| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ernest Adeghate, Hameed Rashed, Satyan Rajbandari, Jaipaul Sing. Pattern of distribution of calcitonin gene-related Peptide in the dorsal root ganglion of animal models of diabetes mellitus. Annals of the New York Academy of Sciences. vol 1084. 2007-03-22. PMID:17151309. |
the reduced number of cgrp-positive neurons in the drg of gk rats indicated that subjects with latent diabetes may already have dysfunctional cgrp metabolism and thus diabetic neuropathy. |
2007-03-22 |
2023-08-12 |
human |
| Laurence Daulhac, Christophe Mallet, Christine Courteix, Monique Etienne, Eliane Duroux, Anne-Marie Privat, Alain Eschalier, Joseph Fiali. Diabetes-induced mechanical hyperalgesia involves spinal mitogen-activated protein kinase activation in neurons and microglia via N-methyl-D-aspartate-dependent mechanisms. Molecular pharmacology. vol 70. issue 4. 2006-11-29. PMID:16868181. |
we have demonstrated, in rats with streptozotocin-induced diabetes, that mechanical hyperalgesia, a common symptom of diabetic neuropathy, was correlated with an early increase in extracellular signal-regulated protein kinase (erk), p38, and c-jun n-terminal kinase (jnk) phosphorylation in the spinal cord and dorsal root ganglion at 3 weeks after induction of diabetes. |
2006-11-29 |
2023-08-12 |
rat |
| Gina M Leinninger, Carey Backus, Ann Marie Sastry, Yun-Bo Yi, Chia-Wei Wang, Eva L Feldma. Mitochondria in DRG neurons undergo hyperglycemic mediated injury through Bim, Bax and the fission protein Drp1. Neurobiology of disease. vol 23. issue 1. 2006-09-06. PMID:16684605. |
dorsal root ganglia (drg) neurons degenerate in diabetic neuropathy (dn) and exhibit mitochondrial damage. |
2006-09-06 |
2023-08-12 |
rat |
| Sally Amanda Price, Leo Arnoldus Hendrikus Zeef, Leanne Wardleworth, Andrew Hayes, David Richard Tomlinso. Identification of changes in gene expression in dorsal root ganglia in diabetic neuropathy: correlation with functional deficits. Journal of neuropathology and experimental neurology. vol 65. issue 7. 2006-08-29. PMID:16825959. |
this study aimed to correlate the onset of functional deficits in diabetic neuropathy with changes in gene expression in rat dorsal root ganglia (drg). |
2006-08-29 |
2023-08-12 |
rat |
| Shuangsong Hong, John W Wile. Altered expression and function of sodium channels in large DRG neurons and myelinated A-fibers in early diabetic neuropathy in the rat. Biochemical and biophysical research communications. vol 339. issue 2. 2006-02-07. PMID:16310161. |
altered expression and function of sodium channels in large drg neurons and myelinated a-fibers in early diabetic neuropathy in the rat. |
2006-02-07 |
2023-08-12 |
rat |
| Shuangsong Hong, John W Wile. Altered expression and function of sodium channels in large DRG neurons and myelinated A-fibers in early diabetic neuropathy in the rat. Biochemical and biophysical research communications. vol 339. issue 2. 2006-02-07. PMID:16310161. |
differential alterations of sodium channels in small nociceptive c-fiber drg neurons have been implicated in diabetic neuropathy. |
2006-02-07 |
2023-08-12 |
rat |
| M Chattopadhyay, D Krisky, D Wolfe, J C Glorioso, M Mata, D J Fin. HSV-mediated gene transfer of vascular endothelial growth factor to dorsal root ganglia prevents diabetic neuropathy. Gene therapy. vol 12. issue 18. 2006-01-13. PMID:15843809. |
at 2 weeks after induction of diabetes, subcutaneous inoculation of t0vegf prevented the reduction in sensory nerve amplitude characteristic of diabetic neuropathy measured 4 weeks later, preserved autonomic function measured by pilocarpine-induced sweating, and prevented the loss of nerve fibers in the skin and reduction of neuropeptide calcitonin gene-related peptide and substance p in drg neurons of the diabetic mice. |
2006-01-13 |
2023-08-12 |
mouse |
| M Chattopadhyay, D Krisky, D Wolfe, J C Glorioso, M Mata, D J Fin. HSV-mediated gene transfer of vascular endothelial growth factor to dorsal root ganglia prevents diabetic neuropathy. Gene therapy. vol 12. issue 18. 2006-01-13. PMID:15843809. |
hsv-mediated transfer of vegf to drg may prove useful in treatment of diabetic neuropathy. |
2006-01-13 |
2023-08-12 |
mouse |
| Shuangsong Hong, Thomas J Morrow, Pamela E Paulson, Lori L Isom, John W Wile. Early painful diabetic neuropathy is associated with differential changes in tetrodotoxin-sensitive and -resistant sodium channels in dorsal root ganglion neurons in the rat. The Journal of biological chemistry. vol 279. issue 28. 2004-08-24. PMID:15123645. |
early painful diabetic neuropathy is associated with differential changes in tetrodotoxin-sensitive and -resistant sodium channels in dorsal root ganglion neurons in the rat. |
2004-08-24 |
2023-08-12 |
rat |
| Alison Berent-Spillson, Amanda M Robinson, David Golovoy, Barbara Slusher, Camilo Rojas, James W Russel. Protection against glucose-induced neuronal death by NAAG and GCP II inhibition is regulated by mGluR3. Journal of neurochemistry. vol 89. issue 1. 2004-04-26. PMID:15030392. |
