| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Richard L Jayaraj, Sheikh Azimullah, Khatija A Parekh, Shreesh K Ojha, Rami Beira. Effect of citronellol on oxidative stress, neuroinflammation and autophagy pathways in an Heliyon. vol 8. issue 11. 2022-11-17. PMID:36387498. |
further, citronellol prevented rotenone induced microglia (iba-1 staining) and astrocyte (gfap staining) activation. |
2022-11-17 |
2023-08-14 |
rat |
| Shveta V Parekh, Lydia O Adams, Gillian A Barkell, Donald T Lysl. MDMA administration attenuates hippocampal IL-β immunoreactivity and subsequent stress-enhanced fear learning: An animal model of PTSD. Brain, behavior, & immunity - health. vol 26. 2022-11-17. PMID:36388136. |
the current studies test the hypothesis that mdma is capable of attenuating sefl and inducing alterations in expression of tnf-α, il-1β, glial fibrillary acidic protein (gfap), an astrocyte specific marker, and ionized calcium-binding adapter molecule -1 (iba-1), a microglial specific marker, in the dorsal hippocampus (dh) following a severe stressor in male animals. |
2022-11-17 |
2023-08-14 |
Not clear |
| Chao Wu, Rongrong Liu, Zhaofei Luo, Meiyan Sun, Muge Qile, Shijin Xu, Shiyun Jin, Li Zhang, Eric R Gross, Ye Zhang, Shufang H. Spinal cord astrocytes regulate myocardial ischemia-reperfusion injury. Basic research in cardiology. vol 117. issue 1. 2022-11-11. PMID:36367592. |
inhibition of spinal astrocytes by intrathecal injection of fluoro-citrate, an astrocyte inhibitor, decreased gfap immunostaining and reduced infarct size by 29% relative to the i/r group. |
2022-11-11 |
2023-08-14 |
rat |
| Chao Wu, Rongrong Liu, Zhaofei Luo, Meiyan Sun, Muge Qile, Shijin Xu, Shiyun Jin, Li Zhang, Eric R Gross, Ye Zhang, Shufang H. Spinal cord astrocytes regulate myocardial ischemia-reperfusion injury. Basic research in cardiology. vol 117. issue 1. 2022-11-11. PMID:36367592. |
using a designer receptor exclusively activated by designer drugs (dreadd) chemogenetic approach, we bi-directionally manipulated astrocyte activity employing gfap promoter-driven gq- or gi-coupled signaling. |
2022-11-11 |
2023-08-14 |
rat |
| P E A Aquino, E A de Siqueira, L C F Paes, E P Magalhães, T M Barbosa, M A J de Carvalho, F V C Serra Azul, I Rosal Lustosa, M Mottin, T L Sampaio, A M C Martins, E R Silveira, G S B Vian. N-Methyl-(2S, 4R)-trans-4-hydroxy-L-proline, the major bioactive compound from Sideroxylon obtusifolium, attenuates pilocarpine-induced injury in cultured astrocytes. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 55. 2022-11-09. PMID:36350974. |
these effects were associated with improvement of pilocarpine-induced gfap and vdac-1 overexpression, which are important biomarkers of astrocyte dysfunction. |
2022-11-09 |
2023-08-14 |
Not clear |
| b' Karol\\xc3\\xadna Bretov\\xc3\\xa1, Viktorie Svobodov\\xc3\\xa1, Petr Dubov\\xc3\\xb. Astrocyte reactivity in the glia limitans superficialis of the rat medial prefrontal cortex following sciatic nerve injury. Histochemistry and cell biology. 2022-11-03. PMID:36326875.' |
the alteration of gls astrocyte reactivity was monitored using immunofluorescence (if) intensities of glial fibrillary acidic protein (gfap), glutamine synthetase (gs), and nfκbp65. |
2022-11-03 |
2023-08-14 |
rat |
| Gennadii Piavchenko, Vladislav Soldatov, Artem Venediktov, Natalia Kartashkina, Natalia Novikova, Marina Gorbunova, Tatiana Boronikhina, Alexander Yatskovskiy, Igor Meglinski, Sergey Kuznetso. A combined use of silver pretreatment and impregnation with consequent Nissl staining for cortex and striatum architectonics study. Frontiers in neuroanatomy. vol 16. 2022-10-31. PMID:36312299. |
