| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Ahnaou, T Broadbelt, R Biermans, H Huysmans, N V Manyakov, W H I M Drinkenbur. The phosphodiesterase-4 and glycine transporter-1 inhibitors enhance in vivo hippocampal theta network connectivity and synaptic plasticity, whereas D-serine does not. Translational psychiatry. vol 10. issue 1. 2021-06-18. PMID:32555167. |
dysfunctional n-methyl-d-aspartate receptors (nmdars) and cyclic adenosine monophosphate (camp) have been associated with deficits in synaptic plasticity and cognition found in neurodegenerative and neuropsychiatric disorders such as alzheimer's disease (ad) and schizophrenia. |
2021-06-18 |
2023-08-13 |
rat |
| Lukas Frase, Lydia Mertens, Arno Krahl, Kriti Bhatia, Bernd Feige, Sven P Heinrich, Stefan Vestring, Christoph Nissen, Katharina Domschke, Michael Bach, Claus Norman. Transcranial direct current stimulation induces long-term potentiation-like plasticity in the human visual cortex. Translational psychiatry. vol 11. issue 1. 2021-06-18. PMID:33414402. |
the results demonstrate that tdcs can directly induce ltp-like plasticity in the human cortex and suggest a mechanism of action of tdcs relying on the restoration of dysregulated synaptic plasticity in psychiatric disorders such as depression and schizophrenia. |
2021-06-18 |
2023-08-13 |
human |
| Ioannis Mavroudis, Foivos Petrides, Dimitrios Kazis, Symela Chatzikonstantinou, Eleni Karantali, Alin Ciobica, Alin-Constantin Iordache, Romeo Dobrin, Constantin Trus, Samuel Njau, Vasiliki Costa, Stavros Baloyanni. Morphological alterations of the pyramidal and stellate cells of the visual cortex in schizophrenia. Experimental and therapeutic medicine. vol 22. issue 1. 2021-05-16. PMID:33986834. |
studies have revealed impaired synaptic plasticity and reduced gamma-aminobutyric acid levels of the visual cortex in patients with schizophrenia. |
2021-05-16 |
2023-08-13 |
Not clear |
| Hongik Hwang, Matthew J Szucs, Lei J Ding, Andrew Allen, Xiaobai Ren, Henny Haensgen, Fan Gao, Hyewhon Rhim, Arturo Andrade, Jen Q Pan, Steven A Carr, Rushdy Ahmad, Weifeng X. Neurogranin, Encoded by the Schizophrenia Risk Gene NRGN, Bidirectionally Modulates Synaptic Plasticity via Calmodulin-Dependent Regulation of the Neuronal Phosphoproteome. Biological psychiatry. vol 89. issue 3. 2021-04-23. PMID:33032807. |
neurogranin, encoded by the schizophrenia risk gene nrgn, bidirectionally modulates synaptic plasticity via calmodulin-dependent regulation of the neuronal phosphoproteome. |
2021-04-23 |
2023-08-13 |
Not clear |
| Sylvie Gory-Fauré, Rebecca Powell, Julie Jonckheere, Fabien Lanté, Eric Denarier, Leticia Peris, Chi Hung Nguyen, Alain Buisson, Laurence Lafanechère, Annie Andrieu. Pyr1-Mediated Pharmacological Inhibition of LIM Kinase Restores Synaptic Plasticity and Normal Behavior in a Mouse Model of Schizophrenia. Frontiers in pharmacology. vol 12. 2021-04-02. PMID:33790791. |
pyr1-mediated pharmacological inhibition of lim kinase restores synaptic plasticity and normal behavior in a mouse model of schizophrenia. |
2021-04-02 |
2023-08-13 |
mouse |
| Sylvie Gory-Fauré, Rebecca Powell, Julie Jonckheere, Fabien Lanté, Eric Denarier, Leticia Peris, Chi Hung Nguyen, Alain Buisson, Laurence Lafanechère, Annie Andrieu. Pyr1-Mediated Pharmacological Inhibition of LIM Kinase Restores Synaptic Plasticity and Normal Behavior in a Mouse Model of Schizophrenia. Frontiers in pharmacology. vol 12. 2021-04-02. PMID:33790791. |
