| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D T Chalmers, J F López, D M Vázquez, H Akil, S J Watso. Regulation of hippocampal 5-HT1A receptor gene expression by dexamethasone. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 10. issue 3. 1994-11-16. PMID:7916919. |
administration of dexamethasone at the time of adrenalectomy significantly attenuated the increases in 5-ht1a mrna expression in all hippocampal subfields (p < .05, fisher test), although 5-ht1a mrna levels remained significantly higher than sham levels in all subfields with the exception of ca1. |
1994-11-16 |
2023-08-12 |
Not clear |
| D T Chalmers, J F López, D M Vázquez, H Akil, S J Watso. Regulation of hippocampal 5-HT1A receptor gene expression by dexamethasone. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 10. issue 3. 1994-11-16. PMID:7916919. |
however, 5-ht1a binding levels were responsive to dexamethasone administration only within particular hippocampal subfields, ca1, and dentate gyrus. |
1994-11-16 |
2023-08-12 |
Not clear |
| I Belcheva, S Belcheva, V V Petkov, V D Petko. Hippocampal asymmetry in the behavioral responses to the 5-HT1A receptor agonist 8-OH-DPAT. Brain research. vol 640. issue 1-2. 1994-07-21. PMID:7911727. |
the present study examined the behavioral responses of rats to unilateral and bilateral injections of the selective serotonin 1a (5-ht1a)-receptor agonist 8-hydroxydipropylaminotetralin hydrobromide (8-oh-dpat) 1 microgram into the hippocampal ca1 area of male wistar rats. |
1994-07-21 |
2023-08-12 |
rat |
| P Barone, D Jordan, F Atger, N Kopp, G Fillio. Quantitative autoradiography of 5-HT1D and 5-HT1E binding sites labelled by [3H]5-HT, in frontal cortex and the hippocampal region of the human brain. Brain research. vol 638. issue 1-2. 1994-07-07. PMID:8199879. |
in ca1 field of hippocampus, (pyramidal layer, stratum radiatum, molecular layer), ca2 and dentate gyrus, 5-ht1a receptors represented the major fraction, 5-ht1d sites a significant fraction and 5-ht1e a minor fraction of the specific [3h]5-ht binding. |
1994-07-07 |
2023-08-12 |
human |
| T Dennis, P Blier, C de Montign. Delayed effects of spiperone on serotonin1A receptors in the dorsal hippocampus of rats. Journal of psychiatry & neuroscience : JPN. vol 18. issue 5. 1994-03-09. PMID:8297925. |
the effects of 5-ht1a antagonists spiperone, methiothepin and bmy 7378 on [3h]-8-oh-dpat binding were determined in vitro and ex vivo in rat hippocampus ca3 membrane preparations, and ex vivo in tissue sections of ca1 and ca3 subfields using quantitative autoradiography. |
1994-03-09 |
2023-08-12 |
rat |
| E K Perry, J A Court, M Johnson, C J Smith, V James, A V Cheng, J M Kerwin, C M Morris, M A Piggott, J A Edwardso. Autoradiographic comparison of cholinergic and other transmitter receptors in the normal human hippocampus. Hippocampus. vol 3. issue 3. 1993-09-22. PMID:8394772. |
by contrast, muscarinic m1 and m2, 5-ht1a, benzodiazepine (including zolpidem-insensitive binding), nmda (mk801), and ampa/quis receptors were higher in ca1 and/or subiculum. |
1993-09-22 |
2023-08-12 |
human |
| C del Arco, I Galende, A Pazo. Autoradiographic mapping of 5-HT1 receptors in the guinea-pig brain with particular reference to the 5-HT1D receptor sites. Naunyn-Schmiedeberg's archives of pharmacology. vol 347. issue 3. 1993-05-27. PMID:8479545. |
areas presenting high densities of 5-ht1a receptors included the neocortex (internal layers), hippocampal formation (dentate gyrus, ca1 field), septum and raphe nuclei, while 5-ht1c sites accounted for most of the [3h]-5-ht binding to the choroid plexus. |
1993-05-27 |
2023-08-12 |
Not clear |
| S Shibata, Y Kagami-Ishi, K Tominaga, K Kodama, S Ueki, S Watanab. Ischemia-induced impairment of 2-deoxyglucose uptake and CA1 field potentials in rat hippocampal slices: protection by 5-HT1A receptor agonists and 5-HT2 receptor antagonists. European journal of pharmacology. vol 229. issue 1. 1993-02-01. PMID:1473560. |
ischemia-induced impairment of 2-deoxyglucose uptake and ca1 field potentials in rat hippocampal slices: protection by 5-ht1a receptor agonists and 5-ht2 receptor antagonists. |
1993-02-01 |
2023-08-11 |
rat |
| M Carli, M Lazarova, E Tatarczynska, R Samani. Stimulation of 5-HT1A receptors in the dorsal hippocampus impairs acquisition and performance of a spatial task in a water maze. Brain research. vol 595. issue 1. 1993-01-26. PMID:1467958. |
the results suggest that stimulation of 5-ht1a receptors in the ca1 region of the dorsal hippocampus causes an impairment of spatial discrimination in rats. |
1993-01-26 |
2023-08-11 |
rat |
| S G Beck, K C Choi, T J Lis. Comparison of 5-hydroxytryptamine1A-mediated hyperpolarization in CA1 and CA3 hippocampal pyramidal cells. The Journal of pharmacology and experimental therapeutics. vol 263. issue 1. 1992-11-20. PMID:1403796. |
the receptor mediating the hyperpolarization in ca1 has been characterized as the 5-ht1a receptor, but has not been identified in area ca3. |
