| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Javed, L D Van de Kar, T S Gra. The 5-HT1A and 5-HT2A/2C receptor antagonists WAY-100635 and ritanserin do not attenuate D-fenfluramine-induced fos expression in the brain. Brain research. vol 791. issue 1-2. 1998-08-03. PMID:9593827. |
the present study investigated whether 5-ht released by d-fenfluramine induces fos expression in the brain by activating 5-ht1a or 5-ht2a/2c receptors. |
1998-08-03 |
2023-08-12 |
rat |
| A Fernández-Guasti, C López-Rubalcav. Modification of the anxiolytic action of 5-HT1A compounds by GABA-benzodiazepine agents in rats. Pharmacology, biochemistry, and behavior. vol 60. issue 1. 1998-07-27. PMID:9610920. |
the general purpose of the present study was to analyze the possible interactions between the gaba benzodiazepine and the serotonin systems in the mediation of the antianxiety actions of 5-ht1a compounds. |
1998-07-27 |
2023-08-12 |
rat |
| D S Lorrain, L Matuszewich, E M Hul. 8-OH-DPAT influences extracellular levels of serotonin and dopamine in the medial preoptic area of male rats. Brain research. vol 790. issue 1-2. 1998-07-07. PMID:9593901. |
in experiment 2, 8-oh-dpat (500 microm) administered directly into the mpoa via reverse dialysis increased extracellular levels of both da and 5-ht; pretreatment with the selective 5-ht1a antagonist 4-iodo-n-[2-[4-(methoxyphenyl)-1-piperazinyl]ethyl]-n-2-pyridinyl-ben benzamide hydrochloride (p-mppi) failed to prevent 8-oh-dpat's stimulatory effects on da and 5-ht levels in the mpoa. |
1998-07-07 |
2023-08-12 |
rat |
| P R Germonpré, G F Joos, R A Pauwel. Modulation by 5-HT1A receptors of the 5-HT2 receptor-mediated tachykinin-induced contraction of the rat trachea in vitro. British journal of pharmacology. vol 123. issue 8. 1998-07-07. PMID:9605563. |
8-oh-dpat (1 microm), as well as the 5-ht1a receptor antagonists pmppi, sdz 216525 and nan-190 (0.1 microm each), caused significant inhibition of the tracheal contractions induced both by nka (10 nm-3 microm) and 5-ht (10 nm-10 microm) (n=4-10). |
1998-07-07 |
2023-08-12 |
rat |
| P R Germonpré, G F Joos, R A Pauwel. Modulation by 5-HT1A receptors of the 5-HT2 receptor-mediated tachykinin-induced contraction of the rat trachea in vitro. British journal of pharmacology. vol 123. issue 8. 1998-07-07. PMID:9605563. |
these data rule out the involvement of a 5-ht1a receptor-mediated positive feedback mechanism of the 5-ht release from mast cells. |
1998-07-07 |
2023-08-12 |
rat |
| M C Wolff, J D Leande. Selective serotonin reuptake inhibitors potentiate 8-OH-DPAT-induced stimulus control in the pigeon. European journal of pharmacology. vol 345. issue 1. 1998-07-06. PMID:9593591. |
the effects of two selective serotonin reuptake inhibitors, fluoxetine and citalopram, and a nonselective monoamine reuptake inhibitor, imipramine, were characterized in pigeons that had been trained to discriminate 0.64 mg/kg of 8-hydroxy-(2-di-n-propylamino)tetralin hydrobromide (8-oh-dpat), a 5-ht1a receptor agonist, from saline. |
1998-07-06 |
2023-08-12 |
pigeon |
| M C Wolff, J D Leande. Selective serotonin reuptake inhibitors potentiate 8-OH-DPAT-induced stimulus control in the pigeon. European journal of pharmacology. vol 345. issue 1. 1998-07-06. PMID:9593591. |
the data support the hypothesis that activation of the 5-ht1a receptor may be relevant to the mechanism of action of serotonin reuptake inhibitors. |
1998-07-06 |
2023-08-12 |
pigeon |