the results of astrocyte visualization in the motor cortex obtained by the developed technique agree well with the alternative studies by glial fibrillary acidic protein (gfap) immunohistochemical reaction. |
2022-10-31 |
2023-08-14 |
Not clear |
| Ewing Duque-Díaz, Hernán Hurtado Giraldo, Linda P Rocha-Muñoz, Rafael Coveña. Glyphosate, AMPA and glyphosate-based herbicide exposure leads to GFAP, PCNA and caspase-3 increased immunoreactive area on male offspring rat hypothalamus. European journal of histochemistry : EJH. vol 66. issue 4. 2022-10-13. PMID:36226530. |
the immunoreactivity for glial fibrillary acidic protein (gfap), proliferating cell nuclear antigen (pcna) and caspase-3 was measured in the anterior, medial preoptic, periventricular, supraoptic and lateroanterior hypothalamic nuclei of p0-p10 male pups after exposure, via lactation, to these xenobiotics. puppies exposed to glyphosate had a moderate level of gfap with no overlapping astrocyte processes, but this overlapping was observed after roundup® active or ampa exposure. |
2022-10-13 |
2023-08-14 |
rat |
| Mason A Hill, Stephen C Gammi. Alzheimer's disease large-scale gene expression portrait identifies exercise as the top theoretical treatment. Scientific reports. vol 12. issue 1. 2022-10-13. PMID:36229643. |
the three most dysregulated genes in the ad portrait were the inositol trisphosphate kinase, itpkb (upregulated), the astrocyte specific intermediate filament protein, gfap (upregulated), and the rho gtpase, rhoq (upregulated). |
2022-10-13 |
2023-08-14 |
human |
| Teresa A Milner, Ryan X Chen, Diedreanna Welington, Batsheva R Rubin, Natalina H Contoreggi, Megan A Johnson, Sanoara Mazid, Jose Marques-Lopes, Roberta Marongiu, Michael J Glas. Angiotensin II differentially affects hippocampal glial inflammatory markers in young adult male and female mice. Learning & memory (Cold Spring Harbor, N.Y.). vol 29. issue 9. 2022-10-07. PMID:36206386. |
in males, angii induced hypertension, and this resulted in an increase in the density of the astrocyte marker glial fibrillary acidic protein (gfap) in the subgranular hilus and a decrease in the density of the microglial marker ionized calcium binding adapter molecule (iba-1) in the ca1 region. |
2022-10-07 |
2023-08-14 |
mouse |
| Min-Jeong Kang, Nuri Jin, Shin-Young Park, Joong-Soo Ha. Phospholipase D1 promotes astrocytic differentiation through the FAK/AURKA/STAT3 signaling pathway in hippocampal neural stem/progenitor cells. Biochimica et biophysica acta. Molecular cell research. 2022-09-26. PMID:36162649. |
we showed that overexpression of pld1 increased the expression level of glial fibrillary acidic protein (gfap), an astrocyte marker, and the number of gfap-positive cells. |
2022-09-26 |
2023-08-14 |
rat |
| Valencia Fernandes, Kumari Preeti, Anika Sood, Kala P Nair, Sabiya Khan, B S Shankaranarayana Rao, Dharmendra Kumar Khatri, Shashi Bala Sing. Neuroepigenetic Changes in DNA Methylation Affecting Diabetes-Induced Cognitive Impairment. Cellular and molecular neurobiology. 2022-09-22. PMID:36138280. |
neuroinflammation, as exhibited by the astrocyte activation (gfap), were further significantly decreased in the 5-azadeoxycytidine group (dnmt inhibitor). |
2022-09-22 |
2023-08-14 |
mouse |
| Alberto Llorente-Ovejero, Iker Bengoetxea de Tena, Jonatan Martínez-Gardeazabal, Marta Moreno-Rodríguez, Laura Lombardero, Iván Manuel, Rafael Rodríguez-Puerta. Cannabinoid Receptors and Glial Response Following a Basal Forebrain Cholinergic Lesion. ACS pharmacology & translational science. vol 5. issue 9. 2022-09-16. PMID:36110372. |
in this study, 7 days after the lesion, decreased astrocyte and increased microglia immunoreactivities (gfap and iba-1) were observed, indicating microglia-mediated neuroinflammation. |
