| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eiichi Maru, Hiroyuki Ur. [GABA(A) receptor trafficking and epilepsy]. Nihon rinsho. Japanese journal of clinical medicine. vol 72. issue 5. 2014-08-26. PMID:24912277. |
gaba(a) synaptic inhibition decreased in the hippocampal ca1 area of patients with intractable temporal lobe epilepsy (tle). |
2014-08-26 |
2023-08-13 |
Not clear |
| Marie Soukupová, Anna Binaschi, Chiara Falcicchia, Silvia Zucchini, Paolo Roncon, Eleonora Palma, Eros Magri, Enrico Grandi, Michele Simonat. Impairment of GABA release in the hippocampus at the time of the first spontaneous seizure in the pilocarpine model of temporal lobe epilepsy. Experimental neurology. vol 257. 2014-08-13. PMID:24768627. |
impairment of gaba release in the hippocampus at the time of the first spontaneous seizure in the pilocarpine model of temporal lobe epilepsy. |
2014-08-13 |
2023-08-13 |
rat |
| Marie Soukupová, Anna Binaschi, Chiara Falcicchia, Silvia Zucchini, Paolo Roncon, Eleonora Palma, Eros Magri, Enrico Grandi, Michele Simonat. Impairment of GABA release in the hippocampus at the time of the first spontaneous seizure in the pilocarpine model of temporal lobe epilepsy. Experimental neurology. vol 257. 2014-08-13. PMID:24768627. |
the alterations in gaba release have not yet been systematically measured along the natural course of temporal lobe epilepsy. |
2014-08-13 |
2023-08-13 |
rat |
| Z-X Li, H-M Yu, K-W Jian. Tonic GABA inhibition in hippocampal dentate granule cells: its regulation and function in temporal lobe epilepsies. Acta physiologica (Oxford, England). vol 209. issue 3. 2014-05-09. PMID:23865761. |
tonic gaba inhibition in hippocampal dentate granule cells: its regulation and function in temporal lobe epilepsies. |
2014-05-09 |
2023-08-12 |
human |
| Z-X Li, H-M Yu, K-W Jian. Tonic GABA inhibition in hippocampal dentate granule cells: its regulation and function in temporal lobe epilepsies. Acta physiologica (Oxford, England). vol 209. issue 3. 2014-05-09. PMID:23865761. |
both human and experimental evidence strongly supports the view of brain region- and cell-specific changes in tonic gaba inhibition in temporal lobe epilepsies (tle). |
2014-05-09 |
2023-08-12 |
human |
| Ivan Pavlov, Matthew C Walke. Tonic GABA(A) receptor-mediated signalling in temporal lobe epilepsy. Neuropharmacology. vol 69. 2013-09-06. PMID:22538087. |
tonic gaba(a) receptor-mediated signalling in temporal lobe epilepsy. |
2013-09-06 |
2023-08-12 |
Not clear |
| Arjun Khanna, Brian Patrick Walcott, Kristopher T Kahl. Limitations of Current GABA Agonists in Neonatal Seizures: Toward GABA Modulation Via the Targeting of Neuronal Cl(-) Transport. Frontiers in neurology. vol 4. 2013-06-28. PMID:23805124. |
moreover, this strategy may have ramifications for other adult seizure syndromes in which gaba receptor-mediated depolarizations play a pathogenic role, such as temporal lobe epilepsy. |
2013-06-28 |
2023-08-12 |
Not clear |
| Naomi Lewin, Emre Aksay, Colleen E Clanc. Computational modeling reveals dendritic origins of GABA(A)-mediated excitation in CA1 pyramidal neurons. PloS one. vol 7. issue 10. 2013-04-04. PMID:23071770. |
gaba is the key inhibitory neurotransmitter in the adult central nervous system, but in some circumstances can lead to a paradoxical excitation that has been causally implicated in diverse pathologies from endocrine stress responses to diseases of excitability including neuropathic pain and temporal lobe epilepsy. |
2013-04-04 |
2023-08-12 |
Not clear |
| Sanaz Eftekhari, Jafar Mehvari Habibabadi, Massoumeh Najafi Ziarani, Seyed Sohrab Hashemi Fesharaki, Marzieh Gharakhani, Hossein Mostafavi, Mohammad Taghi Joghataei, Nahid Beladimoghadam, Elham Rahimian, Mahmoud Reza Hadjighasse. Bumetanide reduces seizure frequency in patients with temporal lobe epilepsy. Epilepsia. vol 54. issue 1. 2013-03-04. PMID:23061490. |
alterations in the balance of k-na-2cl cotransporter (nkcc1) and na-cl cotransporter (kcc2) activity may cause depolarizing effect of γ-aminobutyric acid (gaba), and contribute to epileptogenesis in human temporal lobe epilepsy. |
2013-03-04 |
2023-08-12 |
human |
| Isabella Ferando, Istvan Mod. GABAA receptor modulation by neurosteroids in models of temporal lobe epilepsies. Epilepsia. vol 53 Suppl 9. 2013-02-04. PMID:23216582. |
temporal lobe epilepsy (tle) is accompanied by changes in interneuronal innervation and modifications in different γ-aminobutyric acid (gaba)(a) receptor subunits. |
2013-02-04 |
2023-08-12 |
Not clear |
| José Carlos de Moura, Daniela P C Tirapelli, Luciano Neder, Fabiano P Saggioro, Americo Ceiki Sakamoto, Tonicarlo R Velasco, Rodrigo A Panepucci, João Pereira Leite, João Alberto Assirati Júnior, Benedicto Oscar Colli, Carlos Gilberto Carlotti Júnio. Amygdala gene expression of NMDA and GABA(A) receptors in patients with mesial temporal lobe epilepsy. Hippocampus. vol 22. issue 1. 2012-09-06. PMID:20848605. |
