| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anna Di Maio, Arianna De Rosa, Silvia Pelucchi, Martina Garofalo, Benedetta Marciano, Tommaso Nuzzo, Fabrizio Gardoni, Andrea M Isidori, Monica Di Luca, Francesco Errico, Andrea De Bartolomeis, Elena Marcello, Alessandro Usiell. Analysis of mRNA and Protein Levels of International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163460. |
analysis of mrna and protein levels of schizophrenia (scz) is a mental illness characterized by aberrant synaptic plasticity and connectivity. |
2022-02-15 |
2023-08-13 |
Not clear |
| Junyang Wang, Shiwu Li, Xiaoyan Li, Jiewei Liu, Jinfeng Yang, Yifan Li, Wenqiang Li, Yongfeng Yang, Jiao Li, Rui Chen, Kaiqin Li, Di Huang, Yixing Liu, Luxian Lv, Ming Li, Xiao Xiao, Xiong-Jian Lu. Functional variant rs2270363 on 16p13.3 confers schizophrenia risk by regulating NMRAL1. Brain : a journal of neurology. 2022-01-30. PMID:35094059. |
these lines of evidence suggest that rs2270363 may confer schizophrenia risk by regulating nmral1, a gene whose expression dysregulation might be involved in the pathogenesis of schizophrenia by affecting neurodevelopment and synaptic plasticity. |
2022-01-30 |
2023-08-13 |
mouse |
| Jeremy Hall, Nicholas J Bra. Schizophrenia Genomics: Convergence on Synaptic Development, Adult Synaptic Plasticity, or Both? Biological psychiatry. 2022-01-03. PMID:34974922. |
schizophrenia genomics: convergence on synaptic development, adult synaptic plasticity, or both? |
2022-01-03 |
2023-08-13 |
Not clear |
| Mathias Valstad, Daniël Roelfs, Nora B Slapø, Clara M F Timpe, Ahsan Rai, Anna Maria Matziorinis, Dani Beck, Geneviève Richard, Linn Sofie Sæther, Beathe Haatveit, Jan Egil Nordvik, Christoffer Hatlestad-Hall, Gaute T Einevoll, Tuomo Mäki-Marttunen, Marit Haram, Torill Ueland, Trine V Lagerberg, Nils Eiel Steen, Ingrid Melle, Lars T Westlye, Erik G Jönsson, Ole A Andreassen, Torgeir Moberget, Torbjørn Elvsåshage. Evidence for Reduced Long-Term Potentiation-Like Visual Cortical Plasticity in Schizophrenia and Bipolar Disorder. Schizophrenia bulletin. vol 47. issue 6. 2021-12-02. PMID:33963856. |
several lines of research suggest that impairments in long-term potentiation (ltp)-like synaptic plasticity might be a key pathophysiological mechanism in schizophrenia (sz) and bipolar disorder type i (bdi) and ii (bdii). |
2021-12-02 |
2023-08-13 |
human |
| Gauri Ang, Laurence A Brown, Shu K E Tam, Kay E Davies, Russell G Foster, Paul J Harrison, Rolf Sprengel, Vladyslav V Vyazovskiy, Peter L Oliver, David M Bannerman, Stuart N Peirso. Deletion of AMPA receptor GluA1 subunit gene (Gria1) causes circadian rhythm disruption and aberrant responses to environmental cues. Translational psychiatry. vol 11. issue 1. 2021-11-19. PMID:34782594. |
dysfunction of the glutamate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa) receptor glua1 subunit and deficits in synaptic plasticity are implicated in schizophrenia and sleep and circadian rhythm disruption. |
2021-11-19 |
2023-08-13 |
mouse |
| Jin-Qiong Zhan, Chun-Nuan Chen, Si-Xian Wu, Han-Jun Wu, Ke Zou, Jian-Wen Xiong, Bo Wei, Yuan-Jian Yan. Flavonoid fisetin reverses impaired hippocampal synaptic plasticity and cognitive function by regulating the function of AMPARs in a male rat model of schizophrenia. Journal of neurochemistry. vol 158. issue 2. 2021-11-12. PMID:33882624. |
flavonoid fisetin reverses impaired hippocampal synaptic plasticity and cognitive function by regulating the function of ampars in a male rat model of schizophrenia. |
2021-11-12 |
2023-08-13 |
rat |
| Jin-Qiong Zhan, Chun-Nuan Chen, Si-Xian Wu, Han-Jun Wu, Ke Zou, Jian-Wen Xiong, Bo Wei, Yuan-Jian Yan. Flavonoid fisetin reverses impaired hippocampal synaptic plasticity and cognitive function by regulating the function of AMPARs in a male rat model of schizophrenia. Journal of neurochemistry. vol 158. issue 2. 2021-11-12. PMID:33882624. |
