| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhiying Wang, Xiaoju Lin, Wangpeng Shi, Chuan Ca. Nicotinic Acetylcholine Receptor Alpha6 Contributes to Antiviral Immunity via IMD Pathway in Viruses. vol 16. issue 4. 2024-04-27. PMID:38675904. |
nicotinic acetylcholine receptor alpha6 contributes to antiviral immunity via imd pathway in currently, insecticides that target nicotinic acetylcholine receptors (nachr) are widely used. |
2024-04-27 |
2024-04-29 |
Not clear |
| Uthpala Chandrasekara, Marco Mancuso, Joanna Sumner, Dan Edwards, Christina N Zdenek, Bryan G Fr. Sugar-coated survival: N-glycosylation as a unique bearded dragon venom resistance trait within Australian agamid lizards. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2024-04-26. PMID:38670246. |
this study zeroes in on the particular motifs within the orthosteric sites of post-synaptic nicotinic acetylcholine receptors (nachr) that confer resistance to α-neurotoxins, often through structural alterations of nachr. |
2024-04-26 |
2024-04-29 |
human |
| Jorge L B Neves, Cristoval Urcino, Kevin Chase, Cheryl Dowell, Arik J Hone, David Morgenstern, Victor M Chua, Iris Bea L Ramiro, Julita S Imperial, Lee S Leavitt, Jasmine Phan, Fernando A Fisher, Maren Watkins, Shrinivasan Raghuraman, Jortan O Tun, Beatrix M Ueberheide, J Michael McIntosh, Vitor Vasconcelos, Baldomero M Olivera, Joanna Gajewia. Using Constellation Pharmacology to Characterize a Novel α-Conotoxin from Marine drugs. vol 22. issue 3. 2024-03-27. PMID:38535458. |
α-conotoxins (αctx) interact with nicotinic acetylcholine receptors (nachrs) and are powerful tools for investigating the structure and function of the various nachr subtypes. |
2024-03-27 |
2024-03-29 |
Not clear |
| Yves Haufe, Dominik Loser, Timm Danker, Annette Nick. Symmetrical Bispyridinium Compounds Act as Open Channel Blockers of Cation-Selective Ion Channels. ACS pharmacology & translational science. vol 7. issue 3. 2024-03-18. PMID:38495220. |
current treatments against organophosphate poisoning (opp) do not directly address effects mediated by the overstimulation of nicotinic acetylcholine receptors (nachr). |
2024-03-18 |
2024-03-20 |
human |
| Sae Uchida, Fusako Kagitan. Influence of age on nicotinic cholinergic regulation of blood flow in rat's olfactory bulb and neocortex. The journal of physiological sciences : JPS. vol 74. issue 1. 2024-03-16. PMID:38491428. |
with a focus on nicotinic acetylcholine receptors (nachrs), this review article provides an overview and discussion of the following findings: (1) the nachrs-mediated regulation of regional blood flow in the neocortex and olfactory bulb, (2) the nachr subtypes that mediate their responses, and (3) their activity in old rats. |
2024-03-16 |
2024-03-19 |
rat |
| Aditi Pradhan, Hayley Mounford, Jessica Peixinho, Edward Rea, Emmanouela Epeslidou, Julia S Scott, Joanna Cull, Susan Maxwell, Richard Webster, David Beeson, Yin Yao Dong, Stefan Prekovic, Isabel Bermudez, Dianne F Newbur. Unraveling the molecular interactions between α7 nicotinic receptor and a RIC3 variant associated with backward speech. Cellular and molecular life sciences : CMLS. vol 81. issue 1. 2024-03-13. PMID:38472514. |
ric3 is important for the folding, maturation, and functional expression of α7 nicotinic acetylcholine receptors (nachr). |
2024-03-13 |
2024-03-15 |
human |
| Clelia Dallanoce, Katrin Richter, Clare Stokes, Claudio Papotto, Hina Andleeb, Ganesh A Thakur, Andrew Kerr, Veronika Grau, Roger L Papk. New Alpha9 nAChR Ligands Based on a 5-(Quinuclidin-3-ylmethyl)-1,2,4-oxadiazole Scaffold. ACS chemical neuroscience. 2024-02-09. PMID:38335726. |