we investigated synaptic plasticity defects and behavioral disorders in map6 ko mice, an animal model useful for the study of psychiatric disorders, particularly schizophrenia. |
2021-04-02 |
2023-08-13 |
mouse |
| David Wegrzyn, Nadja Freund, Andreas Faissner, Georg Jucke. Poly I:C Activated Microglia Disrupt Perineuronal Nets and Modulate Synaptic Balance in Primary Hippocampal Neurons Frontiers in synaptic neuroscience. vol 13. 2021-03-13. PMID:33708102. |
recent studies have shown that pnns can highly influence synaptic plasticity and are disrupted in different neuropsychiatric disorders like schizophrenia. |
2021-03-13 |
2023-08-13 |
Not clear |
| Neha Keshri, Hanumanthappa Nandeesha, Medha Rajappa, Vikas Meno. Matrix metalloproteinase-9 increases the risk of cognitive impairment in schizophrenia. Nordic journal of psychiatry. vol 75. issue 2. 2021-02-03. PMID:32815771. |
synaptic plasticity is known to play role in pathogenesis of schizophrenia. |
2021-02-03 |
2023-08-13 |
Not clear |
| Karina Karis, Kattri-Liis Eskla, Maria Kaare, Karin Täht, Jana Tuusov, Tanel Visnapuu, Jürgen Innos, Mohan Jayaram, Tõnis Timmusk, Cynthia S Weickert, Marika Väli, Eero Vasar, Mari-Anne Philip. Altered Expression Profile of IgLON Family of Neural Cell Adhesion Molecules in the Dorsolateral Prefrontal Cortex of Schizophrenic Patients. Frontiers in molecular neuroscience. vol 11. 2020-10-01. PMID:29434535. |
iglon proteins have been shown to be involved in neurite outgrowth, synaptic plasticity and neuronal connectivity, all of which have been shown to be altered in the brains of patients with the diagnosis of schizophrenia. |
2020-10-01 |
2023-08-13 |
human |
| Tatiana V Lipina, Nikolay A Beregovoy, Alina A Tkachenko, Ekaterina S Petrova, Marina V Starostina, Qiang Zhou, Shupeng L. Uncoupling DISC1 × D2R Protein-Protein Interactions Facilitates Latent Inhibition in Disc1-L100P Animal Model of Schizophrenia and Enhances Synaptic Plasticity via D2 Receptors. Frontiers in synaptic neuroscience. vol 10. 2020-10-01. PMID:30245624. |
uncoupling disc1 × d2r protein-protein interactions facilitates latent inhibition in disc1-l100p animal model of schizophrenia and enhances synaptic plasticity via d2 receptors. |
2020-10-01 |
2023-08-13 |
mouse |
| Xiao Chang, Leandro de Araujo Lima, Yichuan Liu, Jin Li, Qingqin Li, Patrick M A Sleiman, Hakon Hakonarso. Common and Rare Genetic Risk Factors Converge in Protein Interaction Networks Underlying Schizophrenia. Frontiers in genetics. vol 9. 2020-09-30. PMID:30323833. |
we identified significantly and consistently over-represented pathways in the largest schizophrenia gwa studies, which are highly relevant to synaptic plasticity, neural development and signaling transduction, such as long-term potentiation, neurotrophin signaling pathway, and the erbb signaling pathway. |
2020-09-30 |
2023-08-13 |
Not clear |
| Katharine N Thakkar, Anna Antinori, Olivia L Carter, Jan W Brascam. Altered short-term neural plasticity related to schizotypal traits: Evidence from visual adaptation. Schizophrenia research. vol 207. 2020-06-22. PMID:29685421. |
abnormalities in synaptic plasticity are argued to underlie the neural dysconnectivity observed in schizophrenia. |
2020-06-22 |
2023-08-13 |
Not clear |
| Urvakhsh Meherwan Mehta, Milind Vijay Thanki, Jaya Padmanabhan, Alvaro Pascual-Leone, Matcheri S Keshava. Motor cortical plasticity in schizophrenia: A meta-analysis of Transcranial Magnetic Stimulation - Electromyography studies. Schizophrenia research. vol 207. 2020-06-22. PMID:30409696. |
