| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tamara Carna. Schizophrenia Hypothesis: Autonomic Nervous System Dysregulation of Fetal and Adult Immune Tolerance. Frontiers in systems neuroscience. vol 16. 2022-07-18. PMID:35844244. |
acetylcholine activation of the α7 subunit of the nicotinic acetylcholine receptor (α7 nachr) on the cell surface of immune cells leads to pi3k/akt pathway activation and can control immune cell polarization. |
2022-07-18 |
2023-08-14 |
Not clear |
| Ruben Bakker, Astrid Ekelmans, Liyan Xie, Riet Vooijs, Dick Roelofs, Jacintha Ellers, Katja M Hoedjes, Cornelis A M van Geste. Biomarker development for neonicotinoid exposure in soil under interaction with the synergist piperonyl butoxide in Folsomia candida. Environmental science and pollution research international. 2022-06-21. PMID:35729387. |
we identified two genes that are reliably indicative for neonicotinoid exposure even under metabolic inhibition of cyps by pbo, nicotinic acetylcholine receptor-subunit alpha 1 (nachr) and sodium-coupled monocarboxylate transporter (smct). |
2022-06-21 |
2023-08-14 |
Not clear |
| Namita Pandey, Jonita Chongtham, Soumyadip Pal, Ashraf Ali, Sanjeev Lalwani, Deepali Jain, Anant Mohan, Tapasya Srivastav. When "No-Smoking" is not enough: Hypoxia and nicotine acetylcholine receptor signaling may drive lung adenocarcinoma progression in never-smokers. Biochimica et biophysica acta. Molecular cell research. 2022-06-01. PMID:35649481. |
our study gives a plausible explanation for the equally worse prognosis of lung adenocarcinoma in never-smokers wherein the nachr signaling is enhanced in hypoxia by acetylcholine in the absence of nicotine. |
2022-06-01 |
2023-08-13 |
Not clear |
| Viktor A Stratilov, Oleg V Vetrovoy, Ekaterina I Tyulkov. Prenatal Hypoxia Affects Nicotine Consumption and Withdrawal in Adult Rats via Impairment of the Glutamate System in the Brain. Molecular neurobiology. 2022-05-17. PMID:35581520. |
after 2 weeks of chronic treatment with nicotine via osmotic minipump (9 mg/kg per day), we assessed the symptoms of withdrawal in the conditioned place aversion test after mecamylamine (an antagonist of nicotinic acetylcholine receptors, nachr) treatment. |
2022-05-17 |
2023-08-13 |
rat |
| Khadija Boukholda, Brahim Gargouri, Bakhta Aouey, Abdelraheim Attaai, Mohamed Abd Elkodous, Mohamed Najimi, Bernd L Fiebich, Michèle Bouchard, Hamadi Fetou. Subacute silica nanoparticle exposure induced oxidative stress and inflammation in rat hippocampus combined with disruption of cholinergic system and behavioral functions. NanoImpact. vol 24. 2022-05-13. PMID:35559817. |
in addition, sinps significantly increased mrna expression level of genes related to inflammation (tnf-α, il-1β, il-6, and cox-2) and decreased mrna expression level of genes related to cholinergic system including choline acetyltransferase (chat), vesicular acetylcholine transporter (vacht), ache, muscarinic acetylcholine receptor m1 (m1achr) and nicotinic acetylcholine receptors (nachr). |
2022-05-13 |
2023-08-13 |
rat |
| E R Shaykhutdinova, A E Kondrakhina, I A Ivanov, D S Kudryavtsev, I A Dyachenko, A N Murashev, V I Tsetlin, Yu N Utki. Synthetic Analogs of 6-Bromohypaphorine, a Natural Agonist of Nicotinic Acetylcholine Receptors, Reduce Cardiac Reperfusion Injury in a Rat Model of Myocardial Ischemia. Doklady. Biochemistry and biophysics. vol 503. issue 1. 2022-05-10. PMID:35538277. |
the data available to date indicate that the activation of nicotinic acetylcholine receptors (nachr) of α7 type can reduce heart damage resulting from ischemia and subsequent reperfusion. |