in the current study, we have determined that the gcp ii inhibitor 2-(phosphonomethyl) pentanedioic acid (2-pmpa) is protective against glucose-induced programmed cell death (pcd) and neurite degeneration in dorsal root ganglion (drg) neurons in a cell culture model of diabetic neuropathy. |
2004-04-26 |
2023-08-12 |
Not clear |
| Ann M Schmeichel, James D Schmelzer, Phillip A Lo. Oxidative injury and apoptosis of dorsal root ganglion neurons in chronic experimental diabetic neuropathy. Diabetes. vol 52. issue 1. 2003-01-16. PMID:12502508. |
oxidative injury and apoptosis of dorsal root ganglion neurons in chronic experimental diabetic neuropathy. |
2003-01-16 |
2023-08-12 |
Not clear |
| Matthew J Craner, Joshua P Klein, Muthukrishnan Renganathan, Joel A Black, Stephen G Waxma. Changes of sodium channel expression in experimental painful diabetic neuropathy. Annals of neurology. vol 52. issue 6. 2002-12-30. PMID:12447933. |
our results demonstrate dysregulated expression of the genes for sodium channels na(v)1.3, na(v)1.6, na(v)1.8, and na(v)1.9 in dorsal root ganglion neurons in experimental diabetes and suggest that misexpression of sodium channels contributes to neuropathic pain associated with diabetic neuropathy. |
2002-12-30 |
2023-08-12 |
rat |
| Z D Luo, N A Calcutt, E S Higuera, C R Valder, Y-H Song, C I Svensson, R R Myer. Injury type-specific calcium channel alpha 2 delta-1 subunit up-regulation in rat neuropathic pain models correlates with antiallodynic effects of gabapentin. The Journal of pharmacology and experimental therapeutics. vol 303. issue 3. 2002-12-24. PMID:12438544. |
our data indicated that even though allodynia occurred in all types of nerve injury investigated, drg and/or spinal cord alpha2delta-1 subunit up-regulation and gabapentin sensitivity only coexisted in the mechanical and diabetic neuropathies. |
2002-12-24 |
2023-08-12 |
rat |
| Matthew J Craner, Joshua P Klein, Joel A Black, Stephen G Waxma. Preferential expression of IGF-I in small DRG neurons and down-regulation following injury. Neuroreport. vol 13. issue 13. 2002-11-26. PMID:12352620. |
in this study, we examined the expression of insulin-like growth factor i (igf-i) and its receptor (igf-ir) in dorsal root ganglia (drg) neurons in two rodent models of nerve injury: sciatic nerve axotomy and streptozotocin-induced (stz) painful diabetic neuropathy. |
2002-11-26 |
2023-08-12 |
rat |
| Motoko Kishi, James Tanabe, James D Schmelzer, Phillip A Lo. Morphometry of dorsal root ganglion in chronic experimental diabetic neuropathy. Diabetes. vol 51. issue 3. 2002-03-15. PMID:11872686. |
morphometry of dorsal root ganglion in chronic experimental diabetic neuropathy. |
2002-03-15 |
2023-08-12 |
rat |
| D W Zochodn. Is early diabetic neuropathy a disorder of the dorsal root ganglion? A hypothesis and critique of some current ideas on the etiology of diabetic neuropathy. Journal of the peripheral nervous system : JPNS. vol 1. issue 2. 2000-09-26. PMID:10975720. |
is early diabetic neuropathy a disorder of the dorsal root ganglion? |
2000-09-26 |
2023-08-12 |
human |
| D W Zochodn. Is early diabetic neuropathy a disorder of the dorsal root ganglion? A hypothesis and critique of some current ideas on the etiology of diabetic neuropathy. Journal of the peripheral nervous system : JPNS. vol 1. issue 2. 2000-09-26. PMID:10975720. |
the interest in using growth factors to treat diabetic neuropathy is at least partly based on the hypothesis that these agents might provide important trophic support for drg neurons. |
2000-09-26 |
2023-08-12 |
human |
| Y H Lee, T G Ryu, S J Park, E J Yang, B H Jeon, G M Hur, K J Ki. Alpha1-adrenoceptors involvement in painful diabetic neuropathy: a role in allodynia. Neuroreport. vol 11. issue 7. 2000-09-06. PMID:10841349. |
these results suggest increased alpha1-adrenoceptors in the drg may play a role in the pathogenesis of painful diabetic neuropathy. |
2000-09-06 |
2023-08-12 |
rat |
| Y Kishi, K K Nickander, J D Schmelzer, P A Lo. Gene expression of antioxidant enzymes in experimental diabetic neuropathy. Journal of the peripheral nervous system : JPNS. vol 5. issue 1. 2000-06-28. PMID:10780678. |
we evaluated the gene expression of glutathione peroxidase, catalase, and superoxide dismutase (cuprozinc and manganese separately) in l4,5 dorsal root ganglion (drg) and superior cervical ganglion, as well as enzyme activity of glutathione peroxidase in drg and sciatic nerve in experimental diabetic neuropathy of 3 months and 12 months durations. |
2000-06-28 |
2023-08-12 |
rat |
| Z D Luo, S R Chaplan, B P Scott, D Cizkova, N A Calcutt, T L Yaks. Neuronal nitric oxide synthase mRNA upregulation in rat sensory neurons after spinal nerve ligation: lack of a role in allodynia development. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 21. 1999-11-19. PMID:10531423. |
to assess the role of no in nerve injury-induced tactile allodynia, we examined neuronal no synthase (nnos) expression in the spinal cord and dorsal root ganglia (drg) of rats with tactile allodynia because of either tight ligation of the left fifth and sixth lumbar spinal nerves or streptozotocin-induced diabetic neuropathy. |
1999-11-19 |
2023-08-12 |
rat |