| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F López-Caballero, R Auksztulewicz, Z Howard, R E Rosch, J Todd, D F Salisbur. Computational Synaptic Modeling of Pitch and Duration Mismatch Negativity in First-Episode Psychosis Reveals Selective Dysfunction of the N-Methyl-D-Aspartate Receptor. Clinical EEG and neuroscience. 2024-03-27. PMID:38533562. |
this finding is in line with literature of prefrontal nmda receptor hypofunction in chronic schizophrenia and suggests impaired nmda-induced synaptic plasticity may be present at psychosis onset where scalp dmmn is only moderately reduced. |
2024-03-27 |
2024-03-29 |
Not clear |
| Yunjia Liu, Hongyan Ren, Yamin Zhang, Wei Deng, Xiaohong Ma, Liansheng Zhao, Xiaojing Li, Pak Sham, Qiang Wang, Tao L. Temporal changes in brain morphology related to inflammation and schizophrenia: an omnigenic Mendelian randomization study. Psychological medicine. 2024-03-06. PMID:38445386. |
building upon synaptic plasticity hypothesis, inflammation may contribute the underlying pathophysiology of schizophrenia. |
2024-03-06 |
2024-03-08 |
Not clear |
| Natalie L Wellard, Nicholas E Clifton, Elliott Rees, Kerrie L Thomas, Jeremy Hal. The Association of Hippocampal Long-Term Potentiation-Induced Gene Expression with Genetic Risk for Psychosis. International journal of molecular sciences. vol 25. issue 2. 2024-01-23. PMID:38256020. |
genomic studies focusing on the contribution of common and rare genetic variants of schizophrenia and bipolar disorder support the view that substantial risk is conferred through molecular pathways involved in synaptic plasticity in the neurons of cortical and subcortical brain regions, including the hippocampus. |
2024-01-23 |
2024-01-25 |
Not clear |
| Renata Markiewicz, Agnieszka Markiewicz-Gospodarek, Bartosz Borowski, Mateusz Trubalski, Bartosz Łoz. Reelin Signaling and Synaptic Plasticity in Schizophrenia. Brain sciences. vol 13. issue 12. 2023-12-23. PMID:38137152. |
reelin signaling and synaptic plasticity in schizophrenia. |
2023-12-23 |
2023-12-25 |
Not clear |
| Laura Ferrucci, Iva Cantando, Federica Cordella, Silvia Di Angelantonio, Davide Ragozzino, Paola Bezz. Microglia at the Tripartite Synapse during Postnatal Development: Implications for Autism Spectrum Disorders and Schizophrenia. Cells. vol 12. issue 24. 2023-12-22. PMID:38132147. |
over the past 15 years, the mechanisms underlying the microglia- and astrocytes-dependent regulation of synaptic plasticity have been thoroughly studied, and researchers have reported that the disruption of these glial cells in early postnatal development may underlie the cause of synaptic dysfunction that leads to neurodevelopmental disorders such as autism spectrum disorder (asd) and schizophrenia. |
2023-12-22 |
2023-12-24 |
Not clear |
| Xiao-Lin Zhong, Yan Huang, Yang Du, Li-Zheng He, Yue-Wen Chen, Yong Cheng, Hua Li. Unlocking the Therapeutic Potential of Exosomes Derived From Nasal Olfactory Mucosal Mesenchymal Stem Cells: Restoring Synaptic Plasticity, Neurogenesis, and Neuroinflammation in Schizophrenia. Schizophrenia bulletin. 2023-12-12. PMID:38086528. |
unlocking the therapeutic potential of exosomes derived from nasal olfactory mucosal mesenchymal stem cells: restoring synaptic plasticity, neurogenesis, and neuroinflammation in schizophrenia. |
2023-12-12 |
2023-12-17 |
Not clear |
| Xiulin Wu, Lianzhong Liu, Xing Xue, Xuhang Li, Kexin Zhao, Jiahang Zhang, Wenshi Li, Wei Yao, Shuang Ding, Chen Jia, Fan Zh. Captive ERVWE1 triggers impairment of 5-HT neuronal plasticity in the first-episode schizophrenia by post-transcriptional activation of HTR1B in ALKBH5-m6A dependent epigenetic mechanisms. Cell & bioscience. vol 13. issue 1. 2023-11-24. PMID:37990254. |
abnormalities in the 5-ht system and synaptic plasticity are hallmark features of schizophrenia. |
2023-11-24 |
2023-11-28 |
human |
| Naser-Aldin Lashgari, Nazanin Momeni Roudsari, Hedieh Sadat Shamsnia, Maryam Shayan, Saeideh Momtaz, Amir Hossein Abdolghaffar. TLR/mTOR inflammatory signaling pathway: novel insight for the treatment of schizophrenia. Canadian journal of physiology and pharmacology. 2023-11-13. PMID:37955633. |
the activity of tlr/mtor signaling has been disrupted, leading to neurodevelopment and deficient synaptic plasticity, which are the main symptoms of schizophrenia. |
2023-11-13 |
2023-11-20 |
Not clear |
| Paul J Harrison, David M Bannerma. GRIN2A (NR2A): a gene contributing to glutamatergic involvement in schizophrenia. Molecular psychiatry. 2023-09-22. PMID:37736757. |
we suggest that one consequence of nr2a dysfunction is impairment in a form of hippocampal synaptic plasticity, producing deficits in short-term habituation and thence elevated and dysregulated levels of attention, a phenotype of relevance to schizophrenia and its cognitive aspects. |
2023-09-22 |
2023-10-07 |
mouse |
| Neha Keshri, Hanumanthappa Nandeesha, Medha Rajappa, Vikas Meno. Neurotrophin-3 gene polymorphism in schizophrenia and its relation with diseases severity and cognitive dysfunction. Journal of neurosciences in rural practice. vol 14. issue 3. 2023-09-11. PMID:37692806. |
