| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Luca Zangrandi, Claudia Schmuckermair, Hussein Ghareh, Federico Castaldi, Regine Heilbronn, Gerald Zernig, Francesco Ferraguti, Arnau Ramos-Prat. Loss of mGluR5 in D1 Receptor-Expressing Neurons Improves Stress Coping. International journal of molecular sciences. vol 22. issue 15. 2021-08-16. PMID:34360592. |
the metabotropic glutamate receptor type 5 (mglur5) has been proposed to play a crucial role in the selection and regulation of cognitive, affective, and emotional behaviors. |
2021-08-16 |
2023-08-13 |
mouse |
| Tiago Marcon Dos Santos, Cassiana Siebert, Larissa Daniele Bobermin, André Quincozes-Santos, Angela T S Wys. Mild Hyperhomocysteinemia Causes Anxiety-like Behavior and Brain Hyperactivity in Rodents: Are ATPase and Excitotoxicity by NMDA Receptor Overstimulation Involved in this Effect? Cellular and molecular neurobiology. 2021-07-29. PMID:34324129. |
in the present study, we evaluated the emotional behavior and neurochemical pathways (atpases, glutamate homeostasis, and cell viability) in amygdala and prefrontal cortex rats subjected to mild hyperhomocysteinemia (in vivo studies). |
2021-07-29 |
2023-08-13 |
rat |
| Tiago Marcon Dos Santos, Cassiana Siebert, Larissa Daniele Bobermin, André Quincozes-Santos, Angela T S Wys. Mild Hyperhomocysteinemia Causes Anxiety-like Behavior and Brain Hyperactivity in Rodents: Are ATPase and Excitotoxicity by NMDA Receptor Overstimulation Involved in this Effect? Cellular and molecular neurobiology. 2021-07-29. PMID:34324129. |
taken together, data showed that mild hyperhomocysteinemia impairs the emotional behavior, which may be associated with changes in atpase and glutamate homeostasis, including glutamine synthetase and nmdar overstimulation that could lead to excitotoxicity. |
2021-07-29 |
2023-08-13 |
rat |
| Dominik Denzel, Lejla Colic, Liliana Ramona Demenescu, Felicia von Düring, Inka Ristow, Hanna Nießen, Luisa Hermann, Jörn Kaufmann, Udo Dannlowski, Jörg Frommer, Matthias Vogel, Meng Li, Anton Lord, Martin Walte. Local glutamate in cingulate cortex subregions differentially correlates with affective network activations during face perception. The European journal of neuroscience. vol 52. issue 3. 2021-06-21. PMID:32239708. |
despite recent accounts of the relevance of cingulate cortex glutamate (glu) on blood-oxygen-level-dependent (bold) responses, the specificity of the subregional glu levels during emotional tasks remains unclear. |
2021-06-21 |
2023-08-13 |
human |
| Johanna C Walker, Giana I Teresi, Rachel L Weisenburger, Jillian R Segarra, Amar Ojha, Artenisa Kulla, Lucinda Sisk, Meng Gu, Daniel M Spielman, Yael Rosenberg-Hasson, Holden T Maecker, Manpreet K Singh, Ian H Gotlib, Tiffany C H. Study Protocol for Teen Inflammation Glutamate Emotion Research (TIGER). Frontiers in human neuroscience. vol 14. 2020-11-18. PMID:33192421. |
study protocol for teen inflammation glutamate emotion research (tiger). |
2020-11-18 |
2023-08-13 |
Not clear |
| Johanna C Walker, Giana I Teresi, Rachel L Weisenburger, Jillian R Segarra, Amar Ojha, Artenisa Kulla, Lucinda Sisk, Meng Gu, Daniel M Spielman, Yael Rosenberg-Hasson, Holden T Maecker, Manpreet K Singh, Ian H Gotlib, Tiffany C H. Study Protocol for Teen Inflammation Glutamate Emotion Research (TIGER). Frontiers in human neuroscience. vol 14. 2020-11-18. PMID:33192421. |
this article provides an overview of the study protocol for the teen inflammation glutamate emotion research (tiger) project, a longitudinal study in which we plan to recruit 60 depressed adolescents (ages 13-18 years) and 30 psychiatrically healthy controls in order to examine the inflammatory and glutamatergic pathways that contribute to the recurrence of depression in adolescents. |
2020-11-18 |
2023-08-13 |
Not clear |
| Paul A Lapcha. Neuronal Dysregulation in Stroke-Associated Pseudobulbar Affect (PBA): Diagnostic Scales and Current Treatment Options. Journal of neurology & neurophysiology. vol 6. issue 5. 2020-10-01. PMID:26693049. |