collectively, our findings demonstrate that fisetin treatment can reverse the deficits of hippocampal synaptic plasticity and memory in a male rat model of schizophrenia by restoring the phosphorylation and surface expression of ampar glua1 subunit, suggesting fisetin as a promising therapeutic candidate for schizophrenia-associated cognitive deficits. |
2021-11-12 |
2023-08-13 |
rat |
| Arne W Mould, Nicola A Hall, Ira Milosevic, Elizabeth M Tunbridg. Targeting synaptic plasticity in schizophrenia: insights from genomic studies. Trends in molecular medicine. vol 27. issue 11. 2021-11-01. PMID:34419330. |
targeting synaptic plasticity in schizophrenia: insights from genomic studies. |
2021-11-01 |
2023-08-13 |
Not clear |
| Arne W Mould, Nicola A Hall, Ira Milosevic, Elizabeth M Tunbridg. Targeting synaptic plasticity in schizophrenia: insights from genomic studies. Trends in molecular medicine. vol 27. issue 11. 2021-11-01. PMID:34419330. |
new information is emerging from genomic findings, which converge on synaptic plasticity and provide a new window on the neurobiology of schizophrenia. |
2021-11-01 |
2023-08-13 |
Not clear |
| Yossi Guterman, Yochai Ataria, Steven M Silverstei. The Imbalanced Plasticity Hypothesis of Schizophrenia-Related Psychosis: A Predictive Perspective. Cognitive, affective & behavioral neuroscience. vol 21. issue 4. 2021-10-25. PMID:34050524. |
we argue that the prediction-oriented perspective on schizophrenia-related psychosis may benefit from a mechanistic model that: 1) gives due weight to the extent to which alterations in short- and long-term synaptic plasticity determine the degree and the direction of the functional disruption that occurs in psychosis; and 2) addresses the distinction between the two central syndromes of psychosis in schizophrenia: disorganization and reality-distortion. |
2021-10-25 |
2023-08-13 |
Not clear |
| Alan S Brown, Karin Borgmann-Winter, Chang-Gyu Hahn, Lorna Role, David Talmage, Raquel Gur, Jacky Chow, Patric Prado, Thelma McCloskey, Yuanyuan Bao, J Chloe Bulinski, Andrew J Dwor. Increased stability of microtubules in cultured olfactory neuroepithelial cells from individuals with schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry. vol 48. 2021-10-21. PMID:24513021. |
mts are essential to growth cone advance and ultrastructural events integral to synaptic plasticity; these functions figure significantly into current pathophysiologic conceptualizations of schizophrenia. |
2021-10-21 |
2023-08-12 |
human |
| Zhi Wei Wu, Hong Hua Yu, Xuan Wang, Heng Yong Guan, Mei Hong Xiu, Xiang Yang Zhan. Interrelationships Between Oxidative Stress, Cytokines, and Psychotic Symptoms and Executive Functions in Patients With Chronic Schizophrenia. Psychosomatic medicine. vol 83. issue 5. 2021-10-20. PMID:34080586. |
accumulating evidence has demonstrated that the pathophysiology of schizophrenia is involved in various abnormalities in oxidative stress markers and cytokines closely related to synaptic plasticity. |
2021-10-20 |
2023-08-13 |
Not clear |
| Ruqayya Afridi, Sihwan Seol, Hyo Jung Kang, Kyoungho Su. Brain-immune interactions in neuropsychiatric disorders: Lessons from transcriptome studies for molecular targeting. Biochemical pharmacology. vol 188. 2021-09-14. PMID:33773976. |
recent transcriptome studies have identified dysregulated genes involved in peripheral immune cell activation, blood-brain barrier integrity, glial cell activation, and synaptic plasticity in major depressive disorder, bipolar disorder, autism spectrum disorder, and schizophrenia. |
2021-09-14 |
2023-08-13 |
Not clear |
| Noriko Kudo, Hidenaga Yamamori, Tamaki Ishima, Kiyotaka Nemoto, Yuka Yasuda, Michiko Fujimoto, Hirotsugu Azechi, Tomihisa Niitsu, Shusuke Numata, Manabu Ikeda, Masaomi Iyo, Tetsuro Ohmori, Masaki Fukunaga, Yoshiyuki Watanabe, Kenji Hashimoto, Ryota Hashimot. Plasma levels of matrix metalloproteinase-9 (MMP-9) are associated with cognitive performance in patients with schizophrenia. Neuropsychopharmacology reports. vol 40. issue 2. 2021-08-16. PMID:32022478. |
