| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Runbo Gao, Amelia M Schneider, Sarah M Mulloy, Anna M Le. Expression pattern of nicotinic acetylcholine receptor subunit transcripts in neurons and astrocytes in the ventral tegmental area and locus coeruleus. The European journal of neuroscience. 2023-08-04. PMID:37539749. |
acetylcholine is the endogenous agonist for the neuronal nicotinic acetylcholine receptor (nachr) system, which is involved in attention, memory, affective behaviours and substance use disorders. |
2023-08-04 |
2023-08-14 |
mouse |
| Carlo Matera, Claudio Papotto, Clelia Dallanoce, Marco De Amic. Advances in small molecule selective ligands for heteromeric nicotinic acetylcholine receptors. Pharmacological research. 2023-06-11. PMID:37302724. |
the study of nicotinic acetylcholine receptors (nachrs) has significantly progressed in the last decade, due to a) the improved techniques available for structural studies; b) the identification of ligands interacting at orthosteric and allosteric recognition sites on the nachr proteins, able to tune channel conformational states; c) the better functional characterization of receptor subtypes/subunits and their therapeutic potential; d) the availability of novel pharmacological agents able to activate or block nicotinic-mediated cholinergic responses with subtype or stoichiometry selectivity. |
2023-06-11 |
2023-08-14 |
Not clear |
| Kechun Yang, Ian McLaughlin, Jessica K Shaw, Natalia Quijano-Cardé, John A Dani, Mariella De Bias. CHRNA5 gene variation affects the response of VTA dopaminergic neurons during chronic nicotine exposure and withdrawal. Neuropharmacology. 2023-04-28. PMID:37116611. |
nicotine is the principal psychoactive component in tobacco that drives addiction through its action on neuronal nicotinic acetylcholine receptors (nachr). |
2023-04-28 |
2023-08-14 |
mouse |
| Masae Kinoshita, Hitoshi Okamot. Acetylcholine potentiates glutamate transmission from the habenula to the interpeduncular nucleus in losers of social conflict. Current biology : CB. 2023-04-27. PMID:37105168. |
these data suggest that acetylcholine released from hb terminals in the vipn induces activation of α7 nachr followed by an increase in postsynaptic membrane glua1. |
2023-04-27 |
2023-08-14 |
zebrafish |
| J R Bloomquist, Q R R Coquerel, D Hulbert, E R Norri. Neurophysiological action of centrally-acting spider toxin polypeptides derived from Hadronyche versuta and Tegenaria agrestis venoms. Pesticide biochemistry and physiology. vol 192. 2023-04-27. PMID:37105624. |
recently, a commercialized formulation of gs-omega/kappa-hxtx-hv1a (hxtx), derived from the venom of the australian blue mountain funnel web spider (hadronyche versuta) was introduced for use in agriculture by vestaron corp. its primary mode of action was found to be central neuroexcitation via positive allosteric modulation of nicotinic acetylcholine receptors (nachr) of cockroach neurons. |
2023-04-27 |
2023-08-14 |
drosophila_melanogaster |
| Sevil Özger İlhan, Gökçe Sevim Öztürk Fincan, Yağmur Okçay, Derya Sebile Koç, Celil İlker Aşkın, Ayşe Kübra Kibar, İsmail Mert Vural, Yusuf Sarıoğl. Enhancing effect of nicotine on electrical field stimulation elicited contractile responses in isolated rabbit bladder straight muscle; the role of cannabinoid and vanilloid receptors. Turkish journal of medical sciences. vol 52. issue 6. 2023-03-22. PMID:36945969. |
nicotine acts as an agonist of nicotinic acetylcholine receptors (nachr). |
2023-03-22 |
2023-08-14 |
rabbit |
