| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fernando Martín-Belmonte, Wei Yu, Alejo E Rodríguez-Fraticelli, Andrew J Ewald, Andrew Ewald, Zena Werb, Miguel A Alonso, Keith Mosto. Cell-polarity dynamics controls the mechanism of lumen formation in epithelial morphogenesis. Current biology : CB. vol 18. issue 7. 2008-07-31. PMID:18394894. |
if polarization in matrigel was perturbed by blocking formation of the apical surface by rnai of cdc42, lumens formed by apoptosis. |
2008-07-31 |
2023-08-12 |
Not clear |
| Celio A Marques, Patricia S Hähnel, Catherine Wölfel, Sonja Thaler, Christoph Huber, Matthias Theobald, Martin Schule. An immune escape screen reveals Cdc42 as regulator of cancer susceptibility to lymphocyte-mediated tumor suppression. Blood. vol 111. issue 3. 2008-03-26. PMID:17971488. |
cdc42 prevents ctl-induced apoptosis via mitogen-activated protein kinase (mapk) signaling and posttranscriptional stabilization of bcl-2. |
2008-03-26 |
2023-08-12 |
Not clear |
| Luis E Arias-Romero, Jonathan Chernof. A tale of two Paks. Biology of the cell. vol 100. issue 2. 2008-02-12. PMID:18199048. |
paks (p21-activated kinases) are effectors for the small gtpases cdc42 (cell division cycle 42) and rac that play fundamental roles in a wide range of cellular processes, including cell morphology, motility, survival, gene transcription, apoptosis and hormone signalling. |
2008-02-12 |
2023-08-12 |
Not clear |
| Fuguo Wu, Yirong Chen, Yuan Li, Jun Ju, Zhiping Wang, Dongwen Ya. RNA-interference-mediated Cdc42 silencing down-regulates phosphorylation of STAT3 and suppresses growth in human bladder-cancer cells. Biotechnology and applied biochemistry. vol 49. issue Pt 2. 2008-02-04. PMID:17705801. |
moreover, rnai-mediated inhibition of cdc42 induced apoptosis of ej cells 96 h after transfection. |
2008-02-04 |
2023-08-12 |
human |
| M Menotta, A Amicucci, G Basili, F Rivero, E Polidori, D Sisti, V Stocch. Molecular characterisation of the small GTPase CDC42 in the ectomycorrhizal fungus Tuber borchii Vittad. Protoplasma. vol 231. issue 3-4. 2008-01-09. PMID:17762910. |
the small gtpase cdc42 is ubiquitously expressed in eukaryotes, where it participates in the regulation of the cytoskeleton and a wide range of cellular processes, including cytokinesis, gene expression, cell cycle progression, apoptosis, and tumorigenesis. |
2008-01-09 |
2023-08-12 |
Not clear |
| Eric Selva, Patrick Brest, Agnès Loubat, Sandra Lassalle, Patrick Auberger, Paul Hofma. Inhibition of apoptosis induced by heat shock preconditioning is associated with decreased phagocytosis in human polymorphonuclear leukocytes through inhibition of Rac and Cdc42. Immunology and cell biology. vol 85. issue 3. 2007-11-08. PMID:17228324. |
inhibition of apoptosis induced by heat shock preconditioning is associated with decreased phagocytosis in human polymorphonuclear leukocytes through inhibition of rac and cdc42. |
2007-11-08 |
2023-08-12 |
human |
| Yogesh C Awasthi, Rajendra Sharma, Sushma Yadav, Seema Dwivedi, Abha Sharma, Sanjay Awasth. The non-ABC drug transporter RLIP76 (RALBP-1) plays a major role in the mechanisms of drug resistance. Current drug metabolism. vol 8. issue 4. 2007-07-13. PMID:17504221. |
rlip76 displays inhibitory gtpase activity toward rho/rac class g-protein cdc42 which is involved in regulation of cytoskeletal organization, lamellipodia, cell migration and apoptosis via ras. |
2007-07-13 |
2023-08-12 |
mouse |
| Xiang-Shun Cui, Xing-Yu Li, Nam-Hyung Ki. Cdc42 is implicated in polarity during meiotic resumption and blastocyst formation in the mouse. Molecular reproduction and development. vol 74. issue 6. 2007-06-20. PMID:17154294. |
cell division cycle 42 (cdc42), a member of the rho family of small guanosine triphosphatase (gtpase) proteins, regulates multiple cell functions, including: motility, proliferation, apoptosis, and cell morphology. |
2007-06-20 |
2023-08-12 |
mouse |
| Jie Zhao, Dong-Sheng Pei, Quan-Guang Zhang, Guang-Yi Zhan. Down-regulation Cdc42 attenuates neuronal apoptosis through inhibiting MLK3/JNK3 cascade during ischemic reperfusion in rat hippocampus. Cellular signalling. vol 19. issue 4. 2007-04-18. PMID:17161586. |
down-regulation cdc42 attenuates neuronal apoptosis through inhibiting mlk3/jnk3 cascade during ischemic reperfusion in rat hippocampus. |
2007-04-18 |
2023-08-12 |
rat |
| Jie Zhao, Dong-Sheng Pei, Quan-Guang Zhang, Guang-Yi Zhan. Down-regulation Cdc42 attenuates neuronal apoptosis through inhibiting MLK3/JNK3 cascade during ischemic reperfusion in rat hippocampus. Cellular signalling. vol 19. issue 4. 2007-04-18. PMID:17161586. |
taken together, our findings strongly suggest that cdc42 serves as an upstream activator and modulates jnk-mediated apoptosis machinery in vivo, which ultimately results in neuronal apoptosis via nuclear and non-nuclear pathways. |
2007-04-18 |
2023-08-12 |
rat |