amygdala gene expression of nmda and gaba(a) receptors in patients with mesial temporal lobe epilepsy. |
2012-09-06 |
2023-08-12 |
Not clear |
| Min Fang, Lan Shen, Huan Yin, Yu-Min Pan, Liang Wang, Dan Chen, Zhi-Qin Xi, Zheng Xiao, Xue-Feng Wang, Sheng-Nian Zho. Downregulation of gephyrin in temporal lobe epilepsy neurons in humans and a rat model. Synapse (New York, N.Y.). vol 65. issue 10. 2012-05-30. PMID:21404332. |
gephyrin, which is a postsynaptic scaffolding protein participated in clustering gaba(a) receptors at inhibitory synapses, has been reported to be involved in temporal lobe epilepsy (tle) recently. |
2012-05-30 |
2023-08-12 |
human |
| Y-X Ge, Y Liu, H-Y Tang, X-G Liu, X Wan. ClC-2 contributes to tonic inhibition mediated by α5 subunit-containing GABA(A) receptor in experimental temporal lobe epilepsy. Neuroscience. vol 186. 2012-01-30. PMID:21549811. |
clc-2 contributes to tonic inhibition mediated by α5 subunit-containing gaba(a) receptor in experimental temporal lobe epilepsy. |
2012-01-30 |
2023-08-12 |
rat |
| L Vivash, A Tostevin, D S H Liu, L Dalic, S Dedeurwaerdere, R J Hicks, D A Williams, D E Myers, T J O'Brie. Changes in hippocampal GABAA/cBZR density during limbic epileptogenesis: relationship to cell loss and mossy fibre sprouting. Neurobiology of disease. vol 41. issue 2. 2011-11-22. PMID:20816783. |
reduced gaba(a)/central benzodiazepine receptor (gaba(a)/cbzr) density, mossy fibre sprouting (mfs) and hippocampal cell loss are well described pathological features of human temporal lobe epilepsy (tle), and animal models thereof. |
2011-11-22 |
2023-08-12 |
human |
| Silje Alvestad, Janniche Hammer, Hong Qu, Asta Håberg, Ole Petter Ottersen, Ursula Sonnewal. Reduced astrocytic contribution to the turnover of glutamate, glutamine, and GABA characterizes the latent phase in the kainate model of temporal lobe epilepsy. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 31. issue 8. 2011-10-13. PMID:21522161. |
reduced astrocytic contribution to the turnover of glutamate, glutamine, and gaba characterizes the latent phase in the kainate model of temporal lobe epilepsy. |
2011-10-13 |
2023-08-12 |
Not clear |
| Jean-Marc Fritsch. Epilepsy, E/I Balance and GABA(A) Receptor Plasticity. Frontiers in molecular neuroscience. vol 1. 2011-07-14. PMID:18946538. |
finally, the relevance of these findings is discussed in light of the involvement of gaba(a) receptors in epileptic disorders, based on recent experimental studies of temporal lobe epilepsy (tle) and absence seizures and on the identification of mutations in gaba(a) receptor subunit genes underlying familial forms of epilepsy. |
2011-07-14 |
2023-08-12 |
Not clear |
| Guohui Li, Kechun Yang, Chao Zheng, Qiang Liu, Yongchang Chang, John F Kerrigan, Jie W. Functional rundown of gamma-aminobutyric acid(A) receptors in human hypothalamic hamartomas. Annals of neurology. vol 69. issue 4. 2011-06-17. PMID:21391233. |
recently, functional gaba(a) receptor (gaba(a) r) rundown has been described in surgically resected human temporal lobe epilepsy tissue. |
2011-06-17 |
2023-08-12 |
human |
| Arash Kia, Fabiola Ribeiro, Renee Nelson, Cezar Gavrilovici, Stephen S G Ferguson, Michael O Poulte. Kindling alters neurosteroid-induced modulation of phasic and tonic GABAA receptor-mediated currents: role of phosphorylation. Journal of neurochemistry. vol 116. issue 6. 2011-04-15. PMID:21175618. |
we have previously shown that after kindling (a model of temporal lobe epilepsy), the neuroactive steroid tetrahydrodeoxycorticosterone (thdoc) was unable to augment gaba type a receptor (gaba(a))-mediated synaptic currents occurring on pyramidal cells of the piriform cortex. |
2011-04-15 |
2023-08-12 |
rat |
| Karthik Rajasekaran, Suchitra Joshi, Chengsan Sun, Zakaria Mtchedlishvilli, Jaideep Kapu. Receptors with low affinity for neurosteroids and GABA contribute to tonic inhibition of granule cells in epileptic animals. Neurobiology of disease. vol 40. issue 2. 2011-01-12. PMID:20682339. |
neurosteroid sensitivity of gaba(a) receptor mediated inhibition of the hippocampal dentate granule cells (dgcs) is reduced in animal models of temporal lobe epilepsy. |
2011-01-12 |
2023-08-12 |
Not clear |
| Benjamin Förstera, Abdel Ali Belaidi, René Jüttner, Carola Bernert, Michael Tsokos, Thomas-N Lehmann, Peter Horn, Christoph Dehnicke, Günter Schwarz, Jochen C Meie. Irregular RNA splicing curtails postsynaptic gephyrin in the cornu ammonis of patients with epilepsy. Brain : a journal of neurology. vol 133. issue Pt 12. 2011-01-07. PMID:21071388. |
identified temporal lobe epilepsy gephyrins have oligomerization deficits and they curtail hippocampal postsynaptic gephyrin and gaba(a) receptor α2 while interacting with regularly spliced gephyrins. |
2011-01-07 |
2023-08-12 |
Not clear |