1992-11-20 |
2023-08-11 |
Not clear |
| S G Beck, K C Choi, T J Lis. Comparison of 5-hydroxytryptamine1A-mediated hyperpolarization in CA1 and CA3 hippocampal pyramidal cells. The Journal of pharmacology and experimental therapeutics. vol 263. issue 1. 1992-11-20. PMID:1403796. |
the selective 5-ht1a antagonist bmy 7378 and the 5-ht1a/2 antagonist spiperone were competitive in area ca1, but insurmountable in area ca3. |
1992-11-20 |
2023-08-11 |
Not clear |
| S G Beck, K C Choi, T J Lis. Comparison of 5-hydroxytryptamine1A-mediated hyperpolarization in CA1 and CA3 hippocampal pyramidal cells. The Journal of pharmacology and experimental therapeutics. vol 263. issue 1. 1992-11-20. PMID:1403796. |
based on these results, we conclude that the hyperpolarization elicited by 5-ht in areas ca1 and ca3 is mediated by the 5-ht1a receptor. |
1992-11-20 |
2023-08-11 |
Not clear |
| S D Mendelson, B S McEwe. Autoradiographic analyses of the effects of adrenalectomy and corticosterone on 5-HT1A and 5-HT1B receptors in the dorsal hippocampus and cortex of the rat. Neuroendocrinology. vol 55. issue 4. 1992-05-21. PMID:1533016. |
no treatment affected binding at 5-ht1a receptors in the ca1 region of the hippocampus or in the cortex. |
1992-05-21 |
2023-08-11 |
rat |
| b' F Radja, G Daval, M Hamon, D Verg\\xc3\\xa. Pharmacological and physicochemical properties of pre-versus postsynaptic 5-hydroxytryptamine1A receptor binding sites in the rat brain: a quantitative autoradiographic study. Journal of neurochemistry. vol 58. issue 4. 1992-04-17. PMID:1548468.' |
however, in most cases, the observed variations were of greater amplitude between the ca1 area and the dentate gyrus, where 5-ht1a sites are located postsynaptically, than between any one of these areas and the dorsal raphe nucleus where they act as (presynaptic) somatodendritic autoreceptors. |
1992-04-17 |
2023-08-11 |
rat |
| D T Chalmers, S J Watso. Comparative anatomical distribution of 5-HT1A receptor mRNA and 5-HT1A binding in rat brain--a combined in situ hybridisation/in vitro receptor autoradiographic study. Brain research. vol 561. issue 1. 1992-04-16. PMID:1797349. |
high levels of both 5-ht1a mrna and 5-ht1a receptors were evident in the hippocampal formation (ca1, ca3, dentate gyrus), entorhinal cortex, and raphe nuclei and lower levels in neocortex and thalamus. |
1992-04-16 |
2023-08-11 |
rat |
| J M Klancnik, A Obenaus, A G Phillips, K G Baimbridg. The effects of serotonergic compounds on evoked responses in the dentate gyrus and CA1 region of the hippocampal formation of the rat. Neuropharmacology. vol 30. issue 11. 1992-03-05. PMID:1837848. |
the effects of serotonin (5-ht), the 5-ht1a receptor subtype agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) and the 5-ht2 receptor subtype agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (doi) on electrophysiological responses in the dentate gyrus and area ca1 were examined in the in vitro hippocampal slice preparation. |
1992-03-05 |
2023-08-11 |
rat |
| J M Klancnik, A Obenaus, A G Phillips, K G Baimbridg. The effects of serotonergic compounds on evoked responses in the dentate gyrus and CA1 region of the hippocampal formation of the rat. Neuropharmacology. vol 30. issue 11. 1992-03-05. PMID:1837848. |
these findings support an inhibitory role for the 5-ht1a receptor in both area ca1 and the dentate gyrus. |
1992-03-05 |
2023-08-11 |
rat |
| S D Mendelson, B S McEwe. Autoradiographic analyses of the effects of restraint-induced stress on 5-HT1A, 5-HT1C and 5-HT2 receptors in the dorsal hippocampus of male and female rats. Neuroendocrinology. vol 54. issue 5. 1992-01-23. PMID:1749460. |
in addition, levels of binding at 5-ht1a receptors in the oriens and lacunosum moleculare layers of the ca1 region were significantly higher in female rats. |
1992-01-23 |
2023-08-11 |
rat |
| P Van den Hooff, M Galva. Electrophysiology of the 5-HT1A ligand MDL 73005EF in the rat hippocampal slice. European journal of pharmacology. vol 196. issue 3. 1991-10-24. PMID:1893914. |
the actions of 5-hydroxytryptamine (5-ht) and the 5-ht1a receptor ligand mdl 73005ef on neuronal activity in the ca1 region of rat hippocampal slices in vitro were recorded using intra- and extracellular recording techniques. |
1991-10-24 |
2023-08-11 |
rat |
| H Tanaka, H Shimizu, Y Kumasaka, A Hirose, T Tatsuno, M Nakamur. Autoradiographic localization and pharmacological characterization of [3H]tandospirone binding sites in the rat brain. Brain research. vol 546. issue 2. 1991-08-22. PMID:1648988. |
in addition, there was no significant difference in the dissociation constant of [3h]tandospirone binding between the dentate gyrus, ca1 area, dorsal raphe nucleus, lateral septum and entorhinal cortex (about 10 nm) suggesting that [3h]tandospirone binds to 5-ht1a receptors with same affinities in these brain structures. |
1991-08-22 |
2023-08-11 |
rat |