| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Coyle, I Jones, E Robertson, C Lendon, N Craddoc. Variation at the serotonin transporter gene influences susceptibility to bipolar affective puerperal psychosis. Lancet (London, England). vol 356. issue 9240. 2000-11-30. PMID:11081536. |
variation at the serotonin transporter gene influences susceptibility to bipolar affective puerperal psychosis. |
2000-11-30 |
2023-08-12 |
Not clear |
| B Bondy, A Erfurth, S de Jonge, M Krüger, H Meye. Possible association of the short allele of the serotonin transporter promoter gene polymorphism (5-HTTLPR) with violent suicide. Molecular psychiatry. vol 5. issue 2. 2000-08-03. PMID:10822348. |
there is abundant evidence that the serotonin (5-ht) system is modulating mood and several behavioural traits and that disturbances in the regulation of this system can be associated with severe behavioural malfunctions, as aggressive implusive and suicidal behaviour.1 recently a functional polymorphism in the promoter region of the serotonin transporter gene (5-httlpr) was identified2 and the presence of one or two short alleles was associated with anxiety-related personality traits3 and several psychiatric disturbances, such as affective disorder4 or severe alcohol dependence.5 with respect to the importance of the 5-ht transporter in serotonergic transmission, we have genotyped the dna of 58 caucasian suicide victims (with unknown psychiatric diagnoses) and 110 healthy controls for the biallelic functional polymorphism in the 5-httlpr. |
2000-08-03 |
2023-08-12 |
Not clear |
| C L Bethea, S J Mirkes, C A Shively, M R Adam. Steroid regulation of tryptophan hydroxylase protein in the dorsal raphe of macaques. Biological psychiatry. vol 47. issue 6. 2000-05-16. PMID:10715363. |
tryptophan hydroxylase (tph) is the rate-limiting enzyme for the synthesis of serotonin, and serotonin is a pivotal neurotransmitter in the regulation of mood, affective behavior, pituitary hormone secretion, and numerous autonomic functions. |
2000-05-16 |
2023-08-12 |
Not clear |
| W H Kaye, K A Gendall, M H Fernstrom, J D Fernstrom, C W McConaha, T E Weltzi. Effects of acute tryptophan depletion on mood in bulimia nervosa. Biological psychiatry. vol 47. issue 2. 2000-03-03. PMID:10664832. |
the present study investigated the role of serotonin in the pathophysiology of bulimia nervosa (bn) by studying the affective and appetitive responses of women ill with bn to an acute tryptophan depletion (atd) paradigm. |
2000-03-03 |
2023-08-12 |
Not clear |
| T Hallikainen, T Saito, H M Lachman, J Volavka, T Pohjalainen, O P Ryynänen, J Kauhanen, E Syvälahti, J Hietala, J Tiihone. Association between low activity serotonin transporter promoter genotype and early onset alcoholism with habitual impulsive violent behavior. Molecular psychiatry. vol 4. issue 4. 1999-10-18. PMID:10483057. |
a common 44-base pair insertion/deletion polymorphism in the promoter region of the human serotonin transporter (5-htt) gene has been observed to be associated with affective illness and anxiety-related traits. |
1999-10-18 |
2023-08-12 |
human |
| E Hollande. Managing aggressive behavior in patients with obsessive-compulsive disorder and borderline personality disorder. The Journal of clinical psychiatry. vol 60 Suppl 15. 1999-07-30. PMID:10418814. |
mood stabilizers such as divalproex, selective serotonin reuptake inhibitors, monoamine oxidase inhibitors, and neuroleptics have documented efficacy in treating aggression and affective instability in impulsive patients. |
1999-07-30 |
2023-08-12 |
Not clear |
| F Bellisle, J E Blundell, L Dye, M Fantino, E Fern, R J Fletcher, J Lambert, M Roberfroid, S Specter, J Westenhöfer, M S Westerterp-Planteng. Functional food science and behaviour and psychological functions. The British journal of nutrition. vol 80 Suppl 1. 1998-12-15. PMID:9849358. |
the effects of food components on activation, sedation, and affective states such as dysphoria are also reviewed, with special attention given to brain function and neuroactive substances such as serotonin and the endorphins. |
1998-12-15 |
2023-08-12 |
Not clear |
| K P Lesch, R Mössne. Genetically driven variation in serotonin uptake: is there a link to affective spectrum, neurodevelopmental, and neurodegenerative disorders? Biological psychiatry. vol 44. issue 3. 1998-11-06. PMID:9693390. |
genetically driven variation in serotonin uptake: is there a link to affective spectrum, neurodevelopmental, and neurodegenerative disorders? |
1998-11-06 |
2023-08-12 |
Not clear |
| L E Mayer, B T Wals. The use of selective serotonin reuptake inhibitors in eating disorders. The Journal of clinical psychiatry. vol 59 Suppl 15. 1998-10-27. PMID:9786308. |
the introduction of selective serotonin reuptake inhibitors (ssris), which are, in general, safer and more easily tolerated than conventional antidepressants, has had a profound effect on the treatment of affective illnesses and obsessive-compulsive disorder (ocd). |
1998-10-27 |
2023-08-12 |
Not clear |
| A Neumeister, N Praschak-Rieder, B Hesselmann, O Vitouch, M Rauh, A Barocka, S Kaspe. Effects of tryptophan depletion in fully remitted patients with seasonal affective disorder during summer. Psychological medicine. vol 28. issue 2. 1998-08-06. PMID:9572083. |
