| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Md Niaj Morshed, Reshmi Akter, Md Rezaul Karim, Safia Iqbal, Se Chan Kang, Deok Chun Yan. Bioconversion, Pharmacokinetics, and Therapeutic Mechanisms of Ginsenoside Compound K and Its Analogues for Treating Metabolic Diseases. Current issues in molecular biology. vol 46. issue 3. 2024-03-27. PMID:38534764. |
current research shows that ck has a wide range of pharmacological actions, including boosting osteogenesis, lipid and glucose metabolism, lipid oxidation, insulin resistance, and anti-inflammatory and anti-apoptosis properties. |
2024-03-27 |
2024-03-29 |
Not clear |
| Miguel Chirivi, Daniela Cortes, C Javier Rendon, G Andres Contrera. Lipolysis inhibition as a treatment of clinical ketosis in dairy cows: Effects on adipose tissue metabolic and immune responses. Journal of dairy science. 2024-01-26. PMID:38278290. |
these data suggest that including nia and fm in ck treatment improves at insulin sensitivity and reduces at inflammation and macrophage infiltration. |
2024-01-26 |
2024-01-29 |
Not clear |
| Jarawee Supanta, Janine L Brown, Pakkanut Bansiddhi, Chatchote Thitaram, Veerasak Punyapornwithaya, Khanittha Punturee, Nopphamas Somboon, Patcharapa Towiboon, Jaruwan Khonme. Physiological changes in captive elephants in Northern Thailand as a result of the COVID-19 tourism ban - muscle, liver, metabolic function, and body condition. Frontiers in veterinary science. vol 10. 2024-01-05. PMID:38179326. |
fifty-eight elephants from six tourist camps were assigned a body condition score (bcs) and blood samples were collected monthly for 2 years during the travel ban to measure: (1) muscle enzymes [creatine kinase (ck), aspartate aminotransferase (ast)]; (2) liver enzymes [aspartate aminotransferase (ast), alkaline phosphatase (alp), gamma-glutamyl transferase (ggt)]; (3) lipids [total cholesterol (tc), triglycerides (tg), low (ldl) and high (hdl) density lipoproteins]; and metabolic function [glucose, insulin, fructosamine]. |
2024-01-05 |
2024-01-07 |
Not clear |
| Miguel Chirivi, Daniela Cortes-Beltran, Amelia Munsterman, Annette O'Connor, G Andres Contrera. Lipolysis inhibition as a treatment of clinical ketosis in dairy cows, a randomized clinical trial. Journal of dairy science. 2023-09-07. PMID:37678786. |
compared with hc, enrolled ck cows exhibited higher blood concentrations of dyslipidemia markers, including nonesterified fatty acids (nefa) and bhb, and lower glucose and insulin levels. |
2023-09-07 |
2023-10-07 |
Not clear |
| Saima Khaliq, Tabinda Ruby, Noreen Samad, Saara Ahmad, Mehtab Alam, Sajjad Ameer Rehman, - Azizuddin, Maaz Shahroz, Sadaf Rizv. Combating effects of Azadirachta indica leaves extract on biochemical and neuropsychological decline observed in diabetes. Pakistan journal of pharmaceutical sciences. vol 35. issue 6(Special). 2023-03-02. PMID:36861235. |
biochemical investigation revealed that ai leaves extract treat diabetes via improving the levels of fasting insulin and hba1c and a significant decrease in ck and sgpt levels were observed in ai leaves treated diabetic rats. |
2023-03-02 |
2023-08-14 |
rat |
| Wenchao Hu, Yingqiang Ma, Lanjie He, Dongming Xin. The correlation between serum creatine kinase with low muscle mass in type 2 diabetes patients. Journal of investigative medicine : the official publication of the American Federation for Clinical Research. vol 71. issue 3. 2023-02-21. PMID:36803038. |
creatine kinase (ck), the key enzyme in regulating energy metabolism, is demonstrated to be correlated with insulin resistance. |
2023-02-21 |
2023-08-14 |
human |
| Svein Ivar Bekkelun. Creatine kinase is associated with glycated haemoglobin in a nondiabetic population. The Tromsø study. PloS one. vol 18. issue 2. 2023-02-02. PMID:36730257. |
