| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Benjamin Förstera, Abdel Ali Belaidi, René Jüttner, Carola Bernert, Michael Tsokos, Thomas-N Lehmann, Peter Horn, Christoph Dehnicke, Günter Schwarz, Jochen C Meie. Irregular RNA splicing curtails postsynaptic gephyrin in the cornu ammonis of patients with epilepsy. Brain : a journal of neurology. vol 133. issue Pt 12. 2011-01-07. PMID:21071388. |
cellular stress such as alkalosis, for example arising from seizure activity, could thus facilitate the development of temporal lobe epilepsy by reducing gaba(a) receptor α2-mediated hippocampal synaptic transmission selectively in the cornu ammonis. |
2011-01-07 |
2023-08-12 |
Not clear |
| Manuela Mazzuferi, Eleonora Palma, Katiuscia Martinello, Francesca Maiolino, Cristina Roseti, Sergio Fucile, Paolo F Fabene, Federica Schio, Michele Pellitteri, Guenther Sperk, Ricardo Miledi, Fabrizio Eusebi, Michele Simonat. Enhancement of GABA(A)-current run-down in the hippocampus occurs at the first spontaneous seizure in a model of temporal lobe epilepsy. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 7. 2010-05-10. PMID:20133704. |
enhancement of gaba(a)-current run-down in the hippocampus occurs at the first spontaneous seizure in a model of temporal lobe epilepsy. |
2010-05-10 |
2023-08-12 |
human |
| Manuela Mazzuferi, Eleonora Palma, Katiuscia Martinello, Francesca Maiolino, Cristina Roseti, Sergio Fucile, Paolo F Fabene, Federica Schio, Michele Pellitteri, Guenther Sperk, Ricardo Miledi, Fabrizio Eusebi, Michele Simonat. Enhancement of GABA(A)-current run-down in the hippocampus occurs at the first spontaneous seizure in a model of temporal lobe epilepsy. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 7. 2010-05-10. PMID:20133704. |
refractory temporal lobe epilepsy (tle) is associated with a dysfunction of inhibitory signaling mediated by gaba(a) receptors. |
2010-05-10 |
2023-08-12 |
human |
| Robert J Simister, Mary A McLean, Gareth J Barker, John S Dunca. Proton MR spectroscopy of metabolite concentrations in temporal lobe epilepsy and effect of temporal lobe resection. Epilepsy research. vol 83. issue 2-3. 2009-06-22. PMID:19118980. |
to use proton magnetic resonance spectroscopy (mrs) to measure in vivo temporal lobe gaba and glutamate plus glutamine (glx) concentrations in patients with temporal lobe epilepsy (tle) attributable to unilateral hippocampal sclerosis (hs) before and following anterior temporal lobe resection (atlr). |
2009-06-22 |
2023-08-12 |
Not clear |
| Xin Wang, Wei Sun, Xilin Zhu, Liping Li, Xiaopan Wu, Hua Lin, Shuying Zhu, Aihua Liu, Te Du, Yang Liu, Nifang Niu, Yuping Wang, Ying Li. Association between the gamma-aminobutyric acid type B receptor 1 and 2 gene polymorphisms and mesial temporal lobe epilepsy in a Han Chinese population. Epilepsy research. vol 81. issue 2-3. 2009-04-09. PMID:18653317. |
association between the gamma-aminobutyric acid type b receptor 1 and 2 gene polymorphisms and mesial temporal lobe epilepsy in a han chinese population. |
2009-04-09 |
2023-08-12 |
Not clear |
| Marcelo Andrés Kauffman, Estrella Mariel Levy, Damian Consalvo, José Mordoh, Silvia Koche. GABABR1 (G1465A) gene variation and temporal lobe epilepsy controversy: new evidence. Seizure. vol 17. issue 6. 2008-12-12. PMID:18255321. |
the g1465a polymorphism in the gene of the gaba type b receptor subunit 1 (gababr1) has been linked to the risk for temporal lobe epilepsy (tle). |
2008-12-12 |
2023-08-12 |
Not clear |
| Kerstin Bethmann, Jean-Marc Fritschy, Claudia Brandt, Wolfgang Lösche. Antiepileptic drug resistant rats differ from drug responsive rats in GABA A receptor subunit expression in a model of temporal lobe epilepsy. Neurobiology of disease. vol 31. issue 2. 2008-11-07. PMID:18562204. |
antiepileptic drug resistant rats differ from drug responsive rats in gaba a receptor subunit expression in a model of temporal lobe epilepsy. |
2008-11-07 |
2023-08-12 |
rat |
