| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A R Hariri, D R Weinberge. Functional neuroimaging of genetic variation in serotonergic neurotransmission. Genes, brain, and behavior. vol 2. issue 6. 2004-01-15. PMID:14653306. |
in this commentary, we discuss how functional neuroimaging can be used to characterize the effects of polymorphisms in 5-ht subsystem genes on the response of neural circuits underlying the generation and regulation of mood and temperament as well as susceptibility to affective illness. |
2004-01-15 |
2023-08-12 |
human |
| Eleni T Tzavara, Richard J Davis, Kenneth W Perry, Xia Li, Craig Salhoff, Frank P Bymaster, Jeffrey M Witkin, George G Nomiko. The CB1 receptor antagonist SR141716A selectively increases monoaminergic neurotransmission in the medial prefrontal cortex: implications for therapeutic actions. British journal of pharmacology. vol 138. issue 4. 2003-08-27. PMID:12598408. |
these results suggest that the cortical selectivity in the release of catecholamines, dopamine in particular, induced by the cannabinoid antagonist sr141716a, its procholinergic properties, together with its mild stimulatory effects on serotonin and norepinephrine efflux make similar compounds unique candidates for the treatment of psychosis, affective and cognitive disorders. |
2003-08-27 |
2023-08-12 |
mouse |
| Mary Perugini, Colleen Mahoney, Vadim Ilivitsky, Simon N Young, Verner Knot. Effects of tryptophan depletion on acute smoking abstinence symptoms and the acute smoking response. Pharmacology, biochemistry, and behavior. vol 74. issue 3. 2003-08-04. PMID:12543214. |
given the putative role of serotonin in the modulation of smoking withdrawal and the central actions of nicotine, this study examined the affective and neuroelectric correlates of smoking abstinence and cigarette smoking following depletion of the serotonin precursor, tryptophan. |
2003-08-04 |
2023-08-12 |
Not clear |
| Takashi Yoshitake, Ilkka Reenilä, Sven Ove Ogren, Tomas Hökfelt, Jan Keh. Galanin attenuates basal and antidepressant drug-induced increase of extracellular serotonin and noradrenaline levels in the rat hippocampus. Neuroscience letters. vol 339. issue 3. 2003-05-05. PMID:12633897. |
galanin is co-localized with classical neurotransmitters, such as acetylcholine, serotonin (5-ht) and noradrenaline (na) in neurons or in brain regions implicated in cognitive and affective behaviour. |
2003-05-05 |
2023-08-12 |
rat |
| T O C Kilkens, A Honig, N Rozendaal, M A Van Nieuwenhoven, R-J M Brumme. Systematic review: serotonergic modulators in the treatment of irritable bowel syndrome--influence on psychiatric and gastrointestinal symptoms. Alimentary pharmacology & therapeutics. vol 17. issue 1. 2003-04-21. PMID:12492731. |
serotonin may play a regulatory role in both gastrointestinal motility and sensitivity, as well as in affective dysregulation, in irritable bowel syndrome. |
2003-04-21 |
2023-08-12 |
Not clear |
| C J Harmer, Z Bhagwagar, D I Perrett, B A Völlm, P J Cowen, G M Goodwi. Acute SSRI administration affects the processing of social cues in healthy volunteers. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 1. 2003-03-17. PMID:12496951. |
this response forms the major evidence for the role of serotonin in affective and social behaviour in humans. |
2003-03-17 |
2023-08-12 |
human |
| b' M O Rojas-Corrales, E Berrocoso, J Gibert-Rahola, J A Mic\\xc3\\xb. Antidepressant-like effects of tramadol and other central analgesics with activity on monoamines reuptake, in helpless rats. Life sciences. vol 72. issue 2. 2002-11-29. PMID:12417248.' |
affective states are regulated mainly by serotonin and noradrenaline. |
2002-11-29 |
2023-08-12 |
rat |
