| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ambrish Kumar, Nadia Al-Sammarraie, Donald J DiPette, Ugra S Sing. Metformin impairs Rho GTPase signaling to induce apoptosis in neuroblastoma cells and inhibits growth of tumors in the xenograft mouse model of neuroblastoma. Oncotarget. vol 5. issue 22. 2015-09-24. PMID:25365944. |
infection of cells by adenoviruses expressing dominant negative rac1 (rac1-n17), cdc42 (cdc42-n17) or constitutively active rhoa (rhoa-v14), or incubation of cells with pharmacological inhibitors of rac1 (nsc23766) or cdc42 (ml141) significantly protected neuroblastoma cells from metformin-induced apoptosis. |
2015-09-24 |
2023-08-13 |
mouse |
| S Okamoto, Y Jiang, K Kawamura, M Shingyoji, Y Tada, I Sekine, Y Takiguchi, K Tatsumi, H Kobayashi, H Shimada, K Hiroshima, M Tagaw. Zoledronic acid induces apoptosis and S-phase arrest in mesothelioma through inhibiting Rab family proteins and topoisomerase II actions. Cell death & disease. vol 5. 2015-07-02. PMID:25393473. |
we further analyzed which small g proteins were responsible for the three zol-induced effects, caspase-mediated apoptosis, s-phase arrest and morphological changes, using inhibitors for respective small g proteins and sirna for cdc42. |
2015-07-02 |
2023-08-13 |
human |
| Trisha R Stankiewicz, Sai Anandi Ramaswami, Ron J Bouchard, Klaus Aktories, Daniel A Linsema. Neuronal apoptosis induced by selective inhibition of Rac GTPase versus global suppression of Rho family GTPases is mediated by alterations in distinct mitogen-activated protein kinase signaling cascades. The Journal of biological chemistry. vol 290. issue 15. 2015-06-26. PMID:25666619. |
we have shown previously that clostridium difficile toxin b (toxb), an inhibitor of rhoa, rac1, and cdc42, induces apoptosis of cerebellar granule neurons (cgns). |
2015-06-26 |
2023-08-13 |
Not clear |
| Ryo Aizawa, Atsushi Yamada, Dai Suzuki, Tadahiro Iimura, Hidetoshi Kassai, Takeshi Harada, Masayuki Tsukasaki, Gou Yamamoto, Tetsuhiko Tachikawa, Kazuki Nakao, Matsuo Yamamoto, Akira Yamaguchi, Atsu Aiba, Ryutaro Kamij. Cdc42 is required for chondrogenesis and interdigital programmed cell death during limb development. Mechanisms of development. vol 129. issue 1-4. 2014-09-08. PMID:22387309. |
cdc42, a member of the rho subfamily of small gtpases, is known to be a regulator of multiple cellular functions, including cytoskeletal organization, cell migration, proliferation, and apoptosis. |
2014-09-08 |
2023-08-12 |
mouse |
| Yu-ting Alex Chiang, Tianru Ji. p21-Activated protein kinases and their emerging roles in glucose homeostasis. American journal of physiology. Endocrinology and metabolism. vol 306. issue 7. 2014-05-30. PMID:24368667. |
their function as effectors of small gtpases rac1 and cdc42 has been extensively studied during the past two decades, particularly in the realms of cell proliferation, apoptosis, and hence tumorigenesis, as well as cytoskeletal remodeling and related cellular events in health and disease. |
2014-05-30 |
2023-08-12 |
mouse |
| Florian Lang, Else K Hoffman. Role of ion transport in control of apoptotic cell death. Comprehensive Physiology. vol 2. issue 3. 2013-12-13. PMID:23723032. |
signaling involved in the modification of cell-volume regulatory ion transport during apoptosis include mitogen-activated kinases p38, jnk, erk1/2, mekk1, mkk4, the small g proteins cdc42, and/or rac and the transcription factor p53. |
2013-12-13 |
2023-08-12 |
Not clear |
| Yixin Jin, Yang Liu, Qiong Lin, Jieli Li, Joseph E Druso, Marc A Antonyak, Cynthia J Meininger, Shenyuan L Zhang, David E Dostal, Jun-Lin Guan, Richard A Cerione, Xu Pen. Deletion of Cdc42 enhances ADAM17-mediated vascular endothelial growth factor receptor 2 shedding and impairs vascular endothelial cell survival and vasculogenesis. Molecular and cellular biology. vol 33. issue 21. 2013-12-09. PMID:23979594. |
