| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ryan Gallagher, Taima Qudah, Thomas Balle, Mary Chebib, Malcolm D McLeo. Novel methyllycaconitine analogues selective for the α4β2 over α7 nicotinic acetylcholine receptors. Bioorganic & medicinal chemistry. vol 51. 2021-12-07. PMID:34798380. |
electrophysiology experiments using xenopus oocytes expressing nicotinic acetylcholine receptors (nachrs) revealed selected analogues served as non-competitive inhibitors that showed selectivity for the α4β2 over α7 nachr subtypes, and selectivity for the (α4) |
2021-12-07 |
2023-08-13 |
xenopus_laevis |
| Farah Deba, Kemburli Munoz, Eloisa Peredia, Gustav Akk, Ayman K Hamoud. Assessing Potentiation of the (α4)3(β2)2 Nicotinic Acetylcholine Receptor by the Allosteric Agonist CMPI. The Journal of biological chemistry. 2021-12-03. PMID:34861241. |
the extracellular domain of the nicotinic acetylcholine receptor isoforms formed by three α4 and two β2 subunits ((α4)3(β2)2 nachr) harbors two high-affinity "canonical" acetylcholine (ach) binding sites located in the two α4:β2 intersubunit interfaces and a low-affinity "non-canonical" ach binding site located in the α4:α4 intersubunit interface. |
2021-12-03 |
2023-08-13 |
xenopus_laevis |
| Luis M Rivera-Perez, Julia T Kwapiszewski, Michael T Robert. α Frontiers in neural circuits. vol 15. 2021-11-20. PMID:34434092. |
application of nachr antagonists revealed that acetylcholine excites vip neurons mainly via activation of α |
2021-11-20 |
2023-08-13 |
mouse |
| Jie Xiang, Long-Yan Ran, Xiao-Xiao Zeng, Wen-Wen He, Yi Xu, Kun Cao, Yang-Ting Dong, Xiao-Lan Qi, Wen-Feng Yu, Yan Xiao, Zhi-Zhong Gua. LiCl attenuates impaired learning and memory of APP/PS1 mice, which in mechanism involves α7 nAChRs and Wnt/β-catenin pathway. Journal of cellular and molecular medicine. vol 25. issue 22. 2021-11-18. PMID:34708522. |
in the cerebral zone of app/ps1 mice, the level of aβ was increased and those of α7 nicotinic acetylcholine receptors (nachr), phosphor-gsk3β (ser9), β-catenin and cyclin d1 (protein and/or mrna levels) reduced. |
2021-11-18 |
2023-08-13 |
mouse |
| Monika I Hollenhorst, Gabriela Krasteva-Chris. Nicotinic Acetylcholine Receptors in the Respiratory Tract. Molecules (Basel, Switzerland). vol 26. issue 20. 2021-11-17. PMID:34684676. |
nicotinic acetylcholine receptors (nachr) are widely distributed in neuronal and non-neuronal tissues, where they play diverse physiological roles. |
2021-11-17 |
2023-08-13 |
Not clear |
| Shachi Shuchi Smita, Mashu Trivedi, Deepika Tripathi, Shashi Pandey-Rai, Rakesh Pande. Neuromodulatory potential of Asparagus racemosus and its bioactive molecule Shatavarin IV by enhancing synaptic acetylcholine level and nAChR activity. Neuroscience letters. vol 764. 2021-11-08. PMID:34655710. |
neuromodulatory potential of asparagus racemosus and its bioactive molecule shatavarin iv by enhancing synaptic acetylcholine level and nachr activity. |
2021-11-08 |
2023-08-13 |
caenorhabditis_elegans |
| Chandrika Abburi, John McDai. Ethanol interaction with α3β4 nicotinic acetylcholine receptors in neurons of the laterodorsal tegmentum. Alcoholism, clinical and experimental research. 2021-11-02. PMID:34625982. |
nicotinic acetylcholine receptors (nachrs) play a key role in the rewarding effects of ethanol (etoh), and while several nachr subtypes have been implicated, attention has recently shifted to a role for the α3β4 nachr. |
2021-11-02 |
2023-08-13 |
Not clear |
| John A Dani, Daniel Jenson, John I Broussard, Mariella De Bias. Neurophysiology of Nicotine Addiction. Journal of addiction research & therapy. vol S1. issue 1. 2021-10-21. PMID:22454789. |
nicotine binds to nicotinic acetylcholine receptors (nachr) to produce its initial effects. |
2021-10-21 |
2023-08-12 |
Not clear |
| Cecilia Gotti, Francesco Clement. Cytisine and cytisine derivatives. More than smoking cessation aids. Pharmacological research. vol 170. 2021-10-18. PMID:34087351. |
its main targets are neuronal nicotinic acetylcholine receptors (nachrs), and pre-clinical studies have shown that its interactions with various nachr subtypes located in different areas of the central and peripheral nervous systems are neuroprotective, have a wide range of biological effects on nicotine and alcohol addiction, regulate mood, food intake and motor activity, and influence the autonomic and cardiovascular systems. |
2021-10-18 |
2023-08-13 |
Not clear |
| Maegan M Weltzin, Andrew A George, Ronald J Lukas, Paul Whiteake. Sleep-related hypermotor epilepsy associated mutations uncover important kinetic roles of α4β2- nicotinic acetylcholine receptor intracellular structures. PloS one. vol 16. issue 3. 2021-10-13. PMID:33657187. |
sleep-related hypermotor epilepsy (she) is a group of seizure disorders prominently associated with mutations in nicotinic acetylcholine receptors (nachr). |
2021-10-13 |
2023-08-13 |
xenopus_laevis |
