsal Root Ganglion Drives Painful Diabetic Neuropathy. The Journal of biological chemistry. vol 291. issue 11. 2016-08-08. PMID:26769971. |
taken together, pdk2/4 induction and the subsequent lactate surge induce the metabolic shift in the diabetic drg, thereby contributing to the pathogenesis of painful diabetic neuropathy. |
2016-08-08 |
2023-08-13 |
mouse |
| Dmytro E Duzhyy, Viacheslav Y Viatchenko-Karpinski, Eugen V Khomula, Nana V Voitenko, Pavel V Bela. Upregulation of T-type Ca2+ channels in long-term diabetes determines increased excitability of a specific type of capsaicin-insensitive DRG neurons. Molecular pain. vol 11. 2016-02-22. PMID:25986602. |
at the same time pain symptoms of diabetic neuropathy other than thermal persist in stz-diabetic animals and patients during progression of diabetes into later stages suggesting that other types of drg neurons may be sensitized and contribute to pain. |
2016-02-22 |
2023-08-13 |
rat |
| Aleksandar Lj Obradovic, Sung Mi Hwang, Joseph Scarpa, Sung Jun Hong, Slobodan M Todorovic, Vesna Jevtovic-Todorovi. CaV3.2 T-type calcium channels in peripheral sensory neurons are important for mibefradil-induced reversal of hyperalgesia and allodynia in rats with painful diabetic neuropathy. PloS one. vol 9. issue 4. 2015-06-15. PMID:24705276. |
we recently showed that streptozotocin (stz) injections in rats lead to the development of painful peripheral diabetic neuropathy (pdn) accompanied by enhancement of cav3.2 t-type calcium currents (t-currents) and hyperexcitability in dorsal root ganglion (drg) neurons. |
2015-06-15 |
2023-08-13 |
rat |
| Michela M Taiana, Raffaella Lombardi, Carla Porretta-Serapiglia, Emilio Ciusani, Norberto Oggioni, Jenny Sassone, Roberto Bianchi, Giuseppe Lauri. Neutralization of schwann cell-secreted VEGF is protective to in vitro and in vivo experimental diabetic neuropathy. PloS one. vol 9. issue 9. 2015-06-10. PMID:25268360. |
moreover, we studied the effects of vegf neutralization on hyperglycemic drg neurons and streptozotocin-induced diabetic neuropathy. |
2015-06-10 |
2023-08-13 |
rat |
| Kathryn L Maier Ortmann, Munmun Chattopadhya. Decrease in neuroimmune activation by HSV-mediated gene transfer of TNFα soluble receptor alleviates pain in rats with diabetic neuropathy. Brain, behavior, and immunity. vol 41. 2015-06-09. PMID:24880032. |
in order to explore the potential role of inflammation in the peripheral nervous system of type 1 diabetic animals with painful neuropathy, we investigated whether tnf-α is a key inflammatory mediator to the diabetic neuropathic pain and whether continuous delivery of tnfα soluble receptor from damaged axons achieved by hsv vector mediated transduction of drg would block or alter the pain perception in animals with diabetic neuropathy. |
2015-06-09 |
2023-08-13 |
rat |
| Yangliang Huang, Ying Zang, Lijun Zhou, Wenshan Gui, Xianguo Liu, Yi Zhon. The role of TNF-alpha/NF-kappa B pathway on the up-regulation of voltage-gated sodium channel Nav1.7 in DRG neurons of rats with diabetic neuropathy. Neurochemistry international. vol 75. 2015-03-30. PMID:24893330. |
the role of tnf-alpha/nf-kappa b pathway on the up-regulation of voltage-gated sodium channel nav1.7 in drg neurons of rats with diabetic neuropathy. |
2015-03-30 |
2023-08-13 |
rat |
| Slobodan M Todorovic, Vesna Jevtovic-Todorovi. Targeting of CaV3.2 T-type calcium channels in peripheral sensory neurons for the treatment of painful diabetic neuropathy. Pflugers Archiv : European journal of physiology. vol 466. issue 4. 2014-11-24. PMID:24482063. |
pain-sensing sensory neurons (nociceptors) of the dorsal root ganglion (drg) can become sensitized (hyperexcitable) in response to pathological conditions such as diabetes, which in turn may lead to the development of painful peripheral diabetic neuropathy (pdn). |
2014-11-24 |
2023-08-12 |
Not clear |
| K-I Cheng, H-C Wang, Y-T Chuang, C-W Chou, H-P Tu, Y-C Yu, L-L Chang, C-S La. Persistent mechanical allodynia positively correlates with an increase in activated microglia and increased P-p38 mitogen-activated protein kinase activation in streptozotocin-induced diabetic rats. European journal of pain (London, England). vol 18. issue 2. 2014-09-04. PMID:23868758. |