| Wataru Koizumi, Shuya Otsubo, Shogo Furutani, Kunihiro Niki, Koichi Takayama, Shota Fujimura, Takanobu Maekawa, Ryosuke Koyari, Makoto Ihara, Kenji Kai, Hideo Hayashi, Mohammad Shaokat Ali, Eriko Kage-Nakadai, David B Sattelle, Kazuhiko Matsud. Molecular pharmacology. 2023-03-22. PMID:36948535. |
this study targeted the basis of paraherquamide a selectivity by determining an x-ray crystal structure of the acetylcholine binding protein (achbp), a surrogate nachr ligand-binding domain, complexed with the compound and by measuring its actions on wild-type and mutant |
2023-03-22 |
2023-08-14 |
Not clear |
| Francisco J Barrante. Structure and function meet at the nicotinic acetylcholine receptor-lipid interface. Pharmacological research. 2023-03-17. PMID:36931540. |
the nicotinic acetylcholine receptor (nachr) is a transmembrane protein that mediates fast intercellular communication in response to the endogenous neurotransmitter acetylcholine. |
2023-03-17 |
2023-08-14 |
Not clear |
| Julia M York, Cecilia M Borghese, Andrew A George, David C Cannatella, Harold H Zako. A potential cost of evolving epibatidine resistance in poison frogs. bioRxiv : the preprint server for biology. 2023-01-30. PMID:36711899. |
when placed in a homologous mammalian nachr this substitution minimized epibatidine binding but also perturbed acetylcholine binding, a clear cost. |
2023-01-30 |
2023-08-14 |
Not clear |
| Nanthip Prathumsap, Benjamin Ongnok, Thawatchai Khuanjing, Apiwan Arinno, Chayodom Maneechote, Nattayaporn Apaijai, Titikorn Chunchai, Busarin Arunsak, Sasiwan Kerdphoo, Sornram Janjek, Siriporn C Chattipakorn, Nipon Chattipakor. Vagus nerve stimulation exerts cardioprotection against doxorubicin-induced cardiotoxicity through inhibition of programmed cell death pathways. Cellular and molecular life sciences : CMLS. vol 80. issue 1. 2022-12-30. PMID:36583785. |
in contrast, either inhibitors of muscarinic (machr) or nicotinic acetylcholine receptor (nachr) completely abrogated the favorable effects mediated by vns and acetylcholine. |
2022-12-30 |
2023-08-14 |
rat |
| Nan Wu, Yu-An Chen, Qian Zhu, Cai-Hua Son, Kun-Ze Gu, Cheng-Gang Zou, Qin-Yi Wu, Yi-Cheng M. The EGL-30 pathway regulates experience-dependent aversive behavior of Caenorhabditis elegans to the pathogenic bacterium Pseudomonas aeruginosa. Biochemical and biophysical research communications. vol 642. 2022-12-25. PMID:36566561. |
in this study, we show that egl-30/gq coupled with egl-8/unc-13 regulates aversive behaviour of c. elegans to pathogenic bacterium pseudomonas aeruginosa pa01 via acetylcholine and its receptor nachr. |
2022-12-25 |
2023-08-14 |
caenorhabditis_elegans |
| Eva Schweickert de Palma, Tilman Günnewig, Michael Rullmann, Julia Luthardt, Mohammed K Hankir, Philipp M Meyer, Georg-Alexander Becker, Marianne Patt, Sarah Martin, Anja Hilbert, Matthias Blüher, Osama Sabri, Swen Hess. Availability of Central α4β2* Nicotinic Acetylcholine Receptors in Human Obesity. Brain sciences. vol 12. issue 12. 2022-12-23. PMID:36552108. |
such motivational processes are regulated by neuromodulators, specifically acetylcholine (ach), via α4β2* nicotinic ach receptors (nachr). |
2022-12-23 |
2023-08-14 |
human |
| Eman Hassan Nadwa, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Engy Elekhnawy, Sarah M Albogami, Mohammed Alorabi, Gaber El-Saber Batiha, Michel De Waar. Cholinergic dysfunction in COVID-19: frantic search and hoping for the best. Naunyn-Schmiedeberg's archives of pharmacology. 2022-12-02. PMID:36460816. |
sars-cov-2 spike protein is similar to neurotoxins, which can bind to nicotinic acetylcholine receptors (nachr) in the ans and brain. |