| Steven T Szabo, Pierre Blie. Effects of serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibition plus 5-HT(2A) receptor antagonism on the firing activity of norepinephrine neurons. The Journal of pharmacology and experimental therapeutics. vol 302. issue 3. 2002-09-18. PMID:12183655. |
this ne activity, resulting from 5-ht reuptake inhibition plus 5-ht(2a) receptor antagonism, might confer additional benefits in affective and anxiety disorders. |
2002-09-18 |
2023-08-12 |
rat |
| Béatrice Bonnier, Philip Gorwood, Michel Hamon, Yves Sarfati, Claudette Boni, Marie-Christine Hardy-Bayl. Association of 5-HT(2A) receptor gene polymorphism with major affective disorders: the case of a subgroup of bipolar disorder with low suicide risk. Biological psychiatry. vol 51. issue 9. 2002-08-21. PMID:11983190. |
the implication of serotonin in suicide and affective disease explains why the 5-ht(2a) receptor gene has been proposed as a candidate gene in these disorders, although with conflicting results. |
2002-08-21 |
2023-08-12 |
Not clear |
| F P Monne. Melatonin modulates [3h]serotonin release in the rat hippocampus: effects of circadian rhythm. Journal of neuroendocrinology. vol 14. issue 3. 2002-08-14. PMID:11999718. |
serotonin (5-ht) participates as a neurotransmitter in the control of the circadian sleep/wake rhythm, feeding and sexual behaviours, and emotional and affective states. |
2002-08-14 |
2023-08-12 |
rat |
| Kurt D Michael, Susan L Crowle. How effective are treatments for child and adolescent depression? A meta-analytic review. Clinical psychology review. vol 22. issue 2. 2002-06-28. PMID:11806021. |
nonetheless, there is recent evidence that selective serotonin reuptake inhibitors (ssris) such as fluoxetine are efficacious, and will likely play an increased role in the management of affective illness in youngsters. |
2002-06-28 |
2023-08-12 |
Not clear |
| M Luciana, E D Burgund, M Berman, K L Hanso. Effects of tryptophan loading on verbal, spatial and affective working memory functions in healthy adults. Journal of psychopharmacology (Oxford, England). vol 15. issue 4. 2002-05-29. PMID:11769814. |
serotonin (5-ht) appears to modulate affective behaviours by providing a homeostatic threshold around which other transmitters respond. |
2002-05-29 |
2023-08-12 |
Not clear |
| Per Svenningsson, Eleni T Tzavara, Feng Liu, Allen A Fienberg, George G Nomikos, Paul Greengar. DARPP-32 mediates serotonergic neurotransmission in the forebrain. Proceedings of the National Academy of Sciences of the United States of America. vol 99. issue 5. 2002-04-26. PMID:11880652. |
serotonin is implicated in the regulation of complex sensory, motor, affective, and cognitive functions. |
2002-04-26 |
2023-08-12 |
mouse |
| O S Brusov, M I Faktor, G P Zlobina, P V Bologov, V G Kaleda, I V Oleĭchik, A N Korenev, A N Piatnitskiĭ, A M Dupin, A B Katasonov, M A Morozova, A G Beniashvili, R Kh Lozier, E V Pavlova, O L Segal, Iu S Massino, A D Dmitrie. [Levels and molecular heterogeneity of serotonin transporter protein in platelets of patients with different mental diseases: a comparative analysis with the use of monoclonal and polyclonal antibodies]. Vestnik Rossiiskoi akademii meditsinskikh nauk. issue 7. 2002-03-18. PMID:11523428. |
polyclonal (pab) and monoclonal (mab) antibodies to ct2-epitope of the c-terminal fragment of serotonin transporter (sert) protein were used to study the levels and molecular heterogeneity of platelet sert in healthy donors and patients with affective (ad) and somatoform (sd) disorders, schizoaffective disorder (sad) and schizophrenia. |
2002-03-18 |
2023-08-12 |
Not clear |
| A Gjedd. [Receptor mapping in living human beings by means of positron emission tomography]. Ugeskrift for laeger. vol 163. issue 38. 2001-10-25. PMID:11577527. |
