| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jian Gu, Wei Li, Dong Xiao, ShengNan Wei, WanLi Cui, WeiJia Chen, YaLi Hu, XiaoJia Bi, YongChol Kim, Jing Li, HongWei Du, Ming Zhang, Li Che. Compound K, a final intestinal metabolite of ginsenosides, enhances insulin secretion in MIN6 pancreatic β-cells by upregulation of GLUT2. Fitoterapia. vol 87. 2014-01-16. PMID:23558203. |
these findings indicate that ck exerts prominent stimulatory effects on insulin secretion in the min6 cells partly via upregulating the expression of glut2. |
2014-01-16 |
2023-08-12 |
Not clear |
| H Zweers, C Timmer, E Rasmussen, M den Heijer, H de Val. Successful weight loss in two adult patients diagnosed with late-onset long-chain Fatty Acid oxidation defect. JIMD reports. vol 6. 2013-02-25. PMID:23430950. |
ck, insulin, tg, and alat blood levels decreased. |
2013-02-25 |
2023-08-12 |
Not clear |
| Vikash Chandra, Swetha G, Smruti Phadnis, Prabha D Nair, Ramesh R Bhond. Generation of pancreatic hormone-expressing islet-like cell aggregates from murine adipose tissue-derived stem cells. Stem cells (Dayton, Ohio). vol 27. issue 8. 2010-01-13. PMID:19544426. |
our stage-specific approach successfully differentiated mesodermic me-ascs into definitive endoderm (cells expressing sox17, foxa2, gata-4, and cytokeratin [ck]-19), then into pancreatic endoderm (cells expressing pancreatic and duodenal homeobox [pdx]-1, ngn3, neurod, pax4, and glucose transporter 2), and finally into cells expressing pancreatic hormones (insulin, glucagon, somatostatin). |
2010-01-13 |
2023-08-12 |
mouse |
| Mei Xiao, Li Long An, Zhong Ying Do. [Research on differentiation features of the monoclonal human pancreatic stem cell]. Fen zi xi bao sheng wu xue bao = Journal of molecular cell biology. vol 41. issue 6. 2009-03-17. PMID:19137817. |
immunohistochemistry showed that the teratoma-like expressed the proteins of the pdx1, insulin, glucagon, ck, mbp and nf. |
2009-03-17 |
2023-08-12 |
mouse |
| Gi Cheol Han, Sung Kwon Ko, Jong Hwan Sung, Sung Hyun Chun. Compound K enhances insulin secretion with beneficial metabolic effects in db/db mice. Journal of agricultural and food chemistry. vol 55. issue 26. 2008-02-28. PMID:18034458. |
in in vitro studies using hit-t15 cells and primary cultured islets, ck enhanced the insulin secretion in a concentration-dependent manner. |
2008-02-28 |
2023-08-12 |
mouse |
| Gi Cheol Han, Sung Kwon Ko, Jong Hwan Sung, Sung Hyun Chun. Compound K enhances insulin secretion with beneficial metabolic effects in db/db mice. Journal of agricultural and food chemistry. vol 55. issue 26. 2008-02-28. PMID:18034458. |
insulin secretion stimulating activity of a single oral ck administration was also confirmed with an oral glucose tolerance test (ogtt) using icr mice. |
2008-02-28 |
2023-08-12 |
mouse |
| Gi Cheol Han, Sung Kwon Ko, Jong Hwan Sung, Sung Hyun Chun. Compound K enhances insulin secretion with beneficial metabolic effects in db/db mice. Journal of agricultural and food chemistry. vol 55. issue 26. 2008-02-28. PMID:18034458. |
from these studies, we may conclude that ck lowered the plasma glucose level by stimulating insulin secretion and this action was presumably associated with an atp-sensitive k+ channel. |
2008-02-28 |
2023-08-12 |
mouse |
| Gi Cheol Han, Sung Kwon Ko, Jong Hwan Sung, Sung Hyun Chun. Compound K enhances insulin secretion with beneficial metabolic effects in db/db mice. Journal of agricultural and food chemistry. vol 55. issue 26. 2008-02-28. PMID:18034458. |
ogtt revealed that ck improved glucose tolerance with increased insulin levels 30 min after the glucose challenge. |
2008-02-28 |
2023-08-12 |
mouse |
| Gi Cheol Han, Sung Kwon Ko, Jong Hwan Sung, Sung Hyun Chun. Compound K enhances insulin secretion with beneficial metabolic effects in db/db mice. Journal of agricultural and food chemistry. vol 55. issue 26. 2008-02-28. PMID:18034458. |
concurrently, ck treatment prevented the destruction of islets and preserved more insulin. |
2008-02-28 |
2023-08-12 |
mouse |
| Gi Cheol Han, Sung Kwon Ko, Jong Hwan Sung, Sung Hyun Chun. Compound K enhances insulin secretion with beneficial metabolic effects in db/db mice. Journal of agricultural and food chemistry. vol 55. issue 26. 2008-02-28. PMID:18034458. |
according to dna microarray analysis, ck shifted glucose metabolism from hepatic glucose production to hepatic glucose utilization in the liver and improved insulin sensitivity through enhancing plasma adiponectin levels, resulting in overexpression of genes for adipogenesis and glucose transporter in the adipose tissue. |
2008-02-28 |
2023-08-12 |
mouse |