pba is now understood to be a disinhibition syndrome in which specific pathways involving serotonin and glutamate are disrupted or modulated causing reduced cortical inhibition of a cerebellar/brainstem-situated "emotional" laughing or crying focal center. |
2020-10-01 |
2023-08-13 |
Not clear |
| Kaitlin E Bountress, Wei Wei, Christina Sheerin, Dongjun Chung, Ananda B Amstadter, Howard Mandel, Zhewu Wan. Relationships between GAT1 and PTSD, Depression, and Substance Use Disorder. Brain sciences. vol 7. issue 1. 2020-10-01. PMID:28067785. |
additionally, genes in the glutamate and gamma-aminobutyric acid (gaba) system are implicated in the encoding of emotional and fear memories, and thus may impact these phenotypes. |
2020-10-01 |
2023-08-13 |
Not clear |
| Brooke Naylor, Negin Hesam-Shariati, James H McAuley, Simon Boag, Toby Newton-John, Caroline D Rae, Sylvia M Gusti. Reduced Glutamate in the Medial Prefrontal Cortex Is Associated With Emotional and Cognitive Dysregulation in People With Chronic Pain. Frontiers in neurology. vol 10. 2020-10-01. PMID:31849800. |
reduced glutamate in the medial prefrontal cortex is associated with emotional and cognitive dysregulation in people with chronic pain. |
2020-10-01 |
2023-08-13 |
human |
| Brooke Naylor, Negin Hesam-Shariati, James H McAuley, Simon Boag, Toby Newton-John, Caroline D Rae, Sylvia M Gusti. Reduced Glutamate in the Medial Prefrontal Cortex Is Associated With Emotional and Cognitive Dysregulation in People With Chronic Pain. Frontiers in neurology. vol 10. 2020-10-01. PMID:31849800. |
given that the mpfc is implicated in emotional appraisal, cognition and extinction of fear, could a potential decrease in glutamate be associated with increased pessimistic thinking, fear and worry symptoms commonly found in people with chronic pain? |
2020-10-01 |
2023-08-13 |
human |
| Shigeo Miyata, Ryota Kumagaya, Toshikazu Kakizaki, Kazuyuki Fujihara, Kaori Wakamatsu, Yuchio Yanagaw. Loss of Glutamate Decarboxylase 67 in Somatostatin-Expressing Neurons Leads to Anxiety-Like Behavior and Alteration in the Akt/GSK3β Signaling Pathway. Frontiers in behavioral neuroscience. vol 13. 2020-09-30. PMID:31275123. |
to address this issue, we investigated the emotional behaviors and relevant molecular mechanism in mice lacking glutamate decarboxylase 67 (gad67), an isoform of gaba-synthesizing enzyme, specifically in som neurons (som-gad67 mice). |
2020-09-30 |
2023-08-13 |
mouse |
| Mizuki Uchida, Hirotake Hida, Kentaro Mori, Akira Yoshimi, Shinji Kitagaki, Kiyofumi Yamada, Yuichi Hiraoka, Tomomi Aida, Kohichi Tanaka, Norio Ozaki, Yukihiro Nod. Functional roles of the glial glutamate transporter (GLAST) in emotional and cognitive abnormalities of mice after repeated phencyclidine administration. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 29. issue 8. 2020-08-07. PMID:31303267. |
functional roles of the glial glutamate transporter (glast) in emotional and cognitive abnormalities of mice after repeated phencyclidine administration. |
2020-08-07 |
2023-08-13 |
mouse |
| Mizuki Uchida, Hirotake Hida, Kentaro Mori, Akira Yoshimi, Shinji Kitagaki, Kiyofumi Yamada, Yuichi Hiraoka, Tomomi Aida, Kohichi Tanaka, Norio Ozaki, Yukihiro Nod. Functional roles of the glial glutamate transporter (GLAST) in emotional and cognitive abnormalities of mice after repeated phencyclidine administration. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 29. issue 8. 2020-08-07. PMID:31303267. |
in the present study, we investigated the functional roles of glast in the emotional and cognitive abnormalities in mice following repeated pcp administration by using glast heterozygous (+/-) mice, since glast mutant mice are a useful tool for elucidating the contribution of glutamate dysfunction to the pathophysiology of schizophrenia. |
2020-08-07 |
2023-08-13 |
mouse |
| Michiko Sakaki, Taiji Ueno, Allison Ponzio, Carolyn W Harley, Mara Mathe. Emotional arousal amplifies competitions across goal-relevant representation: A neurocomputational framework. Cognition. vol 187. 2020-07-15. PMID:30856476. |
