| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Chung, J S Huang, J J Mukherjee, K S Crilly, Z Kis. Expression of human choline kinase in NIH 3T3 fibroblasts increases the mitogenic potential of insulin and insulin-like growth factor I. Cellular signalling. vol 12. issue 5. 2000-08-24. PMID:10822168. |
to validate the role of pcho in mitogenesis, we determined the effects of insulin, insulin-like growth factor i (igf-i), and other growth factors on dna synthesis in nih 3t3 fibroblast sublines highly expressing human choline kinase (ck) without increasing phosphatidylcholine synthesis. |
2000-08-24 |
2023-08-12 |
human |
| T Chung, J S Huang, J J Mukherjee, K S Crilly, Z Kis. Expression of human choline kinase in NIH 3T3 fibroblasts increases the mitogenic potential of insulin and insulin-like growth factor I. Cellular signalling. vol 12. issue 5. 2000-08-24. PMID:10822168. |
in serum-starved ck expressor cells, insulin and igf-i stimulated dna synthesis, p70 s6 kinase (p70 s6k) activity, phosphatidylinositol 3-kinase (pi3k) activity, and activating phosphorylation of p42/p44 mitogen-activated protein kinases (mapk) to greater extents than in the corresponding vector control cells. |
2000-08-24 |
2023-08-12 |
human |
| A Frank, R Danielsson, B Jone. The 'mysterious' disease in Swedish moose. Concentrations of trace elements in liver and kidneys and clinical chemistry. Comparison with experimental molybdenosis and copper deficiency in the goat. The Science of the total environment. vol 249. issue 1-3. 2000-06-13. PMID:10813451. |
increases were recorded for free fatty acids (nefa), the muscle-specific enzyme ck, but especially for urea and insulin. |
2000-06-13 |
2023-08-12 |
Not clear |
| G M Beattie, P Itkin-Ansari, V Cirulli, G Leibowitz, A D Lopez, S Bossie, M I Mally, F Levine, A Haye. Sustained proliferation of PDX-1+ cells derived from human islets. Diabetes. vol 48. issue 5. 1999-05-27. PMID:10331405. |
we believe that the cells resulting from these cultures are of beta-cell origin, since they uniformly express the transcription factor pdx-1 (stf-1, idx-1, ipf-1), which is initially seen only in cells positive for insulin and negative for the ductal cell marker cytokeratin (ck)-19. |
1999-05-27 |
2023-08-12 |
human |
| Z L Jiang, T Harada, M Yokokawa, M Kohzuki, T Sat. Muscle damage induced by experimental hypoglycemia. Metabolism: clinical and experimental. vol 47. issue 12. 1999-01-13. PMID:9867076. |
alterations in serum enzyme activity and creatine kinase (ck) isoenzyme distribution were determined before and after insulin injection. |
1999-01-13 |
2023-08-12 |
Not clear |
| Z L Jiang, T Harada, M Yokokawa, M Kohzuki, T Sat. Muscle damage induced by experimental hypoglycemia. Metabolism: clinical and experimental. vol 47. issue 12. 1999-01-13. PMID:9867076. |
these results suggest that the increase in both serum enzyme and ck band 4 isoenzyme activities during hypoglycemia is primarily due to damage in muscle rather than liver, and that the hypoglycemia duration and insulin dosage may influence the extent of organ damage. |
1999-01-13 |
2023-08-12 |
Not clear |
| Z L Jiang, T Harada, M Kohzuki, M Kamimoto, T Sat. Plasma enzymic changes in insulin-induced hypoglycemia in experimental rabbits. The Tohoku journal of experimental medicine. vol 179. issue 3. 1997-02-03. PMID:8888511. |
the plasma activity of ck rose remarkably and reached a peak at 6 hr after insulin injection in all rabbits. |
1997-02-03 |
2023-08-12 |
Not clear |
| K D Gerbitz, K Gempel, D Brdiczk. Mitochondria and diabetes. Genetic, biochemical, and clinical implications of the cellular energy circuit. Diabetes. vol 45. issue 2. 1996-02-21. PMID:8549853. |
as cytosolic and mitochondrial isozymes of creatine kinase (ck) are observed in insulinoma cells, the phosphocreatine (crp) shuttle, working in brain and muscle, may also be involved in signaling glucose-induced insulin secretion in beta-cells. |
1996-02-21 |
2023-08-12 |
Not clear |
| H Matsui, H Hashimoto, A Fukushima, H Kanayama, S Mitani, Y Toki, K Okumura, T It. MB fraction of cumulative creatine kinase correlates with insulin secretion in patients with acute myocardial infarction: insulin as a possible determinant of myocardial MB creatine kinase. American heart journal. vol 131. issue 1. 1996-02-20. PMID:8554015. |
to test whether insulin is a regulatory factor of myocardial mb creatine kinase content, we investigated the correlation between the ability of insulin secretion and the mb fraction of cumulative ck released in patients with acute myocardial infarction. |
1996-02-20 |
2023-08-12 |
human |
| H Matsui, H Hashimoto, A Fukushima, H Kanayama, S Mitani, Y Toki, K Okumura, T It. MB fraction of cumulative creatine kinase correlates with insulin secretion in patients with acute myocardial infarction: insulin as a possible determinant of myocardial MB creatine kinase. American heart journal. vol 131. issue 1. 1996-02-20. PMID:8554015. |