| L A Dawson, H Q Nguye. Effects of 5-HT1A receptor antagonists on fluoxetine-induced changes in extracellular serotonin concentrations in rat frontal cortex. European journal of pharmacology. vol 345. issue 1. 1998-07-06. PMID:9593592. |
effects of 5-ht1a receptor antagonists on fluoxetine-induced changes in extracellular serotonin concentrations in rat frontal cortex. |
1998-07-06 |
2023-08-12 |
rat |
| L A Dawson, H Q Nguye. Effects of 5-HT1A receptor antagonists on fluoxetine-induced changes in extracellular serotonin concentrations in rat frontal cortex. European journal of pharmacology. vol 345. issue 1. 1998-07-06. PMID:9593592. |
this effect has been attributed to the antagonist effects of pindolol at the presynaptic 5-ht1a receptor which augments the action of the serotonin specific reuptake inhibitors. |
1998-07-06 |
2023-08-12 |
rat |
| L A Dawson, H Q Nguye. Effects of 5-HT1A receptor antagonists on fluoxetine-induced changes in extracellular serotonin concentrations in rat frontal cortex. European journal of pharmacology. vol 345. issue 1. 1998-07-06. PMID:9593592. |
in the present study, we demonstrate that acute fluoxetine-induced increases in extracellular serotonin concentrations, as measured by microdialysis in the frontal cortex, can be potentiated by 5-ht1a receptor blockade using n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-(pyridinyl)cyclohexa necarboxamide (way100635), the silent and selective 5-ht1a receptor antagonist. |
1998-07-06 |
2023-08-12 |
rat |
| L A Dawson, H Q Nguye. Effects of 5-HT1A receptor antagonists on fluoxetine-induced changes in extracellular serotonin concentrations in rat frontal cortex. European journal of pharmacology. vol 345. issue 1. 1998-07-06. PMID:9593592. |
in addition, using antagonists with different intrinsic agonist activities for the 5-ht1a receptor, we have determined that only compounds with very low intrinsic agonist activity can produce a potentiation of the acute fluoxetine-induced increases in extracellular serotonin. |
1998-07-06 |
2023-08-12 |
rat |
| M G Giovannini, I Ceccarelli, B Molinari, M Cecchi, J Goldfarb, P Blandin. Serotonergic modulation of acetylcholine release from cortex of freely moving rats. The Journal of pharmacology and experimental therapeutics. vol 285. issue 3. 1998-07-02. PMID:9618425. |
phenylbiguanide (pbg) and m-chlorophenylbiguanide, two selective 5-ht3 agonists, mimicked the 5-ht responses, but 8-hydroxy-2-(di-n-propylamino)tetralin, a selective 5-ht1a agonist, was without effect. |
1998-07-02 |
2023-08-12 |
rat |
| T E Dudley, L A DiNardo, J D Glas. Endogenous regulation of serotonin release in the hamster suprachiasmatic nucleus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 13. 1998-07-02. PMID:9634570. |
systemic application of the somatodendritic 5-ht1a agonist bmy 7378 had a significantly greater suppressive effect on 5-ht release in the scn during the late dark phase compared with mid light phase, indicating that a variation in raphe autoreceptor response may underlie the time-dependent effects of wheel running on 5-ht release. |
1998-07-02 |
2023-08-12 |
Not clear |
| L E Gonzalez, S E File, D H Overstree. Selectively bred lines of rats differ in social interaction and hippocampal 5-HT1A receptor function: a link between anxiety and depression? Pharmacology, biochemistry, and behavior. vol 59. issue 4. 1998-06-26. PMID:9586832. |
the 5-ht1a receptor antagonist way100635 (200 ng) was administered to the dorsal hippocampus to test for possible differences between the lines in 5-ht tone. |
1998-06-26 |
2023-08-12 |
rat |