several lines of evidence have indicated that nicotinic acetylcholine receptors (nachr) that contain α9 subunits, probably in combination with α10 subunits, may be valuable targets for the management of pain associated with inflammatory diseases through a cholinergic anti-inflammatory system (cas), which has also been associated with α7 nachr. |
2024-02-09 |
2024-02-12 |
Not clear |
| Yong-Il Kim, Seung Hak Lee, Jin Hwa Jung, Seog-Young Kim, Nare Ko, Sang Ju Lee, Seung Jun Oh, Jin-Sook Ryu, Dabin Ko, Won Kim, Kyunggon Ki. EJNMMI research. vol 14. issue 1. 2024-01-22. PMID:38252356. |
the increased expression of the nicotinic acetylcholine receptor (nachr) in muscle denervation is thought to be associated with electrophysiological acetylcholine supersensitivity after nerve injury. |
2024-01-22 |
2024-01-24 |
Not clear |
| Yue Yang, Tatsuya Arai, Daisuke Sasaki, Masahiro Kuramochi, Hidetoshi Inagaki, Sumiko Ohashi, Hiroshi Sekiguchi, Kazuhiro Mio, Tai Kubo, Yuji C Sasak. Real-time tilting and twisting motions of ligand-bound states of α7 nicotinic acetylcholine receptor. European biophysics journal : EBJ. 2024-01-17. PMID:38233601. |
to verify this hypothesis applies to α7 nicotinic acetylcholine receptor, we utilized a diffracted x-ray tracking method to monitor the stable twisting and tilting motion of nachr α7 without a ligand, with acetylcholine, with ivermectin, and with both of them. |
2024-01-17 |
2024-01-20 |
Not clear |
| Susan M O'Connor, Brad E Sleebs, Ian P Street, Bernard L Flynn, Jonathan B Baell, Carolyn Coles, Nurul Quazi, Dharam Paul, Etienne Poiraud, Bertrand Huyard, Stephanie Wagner, Emile Andriambeloson, Errol B de Souz. BNC210, a negative allosteric modulator of the alpha 7 nicotinic acetylcholine receptor, demonstrates anxiolytic- and antidepressant-like effects in rodents. Neuropharmacology. 2024-01-07. PMID:38185416. |
this work describes the characterization of bnc210 (6-[(2,3-dihydro-1h-inden-2-yl)amino]-1-ethyl-3-(4-morpholinylcarbonyl)-1,8-naphthyridin-4(1h)-one), a selective, small molecule, negative allosteric modulator (nam) of α7 nicotinic acetylcholine receptors (α7 nachr). |
2024-01-07 |
2024-01-10 |
mouse |
| Ashwini Wani, Bala Prabhakar, Pravin Shend. Competitive inhibition of nicotine acetylcholine receptors using microneedles of nicotine and varenicline for smoking withdrawal therapy. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2023-12-30. PMID:38159871. |
nicotine released in a sustained manner attaches to the nicotine acetylcholine receptors (nachr) to release dopamine for controlling the withdrawal challenges such as anxiety, irritability, cravings, disturbed sleep pattern, etc. |
2023-12-30 |
2024-01-05 |
Not clear |
| Xingxing Lu, Huan Xu, Xiaoming Zhang, Tengda Sun, Yufan Lin, Honghong Li, Xuesheng Li, Li Zhang, Hongxia Duan, Xinling Yang, Yun Lin. Target-Based Design, Synthesis, and Biological Evaluation of Novel 1,2,4-Triazolone Derivatives as Potential nAChR Modulators. Journal of agricultural and food chemistry. 2023-12-05. PMID:38050804. |
to discover a novel, efficient, and highly selective nicotinic insecticide candidate, we developed a unified pharmacological model using tbdd by studying the binding modes of 11 nicotinic acetylcholine receptor (nachr) modulators with acetylcholine binding protein (achbp) targets for the first time. |
2023-12-05 |
2023-12-10 |
Not clear |
| Hamed Alizadeh Pahlavan. Possible role of exercise therapy on depression: effector neurotransmitters as key players. Behavioural brain research. 2023-12-04. PMID:38048912. |
the expression of m5 receptor and nachr α7 increases after exercise and significantly increases dopamine and acetylcholine and ameliorates depression. |
