| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Feng J Gao, Donna Klinedinst, Fabian-Xosé Fernandez, Bei Cheng, Alena Savonenko, Benjamin Devenney, Yicong Li, Dan Wu, Martin G Pomper, Roger H Reeve. Forebrain Shh overexpression improves cognitive function and locomotor hyperactivity in an aneuploid mouse model of Down syndrome and its euploid littermates. Acta neuropathologica communications. vol 9. issue 1. 2021-10-15. PMID:34399854. |
the aneuploid ds mouse model "ts65dn" shows prominent brain phenotypes, including learning and memory deficits, cerebellar hypoplasia, and locomotor hyperactivity. |
2021-10-15 |
2023-08-13 |
mouse |
| Lora T Likova, Kristyo N Mineff, Spero C Nichola. Mental Visualization in the Cerebellum: Rapid Non-motor Learning at Sub-Lobular and Causal Network Levels. Frontiers in systems neuroscience. vol 15. 2021-09-29. PMID:34566588. |
they represent a basis for a framework of rapid cerebellar reorganization driven by non-motor learning, with implications for the enhancement of cognitive abilities such as learning and memory. |
2021-09-29 |
2023-08-13 |
Not clear |
| Larissa Nitschke, Stephanie L Coffin, Eder Xhako, Dany B El-Najjar, James P Orengo, Elizabeth Alcala, Yanwan Dai, Ying-Wooi Wan, Zhandong Liu, Harry T Orr, Huda Y Zoghb. Modulation of ATXN1 S776 phosphorylation reveals the importance of allele-specific targeting in SCA1. JCI insight. vol 6. issue 3. 2021-05-28. PMID:33554954. |
here, we report that abolishing s776 phosphorylation specifically on the polyq-expanded atxn1 of sca1-knockin mice reduces atxn1 throughout the brain and not only rescues the cerebellar motor incoordination but also improves respiratory function and extends survival while not affecting the hippocampal learning and memory deficits. |
2021-05-28 |
2023-08-13 |
mouse |
| Li-Jie Zhan, Yi Yang, He-Min Yang, Chun-Ping Chu, De-Lai Qiu, Yan La. [Fentanyl attenuates air-puff stimulus-evoked field potential response in the cerebellar molecular layer via inhibiting interneuron activity in mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 73. issue 1. 2021-03-08. PMID:33665658. |
as we know, cerebellum is not only involved in sensory perception, motor coordination, motor learning and precise control of autonomous movement, but also important for the mood regulation, cognition, learning and memory. |
2021-03-08 |
2023-08-13 |
mouse |
| Da-Bing Li, Juan Yao, Lin Sun, Bing Wu, Xuan Li, Shu-Lei Liu, Jing-Ming Hou, Hong-Liang Liu, Jian-Feng Sui, Guang-Yan W. Reevaluating the ability of cerebellum in associative motor learning. Scientific reports. vol 9. issue 1. 2020-10-07. PMID:30988338. |
the present results are of great importance in our understanding of the mechanisms and ability of the cerebellum in associative motor learning and memory. |
2020-10-07 |
2023-08-13 |
rat |
| Dong Cheol Jang, Hyun Geun Shim, Sang Jeong Ki. Intrinsic Plasticity of Cerebellar Purkinje Cells Contributes to Motor Memory Consolidation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 21. 2020-10-07. PMID:32295816. |
intrinsic plasticity of cerebellar purkinje cells (pcs) has recently been demonstrated in cerebellar local circuits; however, its physiological impact on cerebellar learning and memory remains elusive. |
2020-10-07 |
2023-08-13 |
mouse |
| Javad Hami, Saeed Vafaei-Nezhad, Akram Sadeghi, Kazem Ghaemi, Mohammad-Mahdi Hasanzadeh Taheri, Mohammad Fereidouni, Ghasem Ivar, Mehran Hossein. Synaptogenesis in the Cerebellum of Offspring Born to Diabetic Mothers. Journal of pediatric neurosciences. vol 12. issue 3. 2020-10-01. PMID:29204194. |
moreover, recent studies in humans and animals have also implicated the cerebellum in cognitive processing, sensory discrimination, attention, and learning and memory. |
2020-10-01 |
2023-08-13 |
Not clear |