| N K Popova, D F Avgustinovich, V G Kolpakov, I Z Plyusnin. Specific [3H]8-OH-DPAT binding in brain regions of rats genetically predisposed to various defense behavior strategies. Pharmacology, biochemistry, and behavior. vol 59. issue 4. 1998-06-26. PMID:9586833. |
it is hypothesized that 5-ht1a and probably 5-ht1a-like 5-ht7 serotonin receptors are involved in the mechanisms of both active and passive defense reactions, and the high expression of fear-induced defense is associated with their decrease in the frontal cortex. |
1998-06-26 |
2023-08-12 |
rat |
| O Rilke, D Freier, M Jähkel, J Oehle. Dynamic alterations of serotonergic metabolism and receptors during social isolation of low- and high-active mice. Pharmacology, biochemistry, and behavior. vol 59. issue 4. 1998-06-26. PMID:9586845. |
alterations induced by social isolation (1 day to 18 weeks) in low- and high-active mice (lam and ham) were studied in respect to serotonin metabolism, [3h]-8-oh-dpat binding of presynaptic (midbrain), postsynaptic (hippocampus) 5-ht1a receptors and [3h]-ketanserin binding of cortical 5-ht2a receptors. |
1998-06-26 |
2023-08-12 |
mouse |
| J F López, D M Vázquez, D T Chalmers, S J Watso. Regulation of 5-HT receptors and the hypothalamic-pituitary-adrenal axis. Implications for the neurobiology of suicide. Annals of the New York Academy of Sciences. vol 836. 1998-06-24. PMID:9616796. |
the results of these studies can be summarized as follows: (1) chronic unpredictable stress produces high corticosteroid levels in rats; (2) chronic stress also results in changes in specific 5-ht receptors (increases in cortical 5-ht2a and decreases in hipocampal 5-ht1a and 5-ht1b); (3) chronic antidepressant administration prevents many of the 5-ht receptor changes observed after stress; and (4) chronic antidepressant administration reverses the overactivity of the hpa axis. |
1998-06-24 |
2023-08-12 |
rat |
| V Arango, M D Underwood, J J Man. Postmortem findings in suicide victims. Implications for in vivo imaging studies. Annals of the New York Academy of Sciences. vol 836. 1998-06-24. PMID:9616804. |
we found alterations in binding to the serotonin transporter, the 5-ht1a, and the 5-ht2a receptors primarily in the ventral and ventrolateral prefrontal cortex of suicide victims. |
1998-06-24 |
2023-08-12 |
human |
| T Taverne, O Diouf, P Depreux, J H Poupaert, D Lesieur, B Guardiola-Lemaître, P Renard, M C Rettori, D H Caignard, B Pfeiffe. Novel benzothiazolin-2-one and benzoxazin-3-one arylpiperazine derivatives with mixed 5HT1A/D2 affinity as potential atypical antipsychotics. Journal of medicinal chemistry. vol 41. issue 12. 1998-06-24. PMID:9622542. |
since it was known that 5ht properties (5ht1a agonism or 5ht2a antagonism) combined with d2 antagonism may lead to atypical antipsychotic drugs, a series of 19 benzothiazolin-2-one and benzoxazin-3-one derivatives possessing the arylpiperazine moiety was prepared, and their binding profiles were investigated. |
1998-06-24 |
2023-08-12 |
rat |
| A B Reitz, E W Baxter, E E Codd, C B Davis, A D Jordan, B E Maryanoff, C A Maryanoff, M E McDonnell, E T Powell, M J Renzi, M R Schott, M K Scott, R P Shank, J L Vaugh. Orally active benzamide antipsychotic agents with affinity for dopamine D2, serotonin 5-HT1A, and adrenergic alpha1 receptors. Journal of medicinal chemistry. vol 41. issue 12. 1998-06-24. PMID:9622541. |
orally active benzamide antipsychotic agents with affinity for dopamine d2, serotonin 5-ht1a, and adrenergic alpha1 receptors. |
1998-06-24 |
2023-08-12 |
human |