notably, inhibition of adam17 or overexpression of vegfr2 can partially reverse cdc42 deletion-induced ec apoptosis. |
2013-12-09 |
2023-08-12 |
mouse |
| Yuefeng Li, Xiaolan Zhu, Wenlin Xu, Dongqing Wang, Jinchuan Ya. miR-330 regulates the proliferation of colorectal cancer cells by targeting Cdc42. Biochemical and biophysical research communications. vol 431. issue 3. 2013-08-27. PMID:23337504. |
ectopic expression of mir-330 down-regulated cdc42 expression at both protein and mrna level, mimicked the effect of cdc42 knockdown in inhibiting proliferation, inducing g1 cell cycle arrest and apoptosis of the colorectal cancer cells, whereas restoration of cdc42 could partially attenuate the effects of mir-330. |
2013-08-27 |
2023-08-12 |
human |
| Zheng Wu, Zhiyong Wu, Jun Li, Xiaomei Yang, Yahui Wang, Yi Yu, Jun Ye, Congjian Xu, Wenxin Qin, Zhigang Zhan. MCAM is a novel metastasis marker and regulates spreading, apoptosis and invasion of ovarian cancer cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 33. issue 5. 2012-12-26. PMID:22610942. |
after mcam silencing in the mcam high-expression ovarian cancer cell line skov-3, the cell apoptosis was increased, whereas the cell spreading and invasion were significantly reduced, which may be related with dysregulation of small rhogtpase (rhoa and cdc42).these results suggest that mcam expression in ovarian cancer is highly correlated with the metastatic potential of the cancer. |
2012-12-26 |
2023-08-12 |
Not clear |
| Nobuyuki Tachi, Yuichi Hashimoto, Masaaki Matsuok. MOCA is an integrator of the neuronal death signals that are activated by familial Alzheimer's disease-related mutants of amyloid β precursor protein and presenilins. The Biochemical journal. vol 442. issue 2. 2012-04-09. PMID:22115042. |
detailed molecular analysis indicates that moca is a key molecule of the ad-relevant neuronal death signals that links the ps-mediated death signal with the app-mediated death signal at a point between rac1 [or cdc42 (cell division cycle 42)] and ask1 (apoptosis signal-regulating kinase 1). |
2012-04-09 |
2023-08-12 |
Not clear |
| S R Heynen, N Tanimoto, S Joly, M W Seeliger, M Samardzija, C Grim. Retinal degeneration modulates intracellular localization of CDC42 in photoreceptors. Molecular vision. vol 17. 2012-04-02. PMID:22128240. |
rho gtpases such as ras-related c3 botulinum substrate 1 (rac1) and cell division cycle 42 homolog (s. cerevisiae; cdc42) have been linked to cellular processes including movement, development, and apoptosis. |
2012-04-02 |
2023-08-12 |
Not clear |
| R Deevi, A Fatehullah, I Jagan, M Nagaraju, V Bingham, F C Campbel. PTEN regulates colorectal epithelial apoptosis through Cdc42 signalling. British journal of cancer. vol 105. issue 9. 2011-12-14. PMID:21952626. |
pten regulates colorectal epithelial apoptosis through cdc42 signalling. |
2011-12-14 |
2023-08-12 |
Not clear |
| R Deevi, A Fatehullah, I Jagan, M Nagaraju, V Bingham, F C Campbel. PTEN regulates colorectal epithelial apoptosis through Cdc42 signalling. British journal of cancer. vol 105. issue 9. 2011-12-14. PMID:21952626. |
phosphatase and tensin homologue deleted on chromosome 10 (pten) regulation of the rho-like gtpase cdc42 has a central role in epithelial polarised growth, but effects of this molecular network on apoptosis remain unclear. |
2011-12-14 |
2023-08-12 |
Not clear |
| Fukun Guo, Shuangmin Zhang, Pulak Tripathi, Jochen Mattner, James Phelan, Alyssa Sproles, Jun Mo, Marsha Wills-Karp, H Leighton Grimes, David Hildeman, Yi Zhen. Distinct roles of Cdc42 in thymopoiesis and effector and memory T cell differentiation. PloS one. vol 6. issue 3. 2011-07-25. PMID:21455314. |
