| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alessandro Gaeta, Lilian Juliana Lissner, Veronica Alfano, Pierangelo Cifelli, Alessandra Morano, Cristina Roseti, Angela Di Iacovo, Eleonora Aronica, Eleonora Palma, Gabriele Ruffol. Membranes and Synaptosomes Used to Investigate Synaptic GABAergic Currents in Epileptic Patients. Membranes. vol 14. issue 3. 2024-03-27. PMID:38535283. |
using both a "microtransplantation technique" and synaptosomes preparations from drug-resistant temporal lobe epilepsies (tles), we used the technique of two-electrode voltage clamp to record gaba-evoked currents, focusing selectively on the synaptic "fast inhibition" mediated by low-affinity gaba |
2024-03-27 |
2024-03-29 |
human |
| Idrish Ali, Juliana Silva, Pablo M Casillas-Espinosa, Emma Braine, Glenn R Yamakawa, Matthew R Hudson, Rhys D Brady, Brendan Major, Peravina Thergarajan, Mohammad B Haskali, David K Wright, Bianca Jupp, Lucy Vivash, Sandy R Shultz, Richelle Mychasiuk, Patrick Kwan, Nigel C Jones, Kazuyuki Fukushima, Pallavi Sachdev, Jocelyn Y Cheng, Terence J O'Brie. E2730, an uncompetitive GABA transporter-1 inhibitor, suppresses epileptic seizures in a rat model of chronic mesial temporal lobe epilepsy. Epilepsia. 2023-08-04. PMID:37539645. |
e2730, an uncompetitive gaba transporter-1 inhibitor, suppresses epileptic seizures in a rat model of chronic mesial temporal lobe epilepsy. |
2023-08-04 |
2023-08-14 |
rat |
| Mariana de Souza Aranha Garcia-Gomes, Pedro Kenzo Yamamoto, Silvia Maria Gomes Massironi, Orfa Yineth Galvis-Alonso, Jorge Mejia, Dennis Albert Zanatto, Sandra Regina Alexandre-Ribeiro, Susan Ienne, Claudia Madalena Cabrera Mor. Alteration of hippocampal Egr3, GABA A receptors, Il-1β, Il6 and Ccl3 expression in audiogenic tremor mice after seizure. Epilepsy & behavior : E&B. vol 137. issue Pt A. 2022-11-10. PMID:36356419. |
hippocampal alterations of proinflammatory cytokines, egr3, and gaba a receptors in tremor mice reinforce them as an alternative tool to modeling temporal lobe epilepsy. |
2022-11-10 |
2023-08-14 |
mouse |
| Uzair Nisar, Maha Shahid, Maryam Askani, Saima Mahmood Malhi, Farzana Shaheen, Shabana Usman Simje. In vivo anticonvulsant activity of 2-propanone-1,3,5,5-trimethyl-2-cyclohexen-1-ylidine in pilocarpine and strychnine induced-seizure models. Pakistan journal of pharmaceutical sciences. vol 33. issue 4. 2021-10-13. PMID:33583776. |
earlier studies reported that dysregulation of gaba and glutamatergic activities resulted in status epilepticus (se) and ultimately support the development of temporal lobe epilepsy (tle), a type of resistant epilepsy. |
2021-10-13 |
2023-08-13 |
mouse |
| Roni Dhaher, Shaun E Gruenbaum, Mani Ratnesh S Sandhu, Sigrid Ottestad-Hansen, Nathan Tu, Yue Wang, Tih-Shih W Lee, Ketaki Deshpande, Dennis D Spencer, Niels Christian Danbolt, Hitten P Zaveri, Tore Ei. Network-Related Changes in Neurotransmitters and Seizure Propagation During Rodent Epileptogenesis. Neurology. vol 96. issue 18. 2021-06-08. PMID:33722994. |
to test the hypothesis that glutamate and gaba are linked to the formation of epilepsy networks and the triggering of spontaneous seizures, we examined seizure initiation/propagation characteristics and neurotransmitter levels during epileptogenesis in a translationally relevant rodent model of mesial temporal lobe epilepsy. |
2021-06-08 |
2023-08-13 |
Not clear |
| Ahmad Alhourani, Kenneth N Fish, Thomas A Wozny, Vivek Sudhakar, Ronald L Hamilton, R Mark Richardso. GABA bouton subpopulations in the human dentate gyrus are differentially altered in mesial temporal lobe epilepsy. Journal of neurophysiology. vol 123. issue 1. 2021-05-10. PMID:31800363. |
gaba bouton subpopulations in the human dentate gyrus are differentially altered in mesial temporal lobe epilepsy. |
2021-05-10 |
2023-08-13 |
human |