2022-12-02 |
2023-08-14 |
Not clear |
| Roger L Papke, Clare Stoke. Insights into the differential desensitization of α4β2 nicotinic acetylcholine receptor isoforms obtained with positive allosteric modulation of mutant receptors. Molecular pharmacology. 2022-11-22. PMID:36414373. |
the development of highly efficacious positive allosteric modulators (pams) of α7 nicotinic acetylcholine receptors (nachr) has proven useful in defining the ligand dependence of the conformational dynamics of α7 receptors. |
2022-11-22 |
2023-08-14 |
Not clear |
| Sami Alzarea, Muzaffar Abbas, Patrick J Ronan, Kabirullah Lutfy, Shafiqur Rahma. The Effect of an α-7 Nicotinic Allosteric Modulator PNU120596 and NMDA Receptor Antagonist Memantine on Depressive-like Behavior Induced by LPS in Mice: The Involvement of Brain Microglia. Brain sciences. vol 12. issue 11. 2022-11-11. PMID:36358419. |
nicotinic acetylcholine receptors (nachrs), particularly the α7 nachr, play a critical role in neuroinflammation and microglial activation associated with major depressive disorder (mdd). |
2022-11-11 |
2023-08-14 |
mouse |
| Shenhang Cheng, Pingli Dai, Ren Li, Zhibin Chen, Pingzhuo Liang, Xiaoping Xie, Congai Zhen, Xiwu Ga. The sulfoximine insecticide sulfoxaflor exposure reduces the survival status and disrupts the intestinal metabolism of the honeybee Apis mellifera. Journal of hazardous materials. vol 442. 2022-10-28. PMID:36303336. |
sulfoxaflor is a novel sulfoximine insecticide that, like neonicotinoids, acts as a competitive modulator of nicotinic acetylcholine receptors (nachr) in insects. |
2022-10-28 |
2023-08-14 |
Not clear |
| Ya-Qun Zhou, Dai-Qiang Liu, Cheng Liu, Ai-Jun Xu, Yu-Ke Tian, Wei Mei, Xue-Bi Tia. Targeting α7 nicotinic acetylcholine receptors for chronic pain. Frontiers in molecular neuroscience. vol 15. 2022-10-17. PMID:36245927. |
substantial evidence indicates downregulation of α7 nicotinic acetylcholine receptors (α7 nachr) in the sciatic nerve, dorsal root ganglia, and spinal cord dorsal horn in rodent models of chronic pain. |
2022-10-17 |
2023-08-14 |
Not clear |
| Julia K Brynildsen, Kechun Yang, Crystal Lemchi, John A Dani, Mariella De Biasi, Julie A Blend. A common SNP in Chrna5 enhances morphine reward in female mice. Neuropharmacology. 2022-08-16. PMID:35973602. |
the single nucleotide polymorphism (snp) d398n (rs16969968) in chrna5, the gene encoding the α5 subunit of the nicotinic acetylcholine receptors (nachr), has been associated with both nicotine and opiate dependence in human populations. |
2022-08-16 |
2023-08-14 |
mouse |
| Alejandro Español, Yamila Sanchez, Agustina Salem, Jaqueline Obregon, Maria Elena Sale. Nicotinic receptors modulate antitumor therapy response in triple negative breast cancer cells. World journal of clinical oncology. vol 13. issue 6. 2022-08-11. PMID:35949430. |
several authors have highlighted the participation of nicotinic acetylcholine receptors (nachr) in the modulation of conventional chemotherapy treatment in cancers of the airways. |
2022-08-11 |
2023-08-14 |
Not clear |
| Angélica Ruelas-Callejas, Manuel B Aguilar, Rogelio Arteaga-Tlecuitl, Juan Carlos Gomora, Estuardo López-Ver. The T-1 conotoxin μ-SrVA from the worm hunting marine snail Conus spurius preferentially blocks the human Na Peptides. 2022-08-08. PMID:35940316. |
it is well known that this superfamily binds to molecular targets such as calcium channels, g protein-coupled receptors (gpcr), and neuronal nicotinic acetylcholine receptors (nachr) and exerts an effect mainly in the central nervous system. |
2022-08-08 |
2023-08-14 |
human |