| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Thomas, T Giesler, E Whit. p53 mediates bcl-2 phosphorylation and apoptosis via activation of the Cdc42/JNK1 pathway. Oncogene. vol 19. issue 46. 2000-11-21. PMID:11077443. |
furthermore, stable expression of a dominant-negative mutant of cdc42 partially inhibited p53-mediated apoptosis. |
2000-11-21 |
2023-08-12 |
rat |
| A Thomas, T Giesler, E Whit. p53 mediates bcl-2 phosphorylation and apoptosis via activation of the Cdc42/JNK1 pathway. Oncogene. vol 19. issue 46. 2000-11-21. PMID:11077443. |
thus, one mechanism by which p53 promotes apoptosis is through activation of cdc42 and inactivation of bcl-2. |
2000-11-21 |
2023-08-12 |
rat |
| M C Subauste, M Von Herrath, V Benard, C E Chamberlain, T H Chuang, K Chu, G M Bokoch, K M Hah. Rho family proteins modulate rapid apoptosis induced by cytotoxic T lymphocytes and Fas. The Journal of biological chemistry. vol 275. issue 13. 2000-05-04. PMID:10734125. |
activated mutants of each gtpase increased susceptibility to apoptosis, and activation of cdc42 increased within 5 min of fas stimulation. |
2000-05-04 |
2023-08-12 |
Not clear |
| S Na, B Li, I S Grewal, H Enslen, R J Davis, J H Hanke, R A Flavel. Expression of activated CDC42 induces T cell apoptosis in thymus and peripheral lymph organs via different pathways. Oncogene. vol 18. issue 56. 2000-02-04. PMID:10637507. |
expression of activated cdc42 induces t cell apoptosis in thymus and peripheral lymph organs via different pathways. |
2000-02-04 |
2023-08-12 |
mouse |
| T Kanamoto, M Mota, K Takeda, L L Rubin, K Miyazono, H Ichijo, C E Bazene. Role of apoptosis signal-regulating kinase in regulation of the c-Jun N-terminal kinase pathway and apoptosis in sympathetic neurons. Molecular and cellular biology. vol 20. issue 1. 2000-01-10. PMID:10594022. |
we have previously shown that nerve growth factor (ngf) withdrawal-induced death requires the activity of the small gtp-binding protein cdc42 and that overexpression of an active form of cdc42 is sufficient to mediate neuronal apoptosis via activation of the c-jun pathway. |
2000-01-10 |
2023-08-12 |
rat |
| b' V Leblanc, I Delumeau, B Tocqu\\xc3\\xa. Ras-GTPase activating protein inhibition specifically induces apoptosis of tumour cells. Oncogene. vol 18. issue 34. 1999-10-12. PMID:10490822.' |
mab200-induced apoptosis is largely prevented by coinjection of activated rhoa or cdc42 proteins, by injection of a constitutively activated mutant of phosphoinositide 3-oh kinase (pi3-k), but not by injection of v-raf. |
1999-10-12 |
2023-08-12 |
mouse |
| J P Moorman, D Luu, J Wickham, D A Bobak, C S Hah. A balance of signaling by Rho family small GTPases RhoA, Rac1 and Cdc42 coordinates cytoskeletal morphology but not cell survival. Oncogene. vol 18. issue 1. 1999-02-26. PMID:9926919. |
this signaling, however, is not affected by expression of any forms of rac1 or cdc42, and only inactivation of rho led to induction of apoptosis. |
1999-02-26 |
2023-08-12 |
Not clear |
| K Nishida, Y Kaziro, T Sato. Anti-apoptotic function of Rac in hematopoietic cells. Oncogene. vol 18. issue 2. 1999-02-16. PMID:9927197. |
activated rac(g12v), when ectopically expressed in baf3 cells, rendered the cells resistant to apoptosis upon interleukin-3 deprivation, while activated mutants of rho and cdc42 displayed no significant anti-apoptotic effect. |
1999-02-16 |
2023-08-12 |
cattle |
| C E Bazenet, M A Mota, L L Rubi. The small GTP-binding protein Cdc42 is required for nerve growth factor withdrawal-induced neuronal death. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 7. 1998-05-01. PMID:9520479. |
overexpression of activated rac1 or cdc42 in scg neurons maintained in the presence of ngf induced apoptosis, whereas expression of dominant negative mutants of cdc42 or rac1 blocked apoptosis following ngf withdrawal. |
1998-05-01 |
2023-08-12 |
rat |
| T H Chuang, K M Hahn, J D Lee, D E Danley, G M Bokoc. The small GTPase Cdc42 initiates an apoptotic signaling pathway in Jurkat T lymphocytes. Molecular biology of the cell. vol 8. issue 9. 1997-12-04. PMID:9307966. |
when expressed in jurkat t cells, an activated form of the small gtpase cdc42 induces cell death exhibiting the characteristics of apoptosis. |
1997-12-04 |
2023-08-12 |
Not clear |
| T H Chuang, K M Hahn, J D Lee, D E Danley, G M Bokoc. The small GTPase Cdc42 initiates an apoptotic signaling pathway in Jurkat T lymphocytes. Molecular biology of the cell. vol 8. issue 9. 1997-12-04. PMID:9307966. |
apoptosis initiated by cdc42 is inhibited by dominant negative components of the jnk cascade and by reagents that block activity of the ice protease (caspase) family, suggesting that stimulation of the jnk kinase cascade can lead to caspase activation. |
1997-12-04 |
2023-08-12 |
Not clear |