| Giorgia Bovo, Erica Diani, Francesca Bisulli, Carlo Di Bonaventura, Pasquale Striano, Antonio Gambardella, Edoardo Ferlazzo, Gabriella Egeo, Oriano Mecarelli, Maurizio Elia, Amedeo Bianchi, Stefania Bortoluzzi, Andrea Vettori, Umberto Aguglia, Simona Binelli, Arturo De Falco, Giangennaro Coppola, Giuseppe Gobbi, Vito Sofia, Salvatore Striano, Paolo Tinuper, Anna T Giallonardo, Roberto Michelucci, Carlo Nobil. Analysis of LGI1 promoter sequence, PDYN and GABBR1 polymorphisms in sporadic and familial lateral temporal lobe epilepsy. Neuroscience letters. vol 436. issue 1. 2008-07-22. PMID:18355961. |
we also analysed in our study population the gaba(b) receptor 1 c.1465g>a and the prodynorphin promoter 68-bp repeat polymorphisms, previously associated with temporal lobe epilepsy. |
2008-07-22 |
2023-08-12 |
Not clear |
| Douglas A Coulter, Gregory C Carlso. Functional regulation of the dentate gyrus by GABA-mediated inhibition. Progress in brain research. vol 163. 2008-03-14. PMID:17765722. |
both synaptic and extrasynaptic gaba(a) receptors exhibit profound dysregulation in animal models of temporal lobe epilepsy, which may contribute to the hippocampal hyperexcitability that defines this disorder. |
2008-03-14 |
2023-08-12 |
Not clear |
| Eleonora Palma, Cristina Roseti, Francesca Maiolino, Sergio Fucile, Katiuscia Martinello, Manuela Mazzuferi, Eleonora Aronica, Mario Manfredi, Vincenzo Esposito, Gianpaolo Cantore, Ricardo Miledi, Michele Simonato, Fabrizio Euseb. GABA(A)-current rundown of temporal lobe epilepsy is associated with repetitive activation of GABA(A) "phasic" receptors. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 52. 2008-01-15. PMID:18083839. |
gaba(a)-current rundown of temporal lobe epilepsy is associated with repetitive activation of gaba(a) "phasic" receptors. |
2008-01-15 |
2023-08-12 |
human |
| Eleonora Palma, Cristina Roseti, Francesca Maiolino, Sergio Fucile, Katiuscia Martinello, Manuela Mazzuferi, Eleonora Aronica, Mario Manfredi, Vincenzo Esposito, Gianpaolo Cantore, Ricardo Miledi, Michele Simonato, Fabrizio Euseb. GABA(A)-current rundown of temporal lobe epilepsy is associated with repetitive activation of GABA(A) "phasic" receptors. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 52. 2008-01-15. PMID:18083839. |
a study was made of the "rundown" of gaba(a) receptors, microtransplanted to xenopus oocytes from surgically resected brain tissues of patients afflicted with drug-resistant human mesial temporal lobe epilepsy (mtle). |
2008-01-15 |
2023-08-12 |
human |
| Chengsan Sun, Zakaria Mtchedlishvili, Alev Erisir, Jaideep Kapu. Diminished neurosteroid sensitivity of synaptic inhibition and altered location of the alpha4 subunit of GABA(A) receptors in an animal model of epilepsy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 46. 2007-12-19. PMID:18003843. |
in animal models of temporal lobe epilepsy (tle), neurosteroid sensitivity of gaba(a) receptors on dentate granule cells (dgcs) is diminished; the molecular mechanism underlying this phenomenon remains unclear. |
2007-12-19 |
2023-08-12 |
Not clear |
| Eleonora Palma, Davide Ragozzino, Silvia Di Angelantonio, Addolorata Mascia, Francesca Maiolino, Mario Manfredi, Giampaolo Cantore, Vincenzo Esposito, Giancarlo Di Gennaro, Pierpaolo Quarato, Ricardo Miledi, Fabrizio Euseb. The antiepileptic drug levetiracetam stabilizes the human epileptic GABAA receptors upon repetitive activation. Epilepsia. vol 48. issue 10. 2007-11-13. PMID:17521347. |
gabaa receptors from the brain of patients afflicted with mesial temporal lobe epilepsy (mtle) become less efficient (run-down) when repetitively activated by gaba. |
2007-11-13 |
2023-08-12 |
human |
| M González Ramírez, S Orozco Suárez, H Salgado Ceballos, A Feria Velasco, L Roch. Hyperthermia-induced seizures modify the GABA(A) and benzodiazepine receptor binding in immature rat brain. Cellular and molecular neurobiology. vol 27. issue 2. 2007-09-12. PMID:16802192. |