2022-05-10 |
2023-08-13 |
rat |
| Nuno Capela, Artur Sarmento, Sandra Simões, Henrique M V S Azevedo-Pereira, José Paulo Sous. Sub-lethal doses of sulfoxaflor impair honey bee homing ability. The Science of the total environment. 2022-05-08. PMID:35526620. |
in the meantime, new substances like sulfoxaflor, that have a similar mode of action acting on the insect's nicotinic acetylcholine receptors (nachr), have been approved for agricultural use. |
2022-05-08 |
2023-08-13 |
bee |
| Mukesh K Dhillon, Jagdish Jaba, Pallavi Mishra, Mir Asif Iquebal, Sarika Jaiswal, Aditya K Tanwar, Nareshkumar Bharat, Naveen Arora, Suraj Prasad Mishra, Shyam Prasad Gogineni, Fazil Hasan, Anil Rai, Dinesh Kumar, Hari C Sharm. Whole genome sequencing of spotted stem borer, Chilo partellus, reveals multiple genes encoding enzymes for detoxification of insecticides. Functional & integrative genomics. 2022-04-15. PMID:35426546. |
also, target receptors related to insecticide action, 4 acetylcholinesterase (ache), 14 γ-aminobutyric acid (gaba), and 15 nicotinic acetylcholine (nachr) receptors were detected. |
2022-04-15 |
2023-08-13 |
Not clear |
| Omar Alijevic, Oihane Jaka, Ainhoa Alzualde, Diana Maradze, Wenhao Xia, Stefan Frentzel, Andrew N Gifford, Manuel C Peitsch, Julia Hoeng, Kyoko Koshib. Differentiating the Neuropharmacological Properties of Nicotinic Acetylcholine Receptor-Activating Alkaloids. Frontiers in pharmacology. vol 13. 2022-04-08. PMID:35392565. |
alkaloids that target nicotinic acetylcholine receptors (nachr) are of great interest because of the critical role they play in mood and anxiety. |
2022-04-08 |
2023-08-13 |
Not clear |
| Samantha Johnstone, Maryam Sorkhou, Rachel A Rabin, Tony P Georg. Dose-dependent effects of Varenicline on tobacco craving and withdrawal in tobacco smokers with and without schizophrenia. Drug and alcohol dependence. vol 234. 2022-04-08. PMID:35395548. |
varenicline, a partial agonist at α4β2 nicotinic acetylcholine receptors (nachrs) is an effective smoking cessation pharmacotherapy, however, investigation into its effects in scz are less well-studied and mechanisms may differ from non-psychiatric controls due to dysregulation in nachr neurotransmission associated with scz. |
2022-04-08 |
2023-08-13 |
human |
| Hongxing Wang, Yubin Li, Manyi Yang, Maojun Zho. Synthesis and characterization of αM-conotoxin SIIID, a reversible human α7 nicotinic acetylcholine receptor antagonist. Toxicon : official journal of the International Society on Toxinology. vol 210. 2022-03-07. PMID:35255330. |
patch clamp experiments on hek293 cells expressing nachr subtypes showed that 1 μm siiid (1-4, 2-5, 3-6) inhibited pnu-120596 and acetylcholine induced human α7 nachr currents by 48.45%, which was higher than 5.08% of siiid (1-5, 2-4, 3-6) and 9.57% of siiid (1-6, 2-4, 3-5). |
2022-03-07 |
2023-08-13 |
human |
| Hongxing Wang, Yubin Li, Manyi Yang, Maojun Zho. Synthesis and characterization of αM-conotoxin SIIID, a reversible human α7 nicotinic acetylcholine receptor antagonist. Toxicon : official journal of the International Society on Toxinology. vol 210. 2022-03-07. PMID:35255330. |
further study on the most active siiid isomer showed that 10 μm siiid inhibited pnu-120596 and acetylcholine induced human α7 nachr currents by 76.33% but had no obvious effect on acetylcholine induced human α3β4 nachr currents. |
2022-03-07 |
2023-08-13 |
human |
| Hongxing Wang, Yubin Li, Manyi Yang, Maojun Zho. Synthesis and characterization of αM-conotoxin SIIID, a reversible human α7 nicotinic acetylcholine receptor antagonist. Toxicon : official journal of the International Society on Toxinology. vol 210. 2022-03-07. PMID:35255330. |
