| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrea de Bartolomeis, Felice Iasevoli, Carmine Tomasetti, Elisabetta F Buonagur. MicroRNAs in Schizophrenia: Implications for Synaptic Plasticity and Dopamine-Glutamate Interaction at the Postsynaptic Density. New Avenues for Antipsychotic Treatment Under a Theranostic Perspective. Molecular neurobiology. vol 52. issue 3. 2016-08-30. PMID:25394379. |
the biogenesis of mirnas and their role in synaptic plasticity with relevance to schizophrenia will be considered in the context of dopamine-glutamate interaction, with special focus on mirna interaction with psd elements. |
2016-08-30 |
2023-08-13 |
Not clear |
| Natalie Matosin, Francesca Fernandez-Enright, Jeremy S Lum, Martin Engel, Jessica L Andrews, Nils C Gassen, Klaus V Wagner, Mathias V Schmidt, Kelly A Newel. Molecular evidence of synaptic pathology in the CA1 region in schizophrenia. NPJ schizophrenia. vol 2. 2016-07-19. PMID:27430010. |
alterations of postsynaptic density (psd)95-complex proteins in schizophrenia ostensibly induce deficits in synaptic plasticity, the molecular process underlying cognitive functions. |
2016-07-19 |
2023-08-13 |
human |
| Matthew J Huentelman, Leela Muppana, Jason J Corneveaux, Valentin Dinu, Jeremy J Pruzin, Rebecca Reiman, Cassie N Borish, Matt De Both, Amber Ahmed, Alexandre Todorov, C Robert Cloninger, Rui Zhang, Jie Ma, Amelia L Gallitan. Association of SNPs in EGR3 and ARC with Schizophrenia Supports a Biological Pathway for Schizophrenia Risk. PloS one. vol 10. issue 10. 2016-06-02. PMID:26474411. |
we have previously hypothesized a biological pathway of activity-dependent synaptic plasticity proteins that addresses the dual genetic and environmental contributions to schizophrenia. |
2016-06-02 |
2023-08-13 |
Not clear |
| Katarzyna Lepeta, Leszek Kaczmare. Matrix Metalloproteinase-9 as a Novel Player in Synaptic Plasticity and Schizophrenia. Schizophrenia bulletin. vol 41. issue 5. 2016-06-01. PMID:25837304. |
matrix metalloproteinase-9 as a novel player in synaptic plasticity and schizophrenia. |
2016-06-01 |
2023-08-13 |
Not clear |
| Katarzyna Lepeta, Leszek Kaczmare. Matrix Metalloproteinase-9 as a Novel Player in Synaptic Plasticity and Schizophrenia. Schizophrenia bulletin. vol 41. issue 5. 2016-06-01. PMID:25837304. |
recent findings implicate alterations in glutamate signaling, leading to aberrant synaptic plasticity, in schizophrenia. |
2016-06-01 |
2023-08-13 |
Not clear |
| Katarzyna Lepeta, Leszek Kaczmare. Matrix Metalloproteinase-9 as a Novel Player in Synaptic Plasticity and Schizophrenia. Schizophrenia bulletin. vol 41. issue 5. 2016-06-01. PMID:25837304. |
this commentary critically reviews these findings based on the hypothesis that mmp-9 contributes to pathological synaptic plasticity in schizophrenia. |
2016-06-01 |
2023-08-13 |
Not clear |
| Chuanyue Wan. Psychopharmacological treatment for schizophrenia: less is more. Shanghai archives of psychiatry. vol 27. issue 6. 2016-05-20. PMID:27199528. |
more recent evidence also suggests that antipsychotic polypharmacy and the associated high overall dosage of antipsychotic medication lead to excessive striatal d2 receptor occupation (resulting in tolerance and drug withdrawal problems) and exacerbation of the impaired synaptic plasticity seen in schizophrenia (magnifying the cognitive impairment associated with the condition). |