| Che He, Pei Liu, Yalin Wu, Hong Chen, Yijun Song, Jianzhong Yi. Gamma-aminobutyric acid (GABA) changes in the hippocampus and anterior cingulate cortex in patients with temporal lobe epilepsy. Epilepsy & behavior : E&B. vol 115. 2021-04-19. PMID:33360398. |
gamma-aminobutyric acid (gaba) changes in the hippocampus and anterior cingulate cortex in patients with temporal lobe epilepsy. |
2021-04-19 |
2023-08-13 |
human |
| Che He, Pei Liu, Yalin Wu, Hong Chen, Yijun Song, Jianzhong Yi. Gamma-aminobutyric acid (GABA) changes in the hippocampus and anterior cingulate cortex in patients with temporal lobe epilepsy. Epilepsy & behavior : E&B. vol 115. 2021-04-19. PMID:33360398. |
to explore the changes of gamma-aminobutyric acid (gaba) levels in the bilateral hippocampus and anterior cingulate cortex (acc) of healthy control subjects and patients with temporal lobe epilepsy (tle) and the correlation of gaba levels with the clinical symptoms by quantitative magnetic resonance spectroscopy (mrs). |
2021-04-19 |
2023-08-13 |
human |
| Julia Müller, Aline Timmermann, Lukas Henning, Hendrik Müller, Christian Steinhäuser, Peter Bedne. Astrocytic GABA Accumulation in Experimental Temporal Lobe Epilepsy. Frontiers in neurology. vol 11. 2021-01-05. PMID:33391173. |
astrocytic gaba accumulation in experimental temporal lobe epilepsy. |
2021-01-05 |
2023-08-13 |
human |
| Olaf Emg Schijns, Jeroen Bisschop, Kim Rijkers, Jim Dings, Sabina Vanherle, Patrick Lindsey, Hubert Jm Smeets, Govert Hooglan. GAT-1 (rs2697153) and GAT-3 (rs2272400) polymorphisms are associated with febrile seizures and temporal lobe epilepsy. Epileptic disorders : international epilepsy journal with videotape. vol 22. issue 2. 2020-12-07. PMID:32301730. |
the purpose of this study was to determine a possible association between two gaba transporter (gat) single-nucleotide polymorphisms (snps), rs2697153 g>a in slc6a1 (gat-1) and rs2272400 c>t in slc6a11 (gat-3), and drug-resistant temporal lobe epilepsy (tle). |
2020-12-07 |
2023-08-13 |
Not clear |
| Ruili Du, Xiandi Zhu, Shuang Wu, Xiaohui Zhang, Yang He, Kai Zhang, Xiao He, Xiaoqun Wang, Yujie Sun, Qiangbin Wang, Hong Zhang, Mei Tia. PET imaging of metabolic changes after neural stem cells and GABA progenitor cells transplantation in a rat model of temporal lobe epilepsy. European journal of nuclear medicine and molecular imaging. vol 46. issue 11. 2020-10-16. PMID:31338549. |
pet imaging of metabolic changes after neural stem cells and gaba progenitor cells transplantation in a rat model of temporal lobe epilepsy. |
2020-10-16 |
2023-08-13 |
human |
| Eugene Chun, Argyle V Bumanglag, Sara N Burke, Robert S Slovite. Targeted hippocampal GABA neuron ablation by Stable Substance P-saporin causes hippocampal sclerosis and chronic epilepsy in rats. Epilepsia. vol 60. issue 5. 2020-04-27. PMID:30963545. |
in this study, hippocampal gaba neurons were targeted for selective elimination to determine whether a focal hippocampal gabaergic defect in an otherwise normal brain can initiate cryptogenic temporal lobe epilepsy with hippocampal sclerosis. |
2020-04-27 |
2023-08-13 |
rat |
| Jiandong Yu, Archana Proddutur, Bogumila Swietek, Fatima S Elgammal, Vijayalakshmi Santhakuma. Functional Reduction in Cannabinoid-Sensitive Heterotypic Inhibition of Dentate Basket Cells in Epilepsy: Impact on Network Rhythms. Cerebral cortex (New York, N.Y. : 1991). vol 26. issue 11. 2019-11-20. PMID:26400918. |
in the first recordings from dentate interneuronal pairs in a model of temporal lobe epilepsy, we demonstrate that status epilepticus (se) selectively compromises gaba release at synapses from dentate accommodating interneurons (ac-ins) to fs-bcs, while efficacy of homotypic fs-bc synapses is unaltered. |
2019-11-20 |
2023-08-13 |
Not clear |
| Yu-Xing Ge, Xiang-Zhu Tia. Retracted: Clc-2 knockout attenuated experimental temporal lobe epilepsy in mice by tonic inhibition mediated by GABA Brain research bulletin. vol 125. 2019-11-20. PMID:27544299. |
