| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hélène N Davi. Towards a reconceptualization of striatal interactions between glutamatergic and dopaminergic neurotransmission and their contribution to the production of movements. Current neuropharmacology. vol 7. issue 2. 2010-03-05. PMID:19949572. |
in this model, dopaminergic neurotransmission is seen as a motor pacemaker responsible for the basal and primary activation of striatal output neurons and glutamate as a driver providing a multiple combination of tonic, phasic, facilitatory and inhibitory influxes resulting from the processing of environmental, emotional and mnesic stimuli. |
2010-03-05 |
2023-08-12 |
Not clear |
| M J Glass, L Vanyo, L Quimson, V M Picke. Ultrastructural relationship between N-methyl-D-aspartate-NR1 receptor subunit and mu-opioid receptor in the mouse central nucleus of the amygdala. Neuroscience. vol 163. issue 3. 2010-01-14. PMID:19607886. |
thus, postsynaptic co-modulation of central amygdala neurons may be a key cellular substrate mediating glutamate and opioid interaction on neural signaling and plasticity associated with normal and pathological emotional processes associated with addictive behaviors. |
2010-01-14 |
2023-08-12 |
mouse |
| Xiaohong Zhao, Lei Sun, Hongxiao Jia, Qingxuan Meng, Si Wu, Nanxin Li, Shuchang H. Isolation rearing induces social and emotional function abnormalities and alters glutamate and neurodevelopment-related gene expression in rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 33. issue 7. 2009-11-17. PMID:19563853. |
isolation rearing induces social and emotional function abnormalities and alters glutamate and neurodevelopment-related gene expression in rats. |
2009-11-17 |
2023-08-12 |
rat |
| Kjell Fuxe, Daniel Marcellino, Amina S Woods, Leo Giuseppina, Tiziana Antonelli, Luca Ferraro, Sergio Tanganelli, Luigi F Agnat. Integrated signaling in heterodimers and receptor mosaics of different types of GPCRs of the forebrain: relevance for schizophrenia. Journal of neural transmission (Vienna, Austria : 1996). vol 116. issue 8. 2009-09-24. PMID:19156349. |
the ventral striatum transmits emotional information to the cerebral cortex through a d(2) regulated accumbal-ventral pallidal-mediodorsal-prefrontal circuit which is of special interest to schizophrenia in view of the reduced number of glutamate mediodorsal-prefrontal projections associated with this disease. |
2009-09-24 |
2023-08-12 |
Not clear |
| L A Vetrile, V A Evseev, A E Umriukhin, A N Kravtzov, S V Sotnikov, I A Zakharov. Involvement of autoantibodies to neurotransmitters in mechanisms of stress reaction in rats. Bulletin of experimental biology and medicine. vol 146. issue 6. 2009-09-08. PMID:19513355. |
high emotional and behavioral reaction to stress is associated with intensive production of autoantibodies to serotonin, dopamine, norepinephrine, and glutamate. |
2009-09-08 |
2023-08-12 |
rat |
| Daisuke Ibi, Taku Nagai, Yuko Kitahara, Hiroyuki Mizoguchi, Hiroyuki Koike, Anna Shiraki, Kazuhiro Takuma, Hiroyuki Kamei, Yukihiro Noda, Atsumi Nitta, Toshitaka Nabeshima, Yukio Yoneda, Kiyofumi Yamad. Neonatal polyI:C treatment in mice results in schizophrenia-like behavioral and neurochemical abnormalities in adulthood. Neuroscience research. vol 64. issue 3. 2009-08-20. PMID:19447299. |
cognitive and emotional behavior as well as the extracellular level of glutamate in the hippocampus were analyzed at the age of 10-12 weeks old. |
2009-08-20 |
2023-08-12 |
mouse |
| Abdellah Ahnaou, Frank M Dautzenberg, Helena Geys, Hassan Imogai, Antoine Gibelin, Dieder Moechars, Thomas Steckler, Wilhelmus H I M Drinkenbur. Modulation of group II metabotropic glutamate receptor (mGlu2) elicits common changes in rat and mice sleep-wake architecture. European journal of pharmacology. vol 603. issue 1-3. 2009-03-18. PMID:19046965. |
compiling pharmacological evidence implicates metabotropic glutamate mglu(2) receptors in the regulation of emotional states and suggests positive modulators as a novel therapeutic approach of anxiety/depression and schizophrenia. |