deficiencies in brain serotonin function are believed to play an important role in the pathophysiology of seasonal affective disorder/winter type (sad). |
1998-08-06 |
2023-08-12 |
Not clear |
| J F López, D M Vázquez, D T Chalmers, S J Watso. Regulation of 5-HT receptors and the hypothalamic-pituitary-adrenal axis. Implications for the neurobiology of suicide. Annals of the New York Academy of Sciences. vol 836. 1998-06-24. PMID:9616796. |
if indeed 5-ht receptors have a partial role in controlling affective states, then their modulation by corticosteroids provides a potential mechanism by which these hormones may regulate mood. |
1998-06-24 |
2023-08-12 |
rat |
| U Voderholzer, M Hornyak, B Thiel, C Huwig-Poppe, A Kiemen, A König, J Backhaus, D Riemann, M Berger, F Hohage. Impact of experimentally induced serotonin deficiency by tryptophan depletion on sleep EEG in healthy subjects. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 18. issue 2. 1998-02-12. PMID:9430135. |
because serotonin is involved in sleep regulation and the regulation of affective states, we studied the acute polysomnographic effects of tryptophan depletion and expected to induce similar changes of sleep eeg as observed in depressed patients. |
1998-02-12 |
2023-08-12 |
human |
| L Dye, J E Blundel. Menstrual cycle and appetite control: implications for weight regulation. Human reproduction (Oxford, England). vol 12. issue 6. 1997-09-24. PMID:9221991. |
fluctuations in appetite, cravings and energy intake during the menstrual cycle may occur in parallel with cyclical rhythms in serotonin, which can be accompanied by affective symptoms. |
1997-09-24 |
2023-08-12 |
Not clear |
| J L Yau, J Noble, J R Seck. Site-specific regulation of corticosteroid and serotonin receptor subtype gene expression in the rat hippocampus following 3,4-methylenedioxymethamphetamine: role of corticosterone and serotonin. Neuroscience. vol 78. issue 1. 1997-08-01. PMID:9135093. |
abnormal interactions between serotonin (5-hydroxytryptamine) and glucocorticoids, notably in the hippocampus, may underpin neuroendocrine, affective and cognitive dysfunction in depression and ageing. |
1997-08-01 |
2023-08-12 |
rat |
| D A Collier, G Stöber, T Li, A Heils, M Catalano, D Di Bella, M J Arranz, R M Murray, H P Vallada, D Bengel, C R Müller, G W Roberts, E Smeraldi, G Kirov, P Sham, K P Lesc. A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders. Molecular psychiatry. vol 1. issue 6. 1997-06-09. PMID:9154246. |
biochemical studies in suicides and depressed patients suggest that 5-ht uptake function is frequently reduced in affective illness. |
1997-06-09 |
2023-08-12 |
Not clear |
| L Pollak, C Klein, J M Rabey, J Schiffe. Posterior fossa lesions associated with neuropsychiatric symptomatology. The International journal of neuroscience. vol 87. issue 3-4. 1997-04-29. PMID:9003973. |
derangement in the balance of dopamine, serotonin and noradrenergic networks has been implicated in the pathogenesis of schizophrenia, affective and even personality disorders. |
1997-04-29 |
2023-08-12 |
Not clear |
| R Sandy. Suicidal behavior is attenuated in patients with multiple sclerosis by treatment with electromagnetic fields. The International journal of neuroscience. vol 87. issue 1-2. 1997-02-21. PMID:8913816. |
previous studies have demonstrated that extracerebral applications of pulsed electromagnetic fields (emfs) in the picotesla range rapidly improved motor, sensory, affective and cognitive deficits in ms. augmentation of cerebral 5-ht synthesis and resynchronization of circadian melatonin secretion has been suggested as a key mechanism by which these emfs improved symptoms of the disease. |
1997-02-21 |
2023-08-12 |
Not clear |
| F Lebert, F Pasquier, H Peti. Behavioral effects of trazodone in Alzheimer's disease. The Journal of clinical psychiatry. vol 55. issue 12. 1995-02-07. PMID:7814348. |
central serotonin depletion may contribute to the anxiety, restlessness, irritability, and affective disturbance seen in a variety of psychiatric conditions, particularly dementia of the alzheimer's type (dat) in which brain concentrations of both 5-hydroxytryptamine (5-ht) and its 5-hydroxyindoleacetic acid (5-hiaa) metabolite are reduced. |
1995-02-07 |
2023-08-12 |
Not clear |
| K Thies-Flechtner, I Weigel, B Müller-Oerlinghause. 5-HT uptake in platelets of lithium-treated patients with affective disorders and of healthy controls. Pharmacopsychiatry. vol 27 Suppl 1. 1995-01-04. PMID:7984700. |
the effect of longterm lithium treatment (> 2 years of continuous therapy) on 5-ht uptake of 37 euthymic affective patients without relevant additional medication was investigated. |
1995-01-04 |
2023-08-12 |
Not clear |
| B A Faraj, Z L Olkowski, R T Jackso. Expression of a high-affinity serotonin transporter in human lymphocytes. International journal of immunopharmacology. vol 16. issue 7. 1994-11-08. PMID:7928004. |
the expression of a 5-ht transporter in human lymphocytes that resembles 5-ht uptake by platelets and brain synaptosomes may provide insights into the potential role of 5-ht in immune function and its relationship to the neurobiology of affective and addictive disorders. |
1994-11-08 |
2023-08-12 |
human |