2022-09-16 |
2023-08-14 |
rat |
| Runan Yang, Jingjian Yang, Zijing Li, Ruichen Su, Lifang Zou, Lin Li, Xiumei Xu, Guilin Li, Shuangmei Liu, Shangdong Liang, Changshui X. Pinocembrin Inhibits P2X4 Receptor-Mediated Pyroptosis in Hippocampus to Alleviate the Behaviours of Chronic Pain and Depression Comorbidity in Rats. Molecular neurobiology. 2022-09-10. PMID:36088500. |
in the model rats, the mrna and protein levels of the p2x4 receptor in the hippocampus were increased, and the coexpression of p2x4 and the astrocyte marker glial fibrillary acidic protein (gfap) in the hippocampus was increased. |
2022-09-10 |
2023-08-14 |
rat |
| Chia-Shan Wu, Valerie Endre. Prior episode of colitis impairs contextual fear memory. Molecular brain. vol 15. issue 1. 2022-08-29. PMID:36038926. |
furthermore, molecular characterization of hippocampi showed marked but transient increases in the expression of inflammatory genes nfkb, trem2 (microglial marker), gfap (astrocyte marker), il1b, and s100a8 in dss-treated mice. |
2022-08-29 |
2023-08-14 |
mouse |
| Natalia Valle-Tamayo, Rocío Pérez-González, Gemma Chiva-Blanch, Olivia Belbin, Sara Serrano-Requena, Sònia Sirisi, Alba Cervantes González, Oriol Giró, Érika Sánchez-Aced, Oriol Dols-Icardo, Daniel Alcolea, María Carmona-Iragui, Amanda Jimenez, Alberto Lleó, Juan Fortea, M Florencia Iulit. Enrichment of Astrocyte-Derived Extracellular Vesicles from Human Plasma. Journal of visualized experiments : JoVE. issue 186. 2022-08-22. PMID:35993755. |
to validate the enrichment of astrocyte markers, glial fibrillary acidic protein (gfap), or other specific astrocytic markers of intracellular origin, can be measured in the eluate and compared with the flow-through. |
2022-08-22 |
2023-08-14 |
human |
| Álvaro Viedma-Poyatos, Patricia González-Jiménez, María A Pajares, Dolores Pérez-Sal. Alexander disease GFAP R239C mutant shows increased susceptibility to lipoxidation and elicits mitochondrial dysfunction and oxidative stress. Redox biology. vol 55. 2022-08-07. PMID:35933901. |
alexander disease is a fatal neurological disorder caused by mutations in the intermediate filament protein glial fibrillary acidic protein (gfap), which is key for astrocyte homeostasis. |
2022-08-07 |
2023-08-14 |
Not clear |
| Álvaro Viedma-Poyatos, Patricia González-Jiménez, María A Pajares, Dolores Pérez-Sal. Alexander disease GFAP R239C mutant shows increased susceptibility to lipoxidation and elicits mitochondrial dysfunction and oxidative stress. Redox biology. vol 55. 2022-08-07. PMID:35933901. |
these mutations cause gfap aggregation, astrocyte dysfunction and neurodegeneration. |
2022-08-07 |
2023-08-14 |
Not clear |
| Stephan Schacke, Joanna Kirkpatrick, Amy Stocksdale, Reinhard Bauer, Christian Hagel, Lars Björn Riecken, Helen Morriso. Ezrin deficiency triggers glial fibrillary acidic protein upregulation and a distinct reactive astrocyte phenotype. Glia. 2022-08-05. PMID:35929192. |
notably, ezrin deletion in astrocytes provoked (gfap) glial fibrillary acidic protein upregulation - a marker of astrocyte activation and reactive astrogliosis. |
2022-08-05 |
2023-08-14 |
mouse |
| Asami Ikeda, Chiharu Yamasaki, Yurina Kubo, Yudai Doi, Mayu Komamizu, Masaharu Komatsu, Kazuhiro Shiozak. Alteration of the neuronal and glial cell profiles in Neu1-deficient zebrafish. Glycoconjugate journal. 2022-07-25. PMID:35877057. |
additionally, neu1-ko zebrafish induced the hyperactivation of astrocytes accompanied by an increase in gfap and phosphorylated erk levels, while the mrna levels of astrocyte glutamate transporters (eaat1a, eaat1c, and eaat2) were downregulated. |
2022-07-25 |
2023-08-14 |
zebrafish |