we found that in cdc42(-/-) thymus, positive selection of cd4(+)cd8(+) double-positive thymocytes was defective, cd4(+) and cd8(+) single-positive thymocytes were impaired in migration and showed an increase in cell apoptosis triggered by anti-cd3/-cd28 antibodies, and thymocytes were hyporesponsive to anti-cd3/-cd28-induced cell proliferation and hyperresponsive to anti-cd3/-cd28-stimulated map kinase activation. |
2011-07-25 |
2023-08-12 |
mouse |
| Ming Liu, Nan Lang, Xiangzhen Chen, Qiulin Tang, Surui Liu, Juan Huang, Yi Zheng, Feng B. miR-185 targets RhoA and Cdc42 expression and inhibits the proliferation potential of human colorectal cells. Cancer letters. vol 301. issue 2. 2011-02-28. PMID:21186079. |
similar to the effects of knocking down rhoa and/or cdc42 expression, mir-185 effectively inhibited proliferation, induced g1 cell cycle arrest and apoptosis, and blocked invasion of colorectal cancer cells. |
2011-02-28 |
2023-08-12 |
human |
| Yuji Ito, Steven L Teitelbaum, Wei Zou, Yi Zheng, James F Johnson, Jean Chappel, F Patrick Ross, Haibo Zha. Cdc42 regulates bone modeling and remodeling in mice by modulating RANKL/M-CSF signaling and osteoclast polarization. The Journal of clinical investigation. vol 120. issue 6. 2010-06-21. PMID:20501942. |
we further demonstrated that cdc42 modulated m-csf-stimulated cyclin d expression and phosphorylation of rb and induced caspase 3 and bim, thus contributing to osteoclast proliferation and apoptosis rates. |
2010-06-21 |
2023-08-12 |
mouse |
| Masatake Fujimura, Fusako Usuki, Masumi Sawada, William Rostene, David Godefroy, Akihiko Takashim. Methylmercury exposure downregulates the expression of Racl and leads to neuritic degeneration and ultimately apoptosis in cerebrocortical neurons. Neurotoxicology. vol 30. issue 1. 2009-04-13. PMID:19000711. |
to further investigate the factors responsible for neuronal death, we investigated the expression levels of rho-family proteins (rac1, cdc42, and rhoa), which regulate neuritic functions and apoptosis in neurons. |
2009-04-13 |
2023-08-12 |
rat |
| Chiara Ambrogio, Claudia Voena, Andrea D Manazza, Cinzia Martinengo, Carlotta Costa, Tomas Kirchhausen, Emilio Hirsch, Giorgio Inghirami, Roberto Chiarl. The anaplastic lymphoma kinase controls cell shape and growth of anaplastic large cell lymphoma through Cdc42 activation. Cancer research. vol 68. issue 21. 2008-12-08. PMID:18974134. |
in vitro knockdown of vav1 or cdc42 by short hairpin rna, as well as pharmacologic inhibition of cdc42 activity by secramine, resulted in a cell cycle arrest and apoptosis of alcl cells. |
2008-12-08 |
2023-08-12 |
Not clear |
| Chiara Ambrogio, Claudia Voena, Andrea D Manazza, Cinzia Martinengo, Carlotta Costa, Tomas Kirchhausen, Emilio Hirsch, Giorgio Inghirami, Roberto Chiarl. The anaplastic lymphoma kinase controls cell shape and growth of anaplastic large cell lymphoma through Cdc42 activation. Cancer research. vol 68. issue 21. 2008-12-08. PMID:18974134. |
importantly, the concomitant inhibition of cdc42 and npm-alk kinase acted synergistically to induce apoptosis of alcl cells. |
2008-12-08 |
2023-08-12 |
Not clear |
| Natalia Papadopoulou, Ioannis Charalampopoulos, Konstantinos Alevizopoulos, Achille Gravanis, Christos Stournara. Rho/ROCK/actin signaling regulates membrane androgen receptor induced apoptosis in prostate cancer cells. Experimental cell research. vol 314. issue 17. 2008-11-03. PMID:18694745. |
furthermore, dominant-negative rhoa, rhob or cdc42 mutants or pharmacological inhibitors of rock inhibited both actin organization and apoptosis in du145 cells. |
2008-11-03 |
2023-08-12 |
Not clear |