2009-03-18 |
2023-08-12 |
mouse |
| Aleksandra Wisłowska-Stanek, Adam Hamed, Małgorzata Lehner, Andrzej Bidziński, Danuta Turzyńska, Alicja Sobolewska, Jerzy Walkowiak, Adam Płaźni. Effects of midazolam and buspirone on in vivo concentration of amino acids and monoamine metabolites in the rat hippocampus. Pharmacological reports : PR. vol 60. issue 2. 2009-01-09. PMID:18443382. |
it is suggested that the changes in hippocampal glutamate probably are not directly associated with modification of rat emotional behavior after benzodiazepines and azapirones. |
2009-01-09 |
2023-08-12 |
rat |
| N B Saul'skaya, N V Fofonova, S A Savel'e. Glutamatergic regulation of extracellular citrulline levels in the nucleus accumbens during an emotional conditioned reflex. Neuroscience and behavioral physiology. vol 38. issue 5. 2008-12-09. PMID:18607752. |
injection of the selective nmda glutamate receptor antagonist mk-801 (100 microm) into the nucleus accumbens significantly decreased the increase in extracellular citrulline seen in this structure on acquisition of the emotional conditioned reflex and completely blocked the increase induced by execution of the reflex. |
2008-12-09 |
2023-08-12 |
rat |
| Ilse Smolders, Ralph Clinckers, Alfred Meurs, Dimitri De Bundel, Jeanelle Portelli, Guy Ebinger, Yvette Michott. Direct enhancement of hippocampal dopamine or serotonin levels as a pharmacodynamic measure of combined antidepressant-anticonvulsant action. Neuropharmacology. vol 54. issue 6. 2008-07-22. PMID:18378264. |
since glutamate-mediated hyperexcitability in temporal lobe regions seems to be involved in disturbed emotional behaviour, we next investigated possible antidepressant effects and hippocampal da or 5-ht modulations exerted by selective ionotropic and metabotropic glutamate receptor ligands with anticonvulsant properties. |
2008-07-22 |
2023-08-12 |
mouse |
| Guibao Gu, Daniel S Lorrain, Hongbing Wei, Rebecca L Cole, Xin Zhang, Lorrie P Daggett, Herve J Schaffhauser, Linda J Bristow, Sandra M Lechne. Distribution of metabotropic glutamate 2 and 3 receptors in the rat forebrain: Implication in emotional responses and central disinhibition. Brain research. vol 1197. 2008-05-20. PMID:18242587. |
distribution of metabotropic glutamate 2 and 3 receptors in the rat forebrain: implication in emotional responses and central disinhibition. |
2008-05-20 |
2023-08-12 |
rat |
| Daniele Fabio Zullino, Sonia Krenz, Grégoire Zimmerman, Amos Miozzari, Rajini Rajeswaran, Stéphane Kolly, Yasser Khazaa. Topiramate in opiate withdrawal- comparison with clonidine and with carbamazepine/mianserin. Substance abuse. vol 25. issue 4. 2007-09-26. PMID:16172090. |
the blockade of the ampa/kainate subtype of glutamate receptor by topiramate may be of particular interest, as preclinical studies of withdrawal from opioids suggest that whilst ampa-receptor antagonists may not be able to prevent tolerance or dependence from developing, they may ameliorate both physical and emotional consequences of withdrawal. |
2007-09-26 |
2023-08-12 |
Not clear |
| Rina Murai, Yukihiro Noda, Kanae Matsui, Hiroyuki Kamei, Akihiro Mouri, Kazuhisa Matsuba, Astumi Nitta, Hiroshi Furukawa, Toshitaka Nabeshim. Hypofunctional glutamatergic neurotransmission in the prefrontal cortex is involved in the emotional deficit induced by repeated treatment with phencyclidine in mice: implications for abnormalities of glutamate release and NMDA-CaMKII signaling. Behavioural brain research. vol 180. issue 2. 2007-07-24. PMID:17451820. |
hypofunctional glutamatergic neurotransmission in the prefrontal cortex is involved in the emotional deficit induced by repeated treatment with phencyclidine in mice: implications for abnormalities of glutamate release and nmda-camkii signaling. |
2007-07-24 |
2023-08-12 |
mouse |