| Johannes Huelsenbeck, Stefanie Dreger, Ralf Gerhard, Holger Barth, Ingo Just, Harald Gent. Difference in the cytotoxic effects of toxin B from Clostridium difficile strain VPI 10463 and toxin B from variant Clostridium difficile strain 1470. Infection and immunity. vol 75. issue 2. 2007-03-08. PMID:17145947. |
glucosylation of rhoa, rac1, and cdc42 by clostridium difficile toxin b from strain vpi 10463 (tcdb) results in actin reorganization (cytopathic effect) and apoptosis (cytotoxic effect). |
2007-03-08 |
2023-08-12 |
rat |
| Xunwei Wu, Fabio Quondamatteo, Cord Brakebusc. Cdc42 expression in keratinocytes is required for the maintenance of the basement membrane in skin. Matrix biology : journal of the International Society for Matrix Biology. vol 25. issue 8. 2007-02-27. PMID:17049825. |
cdc42 is a small gtpase, which acts as a molecular switch to regulate a wide variety of cellular functions, such as actin cytoskeleton organization, cell proliferation, apoptosis, cell migration and in particular, cell polarity. |
2007-02-27 |
2023-08-12 |
mouse |
| Florencia Meyer, Sandra Perez, Vicki Geiser, Mark Sintek, Melissa Inman, Clinton Jone. A protein encoded by the bovine herpesvirus 1 latency-related gene interacts with specific cellular regulatory proteins, including CCAAT enhancer binding protein alpha. Journal of virology. vol 81. issue 1. 2007-02-12. PMID:16987965. |
the lr fusion protein interacts with two proteins that can induce apoptosis (bid and cdc42) and with ccaat enhancer binding protein alpha (c/ebp-alpha). |
2007-02-12 |
2023-08-12 |
human |
| Dunja Knapp, Nigel Messenger, Amer Ahmed Rana, James C Smit. Neurotrophin receptor homolog (NRH1) proteins regulate mesoderm formation and apoptosis during early Xenopus development. Developmental biology. vol 300. issue 2. 2007-02-07. PMID:17055478. |
apoptosis is delayed by injection of xbra rna, suggesting that cell death is a consequence, at least in part, of the down-regulation of this gene, and it is also delayed by expression of activated forms of rho, rac and cdc42. |
2007-02-07 |
2023-08-12 |
xenopus_laevis |
| Shu-Ling Liang, Hongli Liu, Aimin Zho. Lovastatin-induced apoptosis in macrophages through the Rac1/Cdc42/JNK pathway. Journal of immunology (Baltimore, Md. : 1950). vol 177. issue 1. 2006-08-09. PMID:16785563. |
further investigation of the molecular mechanism has revealed that rac1 and cdc42, the small gtpase family members, may play an important role in lovastatin-induced macrophage apoptosis. |
2006-08-09 |
2023-08-12 |
Not clear |
| Harald Genth, Johannes Huelsenbeck, Birgit Hartmann, Fred Hofmann, Ingo Just, Ralf Gerhar. Cellular stability of Rho-GTPases glucosylated by Clostridium difficile toxin B. FEBS letters. vol 580. issue 14. 2006-07-27. PMID:16730714. |
cellular stability of rho-gtpases glucosylated by clostridium difficile toxin b. mono-glucosylation of rho, rac, and cdc42 by clostridium difficile toxin b (tcdb) induces changes of actin dynamics and apoptosis. |
2006-07-27 |
2023-08-12 |
Not clear |
| Lei Wang, Linda Yang, Kevin Burns, Chia-Yi Kuan, Yi Zhen. Cdc42GAP regulates c-Jun N-terminal kinase (JNK)-mediated apoptosis and cell number during mammalian perinatal growth. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 38. 2005-11-08. PMID:16157885. |
these results reveal a role of cdc42gap in mammalian perinatal growth and implicate the c-jun n-terminal kinase-mediated apoptosis machinery as a cdc42 effector pathway in vivo. |
2005-11-08 |
2023-08-12 |
mouse |
| Guoyan Wang, Frank Beie. Rac1/Cdc42 and RhoA GTPases antagonistically regulate chondrocyte proliferation, hypertrophy, and apoptosis. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 20. issue 6. 2005-10-03. PMID:15883643. |
here we show that the small gtpases, rac1 and cdc42, accelerate the rate of chondrocyte differentiation and apoptosis, thereby antagonizing the activity of rhoa. |
2005-10-03 |
2023-08-12 |
Not clear |
| Linda J Valentijn, Arjen Koppen, Ronald van Asperen, Heather A Root, Franciska Haneveld, Rogier Verstee. Inhibition of a new differentiation pathway in neuroblastoma by copy number defects of N-myc, Cdc42, and nm23 genes. Cancer research. vol 65. issue 8. 2005-06-03. PMID:15833843. |
further silencing of cdc42 by small interfering rna induced massive apoptosis, indicating that tumor cell survival requires a minimal cdc42 activity. |
2005-06-03 |
2023-08-12 |
human |
| Jen-Liang Su, Ming-Tsan Lin, Chih-Chen Hong, Cheng-Chi Chang, Shine-Gwo Shiah, Cheng-Wen Wu, Szu-Ta Chen, Yat-Pang Chau, Min-Liang Ku. Resveratrol induces FasL-related apoptosis through Cdc42 activation of ASK1/JNK-dependent signaling pathway in human leukemia HL-60 cells. Carcinogenesis. vol 26. issue 1. 2005-02-22. PMID:15217905. |
resveratrol induces fasl-related apoptosis through cdc42 activation of ask1/jnk-dependent signaling pathway in human leukemia hl-60 cells. |
2005-02-22 |
2023-08-12 |
human |