| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Tian, T Takasu, C Henk. Functional role of cyclin A on induction of fibroblast apoptosis due to ligation of CD44 matrix receptor by anti-CD44 antibody. Experimental cell research. vol 257. issue 1. 2000-07-06. PMID:10854061. |
functional role of cyclin a on induction of fibroblast apoptosis due to ligation of cd44 matrix receptor by anti-cd44 antibody. |
2000-07-06 |
2023-08-12 |
Not clear |
| B Tian, T Takasu, C Henk. Functional role of cyclin A on induction of fibroblast apoptosis due to ligation of CD44 matrix receptor by anti-CD44 antibody. Experimental cell research. vol 257. issue 1. 2000-07-06. PMID:10854061. |
disruption of cell surface matrix receptor interaction with the extracellular matrix can trigger apoptosis. |
2000-07-06 |
2023-08-12 |
Not clear |
| B Tian, T Takasu, C Henk. Functional role of cyclin A on induction of fibroblast apoptosis due to ligation of CD44 matrix receptor by anti-CD44 antibody. Experimental cell research. vol 257. issue 1. 2000-07-06. PMID:10854061. |
we have found that ligation of the cell surface matrix adhesion receptor cd44 by anti-cd44 antibody induces cell detachment and triggers apoptosis. |
2000-07-06 |
2023-08-12 |
Not clear |
| A B Fog. Glomerular hypertension, abnormal glomerular growth, and progression of renal diseases. Kidney international. Supplement. vol 75. 2000-06-27. PMID:10828756. |
the interplay of these factors determines the balance of cell growth and proliferation versus cell death by necrosis or apoptosis, and the balance of matrix accumulation versus degradation. |
2000-06-27 |
2023-08-12 |
Not clear |
| P Lassus, P Roux, O Zugasti, A Philips, P Fort, U Hibne. Extinction of rac1 and Cdc42Hs signalling defines a novel p53-dependent apoptotic pathway. Oncogene. vol 19. issue 20. 2000-06-14. PMID:10828879. |
we show here that upon detachment from the extracellular matrix, fibroblasts undergo rapid apoptosis that can be rescued by constitutive activation of rac1 and cdc42hs gtpases. |
2000-06-14 |
2023-08-12 |
Not clear |
| E Bergin, J S Levine, J S Koh, W Liebertha. Mouse proximal tubular cell-cell adhesion inhibits apoptosis by a cadherin-dependent mechanism. American journal of physiology. Renal physiology. vol 278. issue 5. 2000-06-12. PMID:10807587. |
adhesion of epithelial cells to matrix is known to inhibit apoptosis. |
2000-06-12 |
2023-08-12 |
mouse |
| M Gourley, J S Williamso. Angiogenesis: new targets for the development of anticancer chemotherapies. Current pharmaceutical design. vol 6. issue 4. 2000-06-02. PMID:10788590. |
strategies for exploiting tumor angiogenesis for novel cancer drug discovery include: (i) inhibition of proteolytic enzymes that breakdown the extracellular matrix surrounding existing capillaries; (ii) inhibition of endothelial cell migration; (iii) inhibition of endothelial cell proliferation; (iv) enhancement of tumor endothelial cell apoptosis. |
2000-06-02 |
2023-08-12 |
Not clear |
| M Segelmark, C Barrett, W Pendergraft, R Falk, G Presto. Expression of p300-truncated fragments results in the modulation of apoptosis in rat mesangial cells. Kidney international. vol 57. issue 5. 2000-06-01. PMID:10792606. |
mesangial cell proliferation, apoptosis, and matrix deposition have pivotal roles in the pathogenesis of renal diseases such as diabetic nephropathy and glomerulonephritis. |
2000-06-01 |
2023-08-12 |
rat |
| P Clézardin, J Gligorov, P Delma. Mechanisms of action of bisphosphonates on tumor cells and prospects for use in the treatment of malignant osteolysis. Joint bone spine. vol 67. issue 1. 2000-05-31. PMID:10773965. |
also, experimental evidence suggest that bisphosphonates act on the tumor cells themselves, either by inhibiting mechanisms involved in the development of bone metastasis (tumor invasion, adhesion of tumor cells to the bone matrix) or by inducing apoptosis of tumor cells. |
2000-05-31 |
2023-08-12 |
Not clear |
| R Zhao, K Gish, M Murphy, Y Yin, D Notterman, W H Hoffman, E Tom, D H Mack, A J Levin. Analysis of p53-regulated gene expression patterns using oligonucleotide arrays. Genes & development. vol 14. issue 8. 2000-05-31. PMID:10783169. |
of 6000 genes examined for p53 regulatory responses, 107 induced and 54 repressed genes fell into categories of apoptosis and growth arrest, cytoskeletal functions, growth factors and their inhibitors, extracellular matrix, and adhesion genes. |
2000-05-31 |
2023-08-12 |
Not clear |
| K Brew, D Dinakarpandian, H Nagas. Tissue inhibitors of metalloproteinases: evolution, structure and function. Biochimica et biophysica acta. vol 1477. issue 1-2. 2000-05-24. PMID:10708863. |
