| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zeyang Chen, Jinxia Huang, Joanne Kwak-Kim, Wenjuan Wan. Immune checkpoint inhibitors and reproductive failures. Journal of reproductive immunology. vol 156. 2023-02-01. PMID:36724630. |
briefly, 1) ctla-4 can weaken t cell receptor (tcr) signals and inhibit t cell response; 2) the pd-1/pd-l1 pathway can reduce t cell proliferation, enhance t cell anergy and fatigue, reduce cytokine production, and increase t regulatory cell activity to complete the immunosuppression; 3) tim3 interacts with t cells by binding gal-9, weakening th1 cell-mediated immunity and t cell apoptosis; 4) the lag-3 binding to mhc ii can inhibit t cell activation by interfering with the binding of cd4 to mhc ii, and; 5) tigit can release inhibitory signals to nk and t cells through the itim structure of its cytoplasmic tail. |
2023-02-01 |
2023-08-14 |
human |
| Yuting Su, Fan Yang, Mingfu Wang, Peter C K Cheun. Cancer immunotherapeutic effect of carboxymethylated β-d-glucan coupled with iron oxide nanoparticles via reprogramming tumor-associated macrophages. International journal of biological macromolecules. 2022-12-25. PMID:36566807. |
cmptr/ionps treatment also promoted apoptosis in cancer cells and increased the infiltration of cd4 and cd8 t-lymphocytes in tumor tissues. |
2022-12-25 |
2023-08-14 |
mouse |
| Jian Hu, Zhen Huang, Min Yu, Pei Zhang, Zhengkun Xia, Chunlin Ga. Caspase-8 activation in neutrophils facilitates autoimmune kidney vasculitis through regulating CD4 Frontiers in immunology. vol 13. 2022-12-12. PMID:36505410. |
caspase-8 activation in neutrophils facilitates autoimmune kidney vasculitis through regulating cd4 anti-neutrophil cytoplasmic antibody (anca)-associated vasculitides (aavs) are closely associated with neutrophil recruitment and activation, but the impact of the neutrophil apoptosis process in autoimmune disease has been rarely explained. |
2022-12-12 |
2023-08-14 |
mouse |
| Xindi Dang, Dechao Cao, Juan Zhao, Madison Schank, Sushant Khanal, Lam Ngoc Thao Nguyen, Xiao Y Wu, Yi Zhang, Jinyu Zhang, Yong Jiang, Shunbin Ning, Ling Wang, Mohamed El Gazzar, Jonathan P Moorman, Zhi Q Ya. Mitochondrial topoisomerase 1 inhibition induces topological DNA damage and T cell dysfunction in patients with chronic viral infection. Frontiers in cellular and infection microbiology. vol 12. 2022-11-21. PMID:36405960. |
moreover, treatment of cd4 t cells from hcv or hiv patients with cpt further increased cellular and mitochondrial reactive oxygen species (ros) production and cell apoptosis, demonstrating a critical role for top1 in preventing mtdna damage and cell death. |
2022-11-21 |
2023-08-14 |
Not clear |
| Sonia André, Marne Azarias da Silva, Morgane Picard, Aurélie Alleaume-Buteau, Lucy Kundura, Renaud Cezar, Calaiselvy Soudaramourty, Santa Cruz André, Ana Mendes-Frias, Alexandre Carvalho, Carlos Capela, Jorge Pedrosa, António Gil Castro, Paul Loubet, Albert Sotto, Laurent Muller, Jean-Yves Lefrant, Claire Roger, Pierre-Géraud Claret, Sandra Duvnjak, Tu-Anh Tran, Ouafa Zghidi-Abouzid, Pierre Nioche, Ricardo Silvestre, Pierre Corbeau, Fabrizio Mammano, Jérôme Estaquie. Low quantity and quality of anti-spike humoral response is linked to CD4 T-cell apoptosis in COVID-19 patients. Cell death & disease. vol 13. issue 8. 2022-08-27. PMID:36030261. |
low quantity and quality of anti-spike humoral response is linked to cd4 t-cell apoptosis in covid-19 patients. |
2022-08-27 |
2023-08-14 |
Not clear |
| Sonia André, Marne Azarias da Silva, Morgane Picard, Aurélie Alleaume-Buteau, Lucy Kundura, Renaud Cezar, Calaiselvy Soudaramourty, Santa Cruz André, Ana Mendes-Frias, Alexandre Carvalho, Carlos Capela, Jorge Pedrosa, António Gil Castro, Paul Loubet, Albert Sotto, Laurent Muller, Jean-Yves Lefrant, Claire Roger, Pierre-Géraud Claret, Sandra Duvnjak, Tu-Anh Tran, Ouafa Zghidi-Abouzid, Pierre Nioche, Ricardo Silvestre, Pierre Corbeau, Fabrizio Mammano, Jérôme Estaquie. Low quantity and quality of anti-spike humoral response is linked to CD4 T-cell apoptosis in COVID-19 patients. Cell death & disease. vol 13. issue 8. 2022-08-27. PMID:36030261. |