several lines of investigations converge upon aberrant synaptic plasticity as a potential pathophysiological characteristic of schizophrenia. |
2020-06-22 |
2023-08-13 |
Not clear |
| Mario Stampanoni Bassi, Ennio Iezzi, Luana Gilio, Diego Centonze, Fabio Buttar. Synaptic Plasticity Shapes Brain Connectivity: Implications for Network Topology. International journal of molecular sciences. vol 20. issue 24. 2020-05-12. PMID:31817968. |
in addition, synaptic plasticity dysfunction may drive brain network disruption in neuropsychiatric conditions such as alzheimer's disease and schizophrenia. |
2020-05-12 |
2023-08-13 |
Not clear |
| S Gulsuner, D J Stein, E S Susser, G Sibeko, A Pretorius, T Walsh, L Majara, M M Mndini, S G Mqulwana, O A Ntola, S Casadei, L L Ngqengelele, V Korchina, C van der Merwe, M Malan, K M Fader, M Feng, E Willoughby, D Muzny, A Baldinger, H F Andrews, R C Gur, R A Gibbs, Z Zingela, M Nagdee, R S Ramesar, M-C King, J M McClella. Genetics of schizophrenia in the South African Xhosa. Science (New York, N.Y.). vol 367. issue 6477. 2020-04-08. PMID:32001654. |
schizophrenia is genetically highly heterogeneous, involving severe ultrarare mutations in genes that are critical to synaptic plasticity. |
2020-04-08 |
2023-08-13 |
human |
| Steven J Girdler, Jamie E Confino, Mary E Woesne. Exercise as a Treatment for Schizophrenia: A Review. Psychopharmacology bulletin. vol 49. issue 1. 2020-03-30. PMID:30858639. |
although no clear etiology of schizophrenia has been discovered, many factors have been identified that contribute to the development of the disease, such as neurotransmitter alterations, decreased synaptic plasticity, and diminished hippocampal volume. |
2020-03-30 |
2023-08-13 |
Not clear |
| Tsung-Ming Hu, Shaw-Ji Chen, Shih-Hsin Hsu, Min-Chih Chen. Functional analyses and effect of DNA methylation on the EGR1 gene in patients with schizophrenia. Psychiatry research. vol 275. 2019-12-30. PMID:30952071. |
egr1, involved in the regulation of synaptic plasticity, learning, and memory, is considered a candidate gene for schizophrenia. |
2019-12-30 |
2023-08-13 |
Not clear |
| Johanna Lilja, Johanna Ivask. Integrin activity in neuronal connectivity. Journal of cell science. vol 131. issue 12. 2019-11-22. PMID:29907643. |
the integrin family of cell adhesion receptors and their ligands play essential roles in the control of several processes regulating neuronal connectivity - including neurite outgrowth, the formation and maintenance of synapses, and synaptic plasticity - that are affected in neurodevelopmental disorders, such as autism spectrum disorders (asds) and schizophrenia. |
2019-11-22 |
2023-08-13 |
Not clear |
| Nicholas E Clifton, Kerrie L Thomas, Jeremy Hal. The effect of ketamine on the consolidation and extinction of contextual fear memory. Journal of psychopharmacology (Oxford, England). vol 32. issue 2. 2019-10-24. PMID:29338491. |
genomic studies further implicate n-methyl-ᴅ-aspartate receptor-mediated processes in schizophrenia pathology, together with more broadly-defined synaptic plasticity and associative learning processes. |
2019-10-24 |
2023-08-13 |
rat |
| Julia C Bartsch, Björn H Schott, Joachim Beh. Hippocampal Dysfunction in Schizophrenia and Aberrant Hippocampal Synaptic Plasticity in Rodent Model Psychosis: a Selective Review. Pharmacopsychiatry. 2019-08-01. PMID:31370081. |
hippocampal dysfunction in schizophrenia and aberrant hippocampal synaptic plasticity in rodent model psychosis: a selective review. |
2019-08-01 |
2023-08-13 |
Not clear |