creatine kinase (ck) has been associated with insulin resistance and identified as a risk marker of cardiovascular disease largely by its relationship with hypertension and increased body mass index. |
2023-02-02 |
2023-08-14 |
Not clear |
| Weili Li, Haiyang Li, Lujuan Zheng, Jing Xia, Xiaoxuan Yang, Shuhan Men, Ye Yuan, Yuying Fa. Ginsenoside CK improves skeletal muscle insulin resistance by activating DRP1/PINK1-mediated mitophagy. Food & function. 2022-12-23. PMID:36562271. |
ginsenoside ck improves skeletal muscle insulin resistance by activating drp1/pink1-mediated mitophagy. |
2022-12-23 |
2023-08-14 |
Not clear |
| Weili Li, Haiyang Li, Lujuan Zheng, Jing Xia, Xiaoxuan Yang, Shuhan Men, Ye Yuan, Yuying Fa. Ginsenoside CK improves skeletal muscle insulin resistance by activating DRP1/PINK1-mediated mitophagy. Food & function. 2022-12-23. PMID:36562271. |
ginsenoside ck is the main active compound of ginseng with a variety of therapeutic effects, but few studies have reported on its mechanism towards skeletal muscle insulin resistance. |
2022-12-23 |
2023-08-14 |
Not clear |
| Weili Li, Haiyang Li, Lujuan Zheng, Jing Xia, Xiaoxuan Yang, Shuhan Men, Ye Yuan, Yuying Fa. Ginsenoside CK improves skeletal muscle insulin resistance by activating DRP1/PINK1-mediated mitophagy. Food & function. 2022-12-23. PMID:36562271. |
here, we found that ck significantly increased skeletal muscle insulin sensitivity, thereby alleviating hyperglycemia and insulin resistance. |
2022-12-23 |
2023-08-14 |
Not clear |
| Siwen Yang, Ting Liu, Chenxing Hu, Weili Li, Yuhan Meng, Haiyang Li, Chengcheng Song, Congcong He, Yifa Zhou, Yuying Fa. Ginsenoside Compound K Protects against Obesity through Pharmacological Targeting of Glucocorticoid Receptor to Activate Lipophagy and Lipid Metabolism. Pharmaceutics. vol 14. issue 6. 2022-06-24. PMID:35745765. |
the anti-obesity potential effects of ck were investigated in obese mice, including through whole-body energy homeostasis, glucose and insulin tolerance, and biochemical and proteomic analysis. |
2022-06-24 |
2023-08-14 |
mouse |
| Trevor C Chen, Min-Jyue Huang, Leonardo C R Lima, Tai-Ying Chou, Hung-Hao Wang, Jui-Hung Tu, Shi-Che Lin, Kazunori Nosak. Changes in Insulin Sensitivity and Lipid Profile Markers Following Initial and Secondary Bouts of Multiple Eccentric Exercises. Frontiers in physiology. vol 13. 2022-06-23. PMID:35733998. |
fasting blood samples were taken before, 2 h and 1-5 days after each exercise bout to analyze plasma creatine kinase (ck) activity, serum glucose (glu), insulin, homeostasis model assessment (homa), triacylglycerols (tg), total (tc) and low- (ldlc) and high-density lipoprotein cholesterol (hdlc) concentrations as well as tc/hdlc ratio. |
2022-06-23 |
2023-08-14 |
Not clear |
| Yanjie Liu, Li Chen, Hao Wu, Hebin Zhan. Protective effect of glucagon-like peptide-1 mediated by ultrasound microbubbles on myocardial injury in rats with diabetic cardiomyopathy. Bioengineered. vol 13. issue 2. 2022-01-24. PMID:35067162. |
ultrasound-targeted microbubble destruction, utmd; glucagon-like peptide-1 receptor, glp-1r; diabetic cardiomyopathy, dcm; goto-kakizaki, gk; velocity vector imaging, vvi; left ventricular end-diastolic diameter lvidd; left ventricular end-systolic diameter, lvids; left ventricular end-diastolic pressure, lvedp; fractional shortening, lvfs; left ventricular ejection fraction, lvef; mean peak radial velocity, vs; radial strain, sr; radial strain rate, srr; superoxide dismutase, sod; malondialdehyde, mda; glutathione peroxidase, gsh-px; peroxisome proliferator-activated receptor-γ, ppar-γ; nuclear transcription factor κb, nf-κb; insulin resistance, ir; total cholesterol, tc; total triglycerides, tg; creatine kinase, ck; lactate dehydrogenase, ldh; cardiac troponin i, ctni; collagen volume fraction, cvf; hematoxylin eosin, h&e. |