synaptic plasticity markers are known to alter in schizophrenia. |
2023-09-11 |
2023-10-07 |
Not clear |
| Tuomo Mäaki-Marttunen, Kim T Blackwell, Ibrahim Akkouh, Alexey Shadrin, Mathias Valstad, Tobjørn Elvsåashagen, Marja-Leena Linne, Srdjan Djurovic, Gaute T Einevoll, Ole A Andreasse. Genetic mechanisms for impaired synaptic plasticity in schizophrenia revealed by computational modelling. bioRxiv : the preprint server for biology. 2023-07-03. PMID:37398070. |
genetic mechanisms for impaired synaptic plasticity in schizophrenia revealed by computational modelling. |
2023-07-03 |
2023-08-14 |
Not clear |
| Kexuan Zhang, Panlin Liao, Jin Wen, Zhonghua H. Synaptic plasticity in schizophrenia pathophysiology. IBRO neuroscience reports. vol 14. 2023-06-30. PMID:37388494. |
synaptic plasticity in schizophrenia pathophysiology. |
2023-06-30 |
2023-08-14 |
Not clear |
| Kexuan Zhang, Panlin Liao, Jin Wen, Zhonghua H. Synaptic plasticity in schizophrenia pathophysiology. IBRO neuroscience reports. vol 14. 2023-06-30. PMID:37388494. |
recently, the synaptopathology and the dysregulated synaptic plasticity and function have emerging as intriguing and prominent biological mechanisms of schizophrenia pathogenesis. |
2023-06-30 |
2023-08-14 |
Not clear |
| Kexuan Zhang, Panlin Liao, Jin Wen, Zhonghua H. Synaptic plasticity in schizophrenia pathophysiology. IBRO neuroscience reports. vol 14. 2023-06-30. PMID:37388494. |
synaptic plasticity is the ability of neurons to change the strength of their connections in response to internal or external stimuli, which is essential for brain development and function, learning and memory, and vast majority of behavior responses relevant to psychiatric diseases including schizophrenia. |
2023-06-30 |
2023-08-14 |
Not clear |
| Kexuan Zhang, Panlin Liao, Jin Wen, Zhonghua H. Synaptic plasticity in schizophrenia pathophysiology. IBRO neuroscience reports. vol 14. 2023-06-30. PMID:37388494. |
recent genome-wide association studies have provided fruitful findings of hundreds of risk gene variances associated with schizophrenia, thus further clarifying the role of these disease-risk genes in synaptic transmission and plasticity will be beneficial to advance our understanding of schizophrenia pathology, as well as the molecular mechanism of synaptic plasticity. |
2023-06-30 |
2023-08-14 |
Not clear |
| Agnieszka Markiewicz-Gospodarek, Renata Markiewicz, Bartosz Borowski, Beata Dobrowolska, Bartosz Łoz. Self-Regulatory Neuronal Mechanisms and Long-Term Challenges in Schizophrenia Treatment. Brain sciences. vol 13. issue 4. 2023-05-16. PMID:37190616. |
to evaluate the therapeutic effect of various rehabilitation methods, we reviewed methods that modify synaptic plasticity and improve the cognitive and executive processes of patients with a diagnosis of schizophrenia. |
2023-05-16 |
2023-08-14 |
Not clear |
| Andrea de Bartolomeis, Mariateresa Ciccarelli, Giuseppe De Simone, Benedetta Mazza, Annarita Barone, Licia Vellucc. Canonical and Non-Canonical Antipsychotics' Dopamine-Related Mechanisms of Present and Next Generation Molecules: A Systematic Review on Translational Highlights for Treatment Response and Treatment-Resistant Schizophrenia. International journal of molecular sciences. vol 24. issue 6. 2023-03-29. PMID:36983018. |
schizophrenia is a severe psychiatric illness affecting almost 25 million people worldwide and is conceptualized as a disorder of synaptic plasticity and brain connectivity. |
2023-03-29 |
2023-08-14 |
Not clear |
| Francesco Matriscian. Functional Nutrition as Integrated Intervention for In- and Outpatient with Schizophrenia. Current neuropharmacology. 2023-03-22. PMID:36946488. |
schizophrenia is a chronic and progressive disorder characterized by cognitive, emotional,and behavioral abnormalities associated with neuronal development and synaptic plasticity alterations. |
2023-03-22 |
2023-08-14 |
Not clear |
| Stephanie Santarriaga, Kaia Gerlovin, Yasmine Layadi, Rakesh Karmachary. Human stem cell-based models to study synaptic dysfunction and cognition in schizophrenia: A narrative review. Schizophrenia research. 2023-03-16. PMID:36925354. |
a comprehensive understanding of synaptic plasticity and the molecular basis of learning and memory in a disease context can provide specific targets for the development of novel therapeutics targeting cognitive impairments in schizophrenia. |
2023-03-16 |
2023-08-14 |
human |
| Stephanie Santarriaga, Kaia Gerlovin, Yasmine Layadi, Rakesh Karmachary. Human stem cell-based models to study synaptic dysfunction and cognition in schizophrenia: A narrative review. Schizophrenia research. 2023-03-16. PMID:36925354. |
here, we describe the role of synaptic plasticity in cognition, summarize evidence for synaptic dysfunction in schizophrenia and demonstrate the use of patient derived induced-pluripotent stem cells for studying synaptic plasticity in vitro. |
2023-03-16 |
2023-08-14 |
human |