2016-05-20 |
2023-08-13 |
Not clear |
| Jicai Wang, Hongbao Cao, Yanhui Liao, Weiqing Liu, Liwen Tan, Yanqing Tang, Jindong Chen, Xiufeng Xu, Haijun Li, Chunrong Luo, Chunyu Liu, Kathleen Ries Merikangas, Vince Calhoun, Jinsong Tang, Yin Yao Shugart, Xiaogang Che. Three dysconnectivity patterns in treatment-resistant schizophrenia patients and their unaffected siblings. NeuroImage. Clinical. vol 8. 2016-03-29. PMID:26106532. |
a few recent studies suggested that schizophrenia may be caused by impaired synaptic plasticity that manifests as functional dysconnectivity in the brain, however, few of those studies focused on the functional connectivity changes in the brains of trs groups. |
2016-03-29 |
2023-08-13 |
Not clear |
| Hong Lin, Ariel A Jacobi, Stewart A Anderson, David R Lync. D-Serine and Serine Racemase Are Associated with PSD-95 and Glutamatergic Synapse Stability. Frontiers in cellular neuroscience. vol 10. 2016-03-04. PMID:26941605. |
it is crucial for synaptic plasticity and is implicated in schizophrenia. |
2016-03-04 |
2023-08-13 |
Not clear |
| Roksana Zakharyan, Sofi Atshemyan, Anaida Gevorgyan, Anna Boyajya. Nerve growth factor and its receptor in schizophrenia. BBA clinical. vol 1. 2015-12-17. PMID:26675984. |
promising studies suggest that defects in synaptic plasticity detected in schizophrenia may be linked to neurodevelopmental and neurodegenerative abnormalities and contribute to disease-associated cognitive impairment. |
2015-12-17 |
2023-08-13 |
human |
| Roksana Zakharyan, Sofi Atshemyan, Anaida Gevorgyan, Anna Boyajya. Nerve growth factor and its receptor in schizophrenia. BBA clinical. vol 1. 2015-12-17. PMID:26675984. |
we aimed to clarify the role of the synaptic plasticity regulatory proteins, nerve growth factor (ngf) and its receptor (ngfr) in the pathogenesis of schizophrenia by comparative analysis of their blood levels and functional single nucleotide polymorphisms (snps) in genes encoding these proteins (ngf and ngfr) in schizophrenia-affected and healthy subjects. |
2015-12-17 |
2023-08-13 |
human |
| M J Varela, S Lage, H J Caruncho, M I Cadavid, M I Loza, J Bre. Reelin influences the expression and function of dopamine D2 and serotonin 5-HT2A receptors: a comparative study. Neuroscience. vol 290. 2015-12-15. PMID:25637489. |
reelin is an extracellular matrix protein that plays a critical role in neuronal guidance during brain neurodevelopment and in synaptic plasticity in adults and has been associated with schizophrenia. |
2015-12-15 |
2023-08-13 |
mouse |
| Norihito Shintani, Yusuke Onaka, Ryota Hashimoto, Hironori Takamura, Tsuyoshi Nagata, Satomi Umeda-Yano, Akihiro Mouri, Takayoshi Mamiya, Ryota Haba, Shinsuke Matsuzaki, Taiichi Katayama, Hidenaga Yamamori, Takanobu Nakazawa, Kazuki Nagayasu, Yukio Ago, Yuki Yagasaki, Toshitaka Nabeshima, Masatoshi Takeda, Hitoshi Hashimot. Behavioral characterization of mice overexpressing human dysbindin-1. Molecular brain. vol 7. 2015-11-10. PMID:25298178. |
the dysbindin-1 gene (dtnbp1: dystrobrevin binding protein 1) is a promising schizophrenia susceptibility gene, known to localize almost exclusively to neurons in the brain, and participates in the regulation of neurotransmitter release, membrane-surface receptor expression, and synaptic plasticity. |
2015-11-10 |
2023-08-13 |
mouse |