the model is based on neurophysiological observations that norepinephrine (ne) released under emotional arousal is locally controlled by glutamate levels, resulting in different ne effects across regions, gating either long-term potentiation or long-term depression by activating different adrenergic receptors depending on ne concentration levels. |
2020-07-15 |
2023-08-13 |
Not clear |
| Mizuki Uchida, Hirotake Hida, Kentaro Mori, Akira Yoshimi, Shinji Kitagaki, Kiyofumi Yamada, Yuichi Hiraoka, Tomomi Aida, Kohichi Tanaka, Norio Ozaki, Yukihiro Nod. Erratum to "Functional roles of the glial glutamate transporter (GLAST) in emotional and cognitive abnormalities of mice after repeated phencyclidine administration" [European Neuropsychopharmacology (2019) 29, 914-924]. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 29. issue 9. 2020-05-22. PMID:31362851. |
erratum to "functional roles of the glial glutamate transporter (glast) in emotional and cognitive abnormalities of mice after repeated phencyclidine administration" [european neuropsychopharmacology (2019) 29, 914-924]. |
2020-05-22 |
2023-08-13 |
mouse |
| Ying-Yan Fang, Peng Zeng, Na Qu, Lin-Na Ning, Jiang Chu, Teng Zhang, Xin-Wen Zhou, Qing Tia. Evidence of altered depression and dementia-related proteins in the brains of young rats after ovariectomy. Journal of neurochemistry. vol 146. issue 6. 2019-06-26. PMID:29939407. |
in the amy, which is important in emotion, higher gaba transporter 3 and lower vesicular glutamate transporter 1 levels indicated an imbalance between excitatory and inhibitory neurotransmission, and the increased calretinin and decreased calbindin levels suggested an adjustment of gabaergic transmission after ovx. |
2019-06-26 |
2023-08-13 |
rat |
| T Femenia, Y Qian, T Arentsen, H Forssberg, R Diaz Heijt. Toll-like receptor-4 regulates anxiety-like behavior and DARPP-32 phosphorylation. Brain, behavior, and immunity. vol 69. 2019-04-23. PMID:29221855. |
this behavioral phenotype was associated with an altered expression of genes known to be involved in emotional behavior [e.g., brain-derived neurotrophic factor (bdnf) and metabotropic glutamate receptors (mglurs)]. |
2019-04-23 |
2023-08-13 |
mouse |
| Ruriko Nishigaki, Yoshihiro Yokoyama, Yuko Shimizu, Ryosuke Marumoto, Sachiyo Misumi, Yoshitomo Ueda, Akimasa Ishida, Yasuyuki Shibuya, Hideki Hid. Monosodium glutamate ingestion during the development period reduces aggression mediated by the vagus nerve in a rat model of attention deficit-hyperactivity disorder. Brain research. vol 1690. 2019-04-11. PMID:29649467. |
we used an umami substance, monosodium glutamate (msg), as a simple stimulant to clarify the mechanism of the formation of emotional behavior. |
2019-04-11 |
2023-08-13 |
rat |
| A G Galyamina, I L Kovalenko, D A Smagin, N N Kudryavtsev. [Altered Expression of Neurotransmitters Systems' Genes in the Ventral Tegmental Area of Depressive Male Mice: Data of RNA-Seq]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 67. issue 1. 2019-02-19. PMID:30695556. |
in this experiment we are focused on the analysis of expression of genes encoding proteins related with the metabolism and receptors of serotonin, catecholamines, gaba and glutamate in the ventral teg- mental area which is important for regulation of motivations, emotions and is involved into mech- anisms of affective disorders. |
2019-02-19 |
2023-08-13 |
mouse |
| S Morley-Fletcher, A R Zuena, J Mairesse, E Gatta, G Van Camp, H Bouwalerh, B Riozzi, G Battaglia, A Pittaluga, G Olivero, E Mocaer, S Bretin, F Nicoletti, S Maccar. The reduction in glutamate release is predictive of cognitive and emotional alterations that are corrected by the positive modulator of AMPA receptors S 47445 in perinatal stressed rats. Neuropharmacology. vol 135. 2019-02-04. PMID:29578034. |
the reduction in glutamate release is predictive of cognitive and emotional alterations that are corrected by the positive modulator of ampa receptors s 47445 in perinatal stressed rats. |
2019-02-04 |
2023-08-13 |
rat |