matrix metalloproteinase-9 (mmp-9) has been shown to modulate synaptic plasticity and may contribute to the pathophysiology of schizophrenia. |
2021-08-16 |
2023-08-13 |
Not clear |
| Jiajun Yin, Yana Lu, Shui Yu, Zhanzhan Dai, Fuquan Zhang, Jianmin Yua. Exploring the mRNA expression level of RELN in peripheral blood of schizophrenia patients before and after antipsychotic treatment. Hereditas. vol 157. issue 1. 2021-07-30. PMID:33158463. |
additionally, this protein may be involved in memory formation, neurotransmission, and synaptic plasticity, which have been shown to be disrupted in schizophrenia (scz). |
2021-07-30 |
2023-08-13 |
Not clear |
| Priya Allimuthu, Hanumanthappa Nandeesha, Raghavi Chinniyappan, Balaji Bhardwaz, Jesudas Blessed Ra. Relationship of Brain-Derived Neurotrophic Factor with Interleukin-23, Testosterone and Disease Severity in Schizophrenia. Indian journal of clinical biochemistry : IJCB. vol 36. issue 3. 2021-07-06. PMID:34220013. |
hormonal imbalance, inflammation and alteration in synaptic plasticity are reported to play a crucial role in the pathogenesis of schizophrenia. |
2021-07-06 |
2023-08-13 |
human |
| Michael S Jacob, Brian J Roach, Holly K Hamilton, Ricardo E Carrión, Aysenil Belger, Erica Duncan, Jason Johannesen, Matcheri Keshavan, Sandra Loo, Margaret Niznikiewicz, Jean Addington, Carrie E Bearden, Kristin S Cadenhead, Tyrone D Cannon, Barbara A Cornblatt, Thomas H McGlashan, Diana O Perkins, William Stone, Ming Tsuang, Elaine F Walker, Scott W Woods, Daniel H Mathalo. Visual cortical plasticity and the risk for psychosis: An interim analysis of the North American Prodrome Longitudinal Study. Schizophrenia research. vol 230. 2021-07-02. PMID:33667856. |
cortical gray matter reduction and dysconnectivity in schizophrenia are hypothesized to result from impaired synaptic plasticity mechanisms, including long-term potentiation (ltp), since deficient ltp may result in too many weak synapses that are then subject to over-pruning. |
2021-07-02 |
2023-08-13 |
human |
| Joseph Scarborough, Daniele Mattei, Cornelia Dorner-Ciossek, Michael Sand, Roberto Arban, Holger Rosenbrock, Juliet Richetto, Urs Meye. Symptomatic and preventive effects of the novel phosphodiesterase-9 inhibitor BI 409306 in an immune-mediated model of neurodevelopmental disorders. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 8. 2021-06-28. PMID:33941860. |
bi 409306, a phosphodiesterase-9 inhibitor under development for treatment of schizophrenia and attenuated psychosis syndrome (aps), promotes synaptic plasticity and cognition. |
2021-06-28 |
2023-08-13 |
mouse |
| b' Eduard Parellada, Patricia Gass\\xc3\\xb. Glutamate and microglia activation as a driver of dendritic apoptosis: a core pathophysiological mechanism to understand schizophrenia. Translational psychiatry. vol 11. issue 1. 2021-06-28. PMID:33958577.' |
overpruning of dendritic spines coupled with aberrant synaptic plasticity, an essential function for learning and memory, would lead to brain misconnections and synaptic inefficiency underlying the primary negative symptoms and cognitive deficits of schizophrenia. |
2021-06-28 |
2023-08-13 |
Not clear |
| Anita L Pinner, Toni M Mueller, Khaled Alganem, Robert McCullumsmith, James H Meador-Woodruf. Protein expression of prenyltransferase subunits in postmortem schizophrenia dorsolateral prefrontal cortex. Translational psychiatry. vol 10. issue 1. 2021-06-18. PMID:32066669. |
the pathophysiology of schizophrenia includes altered neurotransmission, dysregulated intracellular signaling pathway activity, and abnormal dendritic morphology that contribute to deficits of synaptic plasticity in the disorder. |
2021-06-18 |
2023-08-13 |
human |