finally, we found lower s-flow responses in patients with higher cd4 t-cell apoptosis. |
2022-08-27 |
2023-08-14 |
Not clear |
| Sonia André, Marne Azarias da Silva, Morgane Picard, Aurélie Alleaume-Buteau, Lucy Kundura, Renaud Cezar, Calaiselvy Soudaramourty, Santa Cruz André, Ana Mendes-Frias, Alexandre Carvalho, Carlos Capela, Jorge Pedrosa, António Gil Castro, Paul Loubet, Albert Sotto, Laurent Muller, Jean-Yves Lefrant, Claire Roger, Pierre-Géraud Claret, Sandra Duvnjak, Tu-Anh Tran, Ouafa Zghidi-Abouzid, Pierre Nioche, Ricardo Silvestre, Pierre Corbeau, Fabrizio Mammano, Jérôme Estaquie. Low quantity and quality of anti-spike humoral response is linked to CD4 T-cell apoptosis in COVID-19 patients. Cell death & disease. vol 13. issue 8. 2022-08-27. PMID:36030261. |
altogether, these results demonstrate that individuals with high levels of cd4 t-cell apoptosis and cxcl10 have a poor ability to build an efficient anti-s response. |
2022-08-27 |
2023-08-14 |
Not clear |
| Xuan He, Malika Aid, John D Ventura, Erica Borducchi, Michelle Lifton, Jinyan Liu, Dan H Barouc. Rapid Loss of CD4 T Cells by Pyroptosis during Acute SIV Infection in Rhesus Macaques. Journal of virology. 2022-08-24. PMID:36000842. |
in contrast, caspase-3-mediated apoptosis and viral cytotoxicity only accounted for a small fraction of cd4 t cell death. |
2022-08-24 |
2023-08-14 |
Not clear |
| Fan Yang, Leyu Zhou, Yi Shen, Shenglan Zhao, Yanyi Zheng, Ruoting Men, Xiaoli Fan, Li Yan. Metabolic heterogeneity caused by HLA-DRB1*04:05 and protective effect of inosine on autoimmune hepatitis. Frontiers in immunology. vol 13. 2022-08-22. PMID:35990653. |
the results showed that inosine treatment attenuated hepatocyte apoptosis, enhanced antioxidant ability and inhibited the activation and glycolysis of cd4 |
2022-08-22 |
2023-08-14 |
human |
| Hao Wang, Jianwei Chen, Guangxu Bai, Wen Han, Ran Guo, Na Cu. mTOR Modulates the Endoplasmic Reticulum Stress-Induced CD4 Mediators of inflammation. vol 2022. 2022-08-02. PMID:35915740. |
mtor modulates the endoplasmic reticulum stress-induced cd4 when sepsis attacks the body, the excessive reactive oxygen species (ros) production can result to endoplasmic reticulum stress (ers) and eventually cause lymphocyte apoptosis. |
2022-08-02 |
2023-08-14 |
Not clear |
| Hao Wang, Jianwei Chen, Guangxu Bai, Wen Han, Ran Guo, Na Cu. mTOR Modulates the Endoplasmic Reticulum Stress-Induced CD4 Mediators of inflammation. vol 2022. 2022-08-02. PMID:35915740. |
the mammalian target of rapamycin (mtor) is essential for regulating lymphocyte apoptosis; we hypothesized that it mediates cd4 |
2022-08-02 |
2023-08-14 |
Not clear |
| Jianwei Chen, Hao Wang, Ran Guo, Haolong Li, Na Cu. Early Expression of Functional Markers on CD4 Frontiers in immunology. vol 13. 2022-07-28. PMID:35898496. |
early expression of functional markers on cd4 there is evidence that metabolic disorder, dysfunction and abnormal apoptosis of immune cells are closely related to immunosuppression in sepsis. |
2022-07-28 |
2023-08-14 |
Not clear |
| Yasmeen A Albalawi, Srinivas D Narasipura, Lena Al-Harth. Wnt/β-Catenin Protects Lymphocytes from HIV-Mediated Apoptosis via Induction of Bcl-xL. Viruses. vol 14. issue 7. 2022-07-27. PMID:35891449. |
we specifically investigated the role of the wnt/β-catenin pathway in the hiv-associated apoptosis of cd4+ t cells and cd4 |
2022-07-27 |
2023-08-14 |
Not clear |