| Toshitaka Nabeshima, Akihiro Mouri, Rina Murai, Yukihiro Nod. Animal model of schizophrenia: dysfunction of NMDA receptor-signaling in mice following withdrawal from repeated administration of phencyclidine. Annals of the New York Academy of Sciences. vol 1086. 2007-02-13. PMID:17185514. |
since it has been hypothesized that insufficient glutamate neurotransmission is involved in the pathophysiology of schizophrenia, we investigated an involvement of glutamatergic system in emotional and cognitive deficits in mice treated with pcp repeatedly. |
2007-02-13 |
2023-08-12 |
mouse |
| Janel M Boyce-Rustay, Andrew Holme. Genetic inactivation of the NMDA receptor NR2A subunit has anxiolytic- and antidepressant-like effects in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 11. 2006-12-12. PMID:16482087. |
present results support a role for the nr2a subunit in the modulation of emotional behaviors in rodents and provide insight into the role of glutamate in the pathophysiology and treatment of mood and anxiety disorders. |
2006-12-12 |
2023-08-12 |
mouse |
| Zsuzsanna Callaerts-Vegh, Tom Beckers, Simon M Ball, Frank Baeyens, Patrick F Callaerts, John F Cryan, Elek Molnar, Rudi D'Hoog. Concomitant deficits in working memory and fear extinction are functionally dissociated from reduced anxiety in metabotropic glutamate receptor 7-deficient mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 24. 2006-07-11. PMID:16775145. |
metabotropic glutamate receptor 7 (mglur7), a receptor with a distinct brain distribution and a putative role in anxiety, emotional responding, and spatial working memory, could be an interesting therapeutic target for fear and anxiety disorders. |
2006-07-11 |
2023-08-12 |
mouse |
| Andrew Holmes, Anne Marie le Guisquet, Elise Vogel, Rachel A Millstein, Samuel Leman, Catherine Belzun. Early life genetic, epigenetic and environmental factors shaping emotionality in rodents. Neuroscience and biobehavioral reviews. vol 29. issue 8. 2005-12-15. PMID:16095695. |
in rats, postnatal maternal separation can produce lasting increases in emotional behavior and stressor-reactivity, together with alterations in various brain neurotransmitter systems implicated in emotionality, including corticotropin-releasing factor, serotonin, norepinephrine, and glutamate. |
2005-12-15 |
2023-08-12 |
mouse |
| A V Sergutina, L M Gershteĭ. [Morphochemical analysis of hippocampus of rats predisposed (August) or resistant (Wistar) to emotional stress]. Morfologiia (Saint Petersburg, Russia). vol 125. issue 2. 2005-02-18. PMID:15232864. |
using quantitative cytochemical methods it was demonstrated that the activities of aminopeptidase, monoaminooxidase (substrates--tryptamine and serotonin), and glutamate dehydrogenase, were lower in the hippocampus of august rats (predisposed to emotional stress) as compared to that one in wistar rats (resistant to emotional stress). |
2005-02-18 |
2023-08-12 |
rat |
| Karl Ebner, Oliver J Bosch, Simone A Krömer, Nicolas Singewald, Inga D Neuman. Release of oxytocin in the rat central amygdala modulates stress-coping behavior and the release of excitatory amino acids. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 30. issue 2. 2005-02-15. PMID:15536493. |
further, we examined the physiological significance of oxt released within the cea for behavioral responses during forced swimming as well as effects on the local release of selected amino acids including glutamate, aspartate, arginine, taurine, and gaba, which are thought to modulate processing of emotions. |
2005-02-15 |
2023-08-12 |
rat |
| Joanna P Tyszkiewicz, Zhenglin Gu, Xun Wang, Xiang Cai, Zhen Ya. Group II metabotropic glutamate receptors enhance NMDA receptor currents via a protein kinase C-dependent mechanism in pyramidal neurones of rat prefrontal cortex. The Journal of physiology. vol 554. issue Pt 3. 2004-11-16. PMID:14645456. |
the metabotropic glutamate receptors (mglurs) are highly enriched in prefrontal cortex (pfc) - a brain region critically involved in the regulation of cognition and emotion. |
2004-11-16 |
2023-08-12 |
rat |