2023-12-04 |
2023-12-10 |
Not clear |
| Yuanyuan Zhao, Hao Yang, Yanbing Chen, Meijin Du, Wenwen Gu, Wenjin Zha. Synthesis of environmentally friendly neonicotinoid insecticide with proper functional properties by theoretical methodologies. Ecotoxicology and environmental safety. vol 268. 2023-11-18. PMID:37979357. |
modern insecticide substitutes using acetylcholine receptors (nachr) as biochemical targets, such as neonicotinoid insecticides (nnis), have been extensively researched. |
2023-11-18 |
2023-11-20 |
Not clear |
| Xiaosa Wu, Arik J Hone, Yen-Hua Huang, Richard J Clark, J Michael McIntosh, Quentin Kaas, David J Crai. Computational design of α-conotoxins to target specific nicotinic acetylcholine receptor subtypes. Chemistry (Weinheim an der Bergstrasse, Germany). 2023-11-01. PMID:37910861. |
nicotinic acetylcholine receptors (nachrs) are drug targets for neurological diseases and disorders, but selective targeting of the large number of nachr subtypes is challenging. |
2023-11-01 |
2023-11-08 |
Not clear |
| Edouard Montigné, David Balayssa. Exploring Cholinergic Compounds for Peripheral Neuropathic Pain Management: A Comprehensive Scoping Review of Rodent Model Studies. Pharmaceuticals (Basel, Switzerland). vol 16. issue 10. 2023-10-30. PMID:37895835. |
over the past decades, researchers have explored the cholinergic system (muscarinic and nicotinic acetylcholine receptors: machr and nachr) and compounds targeting these receptors as potential analgesics for neuropathic pain management. |
2023-10-30 |
2023-11-08 |
Not clear |
| Edouard Montigné, David Balayssa. Exploring Cholinergic Compounds for Peripheral Neuropathic Pain Management: A Comprehensive Scoping Review of Rodent Model Studies. Pharmaceuticals (Basel, Switzerland). vol 16. issue 10. 2023-10-30. PMID:37895835. |
the most studied compounds were agonists of α4β2 nachr and α7 nachr, and antagonists of α9/α10 nachr, along with those increasing acetylcholine and targeting machrs. |
2023-10-30 |
2023-11-08 |
Not clear |
| Souhei Sakata, Fumihito On. Allosteric inhibition of muscle-type nicotinic acetylcholine receptors by a neuromuscular blocking agent pancuronium. PloS one. vol 18. issue 10. 2023-10-12. PMID:37824562. |
early studies suggested that a classical non-depolarizing muscle relaxant pancuronium competitively binds to the ligand binding site to block nicotinic acetylcholine receptors (nachr). |
2023-10-12 |
2023-10-15 |
zebrafish |
| Markus M Hilscher, Sanja Mikulovic, Sharn Perry, Stina Lundberg, Klas Kullande. The alpha2 nicotinic acetylcholine receptor, a subunit with unique and selective expression in inhibitory interneurons associated with principal cells. Pharmacological research. 2023-08-31. PMID:37652281. |
nicotinic acetylcholine receptors (nachrs) play crucial roles in various human disorders, with the α7, α4, α6, and α3-containing nachr subtypes extensively studied in relation to conditions such as alzheimer's disease, parkinson's disease, nicotine dependence, mood disorders, and stress disorders. |
2023-08-31 |
2023-09-07 |
human |
| Runbo Gao, Amelia M Schneider, Sarah M Mulloy, Anna M Le. Expression pattern of nicotinic acetylcholine receptor subunit transcripts in neurons and astrocytes in the ventral tegmental area and locus coeruleus. The European journal of neuroscience. 2023-08-04. PMID:37539749. |
acetylcholine is the endogenous agonist for the neuronal nicotinic acetylcholine receptor (nachr) system, which is involved in attention, memory, affective behaviours and substance use disorders. |
2023-08-04 |
2023-08-14 |
mouse |