retracted: clc-2 knockout attenuated experimental temporal lobe epilepsy in mice by tonic inhibition mediated by gaba |
2019-11-20 |
2023-08-13 |
mouse |
| Katiuscia Martinello, Miriam Sciaccaluga, Roberta Morace, Addolorata Mascia, Antonietta Arcella, Vincenzo Esposito, Sergio Fucil. Loss of constitutive functional γ-aminobutyric acid type A-B receptor crosstalk in layer 5 pyramidal neurons of human epileptic temporal cortex. Epilepsia. vol 59. issue 2. 2018-10-26. PMID:29283181. |
γ-aminobutyric acid (gaba) is the major inhibitory neurotransmitter in adult central nervous system, and profound alterations of gaba receptor functions are linked to temporal lobe epilepsy (tle). |
2018-10-26 |
2023-08-13 |
human |
| Min Ren, Kunyi Li, Dan Wang, Jiamei Guo, Jing Li, Guang Yang, Xianghua Long, Wenjing Shen, Rong Hu, Xuefeng Wang, Kebin Zen. Neurofibromin Regulates Seizure Attacks in the Rat Pilocarpine-Induced Model of Epilepsy. Molecular neurobiology. vol 53. issue 9. 2018-01-29. PMID:26537900. |
studies have shown that neurofibromin (nf1) restricts gaba release at inhibitory synapses and regulates dendritic spine formation, which may play an important role in temporal lobe epilepsy (tle). |
2018-01-29 |
2023-08-13 |
rat |
| Robert J Buchanan, Klevest Gjini, Pradeep Modur, Kevin T Meier, Zoltan Nadasdy, Jennifer L Robinso. In vivo measurements of limbic glutamate and GABA concentrations in epileptic patients during affective and cognitive tasks: A microdialysis study. Hippocampus. vol 26. issue 5. 2017-01-06. PMID:26606278. |
here, we report changes in the concentrations of the neurotransmitters glutamate (glu) and gamma-aminobutyric acid (gaba) in the hipp and the amg of patients with nonlesional temporal lobe epilepsy undergoing surgery for intracranial subdural and depth electrode implantation. |
2017-01-06 |
2023-08-13 |
human |
| Olaf Schijns, Ümit Karaca, Pablo Andrade, Laurence de Nijs, Benno Küsters, Andrea Peeters, Jim Dings, Heinz Pannek, Alois Ebner, Kim Rijkers, Govert Hooglan. Hippocampal GABA transporter distribution in patients with temporal lobe epilepsy and hippocampal sclerosis. Journal of chemical neuroanatomy. vol 68. 2016-06-29. PMID:26212582. |
hippocampal gaba transporter distribution in patients with temporal lobe epilepsy and hippocampal sclerosis. |
2016-06-29 |
2023-08-13 |
Not clear |
| Sanaz Eftekhari, Soraya Mehrabi, Mansooreh Soleimani, Gholamreza Hassanzadeh, Amene Shahrokhi, Hossein Mostafavi, Parisa Hayat, Mahmood Barati, Hajar Mehdizadeh, Reza Rahmanzadeh, Mahmoud Reza Hadjighassem, Mohammad Taghi Joghatae. BDNF modifies hippocampal KCC2 and NKCC1 expression in a temporal lobe epilepsy model. Acta neurobiologiae experimentalis. vol 74. issue 3. 2015-05-15. PMID:25231847. |
excitatory gaba actions, induced by altered expression of chloride transporters (kcc2/nkcc1), can contribute to seizure generation in temporal lobe epilepsy. |
2015-05-15 |
2023-08-13 |
rat |
| Johan Pallud, Michel Le Van Quyen, Franck Bielle, Christophe Pellegrino, Pascale Varlet, Noemie Cresto, Michel Baulac, Charles Duyckaerts, Nazim Kourdougli, Geneviève Chazal, Bertrand Devaux, Claudio Rivera, Richard Miles, Laurent Capelle, Gilles Huberfel. Cortical GABAergic excitation contributes to epileptic activities around human glioma. Science translational medicine. vol 6. issue 244. 2015-03-04. PMID:25009229. |
this study shows that epileptic activities are sustained by excitatory effects of gaba in human peritumoral neocortex, as reported in temporal lobe epilepsies, suggesting that both glutamate and gaba signaling and cellular chloride regulation processes, all also involved in oncogenesis as already shown, induce an imbalance between synaptic excitation and inhibition underlying epileptic discharges in glioma patients. |
2015-03-04 |
2023-08-13 |
human |