hs-induced gaba(a) and bdz changes are different from those previously described in experimental models of temporal lobe epilepsy in adult animals. |
2007-09-12 |
2023-08-12 |
rat |
| Nianhui Zhang, Weizheng Wei, Istvan Mody, Carolyn R House. Altered localization of GABA(A) receptor subunits on dentate granule cell dendrites influences tonic and phasic inhibition in a mouse model of epilepsy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 28. 2007-08-07. PMID:17626213. |
complex changes in gaba(a) receptors (gaba(a)rs) in animal models of temporal lobe epilepsy during the chronic period include a decrease in the delta subunit and increases in the alpha4 and gamma2 subunits in the dentate gyrus. |
2007-08-07 |
2023-08-12 |
mouse |
| Nianhui Zhang, Weizheng Wei, Istvan Mody, Carolyn R House. Altered localization of GABA(A) receptor subunits on dentate granule cell dendrites influences tonic and phasic inhibition in a mouse model of epilepsy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 28. 2007-08-07. PMID:17626213. |
these gaba(a)r subunit changes appear to impair both tonic and phasic inhibition, particularly at granule cell dendrites, and could reduce the adaptive responses of the gaba system in temporal lobe epilepsy. |
2007-08-07 |
2023-08-12 |
mouse |
| Jean-Luc Boulland, Lotfi Ferhat, Tom Tallak Solbu, Nadine Ferrand, Farrukh Abbas Chaudhry, Jon Storm-Mathisen, Monique Esclape. Changes in vesicular transporters for gamma-aminobutyric acid and glutamate reveal vulnerability and reorganization of hippocampal neurons following pilocarpine-induced seizures. The Journal of comparative neurology. vol 503. issue 3. 2007-07-18. PMID:17503488. |
the reorganizations of the overall intrinsic glutamatergic and gamma-aminobutyric acid (gaba)-ergic hippocampal networks as well as the time course of these reorganizations during development of pilocarpine-induced temporal lobe epilepsy were studied with in situ hybridization and immunohistochemistry experiments for the vesicular glutamate transporter 1 (vglut1) and the vesicular gaba transporter (vgat). |
2007-07-18 |
2023-08-12 |
Not clear |
| Fabienne Loup, Fabienne Picard, Véronique M André, Pierre Kehrli, Yasuhiro Yonekawa, Heinz-Gregor Wieser, Jean-Marc Fritsch. Altered expression of alpha3-containing GABAA receptors in the neocortex of patients with focal epilepsy. Brain : a journal of neurology. vol 129. issue Pt 12. 2006-12-18. PMID:17046856. |
although it is well established that major reorganization of gaba(a) receptor subtypes occurs in the hippocampus of patients with medically refractory temporal lobe epilepsy (tle), it is unclear whether this disorder is also associated with alterations in gaba(a) receptor subtypes in the neocortex. |
2006-12-18 |
2023-08-12 |
Not clear |
| Daniel S Roberts, Yinghui Hu, Ingrid V Lund, Amy R Brooks-Kayal, Shelley J Russe. Brain-derived neurotrophic factor (BDNF)-induced synthesis of early growth response factor 3 (Egr3) controls the levels of type A GABA receptor alpha 4 subunits in hippocampal neurons. The Journal of biological chemistry. vol 281. issue 40. 2006-11-30. PMID:16901909. |
altered function of gamma-aminobutyric acid type a receptors (gaba(a)rs) in dentate granule cells of the hippocampus has been associated with temporal lobe epilepsy (tle) in humans and in animal models of tle. |
2006-11-30 |
2023-08-12 |
Not clear |
| YogendraSinh H Raol, Ingrid V Lund, Sabita Bandyopadhyay, Guojun Zhang, Daniel S Roberts, John H Wolfe, Shelley J Russek, Amy R Brooks-Kaya. Enhancing GABA(A) receptor alpha 1 subunit levels in hippocampal dentate gyrus inhibits epilepsy development in an animal model of temporal lobe epilepsy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 44. 2006-11-14. PMID:17079662. |
enhancing gaba(a) receptor alpha 1 subunit levels in hippocampal dentate gyrus inhibits epilepsy development in an animal model of temporal lobe epilepsy. |
2006-11-14 |
2023-08-12 |
rat |