| Robert Waltereit, Tobias Banaschewski, Andreas Meyer-Lindenberg, Luise Poustk. Interaction of neurodevelopmental pathways and synaptic plasticity in mental retardation, autism spectrum disorder and schizophrenia: implications for psychiatry. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 15. issue 7. 2015-05-27. PMID:24079538. |
interaction of neurodevelopmental pathways and synaptic plasticity in mental retardation, autism spectrum disorder and schizophrenia: implications for psychiatry. |
2015-05-27 |
2023-08-12 |
Not clear |
| Byron K Y Bitanihirwe, Tsung-Ung W Wo. Perineuronal nets and schizophrenia: the importance of neuronal coatings. Neuroscience and biobehavioral reviews. vol 45. 2015-04-16. PMID:24709070. |
until recently, the functions of the pnn had remained enigmatic, but are now considered to be important in development of the central nervous system, neuronal protection and synaptic plasticity, all elements which have been associated with schizophrenia. |
2015-04-16 |
2023-08-13 |
Not clear |
| Ting Martin Ma, Bindu D Paul, Chenglai Fu, Shaohui Hu, Heng Zhu, Seth Blackshaw, Herman Wolosker, Solomon H Snyde. Serine racemase regulated by binding to stargazin and PSD-95: potential N-methyl-D-aspartate-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (NMDA-AMPA) glutamate neurotransmission cross-talk. The Journal of biological chemistry. vol 289. issue 43. 2015-02-12. PMID:25164819. |
d-serine, an endogenous co-agonist for the glycine site of the synaptic nmda glutamate receptor, regulates synaptic plasticity and is implicated in schizophrenia. |
2015-02-12 |
2023-08-13 |
Not clear |
| Yuan-Jian Yang, Yan-Kun Li, Wei Wang, Jian-Guo Wan, Bin Yu, Mei-Zhen Wang, Bin H. Small-molecule TrkB agonist 7,8-dihydroxyflavone reverses cognitive and synaptic plasticity deficits in a rat model of schizophrenia. Pharmacology, biochemistry, and behavior. vol 122. 2015-01-26. PMID:24662915. |
small-molecule trkb agonist 7,8-dihydroxyflavone reverses cognitive and synaptic plasticity deficits in a rat model of schizophrenia. |
2015-01-26 |
2023-08-12 |
rat |
| Alexia Daoust, Sylvain Bohic, Yasmina Saoudi, Clément Debacker, Sylvie Gory-Fauré, Annie Andrieux, Emmanuel Luc Barbier, Jean-Christophe Deloulm. Neuronal transport defects of the MAP6 KO mouse - a model of schizophrenia - and alleviation by Epothilone D treatment, as observed using MEMRI. NeuroImage. vol 96. 2015-01-21. PMID:24704457. |
the map6 (microtubule-associated protein 6) ko mouse is a microtubule-deficient model of schizophrenia that exhibits severe behavioral disorders that are associated with synaptic plasticity anomalies. |
2015-01-21 |
2023-08-13 |
mouse |
| Andrew J Pocklington, Michael O'Donovan, Michael J Owe. The synapse in schizophrenia. The European journal of neuroscience. vol 39. issue 7. 2014-12-18. PMID:24712986. |
a strong case can now be made that disruption of glutamatergic signalling pathways regulating synaptic plasticity contributes to the aetiology of schizophrenia. |
2014-12-18 |
2023-08-13 |
Not clear |
| Gregg W Crabtree, Joseph A Gogo. Synaptic plasticity, neural circuits, and the emerging role of altered short-term information processing in schizophrenia. Frontiers in synaptic neuroscience. vol 6. 2014-12-16. PMID:25505409. |
synaptic plasticity, neural circuits, and the emerging role of altered short-term information processing in schizophrenia. |
2014-12-16 |
2023-08-13 |
mouse |