pet has revealed loss of dopaminergic terminals and dopamine synthetic capacity in parkinson's disease, mptp intoxication, and lesch-nyhan's syndrome; release of dopamine after administration of cocaine and amphetamine, and in motor activity and cognition; increased synaptic dopamine and release of dopamine, and the 70-90% neuroleptic occupancy of dopamine receptors in the striatum, in patients with schizophrenia; loss of muscarinic and nicotinergic receptors in alzheimer's disease, and benzodiazepine and opiate receptors in stroke, epilepsy, and huntington's chorea; altered opiate receptors in chronic pain and drug abuse; and release of opiates in analgesia; but changes in serotonin synthesis, transport, and binding in affective or psychotic disorders remain elusive. |
2001-10-25 |
2023-08-12 |
human |
| B Lerer, F Macciardi, R H Segman, R Adolfsson, D Blackwood, S Blairy, J Del Favero, D G Dikeos, R Kaneva, R Lilli, I Massat, V Milanova, W Muir, M Noethen, L Oruc, T Petrova, G N Papadimitriou, M Rietschel, A Serretti, D Souery, S Van Gestel, C Van Broeckhoven, J Mendlewic. Variability of 5-HT2C receptor cys23ser polymorphism among European populations and vulnerability to affective disorder. Molecular psychiatry. vol 6. issue 5. 2001-10-18. PMID:11526472. |
(3) accordingly, genes that code for the multiple subtypes of serotonin receptors that have been cloned and are expressed in brain,(4) are strong candidates for a role in the genetic etiology of affective illness. |
2001-10-18 |
2023-08-12 |
human |
| A A Harrison, Y T Liem, A Marko. Fluoxetine combined with a serotonin-1A receptor antagonist reversed reward deficits observed during nicotine and amphetamine withdrawal in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 25. issue 1. 2001-08-02. PMID:11377919. |
the reversal of the affective aspects of drug withdrawal by a treatment that enhances serotonin neurotransmission indicates that decreased serotonergic function may mediate the reward decrements characterizing nicotine and amphetamine withdrawal, and that these symptoms may be homologous to a core symptom of non-drug-induced depressions. |
2001-08-02 |
2023-08-12 |
rat |
| F Weiss, R Ciccocioppo, L H Parsons, S Katner, X Liu, E P Zorrilla, G R Valdez, O Ben-Shahar, S Angeletti, R R Richte. Compulsive drug-seeking behavior and relapse. Neuroadaptation, stress, and conditioning factors. Annals of the New York Academy of Sciences. vol 937. 2001-08-02. PMID:11458532. |
considerable evidence exists implicating perturbations in da and 5-ht transmission in the nucleus accumbens--neurochemical systems that are activated by cocaine and ethanol self-administration and deficient during withdrawal--as potential substrates for these affective changes. |
2001-08-02 |
2023-08-12 |
Not clear |
| M Leyton, A M Ghadirian, S N Young, R M Palmour, P Blier, K F Helmers, C Benkelfa. Depressive relapse following acute tryptophan depletion in patients with major depressive disorder. Journal of psychopharmacology (Oxford, England). vol 14. issue 3. 2001-03-29. PMID:11106310. |
these preliminary findings (1) support the hypothesis that depressed states are related to disturbed serotonin neurotransmission and (2) suggest that depressive symptoms following atd might identify a subgroup of patients at high genetic risk for disorders associated with affective lability and dysregulated impulse-control, conditions thought to be related to low serotonin neurotransmission. |
2001-03-29 |
2023-08-12 |
Not clear |
| H Steiger, S N Young, N M Kin, N Koerner, M Israel, P Lageix, J Pari. Implications of impulsive and affective symptoms for serotonin function in bulimia nervosa. Psychological medicine. vol 31. issue 1. 2001-03-29. PMID:11200963. |
implications of impulsive and affective symptoms for serotonin function in bulimia nervosa. |
2001-03-29 |
2023-08-12 |
Not clear |