the two-domain timps are of relatively small size, yet have been found to exhibit several biochemical and physiological/biological functions, including inhibition of active mmps, prommp activation, cell growth promotion, matrix binding, inhibition of angiogenesis and the induction of apoptosis. |
2000-05-24 |
2023-08-12 |
Not clear |
| M S Anggraeni, L Owen. The haemocytic origin of lymphoid organ spheroid cells in the penaeid prawn Penaeus monodon. Diseases of aquatic organisms. vol 40. issue 2. 2000-05-23. PMID:10782341. |
an apoptosis detection assay showed that los cells were often apoptotic whilst stromal matrix cells were not. |
2000-05-23 |
2023-08-12 |
Not clear |
| K Rosen, J Rak, T Leung, N M Dean, R S Kerbel, J Filmu. Activated Ras prevents downregulation of Bcl-X(L) triggered by detachment from the extracellular matrix. A mechanism of Ras-induced resistance to anoikis in intestinal epithelial cells. The Journal of cell biology. vol 149. issue 2. 2000-05-15. PMID:10769035. |
detachment of epithelial cells from the extracellular matrix (ecm) results in a form of apoptosis often referred to as anoikis. |
2000-05-15 |
2023-08-12 |
human |
| S Y Cho, R L Klemk. Extracellular-regulated kinase activation and CAS/Crk coupling regulate cell migration and suppress apoptosis during invasion of the extracellular matrix. The Journal of cell biology. vol 149. issue 1. 2000-05-11. PMID:10747099. |
extracellular-regulated kinase activation and cas/crk coupling regulate cell migration and suppress apoptosis during invasion of the extracellular matrix. |
2000-05-11 |
2023-08-12 |
Not clear |
| S Y Cho, R L Klemk. Extracellular-regulated kinase activation and CAS/Crk coupling regulate cell migration and suppress apoptosis during invasion of the extracellular matrix. The Journal of cell biology. vol 149. issue 1. 2000-05-11. PMID:10747099. |
extracellular-regulated kinase (erk) activation and molecular coupling of the adaptor proteins p130 crk-associated substrate (cas) and c-crkii (crk) represent two distinct pathways that induce cell invasion and protect cells from apoptosis in a three-dimensional collagen matrix. |
2000-05-11 |
2023-08-12 |
Not clear |
| S C Riley, C J Webb, R Leask, F M McCaig, D C How. Involvement of matrix metalloproteinases 2 and 9, tissue inhibitor of metalloproteinases and apoptosis in tissue remodelling in the sheep placenta. Journal of reproduction and fertility. vol 118. issue 1. 2000-05-09. PMID:10793622. |
involvement of matrix metalloproteinases 2 and 9, tissue inhibitor of metalloproteinases and apoptosis in tissue remodelling in the sheep placenta. |
2000-05-09 |
2023-08-12 |
Not clear |
| S C Riley, C J Webb, R Leask, F M McCaig, D C How. Involvement of matrix metalloproteinases 2 and 9, tissue inhibitor of metalloproteinases and apoptosis in tissue remodelling in the sheep placenta. Journal of reproduction and fertility. vol 118. issue 1. 2000-05-09. PMID:10793622. |
it is suggested that digestion of supporting extracellular matrix may trigger apoptosis and in some way increase the branching pattern in the villi. |
2000-05-09 |
2023-08-12 |
Not clear |
| L A Salamonsen, G T Kovacs, J K Findla. Current concepts of the mechanisms of menstruation. Bailliere's best practice & research. Clinical obstetrics & gynaecology. vol 13. issue 2. 2000-05-04. PMID:10755035. |
particular emphasis is placed on the roles of steroids, prostaglandins, endothelin, lysosomal enzymes and matrix metalloproteinases, and the involvement of the fibrinolytic system and apoptosis. |
2000-05-04 |
2023-08-12 |
Not clear |
| A K La. Molecular biology of esophageal squamous cell carcinoma. Critical reviews in oncology/hematology. vol 33. issue 2. 2000-04-24. PMID:10737369. |
the recent development includes research in etiopathogenesis (viruses and cancer susceptibility genes), keratins, tumor related genes (oncogenes, tumor suppressor genes, genes involved in metastasis and apoptosis genes), proliferation-related factors (nuclear proteins, flow cytometry/morphometry, argyrophilic nucleolar organizer region) and factors related to metastases (cell adhesion molecules and enzymes related to degradation of extracellular matrix). |
2000-04-24 |
2023-08-12 |
Not clear |
| S Kook, S R Shim, S J Choi, J Ahnn, J I Kim, S H Eom, Y K Jung, S G Paik, W K Son. Caspase-mediated cleavage of p130cas in etoposide-induced apoptotic Rat-1 cells. Molecular biology of the cell. vol 11. issue 3. 2000-04-14. PMID:10712510. |
apoptosis causes characteristic morphological changes in cells, including membrane blebbing, cell detachment from the extracellular matrix, and loss of cell-cell contacts. |
2000-04-14 |
2023-08-12 |
Not clear |