| Jin-Lei Sun, Tai-Biao Lyu, Zhi-Lei Chen, Chao-Feng Lian, Su-Ying Liu, Ti-Hong Shao, Shuo Zhang, Li-Ling Zhao, Jin-Jing Liu, Lin-Yi Peng, Li Zhang, Yun-Jiao Yang, Feng-Chun Zhang, Hua Che. Methylprednisolone pulse therapy promotes the differentiation of regulatory T cells by inducing the apoptosis of CD4 Clinical immunology (Orlando, Fla.). 2022-07-16. PMID:35842211. |
methylprednisolone pulse therapy promotes the differentiation of regulatory t cells by inducing the apoptosis of cd4 to investigate the differentiation of regulatory t cells (tregs) induced by methylprednisolone (mp) pulse therapy in patients with systemic lupus erythematosus (sle). |
2022-07-16 |
2023-08-14 |
Not clear |
| Guangxu Bai, Hao Wang, Na Cu. mTOR pathway mediates endoplasmic reticulum stress-induced CD4 Apoptosis : an international journal on programmed cell death. 2022-06-27. PMID:35759162. |
mtor pathway mediates endoplasmic reticulum stress-induced cd4 endoplasmic reticulum stress (ers) has been well documented to participate in the pathophysiological processes of apoptosis in many diseases. |
2022-06-27 |
2023-08-14 |
mouse |
| Yanling Wang, Wei Liu, Miaomiao Liu, Hongxian Wang, Lin Zhou, Jian Chen, Hao Sun, Xihang Wei, Meihua Fan, Mingru Yang, Zhi'ang Liu, Zishan Yang, Jiateng Zhong, Chengbiao Lu, Tiesuo Zhao, Huijie Ji. Nifuroxazide in combination with CpG ODN exerts greater efficacy against hepatocellular carcinoma. International immunopharmacology. vol 108. 2022-06-22. PMID:35729838. |
moreover, combined nifuroxazide and cpg odn therapy significantly induced apoptosis, enhanced the infiltration of cd4 |
2022-06-22 |
2023-08-14 |
mouse |
| Xue Yao, Yi Wu, Tengfei Xiao, Chuanxiang Zhao, Fengwei Gao, Shuo Liu, Zehua Tao, Yalan Jiang, Shaodan Chen, Jun Ye, Hua Chen, Qiaoming Long, Hui Wang, Xiaoming Zhou, Qixiang Shao, Ling Qi, Sheng Xi. T-cell-specific Sel1L deletion exacerbates EAE by promoting Th1/Th17-cell differentiation. Molecular immunology. vol 149. 2022-06-13. PMID:35696849. |
moreover, sel1l deficiency promoted the differentiation of th1 and th17 cells and upregulated the proliferation and apoptosis of cd4 t cells in vitro. |
2022-06-13 |
2023-08-14 |
mouse |
| Xue Yao, Yi Wu, Tengfei Xiao, Chuanxiang Zhao, Fengwei Gao, Shuo Liu, Zehua Tao, Yalan Jiang, Shaodan Chen, Jun Ye, Hua Chen, Qiaoming Long, Hui Wang, Xiaoming Zhou, Qixiang Shao, Ling Qi, Sheng Xi. T-cell-specific Sel1L deletion exacerbates EAE by promoting Th1/Th17-cell differentiation. Molecular immunology. vol 149. 2022-06-13. PMID:35696849. |
regarding the mechanism analyzed by rna sequencing, 437 downregulated genes and 271 upregulated genes were detected in sel1l deletion cd4 t cells, which covered the activation, proliferation, differentiation and apoptosis of these t cells. |
2022-06-13 |
2023-08-14 |
mouse |
| Ying-Xian Liu, Yan-Jun Song, Xiao-Hang Liu, Si-Chi Xu, Chang Kong, Lian-Feng Chen, Hao Qian, Wei W. PD-1 inhibitor induces myocarditis by reducing regulatory T cells, activating inflammatory responses, promoting myocardial apoptosis and autophagy. Cytokine. vol 157. 2022-06-12. PMID:35691121. |
the expression level of pd-1 and regulatory t cells (tregs), cd4, cd8 + t cells, inflammation, apoptosis and autophagy-related factors, including il-6, tgf-β, ama-m2, fas/fasl, lc3 and p62 were detected in peripheral blood, muscle or myocardium of mice in each group, using elisa, rt-pcr, western blot and immunofluorescence. |
2022-06-12 |
2023-08-14 |
mouse |
| Hiroyuki Arai, Hideaki Kouzaki, Takuya Murao, Keigo Nakamura, Kento Kawakita, Koji Matsumoto, Hirotaka Kikuoka, Atsushi Yuta, Takeshi Shimiz. Sublingual immunotherapy with Japanese cedar pollen extract induces apoptosis of memory CD4 Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2022-06-08. PMID:35675128. |
sublingual immunotherapy with japanese cedar pollen extract induces apoptosis of memory cd4 |
2022-06-08 |
2023-08-14 |
Not clear |