in experimental early painful diabetic neuropathy, persistent hyperglycaemia induces dys-regulated sodium channel (navs) expression in the dorsal root ganglion (drg) and activates microglia in the spinal dorsal horn (sdh). |
2014-09-04 |
2023-08-12 |
rat |
| b' Natalija Filipovi\\xc4\\x87, Lejla Ferhatovi\\xc4\\x87, Ivana Marelja, Livia Puljak, Ivica Grkovi\\xc4\\x8. Increased vitamin D receptor expression in dorsal root ganglia neurons of diabetic rats. Neuroscience letters. vol 549. 2014-03-06. PMID:23684983.' |
to assess the role of vdr signaling in diabetic neuropathy, we examined expression of vdrs in dorsal root ganglia (drg) neurons in a rat model of streptozotocin-induced diabetes mellitus type 1. |
2014-03-06 |
2023-08-12 |
rat |
| Jun-Long Zhang, Jan-Ping Yang, Ji-Ru Zhang, Rui-Qin Li, Jing Wang, Jin-Jin Jan, Qing Zhuan. Gabapentin reduces allodynia and hyperalgesia in painful diabetic neuropathy rats by decreasing expression level of Nav1.7 and p-ERK1/2 in DRG neurons. Brain research. vol 1493. 2013-06-13. PMID:23183040. |
gabapentin reduces allodynia and hyperalgesia in painful diabetic neuropathy rats by decreasing expression level of nav1.7 and p-erk1/2 in drg neurons. |
2013-06-13 |
2023-08-12 |
rat |
| Jun-Long Zhang, Jan-Ping Yang, Ji-Ru Zhang, Rui-Qin Li, Jing Wang, Jin-Jin Jan, Qing Zhuan. Gabapentin reduces allodynia and hyperalgesia in painful diabetic neuropathy rats by decreasing expression level of Nav1.7 and p-ERK1/2 in DRG neurons. Brain research. vol 1493. 2013-06-13. PMID:23183040. |
the persistent sodium current is found in excitable drg neurons of painful diabetic neuropathy (pdn) rats where it is mediated by tetrodotoxin (ttx) sensitive sodium channels. |
2013-06-13 |
2023-08-12 |
rat |
| Munmun Chattopadhyay, Zhigang Zhou, Shuanglin Hao, Marina Mata, David J Fin. Reduction of voltage gated sodium channel protein in DRG by vector mediated miRNA reduces pain in rats with painful diabetic neuropathy. Molecular pain. vol 8. 2012-10-26. PMID:22439790. |
reduction of voltage gated sodium channel protein in drg by vector mediated mirna reduces pain in rats with painful diabetic neuropathy. |
2012-10-26 |
2023-08-12 |
rat |
| Munmun Chattopadhyay, Zhigang Zhou, Shuanglin Hao, Marina Mata, David J Fin. Reduction of voltage gated sodium channel protein in DRG by vector mediated miRNA reduces pain in rats with painful diabetic neuropathy. Molecular pain. vol 8. 2012-10-26. PMID:22439790. |
to further evaluate the role of na(v)α subunit levels in drg in the pathogenesis of pain in diabetic neuropathy, we constructed a non-replicating herpes simplex virus (hsv)-based vector expressing a microrna (mirna) against na(v)α subunits. |
2012-10-26 |
2023-08-12 |
rat |
| Tomoya Terashima, Hideto Kojima, Lawrence Cha. Bone marrow expression of poly(ADP-ribose) polymerase underlies diabetic neuropathy via hematopoietic-neuronal cell fusion. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 26. issue 1. 2012-02-27. PMID:21978940. |
we hypothesize that diabetes induces the appearance of abnormal bone marrow-derived cells (bmdcs) that fuse with neurons in the dorsal root ganglia (drg) of mice, leading to diabetic neuropathy. |
2012-02-27 |
2023-08-12 |
mouse |
| Asieh Hosseini, Mohammad Abdollahi, Gholamreza Hassanzadeh, Mahdi Rezayat, Shokoufeh Hassani, Nazila Pourkhalili, Kaveh Tabrizian, Tina Khorshidahmad, Cordian Beyer, Mohammad Sharifzade. Protective effect of magnesium-25 carrying porphyrin-fullerene nanoparticles on degeneration of dorsal root ganglion neurons and motor function in experimental diabetic neuropathy. Basic & clinical pharmacology & toxicology. vol 109. issue 5. 2012-02-14. PMID:21668649. |
protective effect of magnesium-25 carrying porphyrin-fullerene nanoparticles on degeneration of dorsal root ganglion neurons and motor function in experimental diabetic neuropathy. |
2012-02-14 |
2023-08-12 |
Not clear |
| Lawrence Chan, Tomoya Terashima, Hiroshi Urabe, Fan Lin, Hideto Kojim. Pathogenesis of diabetic neuropathy: bad to the bone. Annals of the New York Academy of Sciences. vol 1240. 2012-02-02. PMID:22172042. |
in mice and rats with diabetic neuropathy, we also found proinsulin-producing cells in the sciatic nerve and neurons of the dorsal root ganglion (drg). |
2012-02-02 |
2023-08-12 |
mouse |