2022-01-24 |
2023-08-13 |
rat |
| Jeffrey O Adoga, Mahendra L Channa, Anand Nada. Kolaviron attenuates cardiovascular injury in fructose-streptozotocin induced type-2 diabetic male rats by reducing oxidative stress, inflammation, and improving cardiovascular risk markers. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 144. 2021-11-17. PMID:34656062. |
cardiac troponin i (ctni), creatine kinase myocardial band (ck-mb), creatine phosphokinase (ck), and insulin levels were immediately determined in serum, while remaining samples (serum, plasma, and organs) were stored in the bio-freezer at - 80 °c and 10% formalin for enzyme-link immunosorbent assay (elisa), biochemical, molecular, and histopathological studies. |
2021-11-17 |
2023-08-13 |
rat |
| Bei Wang, Jinxiang Dong, Jie Xu, Zhidong Qiu, Fan Ya. Ginsenoside CK inhibits obese insulin resistance by activating PPARγ to interfere with macrophage activation. Microbial pathogenesis. vol 157. 2021-06-21. PMID:34051328. |
ginsenoside ck inhibits obese insulin resistance by activating pparγ to interfere with macrophage activation. |
2021-06-21 |
2023-08-13 |
Not clear |
| Bei Wang, Jinxiang Dong, Jie Xu, Zhidong Qiu, Fan Ya. Ginsenoside CK inhibits obese insulin resistance by activating PPARγ to interfere with macrophage activation. Microbial pathogenesis. vol 157. 2021-06-21. PMID:34051328. |
in addition, ginsenoside ck also promotes the expression of irs-1 in insulin signal pathway. |
2021-06-21 |
2023-08-13 |
Not clear |
| Bei Wang, Jinxiang Dong, Jie Xu, Zhidong Qiu, Fan Ya. Ginsenoside CK inhibits obese insulin resistance by activating PPARγ to interfere with macrophage activation. Microbial pathogenesis. vol 157. 2021-06-21. PMID:34051328. |
the experimental results proved that ginsenoside ck plays a crucial role in alleviating inflammation and insulin resistance in obesity, and inhibits macrophage activation through the key protein pparγ. |
2021-06-21 |
2023-08-13 |
Not clear |
| Hina Akram Mudassir, Saima Khaliq, Muhammad Bilal Azmi, Madiha Bano, Munazzah Naheed, Mahnoor Fatima, - Saeedulla. Persea americana seeds improve glycosylation and dyslipidemia in fructose-fed streptozotocin-injected type 2 diabetic male rats. Pakistan journal of pharmaceutical sciences. vol 33. issue 6. 2021-04-19. PMID:33867333. |
after the appropriate treatments in each group for 2 weeks fasting glucose level (fgl), serum lipids, insulin, alanine aminotransferase (alt), creatine kinase (ck) & uric acid were determined. |
2021-04-19 |
2023-08-13 |
rat |
| Chu-Wen Li, Min-Zhen Deng, Zhi-Jie Gao, Yuan-Ye Dang, Guo-Dong Zheng, Xiu-Juan Yang, Ying-Xin Chao, Ye-Feng Cai, Xiao-Li W. Effects of compound K, a metabolite of ginsenosides, on memory and cognitive dysfunction in db/db mice involve the inhibition of ER stress and the NLRP3 inflammasome pathway. Food & function. vol 11. issue 5. 2021-03-08. PMID:32374299. |
besides, ck decreased the fasting glucose level, increased lipid metabolism, and ameliorated glucose tolerance, insulin sensitivity, and dyslipidemia in diabetic db/db mice. |
2021-03-08 |
2023-08-13 |
mouse |
| Chu-Wen Li, Min-Zhen Deng, Zhi-Jie Gao, Yuan-Ye Dang, Guo-Dong Zheng, Xiu-Juan Yang, Ying-Xin Chao, Ye-Feng Cai, Xiao-Li W. Effects of compound K, a metabolite of ginsenosides, on memory and cognitive dysfunction in db/db mice involve the inhibition of ER stress and the NLRP3 inflammasome pathway. Food & function. vol 11. issue 5. 2021-03-08. PMID:32374299. |
these results suggest that ck improves memory and cognitive dysfunction, possibly by ameliorating glucose tolerance, insulin sensitivity, and dyslipidemia, suppressing oxidative stress and inflammatory response and modulating the nlrp3 inflammasome pathway and er stress. |
2021-03-08 |
2023-08-13 |
mouse |