| Gi Cheol Han, Sung Kwon Ko, Jong Hwan Sung, Sung Hyun Chun. Compound K enhances insulin secretion with beneficial metabolic effects in db/db mice. Journal of agricultural and food chemistry. vol 55. issue 26. 2008-02-28. PMID:18034458. |
taken together, we may suggest that ck could be developed as a therapeutic tool in type 2 diabetic patients with disability of insulin secretion and/or insulin resistance. |
2008-02-28 |
2023-08-12 |
mouse |
| Seo Hyun Yoon, Eun Jung Han, Jong Hwan Sung, Sung Hyun Chun. Anti-diabetic effects of compound K versus metformin versus compound K-metformin combination therapy in diabetic db/db mice. Biological & pharmaceutical bulletin. vol 30. issue 11. 2007-12-27. PMID:17978500. |
in our preliminary studies, ck has shown to exhibit anti-hyperglycemic effect through its insulin-secreting action, similar to that of insulin secretagogue sulfonylureas. |
2007-12-27 |
2023-08-12 |
mouse |
| Anna M Firshman, Stephanie J Valberg, Tami L Karges, Luke E Benedict, Erin J Annandale, Elizabeth R Seaquis. Serum creatine kinase response to exercise during dexamethasone-induced insulin resistance in Quarter Horses with polysaccharide storage myopathy. American journal of veterinary research. vol 66. issue 10. 2006-05-05. PMID:16273902. |
to determine effects of dexamethasone on insulin sensitivity, serum creatine kinase (ck) activity 4 hours after exercise, and muscle glycogen concentration in quarter horses with polysaccharide storage myopathy (pssm). |
2006-05-05 |
2023-08-12 |
Not clear |
| Yuji Nishikawa, Yuko Doi, Hitoshi Watanabe, Takuo Tokairin, Yasufumi Omori, Mu Su, Toshiaki Yoshioka, Katsuhiko Enomot. Transdifferentiation of mature rat hepatocytes into bile duct-like cells in vitro. The American journal of pathology. vol 166. issue 4. 2005-05-17. PMID:15793288. |
hepatocytes expressed several bile duct markers including cytokeratin (ck) 19 soon after culture and underwent branching morphogenesis within the matrix in the presence of insulin and epidermal growth factor. |
2005-05-17 |
2023-08-12 |
rat |
| W P Ribeiro, S J Valberg, J D Pagan, B Essen Gustavsso. The effect of varying dietary starch and fat content on serum creatine kinase activity and substrate availability in equine polysaccharide storage myopathy. Journal of veterinary internal medicine. vol 18. issue 6. 2005-01-27. PMID:15638274. |
postprandial glucose and insulin responses were measured, and 4 hours postexercise, serum ck activity, glucose, insulin, free fatty acids (ffa), and beta-hydroxybutyrate (beta-hba) were analyzed. |
2005-01-27 |
2023-08-12 |
Not clear |
| W P Ribeiro, S J Valberg, J D Pagan, B Essen Gustavsso. The effect of varying dietary starch and fat content on serum creatine kinase activity and substrate availability in equine polysaccharide storage myopathy. Journal of veterinary internal medicine. vol 18. issue 6. 2005-01-27. PMID:15638274. |
postprandial insulin and glucose response was higher for diet a versus d. log ck activity was higher with diets a, b, and c versus d. daily insulin was higher and ffa lower on diet a versus b, c, and d, whereas glucose varied only slightly with diet. |
2005-01-27 |
2023-08-12 |
Not clear |
| Deepak Rai, Gitika Bhatia, Tuhinadri Sen, Gautam Pali. Comparative study of perturbations of peripheral markers in different stressors in rats. Canadian journal of physiology and pharmacology. vol 81. issue 12. 2004-08-24. PMID:14719033. |
immediately after stress, animals were decapitated, blood was collected, and plasma was separated for the estimation of plasma glucose, triglyceride, cholesterol, creatine kinase (ck), corticosterone, and insulin. |
2004-08-24 |
2023-08-12 |
rat |
| Deepak Rai, Gitika Bhatia, Tuhinadri Sen, Gautam Pali. Comparative study of perturbations of peripheral markers in different stressors in rats. Canadian journal of physiology and pharmacology. vol 81. issue 12. 2004-08-24. PMID:14719033. |
as significantly increased the ulcer index, plasma glucose, ck, corticosterone, and insulin. |
2004-08-24 |
2023-08-12 |
rat |
| S Mitani, K Okumura, H Matsui, Y Toki, H Hashimoto, T Ito, T Hayakaw. Insulin alters cardiac muscle creatine kinase activity. Heart and vessels. vol 15. issue 1. 2001-01-17. PMID:11001482. |
the expression of mrnas of creatine kinase (ck)-b and ck-m has been show to be affected by insulin, and myocardial ck-mb activity is suppressed in insulin-deficient rats. |
2001-01-17 |
2023-08-12 |
rat |
| S Mitani, K Okumura, H Matsui, Y Toki, H Hashimoto, T Ito, T Hayakaw. Insulin alters cardiac muscle creatine kinase activity. Heart and vessels. vol 15. issue 1. 2001-01-17. PMID:11001482. |
these findings suggest that insulin possibly regulates the distribution of ck isoenzymes in rat heart muscle, and that the effect of insulin is not due to the sympathetic drive induced by hypoglycemia. |
2001-01-17 |
2023-08-12 |
rat |