| Cheng-Kun Deng, Zhi-Hao Mu, Yi-He Miao, Yi-Dan Liu, Lei Zhou, Yong-Jie Huang, Fan Zhang, Yao-Yi Wang, Zhi-Hong Yang, Zhong-Yi Qian, Xie Wang, Jia-Zhi Guo, Mei-Yan Zhang, Xin-Yu Liao, Qi Wan, Di Lu, Ying-Ying Zo. Gastrodin Ameliorates Motor Learning Deficits Through Preserving Cerebellar Long-Term Depression Pathways in Diabetic Rats. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:31824244. |
recently, the cerebellum was reported to play an important role in learning and memory. |
2020-10-01 |
2023-08-13 |
rat |
| Bernard G Schreur. Changes in cerebellar intrinsic neuronal excitability and synaptic plasticity result from eyeblink conditioning. Neurobiology of learning and memory. vol 166. 2020-07-28. PMID:31542329. |
there is a long history of research documenting plasticity in the cerebellum as well as the role of the cerebellum in learning and memory. |
2020-07-28 |
2023-08-13 |
rat |
| Fredrik Johansso. Intrinsic memory of temporal intervals in cerebellar Purkinje cells. Neurobiology of learning and memory. vol 166. 2020-07-28. PMID:31648018. |
the general consensus for learning and memory, including in the cerebellum, is that modification of synaptic strength via long-term potentiation (ltp) or long-term depression (ltd) are the primary mechanisms for the formation of memories. |
2020-07-28 |
2023-08-13 |
Not clear |
| Wataru Kakegawa, Michisuke Yuzak. [Molecular Mechanisms for Learning and Memory: What Happens at the Synapses?] Brain and nerve = Shinkei kenkyu no shinpo. vol 70. issue 7. 2019-05-09. PMID:29997264. |
especially, in the cerebellum, which underlies motor learning and memory, synapses are highly dynamic throughout life. |
2019-05-09 |
2023-08-13 |
Not clear |
| Ting-Ting Mo, Hua Dai, Hang Du, Rui-Yuan Zhang, Ke-Ping Chai, Yao An, Ji-Ji Chen, Jun-Ke Wang, Zi-Jin Chen, Cheng-Zhi Chen, Xue-Jun Jiang, Rong Tang, Li-Ping Wang, Qiang Tan, Ping Tang, Xin-Yu Miao, Pan Meng, Long-Bin Zhang, Shu-Qun Cheng, Bin Peng, Bai-Jie Tu, Ting-Li Han, Yin-Yin Xia, Philip N Bake. Gas chromatography-mass spectrometry based metabolomics profile of hippocampus and cerebellum in mice after chronic arsenic exposure. Environmental toxicology. vol 34. issue 2. 2019-02-14. PMID:30375170. |
hippocampus is a renowned area in relation to learning and memory, whilst recently, cerebellum is argued to be involved with process of cognition. |
2019-02-14 |
2023-08-13 |
mouse |
| Kristina Kraus, Ralf Kleene, Melad Henis, Ingke Braren, Hardeep Kataria, Ahmed Sharaf, Gabriele Loers, Melitta Schachner, David Lut. A Fragment of Adhesion Molecule L1 Binds to Nuclear Receptors to Regulate Synaptic Plasticity and Motor Coordination. Molecular neurobiology. vol 55. issue 9. 2019-02-04. PMID:29383692. |
mutations of the lxxll motif in the transmembrane domain and of the fxxlf motif in the extracellular domain disturb the interaction of the l1 fragment with these nuclear receptors and, when introduced by viral transduction into mouse embryos in utero, result in impaired motor coordination, learning and memory, as well as synaptic connectivity in the cerebellum, in adulthood. |
2019-02-04 |
2023-08-13 |
mouse |
| Chang-He Shi, Carrie Rubel, Sarah E Soss, Rebekah Sanchez-Hodge, Shuo Zhang, Sabrina C Madrigal, Saranya Ravi, Holly McDonough, Richard C Page, Walter J Chazin, Cam Patterson, Cheng-Yuan Mao, Monte S Willis, Hai-Yang Luo, Yu-Sheng Li, Donte A Stevens, Mi-Bo Tang, Pan Du, Yao-He Wang, Zheng-Wei Hu, Yu-Ming Xu, Jonathan C Schisle. Disrupted structure and aberrant function of CHIP mediates the loss of motor and cognitive function in preclinical models of SCAR16. PLoS genetics. vol 14. issue 9. 2019-01-16. PMID:30222779. |
animals homozygous for t246m had both cognitive and motor cerebellar dysfunction distinct from those observed in the chip null animal model, as well as deficits in learning and memory, reflective of the cognitive deficits reported in scar16 patients. |
2019-01-16 |
2023-08-13 |
mouse |