in addition, siiid inhibited pnu-120596 and acetylcholine induced human α7 nachr currents with an ic |
2022-03-07 |
2023-08-13 |
human |
| Xiao-Tao Jin, Ryan M Drena. Functional α7 nicotinic acetylcholine receptors in GABAergic neurons of the interpeduncular nucleus. Neuropharmacology. 2022-02-15. PMID:35167902. |
ipn neurons express nicotinic acetylcholine receptors (nachr) and receive strong cholinergic innervation from the ventral medial habenula. |
2022-02-15 |
2023-08-13 |
Not clear |
| Yingjie Xia, Qiyun Wu, Shinghung Mak, Etta Y L Liu, Brody Z Y Zheng, Tina T X Dong, Rongbiao Pi, Karl W K Tsi. Regulation of acetylcholinesterase during the lipopolysaccharide-induced inflammatory responses in microglial cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36. issue 3. 2022-02-07. PMID:35129858. |
the non-classical function of acetylcholine (ach) has been reported in neuroinflammation that represents the modulating factor in immune responses via activation of α7 nicotinic acetylcholine receptor (α7 nachr), i.e., a cholinergic anti-inflammatory pathway (cap). |
2022-02-07 |
2023-08-13 |
rat |
| Joseph Hawkins, Eleanor L Mitchell, Andrew K Jone. NACHO permits functional heterologous expression of an insect homomeric α6 nicotinic acetylcholine receptor. Pesticide biochemistry and physiology. vol 181. 2022-01-27. PMID:35082026. |
insect nicotinic acetylcholine receptors (nachr) are molecular targets of highly effective insecticides. |
2022-01-27 |
2023-08-13 |
xenopus_laevis |
| Marta Kopańska, Marta Batoryna, Paulina Bartman, Jacek Szczygielski, Agnieszka Banaś-Ząbczy. Disorders of the Cholinergic System in COVID-19 Era-A Review of the Latest Research. International journal of molecular sciences. vol 23. issue 2. 2022-01-21. PMID:35054856. |
the sars-cov-2 spike protein has a sequence similar to neurotoxins, capable of binding nicotinic acetylcholine receptors (nachr). |
2022-01-21 |
2023-08-13 |
human |
| Zhi-Min Wang, Sha Li, Cheng-Cheng Shi, Lin-Jie Xie, Kai-Yun Fu, Wei-Hua Jian. The actions of neonicotinoid insecticides on nicotinic acetylcholine subunits Ldα1 and Ldα8 of Leptinotarsa decemlineata and assembled receptors. Insect science. 2022-01-17. PMID:35038787. |
in this study, we analyzed the response of acetylcholine and neonicotinoids (thiamethoxam, imidacloprid and clothianidin) on hybrid receptors constructed by nachr α1 and α8 subunits of l. decemlineata (ldα1 and ldα8) co-expressed with rat β2 subunit (rβ2) at different crna ratios in xenopus oocytes. |
2022-01-17 |
2023-08-13 |
rat |
| Konstantin A Petrov, Svetlana E Proskurina, Eric Krejc. Cholinesterases in Tripartite Neuromuscular Synapse. Frontiers in molecular neuroscience. vol 14. 2022-01-10. PMID:35002624. |
one of the strongest is a depression of ach release that depends on the activation of α7 nicotinic acetylcholine receptors (nachr). |
2022-01-10 |
2023-08-13 |
mouse |
| I A Dyachenko, Yu A Palikova, V A Palikov, Y V Korolkova, V A Kazakov, N S Egorova, A I Garifulina, Y N Utkin, V I Tsetlin, E V Kryukov. α-Conotoxin RgIA and oligoarginine R8 in the mice model alleviate long-term oxaliplatin induced neuropathy. Biochimie. 2022-01-03. PMID:34979156. |
Оligoarginines were recently discovered (lebedev et al., 2019 nov) [1] as a novel class of nicotinic acetylcholine receptors (nachrs) inhibitors, octaoligoarginine r8 showing a relatively high affinity (40 nm) for the α9/α10 nachr. |
2022-01-03 |
2023-08-13 |
mouse |