thus mb fraction of cumulative ck released, indicative of myocardial mb ck distribution, strongly related to the ability of insulin secretion in subjects without overt insulin resistance. |
1996-02-20 |
2023-08-12 |
human |
| H Matsui, H Hashimoto, A Fukushima, H Kanayama, S Mitani, Y Toki, K Okumura, T It. MB fraction of cumulative creatine kinase correlates with insulin secretion in patients with acute myocardial infarction: insulin as a possible determinant of myocardial MB creatine kinase. American heart journal. vol 131. issue 1. 1996-02-20. PMID:8554015. |
regulation by insulin of myocardial mb ck is suggested. |
1996-02-20 |
2023-08-12 |
human |
| J L Vanoverschelde, M F Janier, S R Bergman. The relative importance of myocardial energy metabolism compared with ischemic contracture in the determination of ischemic injury in isolated perfused rabbit hearts. Circulation research. vol 74. issue 5. 1994-05-17. PMID:8156629. |
in contrast, increasing the rate of anaerobic glycolysis during ischemia by doubling glucose and insulin in the presence of bdm markedly decreased membrane damage (ck release, 114 +/- 72 u/g dry weight; p < .05) and contractile failure during reperfusion (lvdp, 88 +/- 7% recovery of baseline; p < .01). |
1994-05-17 |
2023-08-12 |
rabbit |
| C Y Su, M Payne, A W Strauss, W H Dillman. Selective reduction of creatine kinase subunit mRNAs in striated muscle of diabetic rats. The American journal of physiology. vol 263. issue 2 Pt 1. 1992-09-25. PMID:1514612. |
diabetes thus exerts a widespread, muscle type-dependent adverse effect on ck expression that we found to be insulin therapy revertible. |
1992-09-25 |
2023-08-11 |
rat |
| B K Popovich, M R Sayen, W H Dillman. Insulin responsiveness of CK-M and CK-B mRNA in the diabetic rat heart. The American journal of physiology. vol 261. issue 3 Pt 1. 1991-10-07. PMID:1887884. |
ck enzyme activity showed only a small response to insulin administration 48 h postinjection. |
1991-10-07 |
2023-08-11 |
rat |
| H Nishio, H Wada, T Matsuo, H Horikawa, K Takahashi, T Nakajima, M Matsuo, H Nakamur. Glucose, free fatty acid and ketone body metabolism in Duchenne muscular dystrophy. Brain & development. vol 12. issue 4. 1990-12-20. PMID:2240459. |
the [glucagon]:[insulin] ratio in low ck patients was significantly higher than that in controls and that in high ck patients. |
1990-12-20 |
2023-08-11 |
Not clear |
| U Zuliani, A Bonetti, M Campana, G Cerioli, F Solito, A Novarin. The influence of ubiquinone (Co Q10) on the metabolic response to work. The Journal of sports medicine and physical fitness. vol 29. issue 1. 1989-09-28. PMID:2671499. |
from the venous blood of 12 healthy untrained subjects (students, volunteers, mean age 25.7 and body mass index 23.3) we examined some biological parameters [free fatty acids (ffa), free glycerol, lactate, glucose, insulin, ck] before, at the end of aerobic work, at the end of exhaustive work, and after 30 and 60 m' of the recovery phase. |
1989-09-28 |
2023-08-11 |
human |
| A Pontecorvi, J R Tata, M Phyillaier, J Robbin. Selective degradation of mRNA: the role of short-lived proteins in differential destabilization of insulin-induced creatine phosphokinase and myosin heavy chain mRNAs during rat skeletal muscle L6 cell differentiation. The EMBO journal. vol 7. issue 5. 1988-09-27. PMID:3044783. |
addition of insulin accompanying the withdrawal of the mitogenic stimulus of serum to myoblasts caused an 80-fold increase in creatine phosphokinase (ck) activity which was largely accounted for by a similar increase in the amount of ck mrna. |
1988-09-27 |
2023-08-11 |
rat |
| A Pontecorvi, J R Tata, M Phyillaier, J Robbin. Selective degradation of mRNA: the role of short-lived proteins in differential destabilization of insulin-induced creatine phosphokinase and myosin heavy chain mRNAs during rat skeletal muscle L6 cell differentiation. The EMBO journal. vol 7. issue 5. 1988-09-27. PMID:3044783. |
measurements of steady-state levels of mrna showed that removal of insulin caused ck mrna, but not mhc mrna, to be rapidly degraded, the effect being reversed upon readdition of the hormone. |
1988-09-27 |
2023-08-11 |
rat |
| A Pontecorvi, J R Tata, M Phyillaier, J Robbin. Selective degradation of mRNA: the role of short-lived proteins in differential destabilization of insulin-induced creatine phosphokinase and myosin heavy chain mRNAs during rat skeletal muscle L6 cell differentiation. The EMBO journal. vol 7. issue 5. 1988-09-27. PMID:3044783. |
under the same conditions of mrna stabilization during de-induction, a superinduction of ck mrna, but not mhc mrna, was observed if the two inhibitors were added during induction in the continuous presence of insulin. |
1988-09-27 |
2023-08-11 |
rat |
| J Sommercorn, E G Kreb. Induction of casein kinase II during differentiation of 3T3-L1 cells. The Journal of biological chemistry. vol 262. issue 8. 1987-04-20. PMID:3469203. |
ck ii induction was coincident with induction of the insulin receptor, but, whereas insulin binding remained elevated, ck ii activity declined after day 4. |
1987-04-20 |
2023-08-11 |
cattle |