| Bruno A Marichal-Cancino, Alfonso Fajardo-Valdez, Alejandra E Ruiz-Contreras, Mónica Méndez-Díaz, Oscar Prospéro-Garcí. Possible role of hippocampal GPR55 in spatial learning and memory in rats. Acta neurobiologiae experimentalis. vol 78. issue 1. 2018-09-18. PMID:29694340. |
although ecbs exert many of their actions on spatial learning and memory via cb1 receptors, the putative cannabinoid receptor gpr55 (expressed in the hippocampus, cortex, forebrain, cerebellum and striatum) seems to be also involved. |
2018-09-18 |
2023-08-13 |
rat |
| Hong-Bo Jiang, Ai-Lin Du, Hai-Yang Luo, Jun Yang, Xiao-Qiu Luo, Rui-Qing Ma, Chang-He Shi, Yu-Ming X. Arginine vasopressin relates with spatial learning and memory in a mouse model of spinocerebellar ataxia type 3. Neuropeptides. vol 65. 2018-06-14. PMID:28619276. |
the results showed that (alves et al., 2010) the swimming velocity, distance traveled and latency to the platform of mwm in sca3 mice were reduced slower than those in wt mice over 4 training days (p<0.05, 0.01 or 0.001); (antunes and zimmerman, 1978) sca3 mice showed a lower performance of spatial learning and memory of mwm during the fifth day (test day) compared to wt mice; (bao et al., 2014) sca3 mice had a decrease of avp concentration in cerebral cortex (6.3±0.6pg/mg vs. 11.4±1.0pg/mg, p<0.01), hypothalamus (6.1±1.3ng/mg vs. 10.3±2.1ng/mg, p<0.05), hippocampus (3.2±0.5pg/mg vs. 5.2±1.0pg/mg, p<0.01) and cerebellum (4.7±0.9pg/mg vs. 8.3±1.1pg/mg, p<0.01), not in spinal cord, pituitary and serum; and (barberies and tribollet, 1996) intraventricular avp could significantly quicken swimming velocity, cut down distance traveled and reduce latency to the platform of mwm in a dose-dependent manner, but intraventricular avp receptor antagonist weakened the spatial learning and memory of mwm in sca3 mice during the fifth day. |
2018-06-14 |
2023-08-13 |
mouse |
| Elinor Tzvi, Christoph Zimmermann, Richard Bey, Thomas F Münte, Matthias Nitschke, Ulrike M Kräme. Cerebellar degeneration affects cortico-cortical connectivity in motor learning networks. NeuroImage. Clinical. vol 16. 2018-04-23. PMID:28761810. |
we found that cerebellar patients showed learning-related increase in activity in two regions known to be involved in learning and memory, namely parahippocampal cortex and cerebellar crus i. |
2018-04-23 |
2023-08-13 |
Not clear |
| Keiichiro Inagaki, Yutaka Hirat. Computational Theory Underlying Acute Vestibulo-ocular Reflex Motor Learning with Cerebellar Long-Term Depression and Long-Term Potentiation. Cerebellum (London, England). vol 16. issue 4. 2018-01-29. PMID:28444617. |
thus, motor learning and memory are thought to be induced mainly by ltd and ltp at parallel fiber-purkinje cell synapses and by rebound potentiation at molecular interneuron-purkinje cell synapses among the multiple forms of plasticity in the cerebellum. |
2018-01-29 |
2023-08-13 |
mouse |
| Michael R Foy, Judith G Fo. The search for the engram in eyeblink conditioning: A synopsis of past and present perspectives on the role of the cerebellum. Behavioral neuroscience. vol 130. issue 6. 2017-11-16. PMID:26820585. |
the focal point of this article is arguably his most influential paper on cerebellar classical conditioning entitled "the neurobiology of learning and memory" that appeared in science in 1986 and has been cited 700 times since its publication. |
2017-11-16 |
2023-08-13 |
Not clear |
| Michael R Foy, Judith G Fo. The search for the engram in eyeblink conditioning: A synopsis of past and present perspectives on the role of the cerebellum. Behavioral neuroscience. vol 130. issue 6. 2017-11-16. PMID:26820585. |
the summary will also discuss how the original 1986 article continues to stimulate and influence new research and provide further insights into the role of the cerebellum in the neurobiology of learning and memory function relevant to studies of mammalian classical conditioning. |
2017-11-16 |
2023-08-13 |
Not clear |