| Mengwen Zhao, Yuequn Ma, Juncai Xin, Changying Cao, Ju Wan. Detection of differential selection pressure and functional-specific sites in subunits of vertebrate neuronal nicotinic acetylcholine receptors. Journal of biomolecular structure & dynamics. 2021-10-01. PMID:34596010. |
the nicotinic acetylcholine receptors (nachr) are made of subunits evolved from a common ancestor. |
2021-10-01 |
2023-08-13 |
human |
| C N Miller, H M Kamen. The role of nicotinic acetylcholine receptors in alcohol-related behaviors. Brain research bulletin. vol 163. 2021-09-29. PMID:32707263. |
nicotine acts directly at nicotinic acetylcholine receptors (nachr) to have its pharmacological effect. |
2021-09-29 |
2023-08-13 |
human |
| Federica Bono, Veronica Mutti, Paola Devoto, Silvia Bolognin, Jens C Schwamborn, Cristina Missale, Chiara Fiorentin. Impaired dopamine D3 and nicotinic acetylcholine receptor membrane localization in iPSCs-derived dopaminergic neurons from two Parkinson's disease patients carrying the LRRK2 G2019S mutation. Neurobiology of aging. vol 99. 2021-09-28. PMID:33422895. |
the results show that mutant lrrk2 prevents the membrane localization of both the dopamine d3 receptors (d3r) and the nicotinic acetylcholine receptors (nachr) and the formation of the d3r-nachr heteromer, a molecular unit crucial for promoting neuronal homeostasis and preserving dopaminergic neuron health. |
2021-09-28 |
2023-08-13 |
Not clear |
| b' Denis Servent, Carole Malgorn, Myl\\xc3\\xa8ne Bernes, Sophie Gil, Christelle Simasotchi, Anne-Sophie H\\xc3\\xa9rard, Thierry Delzescaux, Robert Thai, Peggy Barbe, Mathilde Keck, Fabrice Beau, Armen Zakarian, Vincent Dive, Jordi Molg\\xc3\\xb. First evidence that emerging pinnatoxin-G, a contaminant of shellfish, reaches the brain and crosses the placental barrier. The Science of the total environment. vol 790. 2021-08-13. PMID:34380275.' |
pntx display a potent antagonist effect on nicotinic acetylcholine receptors (nachr), and in this study we assessed in vivo the ability of pntx-g to cross physiological barriers to reach its molecular target. |
2021-08-13 |
2023-08-13 |
Not clear |
| Alican Gulsevi. Nicotinic receptor pharmacology in silico: Insights and challenges. Neuropharmacology. vol 177. 2021-08-12. PMID:32738311. |
nicotinic acetylcholine receptors (nachr) are homo- or hetero-pentameric ligand-gated ion channels of the cys-loop superfamily and play important roles in the nervous system and muscles. |
2021-08-12 |
2023-08-13 |
Not clear |
| Giulia Puia, Federica Ravazzin. Thyroid hormones reduce nicotinic receptor mediated currents in SH-SY5Y neuroblastoma cells. Pharmacological reports : PR. vol 72. issue 6. 2021-08-12. PMID:33085069. |
since ths imbalance affects cognition and the cholinergic system is deeply involved in learning and memory processes we have studied ths effects at the level of the nicotinic acetylcholine receptors (nachr). |
2021-08-12 |
2023-08-13 |
Not clear |
| Strahinja Stevanovic, Djordje S Marjanović, Sasa M Trailović, Nemanja Zdravković, Andrej Perdih, Katarina Nikoli. Potential modulating effect of the Ascaris suum nicotinic acetylcholine receptor (nAChR) by compounds GSK575594A, diazepam and flumazenil discovered by structure-based virtual screening approach. Molecular and biochemical parasitology. vol 242. 2021-07-30. PMID:33422580. |
our aim was to identify compounds with a potential antihelmintic modulatory effect on nicotinic acetylcholine receptors (nachr). |
2021-07-30 |
2023-08-13 |
Not clear |
| Nathalia M Pinheiro, Rosana Banzato, Iolanda Tibério, Marco A M Prado, Vânia F Prado, Ayman K Hamouda, Carla M Prad. Acute Lung Injury in Cholinergic-Deficient Mice Supports Anti-Inflammatory Role of α7 Nicotinic Acetylcholine Receptor. International journal of molecular sciences. vol 22. issue 14. 2021-07-30. PMID:34299169. |
this study investigated changes in the expression levels of nicotinic and muscarinic acetylcholine receptors (nachr and machr) in the lung during acute lung injury. |
2021-07-30 |
2023-08-13 |
mouse |
| Jordana Fox, Drew M Thodeson, Alison M Dolc. Nicotine: A Targeted Therapy for Epilepsy Due to nAChR Gene Variants. Journal of child neurology. vol 36. issue 5. 2021-07-26. PMID:33284031. |
in preclinical models, pathogenic nachr variants cause a gain of function mutation with sensitivity to acetylcholine antagonists and agonists. |
2021-07-26 |
2023-08-13 |
Not clear |
| Miroslav Pohank. Pharmacological Influencing of The Cholinergic Anti-inflammatory Pathway in Infectious Diseases and Inflammatory Pathologies. Mini reviews in medicinal chemistry. vol 21. issue 6. 2021-07-12. PMID:33208075. |
it consists of terminations of the vagal nerve into blood, acetylcholine released from the terminations, macrophages and other cells having α7 nicotinic acetylcholine receptor (α7 nachr), calcium ions crossing through the receptor and interacting with nuclear factors, and erythrocytes with acetylcholinesterase (ache) terminating the neurotransmission. |
2021-07-12 |
2023-08-13 |
Not clear |